Olgu Sunumu
BibTex RIS Kaynak Göster

Topical mitomycin C treatment in corneal and conjunctival intraepithelial neoplasia: A case report

Yıl 2021, Cilt: 5 Sayı: 9, 992 - 994, 01.09.2021

Asena Keleş Şahin Aslıhan Uzun Havva Erdem

https://doi.org/10.28982/josam.858692

Öz

Corneal and conjunctival intraepithelial neoplasia is a slowly progressive ocular surface lesion with low malignant potential. Owing to the high recurrence rates, cryotherapy or topical chemotherapy is used with surgical treatment. In this paper, we report the histopathologic findings and treatment of a case of intraepithelial neoplasia that began in the conjunctiva and progressed to the cornea. A 75-year-old woman presented with complaints of redness, irritation and lacrimation in her left eye for around 1 month. Slit-lamp examination revealed a papilliform mass on the nasal conjunctiva along with involvement of the adjacent corneal epithelium. Conjunctival excisional biopsy showed a moderate epithelial dysplasia. Topical 0.04% mitomycin C was administered 4 times daily for 3 weeks. No recurrence was observed in the following 18 months.

Anahtar Kelimeler

Conjunctival intraepithelial neoplasia Dysplasia Mitomycin C

Kaynakça

  • 1. Kao AA, Galor A, Karp CL, Abdelaziz A, Feuer WJ, Dubovy SR. Clinicopathologic correlation of ocular surface squamous neoplasms at Bascom Palmer Eye Institute: 2001 to 2010. Ophthalmology. 2012;119(9):1773-6. doi: 10.1016/j.ophtha.2012.02.049.
  • 2. Gichuhi S, Ohnuma S, Sagoo MS, Burton MJ. Pathophysiology of ocular surface squamous neoplasia. Exp Eye Res. 2014;129:172-82. doi: 10.1016/j.exer.2014.10.015.
  • 3. Hamam R, Bhat P, Foster CS. Conjunctival/corneal intraepithelial neoplasia. Int Ophthalmol Clin. 2009;49(1):63-70. doi: 10.1097/IIO.0b013e3181924ec3.
  • 4. Scholz SL, Thomasen H, Reis H, Möller I, Darawsha R, Müller B, et al. Frequent TERT promoter mutations in ocular surface squamous neoplasia. Invest Ophthalmol Vis Sci. 2015;56(10):5854-61. doi: 10.1167/iovs.15-17469.
  • 5. Pe'er J. Ocular surface squamous neoplasia: evidence for topical chemotherapy. Int Ophthalmol Clin. 2015;55(1):9-21. doi: 10.1097/IIO.0000000000000050.
  • 6. Frucht-Pery J, Rozenman Y, Pe'er J. Topical mitomycin-C for partially excised conjunctival squamous cell carcinoma. Ophthalmology. 2002;109(3):548-52. doi: 10.1016/s0161-6420(01)00967-8.
  • 7. Giaconi JA, Karp CL. Current treatment options for conjunctival and corneal intraepithelial neoplasia. Ocul Surf. 2003;1:66-73.
  • 8. Galor A, Karp CL, Oellers P, Kao AA, Abdelaziz A, Feuer W, et al. Predictors of ocular surface squamous neoplasia recurrence after excisional surgery. Ophthalmology. 2012;119(10):1974-81. doi: 10.1016/j.ophtha.2012.04.022.
  • 9. Tabin G, Levin S, Snibson G, Loughnan M, Taylor H. Late recurrences and the necessity for long-term follow-up in corneal and conjunctival intraepithelial neoplasia. Ophthalmology. 1997;104(3):485-92. doi: 10.1016/s0161-6420(97)30287-5.
  • 10. Besley J, Pappalardo J, Lee GA, Hirst LW, Vincent SJ. Risk factors for ocular surface squamous neoplasia recurrence after treatment with topical mitomycin C and interferon alpha-2b. Am J Ophthalmol. 2014;157(2):287-93. doi: 10.1016/j.ajo.2013.10.012.
  • 11. McKelvie PA, Daniell M. Impression cytology following mitomycin C therapy for ocular surface squamous neoplasia. Br J Ophthalmol. 2001;85(9):1115-9. doi: 10.1136/bjo.85.9.1115.
  • 12. Frucht-Pery J, Rozenman Y. Mitomycin C therapy for corneal intraepithelial neoplasia. Am J Ophthalmol. 1994;117(2):164-8. doi: 10.1016/s0002-9394(14)73072-7.
  • 13. Soysal HG, Yazar Z. The efficacy of postoperative topical mitomycin C in the treatment of conjunctival epithelial neoplasia. Turk J Ophthalmol. 2008;38(6):464-7.
  • 14. Khong JJ, Muecke J. Complications of mitomycin C therapy in 100 eyes with ocular surface neoplasia. Br J Ophthalmol. 2006;90(7):819-22. doi: 10.1136/bjo.2005.086850.
  • 15. Dudney BW, Malecha MA. Limbal stem cell deficiency following topical mitomycin C treatment of conjunctival-corneal intraepithelial neoplasia. Am J Ophthalmol. 2004;137(5):950-1. doi: 10.1016/j.ajo.2003.10.048.

Korneal ve konjonktival intraepitelyal neoplazide topikal mitomisin C tedavisi: olgu sunumu

Yıl 2021, Cilt: 5 Sayı: 9, 992 - 994, 01.09.2021

Asena Keleş Şahin Aslıhan Uzun Havva Erdem

https://doi.org/10.28982/josam.858692

Öz

Korneal ve konjonktival intraepitelyal neplazi, düşük malignite potansiyeli olan yavaş ilerleyen bir oküler yüzey lezyonudur. Yüksek nüks oranları nedeniyle kriyoterapi veya topikal kemoterapi cerrahi tedavi ile birlikte kullanılmaktadır. Çalışmamızda, konjonktivada başlayıp korneaya ilerleyen intraepitelyal neoplazili olgunun histopatolojik bulgularını ve tedavisini sunduk. Yetmiş beş yaşında kadın hasta yaklaşık 1 aydır devam eden sol gözünde kızarıklık, batma ve sulanma şikayetleri ile kliniğe başvurdu. Biyomikroskobik muayenede; nazal konjonktivada papilliform kitle ve bitişik kornea epitelinde tutulum mevcuttu. Konjonktival eksizyonel biyopsi sonucu orta derecede epitelyal displazi olarak raporlandı. Hastaya günde 4 defa, 3 hafta süresince topikal %0,04 mitomisin C uygulandı. Takip eden 18 aylık sürede nüks gelişmedi.

Anahtar Kelimeler

Konjonktival intraepitelyal neoplazi displazi mitomisin C

Destekleyen Kurum

Yazarlar tarafından bu çalışma için finansal destek alınmamıştır

Kaynakça

  • 1. Kao AA, Galor A, Karp CL, Abdelaziz A, Feuer WJ, Dubovy SR. Clinicopathologic correlation of ocular surface squamous neoplasms at Bascom Palmer Eye Institute: 2001 to 2010. Ophthalmology. 2012;119(9):1773-6. doi: 10.1016/j.ophtha.2012.02.049.
  • 2. Gichuhi S, Ohnuma S, Sagoo MS, Burton MJ. Pathophysiology of ocular surface squamous neoplasia. Exp Eye Res. 2014;129:172-82. doi: 10.1016/j.exer.2014.10.015.
  • 3. Hamam R, Bhat P, Foster CS. Conjunctival/corneal intraepithelial neoplasia. Int Ophthalmol Clin. 2009;49(1):63-70. doi: 10.1097/IIO.0b013e3181924ec3.
  • 4. Scholz SL, Thomasen H, Reis H, Möller I, Darawsha R, Müller B, et al. Frequent TERT promoter mutations in ocular surface squamous neoplasia. Invest Ophthalmol Vis Sci. 2015;56(10):5854-61. doi: 10.1167/iovs.15-17469.
  • 5. Pe'er J. Ocular surface squamous neoplasia: evidence for topical chemotherapy. Int Ophthalmol Clin. 2015;55(1):9-21. doi: 10.1097/IIO.0000000000000050.
  • 6. Frucht-Pery J, Rozenman Y, Pe'er J. Topical mitomycin-C for partially excised conjunctival squamous cell carcinoma. Ophthalmology. 2002;109(3):548-52. doi: 10.1016/s0161-6420(01)00967-8.
  • 7. Giaconi JA, Karp CL. Current treatment options for conjunctival and corneal intraepithelial neoplasia. Ocul Surf. 2003;1:66-73.
  • 8. Galor A, Karp CL, Oellers P, Kao AA, Abdelaziz A, Feuer W, et al. Predictors of ocular surface squamous neoplasia recurrence after excisional surgery. Ophthalmology. 2012;119(10):1974-81. doi: 10.1016/j.ophtha.2012.04.022.
  • 9. Tabin G, Levin S, Snibson G, Loughnan M, Taylor H. Late recurrences and the necessity for long-term follow-up in corneal and conjunctival intraepithelial neoplasia. Ophthalmology. 1997;104(3):485-92. doi: 10.1016/s0161-6420(97)30287-5.
  • 10. Besley J, Pappalardo J, Lee GA, Hirst LW, Vincent SJ. Risk factors for ocular surface squamous neoplasia recurrence after treatment with topical mitomycin C and interferon alpha-2b. Am J Ophthalmol. 2014;157(2):287-93. doi: 10.1016/j.ajo.2013.10.012.
  • 11. McKelvie PA, Daniell M. Impression cytology following mitomycin C therapy for ocular surface squamous neoplasia. Br J Ophthalmol. 2001;85(9):1115-9. doi: 10.1136/bjo.85.9.1115.
  • 12. Frucht-Pery J, Rozenman Y. Mitomycin C therapy for corneal intraepithelial neoplasia. Am J Ophthalmol. 1994;117(2):164-8. doi: 10.1016/s0002-9394(14)73072-7.
  • 13. Soysal HG, Yazar Z. The efficacy of postoperative topical mitomycin C in the treatment of conjunctival epithelial neoplasia. Turk J Ophthalmol. 2008;38(6):464-7.
  • 14. Khong JJ, Muecke J. Complications of mitomycin C therapy in 100 eyes with ocular surface neoplasia. Br J Ophthalmol. 2006;90(7):819-22. doi: 10.1136/bjo.2005.086850.
  • 15. Dudney BW, Malecha MA. Limbal stem cell deficiency following topical mitomycin C treatment of conjunctival-corneal intraepithelial neoplasia. Am J Ophthalmol. 2004;137(5):950-1. doi: 10.1016/j.ajo.2003.10.048.
Toplam 15 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Göz Hastalıkları
Bölüm Olgu sunumu
Yazarlar

Asena Keleş Şahin 0000-0002-2700-0866

Aslıhan Uzun 0000-0002-5787-3879

Havva Erdem 0000-0002-3074-0240

Yayımlanma Tarihi 1 Eylül 2021
Yayımlandığı Sayı Yıl 2021 Cilt: 5 Sayı: 9

Kaynak Göster

APA Keleş Şahin, A., Uzun, A., & Erdem, H. (2021). Topical mitomycin C treatment in corneal and conjunctival intraepithelial neoplasia: A case report. Journal of Surgery and Medicine, 5(9), 992-994. https://doi.org/10.28982/josam.858692
AMA Keleş Şahin A, Uzun A, Erdem H. Topical mitomycin C treatment in corneal and conjunctival intraepithelial neoplasia: A case report. J Surg Med. Eylül 2021;5(9):992-994. doi:10.28982/josam.858692
Chicago Keleş Şahin, Asena, Aslıhan Uzun, ve Havva Erdem. “Topical Mitomycin C Treatment in Corneal and Conjunctival Intraepithelial Neoplasia: A Case Report”. Journal of Surgery and Medicine 5, sy. 9 (Eylül 2021): 992-94. https://doi.org/10.28982/josam.858692.
EndNote Keleş Şahin A, Uzun A, Erdem H (01 Eylül 2021) Topical mitomycin C treatment in corneal and conjunctival intraepithelial neoplasia: A case report. Journal of Surgery and Medicine 5 9 992–994.
IEEE A. Keleş Şahin, A. Uzun, ve H. Erdem, “Topical mitomycin C treatment in corneal and conjunctival intraepithelial neoplasia: A case report”, J Surg Med, c. 5, sy. 9, ss. 992–994, 2021, doi: 10.28982/josam.858692.
ISNAD Keleş Şahin, Asena vd. “Topical Mitomycin C Treatment in Corneal and Conjunctival Intraepithelial Neoplasia: A Case Report”. Journal of Surgery and Medicine 5/9 (Eylül 2021), 992-994. https://doi.org/10.28982/josam.858692.
JAMA Keleş Şahin A, Uzun A, Erdem H. Topical mitomycin C treatment in corneal and conjunctival intraepithelial neoplasia: A case report. J Surg Med. 2021;5:992–994.
MLA Keleş Şahin, Asena vd. “Topical Mitomycin C Treatment in Corneal and Conjunctival Intraepithelial Neoplasia: A Case Report”. Journal of Surgery and Medicine, c. 5, sy. 9, 2021, ss. 992-4, doi:10.28982/josam.858692.
Vancouver Keleş Şahin A, Uzun A, Erdem H. Topical mitomycin C treatment in corneal and conjunctival intraepithelial neoplasia: A case report. J Surg Med. 2021;5(9):992-4.
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