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Hiponatreminin Nadir Bir Nedeni: Siklofosfamit

Yıl 2018, Cilt: 4 Sayı: 1, 71 - 74, 26.03.2018

Mehmet Yıldırım Savaş Sipahi Hamad Dheir Ceyhun Varım

Öz

Hiponatremi en sık görülen elektrolit bozukluğu olup hastanede yatan hastaların %10-15’inde görülmektedir. SİAD ise övolemik hiponatreminin sık bir nedenidir ve başta maligniteler ve bazı ilaçlar olmak üzere pek çok faktöre bağlı görülebilir. Bu ilaçlar arasında siklofosfamit oldukça nadir görülen bir ajandır. Bu yazıda siklofosfamit kullanımına ikincil olarak gelişen akut hiponatremi olgusunu sunmayı ve bu nadir nedene dikkat çekmeyi amaçladık.

Anahtar Kelimeler

hiponatremi siad siklofosfamit

Kaynakça

  • 1. Upadhyay A, Jaber BL, Madias NE. Incidence and prevalence of hyponatremia. Am J Med 2006; 119: 30-35.
  • 2. Spasovski G, Vanholder R, Allolio B, Annane D, Ball S, Bichet D, Decaux G, Fenske W, Hoorn EJ, Ichai C, Joannidis M, Soupart A, Zietse R, Haller M, Van der Veer S, Van Biesen V, Nagler E. Clinical practice guideline on diagnosis and treatment of hyponatraemia. Nephrology Dialysis Transplantation 2014; 29 (Supplement 2) 1–39.
  • 3. Singer GG, Brenner BM. Fluid and electrolyte disturbances. In: Fauci AS, Kasper DL, Longo DL, Braunwald E, Hauser SL, Jameson JL, Loscalzo J. Harrison’s Principals of Internal Medicine. 17thed. New York: Mc Graw Hill, 2008: 274-84.
  • 4. Schwartz WB, Bennett W, Curelop S, Bartter FC: A syndrome of renalsodium loss and hyponatremia probably resulting from inappropriate secretion of antidiuretic hormone. Am J Med 1957; 23: 529–542.
  • 5. Esposito P, Piotti G, Bianzina S, Malul Y, Dal Canton A. The Syndrome of Inappropriate Antidiuresis: Pathophysiology, Clinical Management and New Therapeutic Options. Nephron Clin Pract. 2011; 119(1): 62-73
  • 6. HİPOFİZ HASTALIKLARI TANI, TEDAVİ ve İZLEM KILAVUZU Türkiye Endokrinoloji ve Metabolizma Derneği, 2017; 109-110
  • 7. Pelosof LC and Gerber DE. Paraneoplastic Syndromes: An Approach to Diagnosis and Treatment Mayo Clin Proc. 2010; 85(9): 838–854.
  • 8. Dimitriadis GK, Angelousi A, Weickert MO, Randeva HS, Kaltsas G, Grossman A . Paraneoplastic endocrine syndromes. Endocr Relat Cancer. 2017; 24(6):173-190
  • 9. Erkurt MA, Kuku İ, Kaya E, Aydoğdu İ. Kanser Kemoterapisi ve Böbrek. İnönü Üniversitesi Tıp Fakültesi Dergisi 2009; 16(1). 63-68
  • 10. Esposito P, Domenech MV, Serpieri N, Calatroni M, Massa I, Avella A, La Porta E, Estienne L, Caramella E, Rampino T. Severe cyclophosphamiderelated hyponatremia in a patient with acute glomerulonephritis. World J Nephrol. 2017; 6(4): 217–220.
  • 11. Moses AM, Miller M. Drug-induced dilutional hyponatremia. N Engl J Med. 1974 Dec 5; 291(23): 1234-1239.
  • 12. Baker M, Markman M, Niu J. Cyclophosphamide-Induced Severe Acute Hyponatremic Encephalopathy in Patients with Breast Cancer: Report of Two Cases 2014; 7(2): 550–554.
  • 13. Bruining DM, van Roon EN, de Graaf H, Hoogendoorn M. Cyclophosphamide- induced symptomatic hyponatraemia. Neth J Med. 2011; 69(4): 192-195
  • 14. Park S, Kim W, Choi HY, Yoon JH, Ha SK, Park H. Severe Symptomatic Hyponatremia Caused by Low Dose Oral Cyclophosphamide: A Case Report. The Korean Journal of Nephrology 2011; 30: 647-650
  • 15. Elazzazy S, Mohamed AE, Gulied A. Cyclophosphamide-induced symptomatic hyponatremia, a rare but severe side effect: a case report.Onco Targets Ther. 2014; 7: 1641–1645.
  • 16. Geng C, Tang P, Zhang Y, Gao W. Hyponatremia induced by lowdose cyclophosphamide in two patients with breast cancer. Breast J. 2014;20(4): 442-443.
  • 17. Lazarevic V, Hägg E, Wahlin A. Hiccups and severe hyponatremia associated with high-dose cyclophosphamide in conditioningregimen for allogeneic stem cell transplantation. Am J Hematol. 2007; 82(1):88

A Rare Cause Of Hyponatremia: Cyclophosphamide Hiponatreminin

Yıl 2018, Cilt: 4 Sayı: 1, 71 - 74, 26.03.2018

Mehmet Yıldırım Savaş Sipahi Hamad Dheir Ceyhun Varım

Öz

Hyponatremia is the most common electrolyte disorder and occurs in %10-15 of hospitalized patient. SIADH is a frequent cause of normovolemic hyponatremia and mostly induced by malignancy and many drugs. Cyclophosphamide is a rare agent among this drugs. In this article, we aimed to report the case of acut hyponatremia due to cyclophosphamide and point to this rare cause.

Anahtar Kelimeler

hyponatemia SIADH cyclophosphamide

Kaynakça

  • 1. Upadhyay A, Jaber BL, Madias NE. Incidence and prevalence of hyponatremia. Am J Med 2006; 119: 30-35.
  • 2. Spasovski G, Vanholder R, Allolio B, Annane D, Ball S, Bichet D, Decaux G, Fenske W, Hoorn EJ, Ichai C, Joannidis M, Soupart A, Zietse R, Haller M, Van der Veer S, Van Biesen V, Nagler E. Clinical practice guideline on diagnosis and treatment of hyponatraemia. Nephrology Dialysis Transplantation 2014; 29 (Supplement 2) 1–39.
  • 3. Singer GG, Brenner BM. Fluid and electrolyte disturbances. In: Fauci AS, Kasper DL, Longo DL, Braunwald E, Hauser SL, Jameson JL, Loscalzo J. Harrison’s Principals of Internal Medicine. 17thed. New York: Mc Graw Hill, 2008: 274-84.
  • 4. Schwartz WB, Bennett W, Curelop S, Bartter FC: A syndrome of renalsodium loss and hyponatremia probably resulting from inappropriate secretion of antidiuretic hormone. Am J Med 1957; 23: 529–542.
  • 5. Esposito P, Piotti G, Bianzina S, Malul Y, Dal Canton A. The Syndrome of Inappropriate Antidiuresis: Pathophysiology, Clinical Management and New Therapeutic Options. Nephron Clin Pract. 2011; 119(1): 62-73
  • 6. HİPOFİZ HASTALIKLARI TANI, TEDAVİ ve İZLEM KILAVUZU Türkiye Endokrinoloji ve Metabolizma Derneği, 2017; 109-110
  • 7. Pelosof LC and Gerber DE. Paraneoplastic Syndromes: An Approach to Diagnosis and Treatment Mayo Clin Proc. 2010; 85(9): 838–854.
  • 8. Dimitriadis GK, Angelousi A, Weickert MO, Randeva HS, Kaltsas G, Grossman A . Paraneoplastic endocrine syndromes. Endocr Relat Cancer. 2017; 24(6):173-190
  • 9. Erkurt MA, Kuku İ, Kaya E, Aydoğdu İ. Kanser Kemoterapisi ve Böbrek. İnönü Üniversitesi Tıp Fakültesi Dergisi 2009; 16(1). 63-68
  • 10. Esposito P, Domenech MV, Serpieri N, Calatroni M, Massa I, Avella A, La Porta E, Estienne L, Caramella E, Rampino T. Severe cyclophosphamiderelated hyponatremia in a patient with acute glomerulonephritis. World J Nephrol. 2017; 6(4): 217–220.
  • 11. Moses AM, Miller M. Drug-induced dilutional hyponatremia. N Engl J Med. 1974 Dec 5; 291(23): 1234-1239.
  • 12. Baker M, Markman M, Niu J. Cyclophosphamide-Induced Severe Acute Hyponatremic Encephalopathy in Patients with Breast Cancer: Report of Two Cases 2014; 7(2): 550–554.
  • 13. Bruining DM, van Roon EN, de Graaf H, Hoogendoorn M. Cyclophosphamide- induced symptomatic hyponatraemia. Neth J Med. 2011; 69(4): 192-195
  • 14. Park S, Kim W, Choi HY, Yoon JH, Ha SK, Park H. Severe Symptomatic Hyponatremia Caused by Low Dose Oral Cyclophosphamide: A Case Report. The Korean Journal of Nephrology 2011; 30: 647-650
  • 15. Elazzazy S, Mohamed AE, Gulied A. Cyclophosphamide-induced symptomatic hyponatremia, a rare but severe side effect: a case report.Onco Targets Ther. 2014; 7: 1641–1645.
  • 16. Geng C, Tang P, Zhang Y, Gao W. Hyponatremia induced by lowdose cyclophosphamide in two patients with breast cancer. Breast J. 2014;20(4): 442-443.
  • 17. Lazarevic V, Hägg E, Wahlin A. Hiccups and severe hyponatremia associated with high-dose cyclophosphamide in conditioningregimen for allogeneic stem cell transplantation. Am J Hematol. 2007; 82(1):88
Toplam 17 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Sağlık Kurumları Yönetimi
Bölüm Olgu Sunumu
Yazarlar

Mehmet Yıldırım

Savaş Sipahi Bu kişi benim

Hamad Dheir Bu kişi benim

Ceyhun Varım Bu kişi benim

Yayımlanma Tarihi 26 Mart 2018
Gönderilme Tarihi 15 Şubat 2018
Kabul Tarihi 14 Mart 2018
Yayımlandığı Sayı Yıl 2018 Cilt: 4 Sayı: 1

Kaynak Göster

APA Yıldırım, M., Sipahi, S., Dheir, H., Varım, C. (2018). A Rare Cause Of Hyponatremia: Cyclophosphamide Hiponatreminin. Journal of Human Rhythm, 4(1), 71-74.
AMA Yıldırım M, Sipahi S, Dheir H, Varım C. A Rare Cause Of Hyponatremia: Cyclophosphamide Hiponatreminin. Journal of Human Rhythm. Mart 2018;4(1):71-74.
Chicago Yıldırım, Mehmet, Savaş Sipahi, Hamad Dheir, ve Ceyhun Varım. “A Rare Cause Of Hyponatremia: Cyclophosphamide Hiponatreminin”. Journal of Human Rhythm 4, sy. 1 (Mart 2018): 71-74.
EndNote Yıldırım M, Sipahi S, Dheir H, Varım C (01 Mart 2018) A Rare Cause Of Hyponatremia: Cyclophosphamide Hiponatreminin. Journal of Human Rhythm 4 1 71–74.
IEEE M. Yıldırım, S. Sipahi, H. Dheir, ve C. Varım, “A Rare Cause Of Hyponatremia: Cyclophosphamide Hiponatreminin”, Journal of Human Rhythm, c. 4, sy. 1, ss. 71–74, 2018.
ISNAD Yıldırım, Mehmet vd. “A Rare Cause Of Hyponatremia: Cyclophosphamide Hiponatreminin”. Journal of Human Rhythm 4/1 (Mart 2018), 71-74.
JAMA Yıldırım M, Sipahi S, Dheir H, Varım C. A Rare Cause Of Hyponatremia: Cyclophosphamide Hiponatreminin. Journal of Human Rhythm. 2018;4:71–74.
MLA Yıldırım, Mehmet vd. “A Rare Cause Of Hyponatremia: Cyclophosphamide Hiponatreminin”. Journal of Human Rhythm, c. 4, sy. 1, 2018, ss. 71-74.
Vancouver Yıldırım M, Sipahi S, Dheir H, Varım C. A Rare Cause Of Hyponatremia: Cyclophosphamide Hiponatreminin. Journal of Human Rhythm. 2018;4(1):71-4.