Araştırma Makalesi
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Effects of mean platelet volume and platelet counts on peripheral biodegradable stent restenosis

Yıl 2019, Cilt: 3 Sayı: 9, 663 - 665, 01.09.2019
https://doi.org/10.28982/josam.569158

Öz

Aim: Thrombocytes play a key role in atherosclerosis and acute vascular events. The purpose of this study is to investigate the association between mean platelet volume (MPV), platelet counts as well as other hematological parameters and biodegradable stent re-stenosis.

Methods: 53 patients who underwent percutaneous biodegradable peripheral stent placement procedure were included in this retrospective cohort study. Blood samples were collected a day before the operation. Patients were followed for a mean of 6 months and Doppler ultrasonography (DUSG) was performed for control examination. According to the DUSG results, patients were divided into two groups: Group 1 included patients with ≥50% in-stent re-stenosis and Group 2, with <50% in-stent re-stenosis. 

Results: The mean age of the patients was 58.1 (6.7) years. 6 (11.3%) patients were female and 47 (88.7%) patients were male. Eight (15%) had iliac artery and 45 (84.9%) had superficial femoral artery stenosis. Doppler US reports showed that 11 (20.8%) patients had ≥50% in-stent re-stenosis (Group 1). Re-stenosis rates were higher at younger ages (P=0.020). There was no statistically difference between the groups in terms of gender (P=0.636), MPV (P=0.210), PLT counts (P=0.129) or any other hematologic parameters.

Conclusion: Several studies have shown that some blood parameters, especially MPV, are effective on coronary and peripheral stent stenosis. In our study, we found that none of the hematologic or common blood parameters can predict biodegradable stents re-stenosis.

Kaynakça

  • 1. Karabay Ö, Karaçelik M, Yılık L, Tekin L, İriz A, Kumdereli S, et al Ischemic peripheral arterial disease: A screening survey. Turk Gogus Kalp Dama. 2012;20(3):450-7. DOI: 10.5606/tgkdc.dergisi.2012.089
  • 2. David B, Edward W, Chrisopher T, A New Wave in Treatment of Vascular Occlusive Desease: Biodegradable Stents- Clinical experience and Scientific Principles. JVIR. 2009; 20(3):315-24. DOI: 10.1016/j.jvir.2008.11.007
  • 3. Eren R, Doğu MH, Koç A, Altındal Ş, Yokuş O, Suyanı E. The association of mean platelet volume and platecrit and bone marrow fibrosis in patients with essential thrombocythemia: A cohort study. J Surg Med. 2019;3(2):176-9. DOI: 10.28982/josam.525751
  • 4. Bıyık İ, Aslan MM, Keskin F. Association between platelet indices and missed abortion. J Surg Med. 2019;3(8):549-52 DOI: 10.28982/josam.530098
  • 5. Werner M, Schmidt A, Scheinert S, Banning-Eichenseer U, Ulrich M, Bausback Y, et al. Evaluation of the Biodegradable Igaki-Tamai Scaffold After Drug-Eluting Balloon Treatment of De Novo Superficial Femoral Artery Lesions: The GAIA-DEB Study. J Endovasc Ther. 2016;23(1):92-7. DOI: 10.1177/1526602815620618
  • 6. Onuma Y, Serruys PW. Bioresorbable scaffold: the advent of a new era in percutaneous coronary and peripheral revascularization? Circulation. 2011;123(7):779-97. DOI: 10.1161/CIRCULATIONAHA.110.971606
  • 7. Nishio S, Kosuga K, Igaki K, Okada M, Kyo E, Tsuji T, et al. Long-Term (>10 Years) clinical outcomes of first-in-human biodegradable poly-l-lactic acid coronary stents: Igaki-Tamai stents. Circulation. 2012;15:125(19):2343-53. DOI: 10.1161/CIRCULATIONAHA.110.000901
  • 8. Werner M, Micari A, Cioppa A, Vadalà G, Schmidt A, Sievert H, et al Evaluation of the biodegradable peripheral Igaki-Tamai stent in the treatment of de novo lesions in the superficial femoral artery: the GAIA study JACC. Cardiovasc Interv. 2014;7(3):305-12. DOI: 10.1016/j.jcin.2013.09.009
  • 9. Sansanayudh N, Muntham D, Yamwong S, Sritara P, Akrawichien T, Thakkinstian A. The Association between mean platelet volume and cardiovascular risk factors. Eur J Intern Med. 2016;30(5):37-42. DOI: 10.1016/j.ejim.2015.11.028
  • 10. Yang A, Pizzulli L, Lüderitz B. Mean platelet volume as marker of restenosis after percutaneous transluminal coronary angioplasty in patients with stable and unstable angina pectoris. Thromb Res. 2006;117(4):371-7. DOI: 10.1016/j.thromres.2005.04.004
  • 11. Berger JS, Eraso LH, Xie D, Sha D, Mohler ER. Mean platelet volume and prevalence of peripheral artery disease, the National Health and Nutrition Examination Survey, 1999-2004. Athersclerosis. 2010;213(2):586-91. DOI: 10.1016/j.atherosclerosis.2010.09.010
  • 12. Li S, Wang C, Zhong XW, Li HQ, FUXQ, Ran XW. Variance of mean platelet volume in subjects with normal glucose tolerance, impaired glucose regulation and type 2 diabetic mellitus and its relationship with diabetic peripheral artery disease. Zhonghua Yi Xue Za Zhi. 2012;92(2):232-5. PMID:22490792
  • 13. Karauzum K, Bildirici U, Dervis E, Karauzum I, Baydemir C. Preprocedural Mean Platelet Volume Level Is a Predictor of In-Stent re-stenosis of the superficial femoral Artery Stents in Follow-Up. Cardiol Res Pract. 2018:4572629. DOI: 10.1155/2018/4572629
  • 14. Dai Z, Gao J, Li S, Li R, Chen Z Mean Platelet Volume as a Predictor for Restenosis After Carotid Angioplasty and Stenting. Stroke. 2018;49(4):872-6. DOI: 10.1161/STROKEAHA.117.019748
  • 15. Chan YC, Cheng SW, Cheung GC Predictors of restenosis in the use of helical interwoven nitinol stents to treat femoropopliteal occlusive disease. J Vasc Surg. 2015;62(5):1201-9. DOI: 10.1016/j.jvs.2015.05.030
  • 16. Miller AJ, Takahashi EA, Harmsen WS, Mara KC, Misra S Treatment of Superficial Femoral Artery Restenosis. J Vasc Interv Radiol. 2017;28(12):1681-6. DOI: 10.1016/j.jvir.2017.07.032

Periferik biyoeriyebilir stent restenozu üzerine ortalama trombosit hacminin ve trombosit sayımının etkisi

Yıl 2019, Cilt: 3 Sayı: 9, 663 - 665, 01.09.2019
https://doi.org/10.28982/josam.569158

Öz

Amaç: Trombositlerin ateroskleroz ve akut vasküler olaylarda önemli bir rolü vardır. Bu çalışmanın amacı, ortalama trombosit hacmi (MPV), trombosit sayıları ve diğer hematolojik parametreler ile biyoeriyebilir stent stenozu arasında bir ilişki olup olmadığını araştırmaktır.

Yöntemler: Bu retrospektif kohort çalışmaya biyoeriyebilir periferik stentlerle perkütan müdahale yapılan 53 hasta dahil edildi. Kan örnekleri operasyondan bir gün önce alındı. Hastalar ortalama 6 ay takip edildi ve tüm hastalara kontrol amaçlı Doppler ultrasonografi (DUSG) yapıldı. Doppler ultrasonografi sonuçlarına göre hastalar iki gruba ayrıldı: Grup 1’deki hastalarda ≥%50 stentiçi restenoz ve Grup 2’deki hastalarda <%50 stentiçi restenoz mevcuttu. 

Bulgular: Hastaların yaş ortalaması 58,1 (6,7) yıl olup, 6 (%11,3) hasta kadın, 47 (%88,7) hasta erkekti. Sekiz (%15) hastada iliak arter darlığı, 45 (%84,9) hastada yüzeyel femoral arter darlığı mevcuttu. Doppler US raporları, 11 (%20,8) hastada, ≥%50 stentiçi re-stenoz (Grup 1) olduğunu gösterdi. Re-stenoz oranları genç yaşta daha yüksekti (P=0,020). İki grup arasında cinsiyet (P=0,636), MPV (P=0,210), PLT sayısı (P=0,129) veya diğer hematolojik parametreler açısından istatistiksel olarak fark yoktu.

Sonuç: Birçok çalışmada özellikle MPV olmak üzere bazı kan parametrelerinin koroner ve periferik stent stenozu üzerinde etkili olduğu gösterilmiştir. Çalışmamızda, hematolojik veya kan parametrelerinin hiçbirinin biyobozunur stentlerin restenozunu öngöremediğini tespit ettik.

Kaynakça

  • 1. Karabay Ö, Karaçelik M, Yılık L, Tekin L, İriz A, Kumdereli S, et al Ischemic peripheral arterial disease: A screening survey. Turk Gogus Kalp Dama. 2012;20(3):450-7. DOI: 10.5606/tgkdc.dergisi.2012.089
  • 2. David B, Edward W, Chrisopher T, A New Wave in Treatment of Vascular Occlusive Desease: Biodegradable Stents- Clinical experience and Scientific Principles. JVIR. 2009; 20(3):315-24. DOI: 10.1016/j.jvir.2008.11.007
  • 3. Eren R, Doğu MH, Koç A, Altındal Ş, Yokuş O, Suyanı E. The association of mean platelet volume and platecrit and bone marrow fibrosis in patients with essential thrombocythemia: A cohort study. J Surg Med. 2019;3(2):176-9. DOI: 10.28982/josam.525751
  • 4. Bıyık İ, Aslan MM, Keskin F. Association between platelet indices and missed abortion. J Surg Med. 2019;3(8):549-52 DOI: 10.28982/josam.530098
  • 5. Werner M, Schmidt A, Scheinert S, Banning-Eichenseer U, Ulrich M, Bausback Y, et al. Evaluation of the Biodegradable Igaki-Tamai Scaffold After Drug-Eluting Balloon Treatment of De Novo Superficial Femoral Artery Lesions: The GAIA-DEB Study. J Endovasc Ther. 2016;23(1):92-7. DOI: 10.1177/1526602815620618
  • 6. Onuma Y, Serruys PW. Bioresorbable scaffold: the advent of a new era in percutaneous coronary and peripheral revascularization? Circulation. 2011;123(7):779-97. DOI: 10.1161/CIRCULATIONAHA.110.971606
  • 7. Nishio S, Kosuga K, Igaki K, Okada M, Kyo E, Tsuji T, et al. Long-Term (>10 Years) clinical outcomes of first-in-human biodegradable poly-l-lactic acid coronary stents: Igaki-Tamai stents. Circulation. 2012;15:125(19):2343-53. DOI: 10.1161/CIRCULATIONAHA.110.000901
  • 8. Werner M, Micari A, Cioppa A, Vadalà G, Schmidt A, Sievert H, et al Evaluation of the biodegradable peripheral Igaki-Tamai stent in the treatment of de novo lesions in the superficial femoral artery: the GAIA study JACC. Cardiovasc Interv. 2014;7(3):305-12. DOI: 10.1016/j.jcin.2013.09.009
  • 9. Sansanayudh N, Muntham D, Yamwong S, Sritara P, Akrawichien T, Thakkinstian A. The Association between mean platelet volume and cardiovascular risk factors. Eur J Intern Med. 2016;30(5):37-42. DOI: 10.1016/j.ejim.2015.11.028
  • 10. Yang A, Pizzulli L, Lüderitz B. Mean platelet volume as marker of restenosis after percutaneous transluminal coronary angioplasty in patients with stable and unstable angina pectoris. Thromb Res. 2006;117(4):371-7. DOI: 10.1016/j.thromres.2005.04.004
  • 11. Berger JS, Eraso LH, Xie D, Sha D, Mohler ER. Mean platelet volume and prevalence of peripheral artery disease, the National Health and Nutrition Examination Survey, 1999-2004. Athersclerosis. 2010;213(2):586-91. DOI: 10.1016/j.atherosclerosis.2010.09.010
  • 12. Li S, Wang C, Zhong XW, Li HQ, FUXQ, Ran XW. Variance of mean platelet volume in subjects with normal glucose tolerance, impaired glucose regulation and type 2 diabetic mellitus and its relationship with diabetic peripheral artery disease. Zhonghua Yi Xue Za Zhi. 2012;92(2):232-5. PMID:22490792
  • 13. Karauzum K, Bildirici U, Dervis E, Karauzum I, Baydemir C. Preprocedural Mean Platelet Volume Level Is a Predictor of In-Stent re-stenosis of the superficial femoral Artery Stents in Follow-Up. Cardiol Res Pract. 2018:4572629. DOI: 10.1155/2018/4572629
  • 14. Dai Z, Gao J, Li S, Li R, Chen Z Mean Platelet Volume as a Predictor for Restenosis After Carotid Angioplasty and Stenting. Stroke. 2018;49(4):872-6. DOI: 10.1161/STROKEAHA.117.019748
  • 15. Chan YC, Cheng SW, Cheung GC Predictors of restenosis in the use of helical interwoven nitinol stents to treat femoropopliteal occlusive disease. J Vasc Surg. 2015;62(5):1201-9. DOI: 10.1016/j.jvs.2015.05.030
  • 16. Miller AJ, Takahashi EA, Harmsen WS, Mara KC, Misra S Treatment of Superficial Femoral Artery Restenosis. J Vasc Interv Radiol. 2017;28(12):1681-6. DOI: 10.1016/j.jvir.2017.07.032
Toplam 16 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Kalp ve Damar Cerrahisi
Bölüm Araştırma makalesi
Yazarlar

Engin Akgül 0000-0001-7361-0430

Mesut Engin 0000-0003-2418-5823

Ahmet Fatih Özyazıcıoğlu 0000-0001-8642-5664

Yayımlanma Tarihi 1 Eylül 2019
Yayımlandığı Sayı Yıl 2019 Cilt: 3 Sayı: 9

Kaynak Göster

APA Akgül, E., Engin, M., & Özyazıcıoğlu, A. F. (2019). Effects of mean platelet volume and platelet counts on peripheral biodegradable stent restenosis. Journal of Surgery and Medicine, 3(9), 663-665. https://doi.org/10.28982/josam.569158
AMA Akgül E, Engin M, Özyazıcıoğlu AF. Effects of mean platelet volume and platelet counts on peripheral biodegradable stent restenosis. J Surg Med. Eylül 2019;3(9):663-665. doi:10.28982/josam.569158
Chicago Akgül, Engin, Mesut Engin, ve Ahmet Fatih Özyazıcıoğlu. “Effects of Mean Platelet Volume and Platelet Counts on Peripheral Biodegradable Stent Restenosis”. Journal of Surgery and Medicine 3, sy. 9 (Eylül 2019): 663-65. https://doi.org/10.28982/josam.569158.
EndNote Akgül E, Engin M, Özyazıcıoğlu AF (01 Eylül 2019) Effects of mean platelet volume and platelet counts on peripheral biodegradable stent restenosis. Journal of Surgery and Medicine 3 9 663–665.
IEEE E. Akgül, M. Engin, ve A. F. Özyazıcıoğlu, “Effects of mean platelet volume and platelet counts on peripheral biodegradable stent restenosis”, J Surg Med, c. 3, sy. 9, ss. 663–665, 2019, doi: 10.28982/josam.569158.
ISNAD Akgül, Engin vd. “Effects of Mean Platelet Volume and Platelet Counts on Peripheral Biodegradable Stent Restenosis”. Journal of Surgery and Medicine 3/9 (Eylül 2019), 663-665. https://doi.org/10.28982/josam.569158.
JAMA Akgül E, Engin M, Özyazıcıoğlu AF. Effects of mean platelet volume and platelet counts on peripheral biodegradable stent restenosis. J Surg Med. 2019;3:663–665.
MLA Akgül, Engin vd. “Effects of Mean Platelet Volume and Platelet Counts on Peripheral Biodegradable Stent Restenosis”. Journal of Surgery and Medicine, c. 3, sy. 9, 2019, ss. 663-5, doi:10.28982/josam.569158.
Vancouver Akgül E, Engin M, Özyazıcıoğlu AF. Effects of mean platelet volume and platelet counts on peripheral biodegradable stent restenosis. J Surg Med. 2019;3(9):663-5.