Öz
Granüler hücreli tümör (GHT), nadir görülen mezenkimal bir neoplazmdır. Çoğunlukla baş-boyun bölgesinde özellikle de dilde yerleşim göstermekte olup nadiren rekürrens gösterir. Bu çalışmada 6 ay içerisinde nüks eden bir GHT olgusu sunduk. 53 yaşında erkek hastada sırtta yavaş büyüyen kitle GHT olarak rapor edilmiş olup tümörde pleomorfizim, mitoz, nekroz ve atipi mevcut değildi. Olgunun 6 aylık takibinde lezyon nüks etmiş ve tekrar eksize edilmiştir. Nüks lezyon eskisi ile aynı özelliklere sahipti ancak daha düzensiz sınırlı, etraf dokuya infiltratif görünümde ve yüksek Ki- 67 oranına (%10) sahipti. Belirsiz davranışlı kabul edilen olgumuzun 3 yıllık takiplerinde lokal-uzak yayılım saptanmadı. GHT genellikle benign gidişli stromal bir tümör olmakla beraber öngörülemeyen agresiv davranma potansiyeli nedeniyle tüm olgular takip altında tutulmalıdır.
Anahtar Kelimeler
Destekleyen Kurum
-
Proje Numarası
-
Teşekkür
-
Kaynakça
- Abrikossoff A. Ueber myome auseeheng von der quergestreifien willkurlich muskulatur. Virchows Arch Pathhol Anat 1926; 260: 215-33.
- Cui Y, Tong SS, Zhang YH, et al. Granular cell tumor: A report of three cases and review of literature. Cancer Biomark 2018; 23: 173-8.
- Moten AS, Movva S, von Mehren M, et al. Granular cell tumor experience at a comprehensive cancer center. J Surg Res 2018; 226: 1-7.
- Gross VL, Lynfield Y. Multiple cutaneous granular cell tumors: a case report and review of the literature. Cutis 2002; 69: 343-6.
- Levavi H, Sabah G, Kaplan B, et al. Granular cell tumor of the vulva: six new cases Arch Gynecol Obstet 2006; 273: 246-9.
- Machado I, Cruz J, Lavernia J, et al.Solitary, multiple, benign, atypical, or malignant: the "Granular Cell Tumor" puzzle. Virchows Arch 2016; 468: 527-38.
- Janouskova G, Campr V, Konkolova R, et al. Multiple granular cell tumour. J Eur Acad Dermatol Venereol, 2004; 18: 347-9.
- Wang HX, Zhang LZ, Jin YL, e al. Female vulva granular cell tumor: report of a relapse case. Zhonghua Bing Li Xue Za Zhi 2019; 8; 48: 330-1.
- Corso G, Di Nubila B, Ciccia A, et al. Granular cell tumor of the breast: Molecular pathology and clinical management. Breast J 2018; 24: 778-82.
- 10.Ravich A, Stout AP, Ravich RA. Malignant granular cell myoblastoma involving the urinary bladder. Ann Surg 1945, 121: 361-72. .
- Miracco C, Andreassi A, Laurini L, et al. Granular cell tumour with histological signs of malignancy: report of a case and comparison with 10 benign and 4 atypical cases. Br J Dermatol 1999; 141: 573-5.
- Pérez-González YC, Pagura L, Llamas-Velasco M, et al. Primary cutaneous malignant granular cell tumor: an immunohistochemical study and review of the literature. Am J Dermatopathol 2015; 37: 334-40.
- Akahane K, Kato K, Ogiso S, et al. Malignant granular cell tumor of the breast: case report and literature review. Breast Cancer 2015; 22: 317-23.
- Fanburg-Smith JC, Meis-Kindblom JM, Fante R, et al. Malignant granular cell tumor of soft tissue: diagnostic criteria and clinicopathologic correlation. Am J Surg Pathol 1998; 22: 779-94.
Öz
Granular cell tumour (GHT) is a rare mesenchymal neoplasm. It is mostly located in the head and neck region, especially in the tongue, and it rarely recurs. In this study, we present a case of GHT recurring within 6 months. A slow-growing mass on the back in a 53-year-old male patient was reported as GHT, and the tumour did not have pleomorphism, mitosis, necrosis or atypia. During the 6-month follow-up of the case, the lesion recurred and was excised again. The recurrent lesion had the same features as before, but with a more irregular border, infiltrative appearance to surrounding tissue, and a high Ki-67 ratio (10%). No local-distant spread was detected in the 3-year follow-up of our case, which was considered to have uncertain behaviour. Although GHT is generally a benign stromal tumour, all cases should be followed up because of its unpredictable potential for aggressive behaviour.
Anahtar Kelimeler
Proje Numarası
-
Kaynakça
- Abrikossoff A. Ueber myome auseeheng von der quergestreifien willkurlich muskulatur. Virchows Arch Pathhol Anat 1926; 260: 215-33.
- Cui Y, Tong SS, Zhang YH, et al. Granular cell tumor: A report of three cases and review of literature. Cancer Biomark 2018; 23: 173-8.
- Moten AS, Movva S, von Mehren M, et al. Granular cell tumor experience at a comprehensive cancer center. J Surg Res 2018; 226: 1-7.
- Gross VL, Lynfield Y. Multiple cutaneous granular cell tumors: a case report and review of the literature. Cutis 2002; 69: 343-6.
- Levavi H, Sabah G, Kaplan B, et al. Granular cell tumor of the vulva: six new cases Arch Gynecol Obstet 2006; 273: 246-9.
- Machado I, Cruz J, Lavernia J, et al.Solitary, multiple, benign, atypical, or malignant: the "Granular Cell Tumor" puzzle. Virchows Arch 2016; 468: 527-38.
- Janouskova G, Campr V, Konkolova R, et al. Multiple granular cell tumour. J Eur Acad Dermatol Venereol, 2004; 18: 347-9.
- Wang HX, Zhang LZ, Jin YL, e al. Female vulva granular cell tumor: report of a relapse case. Zhonghua Bing Li Xue Za Zhi 2019; 8; 48: 330-1.
- Corso G, Di Nubila B, Ciccia A, et al. Granular cell tumor of the breast: Molecular pathology and clinical management. Breast J 2018; 24: 778-82.
- 10.Ravich A, Stout AP, Ravich RA. Malignant granular cell myoblastoma involving the urinary bladder. Ann Surg 1945, 121: 361-72. .
- Miracco C, Andreassi A, Laurini L, et al. Granular cell tumour with histological signs of malignancy: report of a case and comparison with 10 benign and 4 atypical cases. Br J Dermatol 1999; 141: 573-5.
- Pérez-González YC, Pagura L, Llamas-Velasco M, et al. Primary cutaneous malignant granular cell tumor: an immunohistochemical study and review of the literature. Am J Dermatopathol 2015; 37: 334-40.
- Akahane K, Kato K, Ogiso S, et al. Malignant granular cell tumor of the breast: case report and literature review. Breast Cancer 2015; 22: 317-23.
- Fanburg-Smith JC, Meis-Kindblom JM, Fante R, et al. Malignant granular cell tumor of soft tissue: diagnostic criteria and clinicopathologic correlation. Am J Surg Pathol 1998; 22: 779-94.
Ayrıntılar
| Birincil Dil | Türkçe |
|---|---|
| Konular | Sağlık Kurumları Yönetimi |
| Bölüm | Case Report [en] Olgu Sunumu [tr] |
| Yazarlar | |
| Proje Numarası | - |
| Yayımlanma Tarihi | 5 Haziran 2021 |
| Yayımlandığı Sayı | Yıl 2021 Cilt: 2 Sayı: 2 |
|
|
|
|
|
|
|
|
Dergimiz; TR-Dizin ULAKBİM, ICI World of Journal's, Index Copernicus, Directory of Research Journals Indexing (DRJI), General Impact Factor, Google Scholar, Researchgate, WorldCat (OCLC), CrossRef (DOI), ROAD, ASOS İndeks, Türk Medline İndeks, Eurasian Scientific Journal Index (ESJI) ve Türkiye Atıf Dizini'nde indekslenmektedir.
EBSCO, DOAJ, OAJI, ProQuest dizinlerine müracaat yapılmış olup, değerlendirme aşamasındadır.
Makaleler "Çift-Kör Hakem Değerlendirmesi”nden geçmektedir.
Üniversitelerarası Kurul (ÜAK) Eşdeğerliği: Ulakbim TR Dizin'de olan dergilerde yayımlanan makale [10 PUAN] ve 1a, b, c hariç uluslararası indekslerde (1d) olan dergilerde yayımlanan makale [5 PUAN].
Note: Our journal is not WOS indexed and therefore is not classified as Q.
You can download Council of Higher Education (CoHG) [Yüksek Öğretim Kurumu (YÖK)] Criteria) decisions about predatory/questionable journals and the author's clarification text and journal charge policy from your browser. About predatory/questionable journals and journal charge policy
Not: Dergimiz WOS indeksli değildir ve bu nedenle Q sınıflamasına dahil değildir.
Yağmacı/şüpheli dergilerle ilgili Yüksek Öğretim Kurumu (YÖK) kararları ve yazar açıklama metni ile dergi ücret politikası: Yağmacı/Şaibeli Dergiler ve Dergi Ücret Politikası