Klinik Araştırma
BibTex RIS Kaynak Göster

Can the systemic immune-inflammatory index be a new indicator for the diagnosis and follow-up of alzheimer's disease?

Yıl 2022, Cilt: 1 Sayı: 1, 1 - 13, 29.04.2022

Öz

Background: Alzheimer's disease (AD) is a chronic neurodegenerative disease whose prevalence continues to increase in the elderly population. It has been shown that the neutrophil/lymphocyte ratio (NLR), is increased in AD compared to the normal population. However, there is no study in the literature regarding the role of systemic immune-inflammatory index (SII), which is calculated according to the formula of peripheral platelet count X neutrophil count/lymphocyte count, in AD. Therefore, our aim in this study was to reveal the role of SII in the diagnosis and follow-up of AD and to determine the relationship of this value with severity, duration of disease and drug use by comparing it with NLR.
Materials and Methods: Our retrospective study consisted of 94 gender and age matched healthy volunteers and 102 patients who applied to our clinic were diagnosed with AD.
Results: There was no difference between the patient and control groups in terms of age, gender, platelet and neutrophil counts, and SII values. While lymphocyte count was lower in-patient group; NLR and CRP detected higher (p=0.001, p=0.001, p=0.001, respectively). While SII increased as both disease duration and severity elevated; no statistically significant correlation was found between NLR and the severity and duration of the disease and drug use.
Conclusions: Based on the data of our study, we can suggest that inflammatory process increases in AD. However, the relationship of this inflammatory process with the severity and duration of the disease and drug use is still unknown.

Destekleyen Kurum

-

Proje Numarası

-

Teşekkür

-

Kaynakça

  • Albert, M.S., DeKosky, S.T., Dickson, D., Dubois, B., Feldman, H.H., Fox, N.C., ... & Phelps, C.H. (2011). The diagnosis of mild cognitive impairment due to Alzheimer's disease: recommendations from the National Institute on Aging‐Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimer's & Dementia, 7(3), 270-279.
  • Catricala, S., Torti, M. & Ricevuti, G. (2012). Alzheimer disease and platelets: how’s that relevant. Immunity & Ageing, 9(1), 1-11.
  • Dong, X., Nao, J., Shi, J. & Zheng, D. (2019). Predictive value of routine peripheral blood biomarkers in Alzheimer’s disease. Frontiers in Aging Neuroscience, 332.
  • Dong, Y., Lagarde, J., Xicota, L., Corne, H., Chantran, Y., Chaigneau, T., ... & Elbim, C. (2018). Neutrophil hyperactivation correlates with Alzheimer's disease progression. Annals of Neurology, 83(2), 387-405.
  • Folstein, M.F., Folstein, S.E. & McHugh, P.R. (1975). "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. Journal of Psychiatric Research, 12(3), 189–198.
  • Holmes, C., Cunningham, C., Zotova, E., Culliford, D. & Perry, V. H. (2011). Proinflammatory cytokines, sickness behavior, and Alzheimer disease. Neurology, 77(3), 212-218.
  • Hu, B., Yang, X. R., Xu, Y., Sun, Y. F., Sun, C., Guo, W., ... & Fan, J. (2014). Systemic immune-inflammation index predicts prognosis of patients after curative resection for hepatocellular carcinoma. Clinical Cancer Research, 20(23), 6212-6222.
  • Kuyumcu, M.E., Yesil, Y., Oztürk, Z. A., Kizilarslanoğlu, C., Etgül, S., Halil, M., ... & Arıoğul, S. (2012). The evaluation of neutrophil-lymphocyte ratio in Alzheimer’s disease. Dementia and Geriatric Cognitive Disorders, 34(2), 69-74.
  • Lee, K.S., Chung, J.H., Choi, T. K., Suh, S. Y., Oh, B. H. & Hong, C. H. (2009). Peripheral cytokines and chemokines in Alzheimer’s disease. Dementia and Geriatric Cognitive Disorders, 28(4), 281-287.
  • Li, Y., Xia, F., Chen, Y., Wen, D., Zhang, F., Yuan, M., ... & You, C. (2021). The prognosis value of acute phase systemic immune-inflammation index in intracerebral hemorrhage patients. Frontiers in Neurology, 12, 606.
  • Liu, Y.J., Guo, D.W., Tian, L., Shang, D. S., Zhao, W. D., Li, B., ... & Chen, Y.H. (2010). Peripheral T cells derived from Alzheimer's disease patients overexpress CXCR2 contributing to its transendothelial migration, which is microglial TNF-α-dependent. Neurobiology of Aging, 31(2), 175-188.
  • Mckhann, G. (1984). Report of the NINCDS-ADRDA work group under the auspices of department of health and human service task force on Alzheimer's disease. Neurology, 34, 939-944.
  • Mielke, M.M., Rosenberg, P.B., Tschanz, J., Cook, L., Corcoran, C., Hayden, K.M., ... & Lyketsos, C. G. (2007). Vascular factors predict rate of progression in Alzheimer disease. Neurology, 69(19), 1850-1858.
  • P Ponce, D., Salech, F., D SanMartin, C., Silva, M., Xiong, C., M Roe, C., ... & I Behrens, M. (2014). Increased susceptibility to oxidative death of lymphocytes from Alzheimer patients correlates with dementia severity. Current Alzheimer Research, 11(9), 892-898.
  • Querfurth, H.W. & LaFerla, F.M. (2010). Mechanisms of disease. N Engl J Med., 362(4), 329-344.
  • Rabe-Jabłońska, J. & Bieńkiewicz, W. (1994). Anxiety disorders in the fourth edition of the classification of mental disorders prepared by the American Psychiatric Association: diagnostic and statistical manual of mental disorders (DMS-IV--options book. Psychiatria Polska, 28(2), 255-268.
  • Rembach, A., Watt, A.D., Wilson, W.J., Rainey-Smith, S., Ellis, K.A., Rowe, C.C., ... & AIBL Research Group. (2014). An increased neutrophil–lymphocyte ratio in Alzheimer's disease is a function of age and is weakly correlated with neocortical amyloid accumulation. Journal of Neuroimmunology, 273(1-2), 65-71.
  • Rezai-Zadeh, K., Gate, D., Szekely, C.A. & Town, T. (2009). Can peripheral leukocytes be used as Alzheimer’s disease biomarkers?. Expert Review of Neurotherapeutics, 9(11), 1623-1633.
  • Shad, K.F., Aghazadeh, Y., Ahmad, S. & Kress, B. (2013). Peripheral markers of Alzheimer's disease: surveillance of white blood cells. Synapse, 67(8), 541-543.
  • Stalder, A. K., Ermini, F., Bondolfi, L., Krenger, W., Burbach, G. J., Deller, T., ... & Jucker, M. (2005). Invasion of hematopoietic cells into the brain of amyloid precursor protein transgenic mice. Journal of Neuroscience, 25(48), 11125-11132.
  • Thal, D.R., Griffin, W.S. T., de Vos, R.A. & Ghebremedhin, E. (2008). Cerebral amyloid angiopathy and its relationship to Alzheimer’s disease. Acta Neuropathologica, 115(6), 599-609.
  • Trifan, G. & Testai, F.D. (2020). Systemic Immune-Inflammation (SII) index predicts poor outcome after spontaneous supratentorial intracerebral hemorrhage. Journal of Stroke and Cerebrovascular Diseases, 29(9), 105057.
  • Veitinger, M., Varga, B., Guterres, S.B. & Zellner, M. (2014). Platelets, a reliable source for peripheral Alzheimer’s disease biomarkers? Acta Neuropathologica Communications, 2(1), 1-15.
  • Yang, Y.L., Wu, C.H., Hsu, P. F., Chen, S.C., Huang, S. S., Chan, W.L., ... & Leu, H.B. (2020). Systemic immune‐inflammation index (SII) predicted clinical outcome in patients with coronary artery disease. European Journal of Clinical Investigation, 50(5), e13230.
  • Yu, D., Corbett, B., Yan, Y., Zhang, G.X., Reinhart, P., Cho, S.J. & Chin, J. (2012). Early cerebrovascular inflammation in a transgenic mouse model of Alzheimer's disease. Neurobiology of Aging, 33(12), 2942-2947.

Sistemik immun-inflamatuar indeks alzheimer hastalığının tanısı ve takibi için yeni bir gösterge olabilir mi?

Yıl 2022, Cilt: 1 Sayı: 1, 1 - 13, 29.04.2022

Öz

Amaç: Tanısı ve takibinde kullanılan ideal bir biyobelirteç olmayan Alzheimer hastalığı (AH), prevalansı ileri yaş popülasyonunda artmaya devam eden kronik bir nörodejeneratif hastalıktır. Nötrofil /lenfosit oranın (NLR) AH’da normal popülasyona göre artmış olduğu gösterilmiştir. Ancak periferik platelet sayısı X nötrofil sayısı/ lenfosit sayısı formülüne göre hesaplanan sistemik immun-inflamatuar indeks (SII)’in AH’ndaki yeri ile ilgili literatürde henüz bir çalışma bulunmamaktadır. Bu nedenle bu çalışmadaki amacımız AH’nın teşhis ve takibinde NLR ile kıyaslayarak SII’nin yerini ortaya koymak ve bu değerin hastalığın ciddiyeti, süresi ve ilaç kullanımı ile ilişkisini tespit etmektir.
Materyal ve Metot: Retrospektif olarak dizayn edilmiş çalışmamıza kliniğimize başvurmuş, alınan anamnez ve yapılan nörolojik muayene ile AH tanısı konulmuş 102 hasta ile hasta grubumuza benzer yaş ve cinsiyete sahip 94 gönüllü dahil edildi.
Bulgular: Hasta ve kontrol grubu arasında yaş, cinsiyet, platelet ve nötrofil sayıları ve SII değerleri açısından fark yoktu. Lenfosit sayısı hasta grupta daha düşükken; NLR ve CRP düzeyi daha yüksek olarak tespit edildi (sırasıyla p=0.001, p=0.001, p=0.001). SII hem hastalık süresi hem de ciddiyeti arttıkça artmaktayken; NLR ile hastalığın ciddiyeti, süresi ve ilaç kullanımı arasında istatistiksel olarak anlamlı ilişki saptanmadı.
Sonuç: Çalışmamızın verilerine dayanarak AH’da her aşamada inflamatuar sürecin arttığı öne sürülebilir. Ancak bu durumun hastalığın ciddiyeti, süresi ve ilaç kullanımı ile ilişkisi henüz bilinmemektedir.

Proje Numarası

-

Kaynakça

  • Albert, M.S., DeKosky, S.T., Dickson, D., Dubois, B., Feldman, H.H., Fox, N.C., ... & Phelps, C.H. (2011). The diagnosis of mild cognitive impairment due to Alzheimer's disease: recommendations from the National Institute on Aging‐Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimer's & Dementia, 7(3), 270-279.
  • Catricala, S., Torti, M. & Ricevuti, G. (2012). Alzheimer disease and platelets: how’s that relevant. Immunity & Ageing, 9(1), 1-11.
  • Dong, X., Nao, J., Shi, J. & Zheng, D. (2019). Predictive value of routine peripheral blood biomarkers in Alzheimer’s disease. Frontiers in Aging Neuroscience, 332.
  • Dong, Y., Lagarde, J., Xicota, L., Corne, H., Chantran, Y., Chaigneau, T., ... & Elbim, C. (2018). Neutrophil hyperactivation correlates with Alzheimer's disease progression. Annals of Neurology, 83(2), 387-405.
  • Folstein, M.F., Folstein, S.E. & McHugh, P.R. (1975). "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. Journal of Psychiatric Research, 12(3), 189–198.
  • Holmes, C., Cunningham, C., Zotova, E., Culliford, D. & Perry, V. H. (2011). Proinflammatory cytokines, sickness behavior, and Alzheimer disease. Neurology, 77(3), 212-218.
  • Hu, B., Yang, X. R., Xu, Y., Sun, Y. F., Sun, C., Guo, W., ... & Fan, J. (2014). Systemic immune-inflammation index predicts prognosis of patients after curative resection for hepatocellular carcinoma. Clinical Cancer Research, 20(23), 6212-6222.
  • Kuyumcu, M.E., Yesil, Y., Oztürk, Z. A., Kizilarslanoğlu, C., Etgül, S., Halil, M., ... & Arıoğul, S. (2012). The evaluation of neutrophil-lymphocyte ratio in Alzheimer’s disease. Dementia and Geriatric Cognitive Disorders, 34(2), 69-74.
  • Lee, K.S., Chung, J.H., Choi, T. K., Suh, S. Y., Oh, B. H. & Hong, C. H. (2009). Peripheral cytokines and chemokines in Alzheimer’s disease. Dementia and Geriatric Cognitive Disorders, 28(4), 281-287.
  • Li, Y., Xia, F., Chen, Y., Wen, D., Zhang, F., Yuan, M., ... & You, C. (2021). The prognosis value of acute phase systemic immune-inflammation index in intracerebral hemorrhage patients. Frontiers in Neurology, 12, 606.
  • Liu, Y.J., Guo, D.W., Tian, L., Shang, D. S., Zhao, W. D., Li, B., ... & Chen, Y.H. (2010). Peripheral T cells derived from Alzheimer's disease patients overexpress CXCR2 contributing to its transendothelial migration, which is microglial TNF-α-dependent. Neurobiology of Aging, 31(2), 175-188.
  • Mckhann, G. (1984). Report of the NINCDS-ADRDA work group under the auspices of department of health and human service task force on Alzheimer's disease. Neurology, 34, 939-944.
  • Mielke, M.M., Rosenberg, P.B., Tschanz, J., Cook, L., Corcoran, C., Hayden, K.M., ... & Lyketsos, C. G. (2007). Vascular factors predict rate of progression in Alzheimer disease. Neurology, 69(19), 1850-1858.
  • P Ponce, D., Salech, F., D SanMartin, C., Silva, M., Xiong, C., M Roe, C., ... & I Behrens, M. (2014). Increased susceptibility to oxidative death of lymphocytes from Alzheimer patients correlates with dementia severity. Current Alzheimer Research, 11(9), 892-898.
  • Querfurth, H.W. & LaFerla, F.M. (2010). Mechanisms of disease. N Engl J Med., 362(4), 329-344.
  • Rabe-Jabłońska, J. & Bieńkiewicz, W. (1994). Anxiety disorders in the fourth edition of the classification of mental disorders prepared by the American Psychiatric Association: diagnostic and statistical manual of mental disorders (DMS-IV--options book. Psychiatria Polska, 28(2), 255-268.
  • Rembach, A., Watt, A.D., Wilson, W.J., Rainey-Smith, S., Ellis, K.A., Rowe, C.C., ... & AIBL Research Group. (2014). An increased neutrophil–lymphocyte ratio in Alzheimer's disease is a function of age and is weakly correlated with neocortical amyloid accumulation. Journal of Neuroimmunology, 273(1-2), 65-71.
  • Rezai-Zadeh, K., Gate, D., Szekely, C.A. & Town, T. (2009). Can peripheral leukocytes be used as Alzheimer’s disease biomarkers?. Expert Review of Neurotherapeutics, 9(11), 1623-1633.
  • Shad, K.F., Aghazadeh, Y., Ahmad, S. & Kress, B. (2013). Peripheral markers of Alzheimer's disease: surveillance of white blood cells. Synapse, 67(8), 541-543.
  • Stalder, A. K., Ermini, F., Bondolfi, L., Krenger, W., Burbach, G. J., Deller, T., ... & Jucker, M. (2005). Invasion of hematopoietic cells into the brain of amyloid precursor protein transgenic mice. Journal of Neuroscience, 25(48), 11125-11132.
  • Thal, D.R., Griffin, W.S. T., de Vos, R.A. & Ghebremedhin, E. (2008). Cerebral amyloid angiopathy and its relationship to Alzheimer’s disease. Acta Neuropathologica, 115(6), 599-609.
  • Trifan, G. & Testai, F.D. (2020). Systemic Immune-Inflammation (SII) index predicts poor outcome after spontaneous supratentorial intracerebral hemorrhage. Journal of Stroke and Cerebrovascular Diseases, 29(9), 105057.
  • Veitinger, M., Varga, B., Guterres, S.B. & Zellner, M. (2014). Platelets, a reliable source for peripheral Alzheimer’s disease biomarkers? Acta Neuropathologica Communications, 2(1), 1-15.
  • Yang, Y.L., Wu, C.H., Hsu, P. F., Chen, S.C., Huang, S. S., Chan, W.L., ... & Leu, H.B. (2020). Systemic immune‐inflammation index (SII) predicted clinical outcome in patients with coronary artery disease. European Journal of Clinical Investigation, 50(5), e13230.
  • Yu, D., Corbett, B., Yan, Y., Zhang, G.X., Reinhart, P., Cho, S.J. & Chin, J. (2012). Early cerebrovascular inflammation in a transgenic mouse model of Alzheimer's disease. Neurobiology of Aging, 33(12), 2942-2947.
Toplam 25 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Klinik Tıp Bilimleri
Bölüm Araştırma Makaleleri
Yazarlar

Aslı Bolayır 0000-0001-6566-3751

Tuğba Raika Kıran 0000-0002-3724-0249

Aysun Bay Karabulut 0000-0002-7873-2805

Proje Numarası -
Yayımlanma Tarihi 29 Nisan 2022
Gönderilme Tarihi 6 Nisan 2022
Yayımlandığı Sayı Yıl 2022 Cilt: 1 Sayı: 1

Kaynak Göster

APA Bolayır, A., Kıran, T. R., & Bay Karabulut, A. (2022). Can the systemic immune-inflammatory index be a new indicator for the diagnosis and follow-up of alzheimer’s disease?. Journal of Medical Topics and Updates, 1(1), 1-13.