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Apelin-13 and Epilepsy

Yıl 2023, Cilt: 5 Sayı: 2, 82 - 88, 31.12.2023

Fatma Banu Ayçık Erdal Agar

Öz

Apelin, a neuropeptide, is a typical endogenous ligand of G protein-coupled apelin receptor, APJ. Apelin mRNAs, proteins and APJ are commonly found in peripheral tissues and the central nervous system (CNS). Thus apelin-APJ system may be related to many physiological and pathological processes such as epilepsy. Epilepsy is severe chronic neurological disease and affects millions of people worldwide. Disruption of the balance between excitation and inhibition can cause epilepsy. There are few studies about apelin and epilepsy interactions. Clarifying the effect of apelin on epilepsy will be important for the development of treatment.

Anahtar Kelimeler

Apelin-13 APJ Neuroprotection Epilepsy

Kaynakça

  • Chen B, Wu J, Hu S, Liu Q, Yang H, You Y. (2023). Apelin-13 Improves Cognitive Impairment and Repairs Hippocampal Neuronal Damage by Activating PGC-1α/PPARγ Signaling. Neurochem Res. 48(5):1504-1515.
  • Choe W, Albright A, Sulcove J, Jaffer S, Hesselgesser J, Lavi E, et al. (2000). Functional expression of the seven-transmembrane HIV-1 co-receptor APJ in neural cells. J Neurovirol, 6: 61-S9.
  • Cook DR, Gleichman AJ, Cross SA, Doshi S, Ho W, Jordan-Sciutto KL, Lynch DR, Kolson DL. (2011). NMDA receptor modulation by the neuropeptide apelin: implications for excitotoxic injury. J Neurochem. Sep;118(6):1113-23.
  • Deiva K, Geeraerts T, Salim H, Leclerc P, Héry C, Hugel B, Freyssinet JM, Tardieu M. (2004). Fractalkine reduces N-methyl-d-aspartate-induced calcium flux and apoptosis in human neurons through extracellular signal-regulated kinase activation. Eur J Neurosci. Dec;20(12):3222-3232.
  • Dingledine R, Varvel NH, Dudek FE (2014) When and how do seizures kill neurons, and is cell death relevant to epileptogenesis? Adv Exp Med Biol 813:109–122.
  • Dong H, Dong B, Zhang N, Liu S & Zhao H, microRNA-182 Negatively Influences the Neuroprotective Effect of Apelin Against Neuronal Injury in Epilepsy. Neuropsychiatr Dis Treat. 16 (2020) 327-338.
  • Dong H, Dong B, Zhang N, Liu S, Zhao H. (2020). microRNA-182 Negatively Influences the Neuroprotective Effect of Apelin Against Neuronal Injury in Epilepsy. Neuropsychiatr Dis Treat. Jan 30;16:327-338.
  • Haghparast, E., Esmaeili-Mahani, S., Abbasnejad, M., and Sheibani, V. (2018). Apelin-13 ameliorates cognitive impairments in 6-hydroxydopamine-induced substantia nigra lesion in rats. Neuropeptides 68, 28–35.
  • Han, R.-w., Xu, H.-j., Zhang, R.-s., and Wang, R. (2014). The role of apelin-13 in novel object recognition memory. Peptides 62, 155–158. doi: 10.1016/j.peptides.2014.10.003.
  • Hosoya M, Kawamata Y, Fukusumi S, Fujii R, Habata Y, Hinuma S, et al. (2000). Molecular and functional characteristics of APJ Tissue distribution of mRNA and interaction with the endogenous ligand apelin. Journal of Biological Chemistry.;275(28):21061-7.
  • Ivanov MN, Stoyanov DS, Pavlov SP, Tonchev AB. (2022). Distribution, Function, and Expression of the Apelinergic System in the Healthy and Diseased Mammalian Brain. Genes (Basel). Nov 21;13(11):2172.
  • J.A. Gorter, E.A. van Vliet, E. Aronica, T. Breit, H. Rauwerda, F.H. Lopes da Silva, W.J. Wadman. (2006). Potential new antiepileptogenic targets indicated by microarray analysis in a rat model for temporal lobe epilepsy, J. Neurosci. 26 11083–11110.
  • Kalantaripour, T.P., Esmaeili-Mahani, S., Sheibani, V., Asadi-Shekaari, M., Pasban- Aliabadi, H., (2016). Anticonvulsant and neuroprotective effects of apelin-13 on pentylenetetrazole-induced seizures in male rats. Biomed. Pharmacother. 84, 258–263.
  • Kalantaripour, T.P., Esmaeili-Mahani, S., Sheibani, V., Najafipour, H., Asadi-Shekaari, M. M., (2017). Apelin-13 protects rat primary cortical glia-neuron co-culture against pentylenetetrazole-induced toxicity. Biomed. Pharmacother. 87, 661–668.
  • Lee, D. K., Cheng, R., Nguyen, T., Fan, T., Kariyawasam, A. P., Liu, Y., et al. (2000). Characterization of apelin, the ligand for the APJ receptor. J. Neurochem. 74, 34–41.
  • Li A, Zhao Q, Chen L, Li Z. (2023).Apelin/APJ system: an emerging therapeutic target for neurological diseases. Mol Biol Rep. Feb;50(2):1639-1653.
  • Li, E., Deng, H., Wang, B., Fu, W., You, Y., and Tian, S. (2016). Apelin-13 exerts antidepressant-like and recognitionmemory improving activities in stressed rats. Eur. Neuropsychopharmacol. 26, 420–430. doi: 10.1016/j.euroneuro.2016.01.007
  • Limatola C, Lauro C, Catalano M, Ciotti MT, Bertollini C, Di Angelantonio S, Ragozzino D, Eusebi F. (2005). Chemokine CX3CL1 protects rat hippocampal neurons against glutamate-mediated excitotoxicity. J Neuroimmunol.; 166:19–28.
  • Lv SY, Chen WD, Wang YD (2020). The apelin/APJ system in psychosis and neuropathy. Front Pharmacol 11:320.
  • Lv SY, Qin YJ, Wang HT, Xu N, Yang YJ, Chen Q. (2012). Centrally administered apelin-13 induces depression-like behavior in mice. Brain Res Bull. Sep 1;88(6):574-80.
  • Lv SY, Yang YJ, Qin YJ, Xiong W, Chen Q. (2011). Effect of centrally administered apelin-13 on gastric emptying and gastrointestinal transit in mice. Peptides.;32(5):978-82.
  • Lv, S., Zhang, X., Zhou, Y., Feng, Y., Yang, Y., Wang, X., (2020). Intrathecally administered apelin-13 alleviated complete Freund’s adjuvant-induced inflammatory pain in mice. Front. Pharmacol. 11, 1335.
  • M.G. De Simoni, C. Perego, T. Ravizza, D. Moneta, M. Conti, F. Marchesi, A. De Luigi, S. Garattini, A. Vezzani. (2000). Inflammatory cytokines and related genes are induced in the rat hippocampus by limbic status epilepticus, Eur. J. Neurosci.12 2623–2633.
  • Masri B, Morin N, Cornu M, Knibiehler B, Audigier Y. Apelin (65-77) activates p70 S6 kinase and is mitogenic for umbilical endothelial cells. (2004). FASEB J. Dec;18(15):1909-11.
  • Medhurst, A. D., Jennings, C. A., Robbins, M. J., Davis, R. P., Ellis, C., Winborn, K. Y., et al. (2003). Pharmacological and immunohistochemical characterization of the APJ receptor and its endogenous ligand apelin. J. Neurochem. 84, 1162–1172.
  • Meral C, Cekmez F, Vurucu S, Tascılar E, Pirgon O, Canpolat FE, Ipcioglu OM, Aydemir G, Aydınoz S. (2011). New adipocytokines (vaspin, apelin, visfatin, adiponectin) levels in children treated with valproic acid. Eur Cytokine Netw. Jun;22(2):118-22.
  • Meucci O, Fatatis A, Simen AA, Miller RJ. (2000). Expression of CX3CR1 chemokine receptors on neurons and their role in neuronal survival. Proc Natl Acad Sci U S A. Jul 5;97(14):8075-80.
  • N. Xu, H. Wang, L. Fan, Q. Chen. (2009). Supraspinal administration of apelin-13 induces antinociception via the opioid receptor in mice, Peptides 30 (6) 1153–1157.
  • N.P. Turrin, S. Rivest, Innate immune reaction in response to seizures: implications for the neuropathology associated with epilepsy. (2004). Neurobiol. Dis.16 321–324.
  • O'Donnell LA, Agrawal A, Sabnekar P, Dichter MA, Lynch DR, Kolson DL. (2007). Apelin, an endogenous neuronal peptide, protects hippocampal neurons against excitotoxic injury. J Neurochem. Sep;102(6).
  • O'Dowd BF, Heiber M, Chan A, Heng HH, Tsui LC, Kennedy JL, Shi X, Petronis A, George SR, Nguyen T. (1993). A human gene that shows identity with the gene encoding the angiotensin receptor is located on chromosome 11. Gene. Dec 22;136(1-2):355-360.
  • S.Y. Lv, Y.J. Qin, N.B. Wang, Y.J. Yang, Q. Chen. (2012). Supraspinal antinociceptive effect of apelin-13 in a mouse visceral pain model, Peptides 37 (1) 165–170.
  • Şen FB, Ucar D, Ayyıldız M, Ağar E. (2016) Role of Cannabinoid CB1 Receptor in Proconvulsant Effect of Apelin-13 on Penicillin-induced Epileptiform Activity, Poster Communications. Acta Physiol, 218 , pp.83-83
  • Sen FB. (2016). The role of cannabinoid CB1 receptor in the proconvulsant effect of apelin-13 on penicillin-induced epileptiform activity. Ondokuz Mayıs University Institute of Graduate Studies, Samsun, Master thesis.
  • T. Ravizza, A. Vezzani. (2006). Status epilepticus induces time-dependent neuronal and astrocytic expression of interleukin-1 receptor type I in the rat limbic system, Neuroscience, 137 301–308.
  • Taiwo RO, Sandouka S, Saadi A, Kovac S, Shekh-Ahmad T. (2023). Sestrin 3 promotes oxidative stress primarily in neurons following epileptic seizures in rats. Neuropharmacology. Nov 1;238:109670.
  • Tian Y, Chen R, Jiang Y, Bai B, Yang T, Liu H. (2020). The Protective Effects and Mechanisms of Apelin/APJ System on Ischemic Stroke: A Promising Therapeutic Target. Front Neurol. 3;11:75.
  • Ucar D. (2015). The Effect of Apelin-13 on Penicillin-Induced Epileptiform Activity in Rats, Poster Communications. Acta Physiol, PC041, 215 32-109.
  • Uçar D. (2015). The effect of apelin on penicillin-induced epileptiform activity and the role of t-type calcium channels. Ondokuz Mayıs University Faculty of Medicine, Samsun, Dissertation.
  • Vezzani A, Balosso S, Ravizza T. (2008). The role of cytokines in the pathophysiology of epilepsy. Brain Behav Immun. Aug;22(6):797-803.
  • Xie H, Yuan LQ, Luo XH, Huang J, Cui RR, Guo LJ, Zhou HD, Wu XP, Liao EY. (2007). Apelin suppresses apoptosis of human osteoblasts. Apoptosis. Jan;12(1):247-54.
  • Xu N, Wang H, Fan L, Chen Q. (2009). Supraspinal administration of apelin-13 induces antinociception via the opioid receptor in mice. Peptides.;30(6):1153-7.
  • Yao H, Peng F, Dhillon N, Callen S, Bokhari S, Stehno-Bittel L, Ahmad SO, Wang JQ, Buch S. (2009). Involvement of TRPC channels in CCL2-mediated neuroprotection against tat toxicity. J Neurosci.; 29:1657–1669.
  • Yu H, Shao M, Luo X, Pang C, So KF, Yu J, Zhang L. (2024). Treadmill exercise improves hippocampal neural plasticity and relieves cognitive deficits in a mouse model of epilepsy. Neural Regen Res. Mar;19(3):657-662.
  • Zeng XJ, Yu SP, Zhang L, Wei L. (2010). Neuroprotective effect of the endogenous neural peptide apelin in cultured mouse cortical neurons. Exp Cell Res. Jul 1;316(11):1773-83.
  • Zeng, X.J., Zhang, L.K., Wang, H.X., Lu, L.Q., Ma, L.Q., Tang, C.S. (2009). Apelin protects heart against ischemia/reperfusion injury in rat. Peptides 30, 1144–1152.
  • Zhang X, Gu Y, Ma Y, Wu J, Chen Y, Tao K, Sun H, Liu Z, Wang X, Tian X. (2023). The Apelin/APJ system modulates seizure activity and endocytosis of the NMDA receptor GluN2B subunit. Neurochem Int. Jul;167:105545.
  • Zhang X, Peng X, Fang M, et al. (2011). Up-regulation of apelin in brain tissue of patients with epilepsy and an epileptic rat model. Peptides.;32(9):1793–1799.
  • Zhang X, Peng X, Fang M, Zhou C, Zhao F, Zhang Y, Xu Y, Zhu Q, Luo J, Chen G, Wang X. (2011). Up-regulation of apelin in brain tissue of patients with epilepsy and an epileptic rat model. Peptides. 32(9):1793-9.
  • Zhang Y, Jiang W, Sun W, Guo W, Xia B, Shen X, Fu M, Wan T, Yuan M. (2023). Neuroprotective Roles of Apelin-13 in Neurological Diseases. Neurochem Res. Jun;48(6):1648-1662. doi: 10.1007/s11064-023-03869-0. Epub 2023 Feb 6. PMID: 36745269.
  • Zhou, J.X., Shuai, N.N., Wang, B., Jin, X., Kuang, X., Tian, S.W. (2021). Neuroprotective gain of Apelin/APJ system. Neuropeptides 87, 102131.

Apelin-13 ve Epilepsi

Yıl 2023, Cilt: 5 Sayı: 2, 82 - 88, 31.12.2023

Fatma Banu Ayçık Erdal Agar

Öz

Bir nöropeptid olan Apelin, G proteinine bağlı olan apelin reseptörü APJ'nin tipik bir endojen ligandıdır. Apelin mRNA'sı, proteinleri ve APJ periferik dokularda ve merkezi sinir sisteminde (MSS) yaygın olarak bulunur. Apelin-APJ sistemi epilepsi gibi birçok fizyolojik ve patolojik süreçlere dahil olabilir. Epilepsi ciddi kronik bir nörolojik hastalıktır ve dünya çapında milyonlarca insanı etkilemektedir. Eksitasyon ve inhibisyon arasındaki dengenin bozulması epilepsiye neden olabilir. Apelin ve epilepsi arasındaki ilişkiyi inceleyen az sayıda çalışma bulunmaktadır. Apelinin epilepsi üzerindeki etkisinin aydınlatılması tedavinin geliştirilmesi açısından önemli olacaktır.

Anahtar Kelimeler

Apelin-13 APJ Neuroproteksiyon Epilepsi

Kaynakça

  • Chen B, Wu J, Hu S, Liu Q, Yang H, You Y. (2023). Apelin-13 Improves Cognitive Impairment and Repairs Hippocampal Neuronal Damage by Activating PGC-1α/PPARγ Signaling. Neurochem Res. 48(5):1504-1515.
  • Choe W, Albright A, Sulcove J, Jaffer S, Hesselgesser J, Lavi E, et al. (2000). Functional expression of the seven-transmembrane HIV-1 co-receptor APJ in neural cells. J Neurovirol, 6: 61-S9.
  • Cook DR, Gleichman AJ, Cross SA, Doshi S, Ho W, Jordan-Sciutto KL, Lynch DR, Kolson DL. (2011). NMDA receptor modulation by the neuropeptide apelin: implications for excitotoxic injury. J Neurochem. Sep;118(6):1113-23.
  • Deiva K, Geeraerts T, Salim H, Leclerc P, Héry C, Hugel B, Freyssinet JM, Tardieu M. (2004). Fractalkine reduces N-methyl-d-aspartate-induced calcium flux and apoptosis in human neurons through extracellular signal-regulated kinase activation. Eur J Neurosci. Dec;20(12):3222-3232.
  • Dingledine R, Varvel NH, Dudek FE (2014) When and how do seizures kill neurons, and is cell death relevant to epileptogenesis? Adv Exp Med Biol 813:109–122.
  • Dong H, Dong B, Zhang N, Liu S & Zhao H, microRNA-182 Negatively Influences the Neuroprotective Effect of Apelin Against Neuronal Injury in Epilepsy. Neuropsychiatr Dis Treat. 16 (2020) 327-338.
  • Dong H, Dong B, Zhang N, Liu S, Zhao H. (2020). microRNA-182 Negatively Influences the Neuroprotective Effect of Apelin Against Neuronal Injury in Epilepsy. Neuropsychiatr Dis Treat. Jan 30;16:327-338.
  • Haghparast, E., Esmaeili-Mahani, S., Abbasnejad, M., and Sheibani, V. (2018). Apelin-13 ameliorates cognitive impairments in 6-hydroxydopamine-induced substantia nigra lesion in rats. Neuropeptides 68, 28–35.
  • Han, R.-w., Xu, H.-j., Zhang, R.-s., and Wang, R. (2014). The role of apelin-13 in novel object recognition memory. Peptides 62, 155–158. doi: 10.1016/j.peptides.2014.10.003.
  • Hosoya M, Kawamata Y, Fukusumi S, Fujii R, Habata Y, Hinuma S, et al. (2000). Molecular and functional characteristics of APJ Tissue distribution of mRNA and interaction with the endogenous ligand apelin. Journal of Biological Chemistry.;275(28):21061-7.
  • Ivanov MN, Stoyanov DS, Pavlov SP, Tonchev AB. (2022). Distribution, Function, and Expression of the Apelinergic System in the Healthy and Diseased Mammalian Brain. Genes (Basel). Nov 21;13(11):2172.
  • J.A. Gorter, E.A. van Vliet, E. Aronica, T. Breit, H. Rauwerda, F.H. Lopes da Silva, W.J. Wadman. (2006). Potential new antiepileptogenic targets indicated by microarray analysis in a rat model for temporal lobe epilepsy, J. Neurosci. 26 11083–11110.
  • Kalantaripour, T.P., Esmaeili-Mahani, S., Sheibani, V., Asadi-Shekaari, M., Pasban- Aliabadi, H., (2016). Anticonvulsant and neuroprotective effects of apelin-13 on pentylenetetrazole-induced seizures in male rats. Biomed. Pharmacother. 84, 258–263.
  • Kalantaripour, T.P., Esmaeili-Mahani, S., Sheibani, V., Najafipour, H., Asadi-Shekaari, M. M., (2017). Apelin-13 protects rat primary cortical glia-neuron co-culture against pentylenetetrazole-induced toxicity. Biomed. Pharmacother. 87, 661–668.
  • Lee, D. K., Cheng, R., Nguyen, T., Fan, T., Kariyawasam, A. P., Liu, Y., et al. (2000). Characterization of apelin, the ligand for the APJ receptor. J. Neurochem. 74, 34–41.
  • Li A, Zhao Q, Chen L, Li Z. (2023).Apelin/APJ system: an emerging therapeutic target for neurological diseases. Mol Biol Rep. Feb;50(2):1639-1653.
  • Li, E., Deng, H., Wang, B., Fu, W., You, Y., and Tian, S. (2016). Apelin-13 exerts antidepressant-like and recognitionmemory improving activities in stressed rats. Eur. Neuropsychopharmacol. 26, 420–430. doi: 10.1016/j.euroneuro.2016.01.007
  • Limatola C, Lauro C, Catalano M, Ciotti MT, Bertollini C, Di Angelantonio S, Ragozzino D, Eusebi F. (2005). Chemokine CX3CL1 protects rat hippocampal neurons against glutamate-mediated excitotoxicity. J Neuroimmunol.; 166:19–28.
  • Lv SY, Chen WD, Wang YD (2020). The apelin/APJ system in psychosis and neuropathy. Front Pharmacol 11:320.
  • Lv SY, Qin YJ, Wang HT, Xu N, Yang YJ, Chen Q. (2012). Centrally administered apelin-13 induces depression-like behavior in mice. Brain Res Bull. Sep 1;88(6):574-80.
  • Lv SY, Yang YJ, Qin YJ, Xiong W, Chen Q. (2011). Effect of centrally administered apelin-13 on gastric emptying and gastrointestinal transit in mice. Peptides.;32(5):978-82.
  • Lv, S., Zhang, X., Zhou, Y., Feng, Y., Yang, Y., Wang, X., (2020). Intrathecally administered apelin-13 alleviated complete Freund’s adjuvant-induced inflammatory pain in mice. Front. Pharmacol. 11, 1335.
  • M.G. De Simoni, C. Perego, T. Ravizza, D. Moneta, M. Conti, F. Marchesi, A. De Luigi, S. Garattini, A. Vezzani. (2000). Inflammatory cytokines and related genes are induced in the rat hippocampus by limbic status epilepticus, Eur. J. Neurosci.12 2623–2633.
  • Masri B, Morin N, Cornu M, Knibiehler B, Audigier Y. Apelin (65-77) activates p70 S6 kinase and is mitogenic for umbilical endothelial cells. (2004). FASEB J. Dec;18(15):1909-11.
  • Medhurst, A. D., Jennings, C. A., Robbins, M. J., Davis, R. P., Ellis, C., Winborn, K. Y., et al. (2003). Pharmacological and immunohistochemical characterization of the APJ receptor and its endogenous ligand apelin. J. Neurochem. 84, 1162–1172.
  • Meral C, Cekmez F, Vurucu S, Tascılar E, Pirgon O, Canpolat FE, Ipcioglu OM, Aydemir G, Aydınoz S. (2011). New adipocytokines (vaspin, apelin, visfatin, adiponectin) levels in children treated with valproic acid. Eur Cytokine Netw. Jun;22(2):118-22.
  • Meucci O, Fatatis A, Simen AA, Miller RJ. (2000). Expression of CX3CR1 chemokine receptors on neurons and their role in neuronal survival. Proc Natl Acad Sci U S A. Jul 5;97(14):8075-80.
  • N. Xu, H. Wang, L. Fan, Q. Chen. (2009). Supraspinal administration of apelin-13 induces antinociception via the opioid receptor in mice, Peptides 30 (6) 1153–1157.
  • N.P. Turrin, S. Rivest, Innate immune reaction in response to seizures: implications for the neuropathology associated with epilepsy. (2004). Neurobiol. Dis.16 321–324.
  • O'Donnell LA, Agrawal A, Sabnekar P, Dichter MA, Lynch DR, Kolson DL. (2007). Apelin, an endogenous neuronal peptide, protects hippocampal neurons against excitotoxic injury. J Neurochem. Sep;102(6).
  • O'Dowd BF, Heiber M, Chan A, Heng HH, Tsui LC, Kennedy JL, Shi X, Petronis A, George SR, Nguyen T. (1993). A human gene that shows identity with the gene encoding the angiotensin receptor is located on chromosome 11. Gene. Dec 22;136(1-2):355-360.
  • S.Y. Lv, Y.J. Qin, N.B. Wang, Y.J. Yang, Q. Chen. (2012). Supraspinal antinociceptive effect of apelin-13 in a mouse visceral pain model, Peptides 37 (1) 165–170.
  • Şen FB, Ucar D, Ayyıldız M, Ağar E. (2016) Role of Cannabinoid CB1 Receptor in Proconvulsant Effect of Apelin-13 on Penicillin-induced Epileptiform Activity, Poster Communications. Acta Physiol, 218 , pp.83-83
  • Sen FB. (2016). The role of cannabinoid CB1 receptor in the proconvulsant effect of apelin-13 on penicillin-induced epileptiform activity. Ondokuz Mayıs University Institute of Graduate Studies, Samsun, Master thesis.
  • T. Ravizza, A. Vezzani. (2006). Status epilepticus induces time-dependent neuronal and astrocytic expression of interleukin-1 receptor type I in the rat limbic system, Neuroscience, 137 301–308.
  • Taiwo RO, Sandouka S, Saadi A, Kovac S, Shekh-Ahmad T. (2023). Sestrin 3 promotes oxidative stress primarily in neurons following epileptic seizures in rats. Neuropharmacology. Nov 1;238:109670.
  • Tian Y, Chen R, Jiang Y, Bai B, Yang T, Liu H. (2020). The Protective Effects and Mechanisms of Apelin/APJ System on Ischemic Stroke: A Promising Therapeutic Target. Front Neurol. 3;11:75.
  • Ucar D. (2015). The Effect of Apelin-13 on Penicillin-Induced Epileptiform Activity in Rats, Poster Communications. Acta Physiol, PC041, 215 32-109.
  • Uçar D. (2015). The effect of apelin on penicillin-induced epileptiform activity and the role of t-type calcium channels. Ondokuz Mayıs University Faculty of Medicine, Samsun, Dissertation.
  • Vezzani A, Balosso S, Ravizza T. (2008). The role of cytokines in the pathophysiology of epilepsy. Brain Behav Immun. Aug;22(6):797-803.
  • Xie H, Yuan LQ, Luo XH, Huang J, Cui RR, Guo LJ, Zhou HD, Wu XP, Liao EY. (2007). Apelin suppresses apoptosis of human osteoblasts. Apoptosis. Jan;12(1):247-54.
  • Xu N, Wang H, Fan L, Chen Q. (2009). Supraspinal administration of apelin-13 induces antinociception via the opioid receptor in mice. Peptides.;30(6):1153-7.
  • Yao H, Peng F, Dhillon N, Callen S, Bokhari S, Stehno-Bittel L, Ahmad SO, Wang JQ, Buch S. (2009). Involvement of TRPC channels in CCL2-mediated neuroprotection against tat toxicity. J Neurosci.; 29:1657–1669.
  • Yu H, Shao M, Luo X, Pang C, So KF, Yu J, Zhang L. (2024). Treadmill exercise improves hippocampal neural plasticity and relieves cognitive deficits in a mouse model of epilepsy. Neural Regen Res. Mar;19(3):657-662.
  • Zeng XJ, Yu SP, Zhang L, Wei L. (2010). Neuroprotective effect of the endogenous neural peptide apelin in cultured mouse cortical neurons. Exp Cell Res. Jul 1;316(11):1773-83.
  • Zeng, X.J., Zhang, L.K., Wang, H.X., Lu, L.Q., Ma, L.Q., Tang, C.S. (2009). Apelin protects heart against ischemia/reperfusion injury in rat. Peptides 30, 1144–1152.
  • Zhang X, Gu Y, Ma Y, Wu J, Chen Y, Tao K, Sun H, Liu Z, Wang X, Tian X. (2023). The Apelin/APJ system modulates seizure activity and endocytosis of the NMDA receptor GluN2B subunit. Neurochem Int. Jul;167:105545.
  • Zhang X, Peng X, Fang M, et al. (2011). Up-regulation of apelin in brain tissue of patients with epilepsy and an epileptic rat model. Peptides.;32(9):1793–1799.
  • Zhang X, Peng X, Fang M, Zhou C, Zhao F, Zhang Y, Xu Y, Zhu Q, Luo J, Chen G, Wang X. (2011). Up-regulation of apelin in brain tissue of patients with epilepsy and an epileptic rat model. Peptides. 32(9):1793-9.
  • Zhang Y, Jiang W, Sun W, Guo W, Xia B, Shen X, Fu M, Wan T, Yuan M. (2023). Neuroprotective Roles of Apelin-13 in Neurological Diseases. Neurochem Res. Jun;48(6):1648-1662. doi: 10.1007/s11064-023-03869-0. Epub 2023 Feb 6. PMID: 36745269.
  • Zhou, J.X., Shuai, N.N., Wang, B., Jin, X., Kuang, X., Tian, S.W. (2021). Neuroprotective gain of Apelin/APJ system. Neuropeptides 87, 102131.
Toplam 51 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Klinik Tıp Bilimleri (Diğer)
Bölüm Derlemeler
Yazarlar

Fatma Banu Ayçık 0000-0002-4529-6795

Erdal Agar 0000-0001-8450-5791

Yayımlanma Tarihi 31 Aralık 2023
Gönderilme Tarihi 16 Ekim 2023
Kabul Tarihi 6 Aralık 2023
Yayımlandığı Sayı Yıl 2023 Cilt: 5 Sayı: 2

Kaynak Göster

APA Ayçık, F. B., & Agar, E. (2023). Apelin-13 and Epilepsy. Doğal Yaşam Tıbbı Dergisi, 5(2), 82-88.
AMA Ayçık FB, Agar E. Apelin-13 and Epilepsy. DYT. Aralık 2023;5(2):82-88.
Chicago Ayçık, Fatma Banu, ve Erdal Agar. “Apelin-13 and Epilepsy”. Doğal Yaşam Tıbbı Dergisi 5, sy. 2 (Aralık 2023): 82-88.
EndNote Ayçık FB, Agar E (01 Aralık 2023) Apelin-13 and Epilepsy. Doğal Yaşam Tıbbı Dergisi 5 2 82–88.
IEEE F. B. Ayçık ve E. Agar, “Apelin-13 and Epilepsy”, DYT, c. 5, sy. 2, ss. 82–88, 2023.
ISNAD Ayçık, Fatma Banu - Agar, Erdal. “Apelin-13 and Epilepsy”. Doğal Yaşam Tıbbı Dergisi 5/2 (Aralık 2023), 82-88.
JAMA Ayçık FB, Agar E. Apelin-13 and Epilepsy. DYT. 2023;5:82–88.
MLA Ayçık, Fatma Banu ve Erdal Agar. “Apelin-13 and Epilepsy”. Doğal Yaşam Tıbbı Dergisi, c. 5, sy. 2, 2023, ss. 82-88.
Vancouver Ayçık FB, Agar E. Apelin-13 and Epilepsy. DYT. 2023;5(2):82-8.
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