Inflammation in Chronic Psychiatric Patients: Neutrophil/Lymphocyte Ratios, Platelet/Lymphocyte Ratios, and Mean Platelet Volume
Öz
Objective: The aim of this study was to examine the Neutrophil/Lymphocyte Ratio (NLR), Platelet/Lymphocyte Ratios (PLR), and Mean Platelet Volume
(MPV), red blood cell distribution width (RDW) and leukocyte cell levels of inpatients with mental illness by comparing them with each other and healthy
controls.
Materials and Methods: A total of 600 people were included in our study, 500 of whom were taken as the patient and 100 as the control group. The diagnosis
of patients according to DSM-5-Criteria were 34.8% Schizophrenia, 21% had Generalized-Anxiety-Disorder, 14.4% had Bipolar-Affective-Disorder,
14% had Major-Depressive-Disorder, 7.2% had Adjustment-Disorder, 4.2% had Schizoaffective-Disorder, 3.6% had other psychiatric illnesses.
Results: It was seen that hemoglobin, platelet, monocyte, blood platelet distribution (PCT), percentage account of RDW (RDW-CV) did not have statistically
significant differences between groups (p values were 0.082, 0.214, 0.526, 0.082, 0.771, respectively). The lymphocyte, eosinophil, basophil, MPV,
standard deviation of RDW (RDW-SD) were higher compared with healthy controls (p values were 0.002, 0.003, <0.001, <0.001, 0.003, 0.003, respectively).
NLR and PLR were low in the patient group compared to healthy controls (p<0.001).
Conclusion: It was found that some of the inflammation parameters of chronic with mental illness were different from those of healthy controls. However,
further prospective studies are needed to better reveal the relationship between inflammatory parameters and mental illnesses..
Anahtar Kelimeler
Inflammation neutrophil/lymphocyte rates platelet/lymphocyte ratios schizophrenia bipolar disorder.
Kaynakça
- Murphy K, Weaver C. Janeway’s Immunobiology. 9th ed. New York, London: Garland Science/Taylor & Francis Group; 2016.
- Hohlfeld R, Kerschensteiner M, Meinl E. Dual role of inflammation in CNS disease. Neurology. 2007;68:58–63.
- Yuan N, Chen Y, Xia Y, Dai J, Liu C. Inflammation-related biomarkers in major psychiatric disorders: a cross-disorder assessment of reproducibility and specificity in 43 meta-analyses. Transl Psychiatry. 2019;9:1-13.
- Müller N. Inflammation in schizophrenia: pathogenetic aspects and therapeutic considerations. Schizophr Bull. 2018;44:973-982.
- Michopoulos V, Powers A, Gillespie CF, Ressler KJ, Jovanovic, T. Inflammation in fear-and anxiety-based disorders: PTSD, GAD, and beyond. Neuropsychopharmacol. 2017;42:254-270.
- Sunbul M, Gerin F, Durmus E, Kivrak T, Sari I, Tigen K et al. Neutrophil to lymphocyte and platelet to lymphocyte ratio in patients with dipper versus non-dipper hypertension. Clin Exp Hypertens 2014;36:217-221.
- Irwin AD, Carrol ED. Procalcitonin. Arch Dis Child Educ Pract Ed. 2011;96:228-233.
- Muneer A. Bipolar disorder: role of inflammation and the development of disease biomarkers. Psychiatry Investig. 2016;13:18-33.
- Bauer ME, Teixeira AL. Inflammation in psychiatric disorders: what comes first? Ann N Y Acad Sci. 2019;1437:57-67.
- Kohler O, Krogh J, Mors O, Benros ME. Inflammation in depression and the potential for anti-inflammatory treatment. Curr Neuropharmacol. 2016;14:732-742.
- Ayhan MG, Dağistan AA, Tanrikulu CŞ, Bozdoğan ŞY, Eren I. İntihar girişiminde bulunanlarda artmış nötrofil/lenfosit oranı. Anatolian J Psyachiatry. 2019;20:305-312.
- Ivković M, Pantović Stefanović M, Dunjić Kostić B, Jurišić V, Lačković M, Totić Poznanović S, et al. Neutrophil to lymphocyte ratio predicting sui-cide risk in euthymic patients with bipolar disorder: Moderatory effect of family history. Compr Psychiatry. 2016;66:87-95.
- Meydaneri GG, Meydaneri S. Can neutrophil lymphocyte ratio predict the likelihood of suicide in patients with major depression? Cureus. 2018;10:2510.
- Kulaksizoglu B, Kulaksizoglu S. Relationship between neutrophil/lymphocyte ratio with oxidative stress and psychopathology in patients with schizophrenia. Neuropsychiatr Dis Treat. 2016;12:1999.
- Özdin S, Sarisoy G, Böke Ö. A comparison of the neutrophil-lymphocyte, platelet-lymphocyte and monocyte-lymphocyte ratios in schizophrenia and bipolar disorder patients–a retrospective file review. Nordic J Psychiatr. 2017;71:509-512.
- Herdi O, Sayar-Akaslan D, İlhan RS, Çolak B, Duman B. Associations Between Subclinical Inflammatory Markers and OCD: A Retrospective Study. Psychiatr Res. 2020;2019:113065.
- Özyurt G, Binici NC. The neutrophil-lymphocyte ratio and platelet-lymphocyte ratio in adolescent obsessive-compulsive disorder: Does comorbid anxiety disorder affect inflammatory response?. Psychiatr Res. 2019;272:311-315.
- Arabska J, Łucka A, Magierski R, Sobów T, Wysokiński A. Neutrophil-lymphocyte ratio is increased in elderly patients with first episode depression, but not in recurrent depression. Psychiatry Res. 2018;263:35-40.
- Binici NC, Güney SA, Emiroğlu FNİ. Neutrophil-lymphocyte and platelet-lymphocyte ratios among adolescents with bipolar disorder: A preliminary study. Psychiatry Res. 2018;269:178-182.
- Kayhan F, Gündüz Ş, Ersoy SA, Kandeğer A, Annagür BB. Relationships of neutrophil–lymphocyte and platelet–lymphocyte ratios with the severity of major depression. Psychiatry Res. 2017;247:332-335.
- Inanli I, Aydin M, Çaliskan AM, Eren I. Neutrophil/lymphocyte ratio, monocyte/lymphocyte ratio, and mean platelet volume as systemic inflammatory markers in different states of bipolar disorder. Nordic J Psychiatr. 2019;73(6):372-379.
- Özdin S, Böke Ö Neutrophil/lymphocyte, platelet/lymphocyte and monocyte/lymphocyte ratios in different stages of schizophrenia. Psychiatr Res. 2019;271:131-135.
- Usta MB, Aral A, Bozkurt A, Sahin B, Karabekiroglu K. Examination of neutrophil, platelet, and monocyte-lymphocyte ratios in adolescents with bipolar disorder-manic episode and depression. Neurological Sci. 2019;32:328-333.
- Garipardic M, Doğan M, Bala KA, Mutluer T, Kaba S, Aslan O et al. Association of attention deficit hyperactivity disorder and autism spectrum disorders with mean platelet volume and vitamin D. Med Sci Monit. 2017;23:1378.
- Mert DG, Terzi H. Mean platelet volume in bipolar disorder: the search for an ideal biomarker. Neuropsychiatr Dis Treat. 2016;12:2057.
- Asoglu M, Aslan M, Imre O, Kivrak Y, Akil O, Savık E et al. Mean platelet volume and red cell distribution width levels in initial evaluation of panic disorder. Neuropsychiatr Dis Treat 2016;12:2435.
- Gül IG, Eryılmaz G, Özten E, Sayar GH. Decreased mean platelet volume in panic disorder. Neuropsychiatr Dis Treat. 2014;10:1665.
- Demircan F, Gözel N, Kılınç F, Ulu, R, Atmaca M. The impact of red blood cell distribution width and neutrophil/lymphocyte ratio on the diagnosis of major depressive disorder. Neurolog Ther. 2016;5:27-33.
- Korkmaz S, Yıldız S, Korucu T, Gundogan B, Sunbul ZE, Korkmaz H et al. Frequency of anemia in chronic psychiatry patients. Neuropsychi
Kronik Psikiyatrik Hastalarda Enflamasyon: Nötrofil/Lenfosit Oranları, Trombosit/Lenfosit Oranları ve Ortalama Trombosit Hacmi
Öz
Amaç: Bu çalışmanın amacı ruhsal hastalık tanısı olan ve yatarak tedavi gören hastaların nötrofil/lenfosit oranı (NLO), platelet/lenfosit oranı (PLO), kırmızı
kan hücre dağılımı (RDW) ve lökosit hücre düzeylerini sağlıklı kontroller ve bir birleri ile karşılaştırarak incelemektir.
Gereç ve Yöntemler: Çalışmamıza 600 kişi dâhil edildi. Hasta grubu olarak 500 kişi, sağlıklı kontrol grubu olarak 100 kişi alındı. Hastaların DSM-5 kriterlerine
göre tanıları sırası ile; 174 (%34.8) şizofreni, 105 (%21) yaygın anksiyete bozukluğu, 72 (%14.4) bipolar affektif bozukluk, 70 (%14) majör depresif
bozukluk, 36 (%7.2) uyum bozukluğu, 21 (%4.2) şizoaffektif bozukluk ve 18 (%3.6) diğer psikiyatrik hastalıklar idi. Tüm katılımcıların demografik veri
formu ve laboratuvar parametreleri için hemogram testleri alınmıştır.
Bulgular: Çalışmamıza katılanlardan; 315 (%52.5) kişi kadın, 285 (%47.5) kişi erkekti. Yaşları 18-65 arasında değişmekle birlikte, ortalaması 39.6±15.22
idi. Laboratuvar parametrelerinin dağılımı incelendiğinde; hemoglobin, platelet, monosit, kan platelet dağılım genişliği (PCT), RDW-standart sapma üzerinden
yüzdeli hesabı (RDW-CV) değerleri gruplar arasında istatistiksel olarak anlamlı farklılık tespit edilmedi (Sırası ile p değerleri; 0.082, 0.214, 0.526,
0.082, 0.771 idi). Hastaların lenfosit, eozinofil, bazofil, ortalama platelet hacmi (MPV), alyuvarlar hücre boyutunun standart sapma olarak hesabı (RDWSD)
değerleri sağlıklı kontroller ile karşılaştırıldığında yüksek olarak hesaplandı (sırası ile p değerleri; 0.002, 0.003, <0.001, <0.001, 0.003 idi). NLO ve
PLO hasta grubunda sağlıklı kontrollere göre düşüktü (sırası ile p değeri her iki ölçüm için de <0.001).
Sonuç: Çalışmamızda kronik ruhsal hastalığı olan bireylerin bazı inflamasyon parametrelerinin sağlıklı kontrollerden farklı olduğu saptanmıştır. Ancak
inflamasyon parametrelerinin ruhsal hastalıklar ile olan ilişkisini daha iyi ortaya koyabilmek için prospektif nitelikte daha ileri araştırmalara ihtiyaç duyulmaktadır.
Anahtar Kelimeler
İnflamasyon nötrofil/lenfosit oranları platelet/lenfosit oranları şizofreni bipolar bozukluk.
Kaynakça
- Murphy K, Weaver C. Janeway’s Immunobiology. 9th ed. New York, London: Garland Science/Taylor & Francis Group; 2016.
- Hohlfeld R, Kerschensteiner M, Meinl E. Dual role of inflammation in CNS disease. Neurology. 2007;68:58–63.
- Yuan N, Chen Y, Xia Y, Dai J, Liu C. Inflammation-related biomarkers in major psychiatric disorders: a cross-disorder assessment of reproducibility and specificity in 43 meta-analyses. Transl Psychiatry. 2019;9:1-13.
- Müller N. Inflammation in schizophrenia: pathogenetic aspects and therapeutic considerations. Schizophr Bull. 2018;44:973-982.
- Michopoulos V, Powers A, Gillespie CF, Ressler KJ, Jovanovic, T. Inflammation in fear-and anxiety-based disorders: PTSD, GAD, and beyond. Neuropsychopharmacol. 2017;42:254-270.
- Sunbul M, Gerin F, Durmus E, Kivrak T, Sari I, Tigen K et al. Neutrophil to lymphocyte and platelet to lymphocyte ratio in patients with dipper versus non-dipper hypertension. Clin Exp Hypertens 2014;36:217-221.
- Irwin AD, Carrol ED. Procalcitonin. Arch Dis Child Educ Pract Ed. 2011;96:228-233.
- Muneer A. Bipolar disorder: role of inflammation and the development of disease biomarkers. Psychiatry Investig. 2016;13:18-33.
- Bauer ME, Teixeira AL. Inflammation in psychiatric disorders: what comes first? Ann N Y Acad Sci. 2019;1437:57-67.
- Kohler O, Krogh J, Mors O, Benros ME. Inflammation in depression and the potential for anti-inflammatory treatment. Curr Neuropharmacol. 2016;14:732-742.
- Ayhan MG, Dağistan AA, Tanrikulu CŞ, Bozdoğan ŞY, Eren I. İntihar girişiminde bulunanlarda artmış nötrofil/lenfosit oranı. Anatolian J Psyachiatry. 2019;20:305-312.
- Ivković M, Pantović Stefanović M, Dunjić Kostić B, Jurišić V, Lačković M, Totić Poznanović S, et al. Neutrophil to lymphocyte ratio predicting sui-cide risk in euthymic patients with bipolar disorder: Moderatory effect of family history. Compr Psychiatry. 2016;66:87-95.
- Meydaneri GG, Meydaneri S. Can neutrophil lymphocyte ratio predict the likelihood of suicide in patients with major depression? Cureus. 2018;10:2510.
- Kulaksizoglu B, Kulaksizoglu S. Relationship between neutrophil/lymphocyte ratio with oxidative stress and psychopathology in patients with schizophrenia. Neuropsychiatr Dis Treat. 2016;12:1999.
- Özdin S, Sarisoy G, Böke Ö. A comparison of the neutrophil-lymphocyte, platelet-lymphocyte and monocyte-lymphocyte ratios in schizophrenia and bipolar disorder patients–a retrospective file review. Nordic J Psychiatr. 2017;71:509-512.
- Herdi O, Sayar-Akaslan D, İlhan RS, Çolak B, Duman B. Associations Between Subclinical Inflammatory Markers and OCD: A Retrospective Study. Psychiatr Res. 2020;2019:113065.
- Özyurt G, Binici NC. The neutrophil-lymphocyte ratio and platelet-lymphocyte ratio in adolescent obsessive-compulsive disorder: Does comorbid anxiety disorder affect inflammatory response?. Psychiatr Res. 2019;272:311-315.
- Arabska J, Łucka A, Magierski R, Sobów T, Wysokiński A. Neutrophil-lymphocyte ratio is increased in elderly patients with first episode depression, but not in recurrent depression. Psychiatry Res. 2018;263:35-40.
- Binici NC, Güney SA, Emiroğlu FNİ. Neutrophil-lymphocyte and platelet-lymphocyte ratios among adolescents with bipolar disorder: A preliminary study. Psychiatry Res. 2018;269:178-182.
- Kayhan F, Gündüz Ş, Ersoy SA, Kandeğer A, Annagür BB. Relationships of neutrophil–lymphocyte and platelet–lymphocyte ratios with the severity of major depression. Psychiatry Res. 2017;247:332-335.
- Inanli I, Aydin M, Çaliskan AM, Eren I. Neutrophil/lymphocyte ratio, monocyte/lymphocyte ratio, and mean platelet volume as systemic inflammatory markers in different states of bipolar disorder. Nordic J Psychiatr. 2019;73(6):372-379.
- Özdin S, Böke Ö Neutrophil/lymphocyte, platelet/lymphocyte and monocyte/lymphocyte ratios in different stages of schizophrenia. Psychiatr Res. 2019;271:131-135.
- Usta MB, Aral A, Bozkurt A, Sahin B, Karabekiroglu K. Examination of neutrophil, platelet, and monocyte-lymphocyte ratios in adolescents with bipolar disorder-manic episode and depression. Neurological Sci. 2019;32:328-333.
- Garipardic M, Doğan M, Bala KA, Mutluer T, Kaba S, Aslan O et al. Association of attention deficit hyperactivity disorder and autism spectrum disorders with mean platelet volume and vitamin D. Med Sci Monit. 2017;23:1378.
- Mert DG, Terzi H. Mean platelet volume in bipolar disorder: the search for an ideal biomarker. Neuropsychiatr Dis Treat. 2016;12:2057.
- Asoglu M, Aslan M, Imre O, Kivrak Y, Akil O, Savık E et al. Mean platelet volume and red cell distribution width levels in initial evaluation of panic disorder. Neuropsychiatr Dis Treat 2016;12:2435.
- Gül IG, Eryılmaz G, Özten E, Sayar GH. Decreased mean platelet volume in panic disorder. Neuropsychiatr Dis Treat. 2014;10:1665.
- Demircan F, Gözel N, Kılınç F, Ulu, R, Atmaca M. The impact of red blood cell distribution width and neutrophil/lymphocyte ratio on the diagnosis of major depressive disorder. Neurolog Ther. 2016;5:27-33.
- Korkmaz S, Yıldız S, Korucu T, Gundogan B, Sunbul ZE, Korkmaz H et al. Frequency of anemia in chronic psychiatry patients. Neuropsychi
Ayrıntılar
| Birincil Dil | İngilizce |
|---|---|
| Konular | Sağlık Kurumları Yönetimi |
| Bölüm | Araştırma Makaleleri |
| Yazarlar | |
| Erken Görünüm Tarihi | 10 Temmuz 2023 |
| Yayımlanma Tarihi | 12 Temmuz 2023 |
| Gönderilme Tarihi | 13 Haziran 2022 |
| Kabul Tarihi | 31 Ağustos 2022 |
| Yayımlandığı Sayı | Yıl 2023 Cilt: 18 Sayı: 2 |
