Öz
Amaç: Pulmoner emboli acil servislerde sık karşılaşılan ve yüksek mortaliteye sahip bir pulmoner vasküler hastalıktır. Pulmoner emboli tanısı için geliştirilmiş spesik bir biyobelirteç henüz dünyada bulunmamaktadır. Çalışmamızda acil servise başvuran akut pulmoner emboli tanısı alan hastaların başvuru anındaki ortalama trombosit hacmi (mean platelet volume, MPV) değerlerini incelemeyi, MPV değerlerinin pulmoner emboli hastalığından kuşku duymada kullanılıp kullanılamayacağını araştırmayı amaçladık.
Gereç ve Yöntemler: Çalışmamıza dahil etme kriterlerine uyan 51 pulmoner emboli tanısı konulan hasta ve aynı demografik özelliklere sahip, 18 yaş üzeri aktif bir şikâyeti / kronik hastalığı olmayan ve genel kontrol amaçlı hastanemize başvurmuş 25 sağlıklı gönüllü kişi dahil edilmiştir. Hastaların verileri, hastanenin sisteminden ve hastaların takip dosyalarından elde edilmiştir. Çalışmamızda hastaların yaş, cinsiyet ve başvuru anındaki MPV değerleri incelenmiş ve kontrol grubu ile karşılaştırılmıştır.
Bulgular: MPV değeri hasta grubunda 7.87±1.85 fL, kontrol grubunda 7.94±1.24 fL olarak bulundu. Hasta grubunda kontrol grubuna göre daha yüksek değerler saptanmasına rağmen istatistiksel olarak anlamlı değerlendirilmedi (p=0.176, p<0.05). Hastaların trombosit değerleri 268.14±104.86 x10³/ μL, kontrol grubunun ise 276.04±83.36 x10³/μL olarak bulundu ve istatistiksel olarak anlamlı saptanmadı (p=0.441, p<0.05).
Sonuç: Sonuç olarak çalışmamızda pulmoner emboli hastalığı ile MPV değeri arasında anlamlı bir ilişki bulun-mamıştır. Bu yüzden MPV değerinin pulmoner emboliden kuşku duymada veya tanısında etkili olmadığını düşünmekteyiz
Anahtar Kelimeler
Kaynakça
- Stashenko GJ, Tapson VF. Prevention of venous thromboembolism in medical patients and outpatients. Nat Rev Cardiol. 2009;6(5):356-63.
- Raskob GE, Angchaisuksiri P, Blanco AN, Buller H, Gallus A, Hunt BJ et al. ISTH Steering Committee for World Thrombosis Day. Thrombosis: a major contributor to global disease burden. Arterioscler Thromb Vasc Biol. 2014;34(11):2363-71.
- Stein PD, Terrin ML, Hales CA, Palevsky HI , Saltzman HA , Thompson BT et al. Clinical, laboratory, roentgenographic, and electrocardiographic findings in patients with acute pulmonary embolism and nopreexisting cardiacorpulmonary disease. Chest. 1991;100(3):598-603.
- Kruip MJ, Leclercq MG, Heul Cvd, Prins MH, Bller HR. Diagnostic strategies for excluding pulmonary embolism in clinical out come studies: a systematic review. Annals of internal medicine. 2003;138(12):941-51.
- Gawaz M, Langer H, and May AE. Platelets in inflammation and atherogenesis. Journal of Clinical Investigation. 2005;115(12):p.3378.
- Endler G, Klimesch A, Sunder-Plassmann H, Schillinger M, Exner M, Mannhalter C et al. Mean platelet volüme is an independent risk factor for myocardial infarction but not for coronary artery disease. Br J Haematol. 2002;117(2):399-404.
- Senaran H, Ileri M, Altinbas A, Koşar A, Yetkin E, Oztürk M et al. Thrombopoietin and mean platelet volume in coronary artery disease. Clin Cardiol. 2001;24(5):405-8.
- Fei Y, Zong GQ, Chen J, Liu RM. Evaluation of thevalue of d-dimer, P-selectin, and platelet count for prediction of portal vein thrombosis after devascularization. Clinical and Applied Thrombosis/Hemostasis. 2016;22(5):471-5.
- Chung T, Connor D, Joseph J, Emmett L, Mansberg R, Peters M et al. Platelet activation in acute pulmonary embolism. Journal of Thrombosis and Haemostasis. 2007;5(5):918-24.
- Pomero F, Fenoglio L, Melchio R, Serraino C, Ageno W, Dentali F. Incidence and diagnosis of pulmonar embolism in Northern Italy: a population-based study. European Journal of Internal Medicine. 2013;24(7):e77-8.
- Mathur A, Robinson MS, Cotton J, Martin JF, Erusalimsky JD. Platelet reactivity in acute coronary syndromes: evidence for differences in platelet behaviour between unstable angina and myocardial infarction. Thromb Haemost. 2001;85(6):989-94.
- Braekkan SK, Mathiesen EB, Njolstad I, Wilsgaard T, Størmer J, Hansen JB. Mean platelet volume is a risk factor for venous thromboembolism - the Tromso study. J Thromb Haemost. 2010;8(1):157-62.
- Yardan T, Meric M, Kati C, Celenk Y, Atici AG. Mean platelet volume and mean platelet volume/platelet count ratio in risk stratification of pulmonary embolism. Medicina. 2016;52(2):110-5.
- Günay E, Ulaşlı SS, Kacar E, Halici B, Unlu E, Tünay K et al. Can platelet indices predict obstruction level of pulmonary vascular bed in patients with acute pulmonary embolism? The Clinical Respiratory Journal. 2014;8(1):33-40.
- Lin W, Wu Y, Lu X, Hu Y. Association between mean platelet volume and pulmonary embolism: a systematic review and meta-analysis Aging (Albany NY). 2021;13(13):17253-73.
- Varol E, Icli A, Uysal BA, Ozaydin M. Platelet indices in patients with acute pulmonary embolism. Scandinavian Journal of Clinical and Laboratory Investigation. 2011;71(2):163-7.
- Ermis H, Yucel N, Gulbas G, Turkkan S, Aytemur ZA. Does the mean platelet volume have any importance in patients with acute pulmonary embolism. Wien Klin Wochenschr. 2013;125(13–14):381-5.
- Kostrubiec M, Łabyk A, Pedowska-Włoszek J, Hrynkiewicz- Szyman´ska A, Pacho S, Jankowski K et al. Mean platelet volume predicts early death in acute pulmonary embolism. Heart. 2010;96(6):460-5.
Öz
Objective: Pulmonary embolism is a pulmonary vascular disease that is frequently encountered in emergency departments and has a high mortality. A specic biomarker developed for the diagnosis of pulmonary embolism is not yet available in the world. In our study, we aimed to examine the mean platelet volume (MPV) values of the patients who were diagnosed with acute pulmonary embolism and admitted to the emergency department, and to investigate whether MPV values could be used to suspect pulmonary embolism.
Material and Methods: Our study included 51 patients diagnosed with pulmonary embolism who met our inclusion criteria, and 25 healthy volunteers with the same demographic characteristics, over the age of 18 without any active complaint / chronic disease, and who admitted to our hospital for general control. The data of the patients were obtained from the hospital’s system and from the follow-up files of the patients. In our study, the age, gender and MPV values of the patients at the time of admission were examined and compared with the control group.
Results: The MPV value was 7.87±1.85 fL in the patient group and 7.94±1.24 fL in the control group. Although higher values were found in the patient group than in the control group, it was not statistically signicant (p=0.176, p<0.05). The platelet values of the patients were found to be 268.14±104.86 x10³/μL, and the control group as 276.04±83.36 x10³/μL, and it was not statistically significant (p=0.441, p<0.05).
Conclusion: In conclusion, no signicant relationship was found between pulmonary embolism and MPV in our study. Therefore, we think that the MPV is not eective in suspecting or diagnosing pulmonary embolism.
Anahtar Kelimeler
Kaynakça
- Stashenko GJ, Tapson VF. Prevention of venous thromboembolism in medical patients and outpatients. Nat Rev Cardiol. 2009;6(5):356-63.
- Raskob GE, Angchaisuksiri P, Blanco AN, Buller H, Gallus A, Hunt BJ et al. ISTH Steering Committee for World Thrombosis Day. Thrombosis: a major contributor to global disease burden. Arterioscler Thromb Vasc Biol. 2014;34(11):2363-71.
- Stein PD, Terrin ML, Hales CA, Palevsky HI , Saltzman HA , Thompson BT et al. Clinical, laboratory, roentgenographic, and electrocardiographic findings in patients with acute pulmonary embolism and nopreexisting cardiacorpulmonary disease. Chest. 1991;100(3):598-603.
- Kruip MJ, Leclercq MG, Heul Cvd, Prins MH, Bller HR. Diagnostic strategies for excluding pulmonary embolism in clinical out come studies: a systematic review. Annals of internal medicine. 2003;138(12):941-51.
- Gawaz M, Langer H, and May AE. Platelets in inflammation and atherogenesis. Journal of Clinical Investigation. 2005;115(12):p.3378.
- Endler G, Klimesch A, Sunder-Plassmann H, Schillinger M, Exner M, Mannhalter C et al. Mean platelet volüme is an independent risk factor for myocardial infarction but not for coronary artery disease. Br J Haematol. 2002;117(2):399-404.
- Senaran H, Ileri M, Altinbas A, Koşar A, Yetkin E, Oztürk M et al. Thrombopoietin and mean platelet volume in coronary artery disease. Clin Cardiol. 2001;24(5):405-8.
- Fei Y, Zong GQ, Chen J, Liu RM. Evaluation of thevalue of d-dimer, P-selectin, and platelet count for prediction of portal vein thrombosis after devascularization. Clinical and Applied Thrombosis/Hemostasis. 2016;22(5):471-5.
- Chung T, Connor D, Joseph J, Emmett L, Mansberg R, Peters M et al. Platelet activation in acute pulmonary embolism. Journal of Thrombosis and Haemostasis. 2007;5(5):918-24.
- Pomero F, Fenoglio L, Melchio R, Serraino C, Ageno W, Dentali F. Incidence and diagnosis of pulmonar embolism in Northern Italy: a population-based study. European Journal of Internal Medicine. 2013;24(7):e77-8.
- Mathur A, Robinson MS, Cotton J, Martin JF, Erusalimsky JD. Platelet reactivity in acute coronary syndromes: evidence for differences in platelet behaviour between unstable angina and myocardial infarction. Thromb Haemost. 2001;85(6):989-94.
- Braekkan SK, Mathiesen EB, Njolstad I, Wilsgaard T, Størmer J, Hansen JB. Mean platelet volume is a risk factor for venous thromboembolism - the Tromso study. J Thromb Haemost. 2010;8(1):157-62.
- Yardan T, Meric M, Kati C, Celenk Y, Atici AG. Mean platelet volume and mean platelet volume/platelet count ratio in risk stratification of pulmonary embolism. Medicina. 2016;52(2):110-5.
- Günay E, Ulaşlı SS, Kacar E, Halici B, Unlu E, Tünay K et al. Can platelet indices predict obstruction level of pulmonary vascular bed in patients with acute pulmonary embolism? The Clinical Respiratory Journal. 2014;8(1):33-40.
- Lin W, Wu Y, Lu X, Hu Y. Association between mean platelet volume and pulmonary embolism: a systematic review and meta-analysis Aging (Albany NY). 2021;13(13):17253-73.
- Varol E, Icli A, Uysal BA, Ozaydin M. Platelet indices in patients with acute pulmonary embolism. Scandinavian Journal of Clinical and Laboratory Investigation. 2011;71(2):163-7.
- Ermis H, Yucel N, Gulbas G, Turkkan S, Aytemur ZA. Does the mean platelet volume have any importance in patients with acute pulmonary embolism. Wien Klin Wochenschr. 2013;125(13–14):381-5.
- Kostrubiec M, Łabyk A, Pedowska-Włoszek J, Hrynkiewicz- Szyman´ska A, Pacho S, Jankowski K et al. Mean platelet volume predicts early death in acute pulmonary embolism. Heart. 2010;96(6):460-5.
Ayrıntılar
| Birincil Dil | Türkçe |
|---|---|
| Konular | Sağlık Kurumları Yönetimi |
| Bölüm | Özgün Araştırma |
| Yazarlar | |
| Yayımlanma Tarihi | 31 Aralık 2022 |
| Gönderilme Tarihi | 5 Nisan 2022 |
| Yayımlandığı Sayı | Yıl 2022 Cilt: 24 Sayı: 3 |
Kaynak Göster
Bu Dergi, Kırıkkale Üniversitesi Tıp Fakültesi Yayınıdır.