Araştırma Makalesi
BibTex RIS Kaynak Göster
Yıl 2023, Cilt: 16 Sayı: 1, 1 - 5, 31.01.2023

Öz

Kaynakça

  • Sylvester FA. Bone abnormalities in gastrointes-tinal and hepatic disease. Curr Opin Pediatr 1999;11: 402-407.
  • Southerland JC, Valentine JF. Osteopenia and osteoporosis in gastrointestinal diseases: Diag-nosis and treatment. Curr Gastroenterol Rep 2001;3:399-407.
  • Ginde AA, Liu MC, Camargo CA Jr. Demog-raphic differences and trends of vitamin D in-sufficiency in the US population, 1988–2004. Arch Intern Med 2009;23:626-632.
  • Maalouf NM, Shane E. Osteoporosis after solid organ transplantation. J Clin Endocrinol Metab 2005;90:2456-2465.
  • D’antiga L, Moniz C, Buxton-Thomas M, Che-eseman P, Gray B, Abraha H, et al. Bone mine-ral density and height gain in children with chronic cholestatic liver disease undergoing transplantation. Transplantation 2002;73:1788-1793.
  • Eyal O, Aharon M, Safadi R, Elhalel MD. Se-rum vitamin D levels in kidney transplant reci-pients: the importance of an immunosuppres-sion regimen and sun exposure. Isr Med Assoc J 2013;15:628-633.
  • Pascussi JM, Robert A, Nguyen M, Walrant-Debray O, Garabedian M, Martin P, et al. Pos-sible involvement of pregnane X receptor-enhanced CYP24 expression in drug-induced osteomalacia. J Clin Invest 2005;115:177-186.Morris HA. Vitamin D: A hormone for all sea-sons–how much is enough? Clin Biochem Rev 2005;26:21-32.
  • Kumar J, Muntner P, Kaskel FJ, Hailpern SM, Melamed ML. Prevalence and associations of 25-hydroxyvitamin D deficiency in US children: NHANES 2001–2004. Pediatrics 2009;124:371-379.
  • Reis JP, von Mühlen D, Miller ER 3rd, Michos ED, Appel LJ. Vitamin D status and cardiome-tabolic risk factors in the United States adoles-cent population. Pediatrics 2009;124:371-379.
  • Zittermann A, Schleithoff SS, Koerfer R. Putting cardiovascular disease and vitamin D insuffici-ency into perspective. Br J Nutr 2005;94:483-492.
  • Branch AD, Barin B, Rahman A, Stock P, Schiano TD. Vitamin D status of human immu-nodeficiency virus-positive patients with ad-vanced liver disease enrolled in the solid organ transplantation in HIV: Multi-site study. Liver Transpl 2014;20:156-164.
  • Valta H, Jalanko H, Holmberg C, Helenius I, Mäkitie O. Impaired bone health in adolescents after liver transplantation. Am J Transplant 2008;8:150-157.
  • D’antıga L, Ballan D, Luisetto G, Cillo U, Guari-so G, Zancan L. Long-term outcome of bone mineral density in children who underwent a successful liver transplantation. Transplantation 2004;78:899-903.
  • American Diabetes Association. Standards of Medical Care in Diabetes-2011. Diabetes Care 2011;34:11-61.
  • Zhou C, Assem M, Tay JC, Watkins PB, Blum-berg B, Schuetz EG, et al. Steroid and xenobio-tic receptor and vitamin D receptor crosstalk mediates CYP24 expression and drug-induced osteomalacia. J Clin Invest 2006;116:1703-1712.
  • Stein EM, Cohen A, Freeby M, Rogers H, Koko-lus S, Scott V, et al. Severe vitamin D deficiency among heart and liver transplant recipients. Clin Transplant 2009;23:861-865.
  • Legarda M, Gordon G, Lloyd C, Baumann U, Kelly DA, Shaw N, et al. Vitamin D deficiency and insufficiency after pediatric liver transplan-tation. Pediatr Transplant 2013;17:631-637.

Potential independent risk factors associated with vitamin D deficiency in the post liver transplant patients

Yıl 2023, Cilt: 16 Sayı: 1, 1 - 5, 31.01.2023

Öz

Background: Deficiency of native vitamin D [cholecalciferol, 25(OH)D3] is a common in patients with end stage liver failure.
Aim: Our study aimed to determine the risk factors and their frequency associated with 25(OH)D3 deficiency after liver transplantation.
Method: This study includes the patients with liver transplantation and carried out at the tertiary care center. Serum 25(OH)D3 levels were measured in those patients.
Results: A total of 148 patients were entered the study. Chronic viral hepatitis was the most common reason for transplantation (66.2%). Postoperative follow-up period was shorter than 1 year in eightytwo patients (55.4 %). Post-transplant 25(OH)D3 levels were below 20 ng/mL in 93 (62.8 %) patients Post-transplant 25(OH)D3 deficiency was greater in patients with follow-up periods shorter than 1 year (p = <0.001), in those receiving immunosupression with mycophenolate mofetil, tacrolimus, steroids and in those with low hematocrit rate and, albumin levels. On multivariate analysis, post-transplant follow-up period shorter than 1 year (OR: 6.18, 95% CI: 2.681-14.255, p<0.001) and steroid use in chronic immunosuppression (OR: 9.47, 95% CI: 1.165-77.009, p=0.035) were detected asindependent accompanying factors with 25(OH)D3 deficiency.
Conclusions: The The risk of 25(OH)D3 deficiency in p atients receiving immunosuppressive treatment with steroids to prevent rejection or those in the first post-transplant year was high. Therefore, serum 25(OH)D3 levels of the patients after liver transplantation should be monitored regularly.

Kaynakça

  • Sylvester FA. Bone abnormalities in gastrointes-tinal and hepatic disease. Curr Opin Pediatr 1999;11: 402-407.
  • Southerland JC, Valentine JF. Osteopenia and osteoporosis in gastrointestinal diseases: Diag-nosis and treatment. Curr Gastroenterol Rep 2001;3:399-407.
  • Ginde AA, Liu MC, Camargo CA Jr. Demog-raphic differences and trends of vitamin D in-sufficiency in the US population, 1988–2004. Arch Intern Med 2009;23:626-632.
  • Maalouf NM, Shane E. Osteoporosis after solid organ transplantation. J Clin Endocrinol Metab 2005;90:2456-2465.
  • D’antiga L, Moniz C, Buxton-Thomas M, Che-eseman P, Gray B, Abraha H, et al. Bone mine-ral density and height gain in children with chronic cholestatic liver disease undergoing transplantation. Transplantation 2002;73:1788-1793.
  • Eyal O, Aharon M, Safadi R, Elhalel MD. Se-rum vitamin D levels in kidney transplant reci-pients: the importance of an immunosuppres-sion regimen and sun exposure. Isr Med Assoc J 2013;15:628-633.
  • Pascussi JM, Robert A, Nguyen M, Walrant-Debray O, Garabedian M, Martin P, et al. Pos-sible involvement of pregnane X receptor-enhanced CYP24 expression in drug-induced osteomalacia. J Clin Invest 2005;115:177-186.Morris HA. Vitamin D: A hormone for all sea-sons–how much is enough? Clin Biochem Rev 2005;26:21-32.
  • Kumar J, Muntner P, Kaskel FJ, Hailpern SM, Melamed ML. Prevalence and associations of 25-hydroxyvitamin D deficiency in US children: NHANES 2001–2004. Pediatrics 2009;124:371-379.
  • Reis JP, von Mühlen D, Miller ER 3rd, Michos ED, Appel LJ. Vitamin D status and cardiome-tabolic risk factors in the United States adoles-cent population. Pediatrics 2009;124:371-379.
  • Zittermann A, Schleithoff SS, Koerfer R. Putting cardiovascular disease and vitamin D insuffici-ency into perspective. Br J Nutr 2005;94:483-492.
  • Branch AD, Barin B, Rahman A, Stock P, Schiano TD. Vitamin D status of human immu-nodeficiency virus-positive patients with ad-vanced liver disease enrolled in the solid organ transplantation in HIV: Multi-site study. Liver Transpl 2014;20:156-164.
  • Valta H, Jalanko H, Holmberg C, Helenius I, Mäkitie O. Impaired bone health in adolescents after liver transplantation. Am J Transplant 2008;8:150-157.
  • D’antıga L, Ballan D, Luisetto G, Cillo U, Guari-so G, Zancan L. Long-term outcome of bone mineral density in children who underwent a successful liver transplantation. Transplantation 2004;78:899-903.
  • American Diabetes Association. Standards of Medical Care in Diabetes-2011. Diabetes Care 2011;34:11-61.
  • Zhou C, Assem M, Tay JC, Watkins PB, Blum-berg B, Schuetz EG, et al. Steroid and xenobio-tic receptor and vitamin D receptor crosstalk mediates CYP24 expression and drug-induced osteomalacia. J Clin Invest 2006;116:1703-1712.
  • Stein EM, Cohen A, Freeby M, Rogers H, Koko-lus S, Scott V, et al. Severe vitamin D deficiency among heart and liver transplant recipients. Clin Transplant 2009;23:861-865.
  • Legarda M, Gordon G, Lloyd C, Baumann U, Kelly DA, Shaw N, et al. Vitamin D deficiency and insufficiency after pediatric liver transplan-tation. Pediatr Transplant 2013;17:631-637.
Toplam 17 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Cerrahi
Bölüm Araştırma Makalesi
Yazarlar

Arif Atay 0000-0001-8163-2357

Deniz Yavuz Başkıran 0000-0001-9129-9762

Adil Baskiran 0000-0002-7536-1631

Sezai Yılmaz 0000-0002-8044-0297

Yayımlanma Tarihi 31 Ocak 2023
Gönderilme Tarihi 1 Ocak 2023
Yayımlandığı Sayı Yıl 2023 Cilt: 16 Sayı: 1

Kaynak Göster

Vancouver Atay A, Yavuz Başkıran D, Baskiran A, Yılmaz S. Potential independent risk factors associated with vitamin D deficiency in the post liver transplant patients. JSurgArts. 2023;16(1):1-5.

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