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Seizure worsening caused by low serum valproate levels from an interaction between valproate and meropenem

Yıl 2015, Cilt: 28 Sayı: 2, 116 - 119, 14.09.2015

Suat Biçer Gülay Çiler Erdağ Canan Kocaman Yıldırım Tuba Giray Defne Çöl Öznur Küçük Zerrin Yalvaç Ayça Vitrinel

https://doi.org/10.5472/MMJcr.2802.12
Cited By: 1

Öz

We present an interaction of meropenem with valproate in an epileptic child, leading to seizure exacerbations owing to the rapid lowering of serum valproate concentration. An increase of seizure frequency and somnolence were observed in the patient after the addition of meropenem to the treatment, and a rapid decline of valproate serum concentrations was observed after two doses of meropenem. This decline was the most likely cause of the increase in seizure frequency. The dosage of valproate was raised and meropenem was stopped. Two days later, the seizures stopped. Five days later, the serum valproate concentrations raised to three fold, and they rose to therapeutic levels four weeks later. To avoid drug interaction that reduces the serum concentration of valproate, meropenem in epileptic patients using valproate for the treatment of epilepsy should be administered cautiously. If concominant administration is essential, close observation of serum concentration of valproate and clinical course of the patient are necessary.

Keywords: Carbapenems, Drug interactions, Meropenem, Seizures, Valproate

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Yıl 2015, Cilt: 28 Sayı: 2, 116 - 119, 14.09.2015

Suat Biçer Gülay Çiler Erdağ Canan Kocaman Yıldırım Tuba Giray Defne Çöl Öznur Küçük Zerrin Yalvaç Ayça Vitrinel

https://doi.org/10.5472/MMJcr.2802.12
Cited By: 1

Öz

-

Anahtar Kelimeler

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Kaynakça

  • BLANK NO CITATIONS
Toplam 1 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Bölüm Olgu Sunumu
Yazarlar

Suat Biçer

Gülay Çiler Erdağ Bu kişi benim

Canan Kocaman Yıldırım Bu kişi benim

Tuba Giray Bu kişi benim

Defne Çöl Bu kişi benim

Öznur Küçük Bu kişi benim

Zerrin Yalvaç Bu kişi benim

Ayça Vitrinel Bu kişi benim

Yayımlanma Tarihi 14 Eylül 2015
Yayımlandığı Sayı Yıl 2015 Cilt: 28 Sayı: 2

Kaynak Göster

APA Biçer, S., Çiler Erdağ, G., Kocaman Yıldırım, C., Giray, T., vd. (2015). Seizure worsening caused by low serum valproate levels from an interaction between valproate and meropenem. Marmara Medical Journal, 28(2), 116-119. https://doi.org/10.5472/MMJcr.2802.12
AMA Biçer S, Çiler Erdağ G, Kocaman Yıldırım C, Giray T, Çöl D, Küçük Ö, Yalvaç Z, Vitrinel A. Seizure worsening caused by low serum valproate levels from an interaction between valproate and meropenem. Marmara Med J. Eylül 2015;28(2):116-119. doi:10.5472/MMJcr.2802.12
Chicago Biçer, Suat, Çiler Erdağ Gülay, Canan Kocaman Yıldırım, Tuba Giray, Defne Çöl, Küçük Öznur, Zerrin Yalvaç, ve Ayça Vitrinel. “Seizure Worsening Caused by Low Serum Valproate Levels from an Interaction Between Valproate and Meropenem”. Marmara Medical Journal 28, sy. 2 (Eylül 2015): 116-19. https://doi.org/10.5472/MMJcr.2802.12.
EndNote Biçer S, Çiler Erdağ G, Kocaman Yıldırım C, Giray T, Çöl D, Küçük Ö, Yalvaç Z, Vitrinel A (01 Eylül 2015) Seizure worsening caused by low serum valproate levels from an interaction between valproate and meropenem. Marmara Medical Journal 28 2 116–119.
IEEE S. Biçer, “Seizure worsening caused by low serum valproate levels from an interaction between valproate and meropenem”, Marmara Med J, c. 28, sy. 2, ss. 116–119, 2015, doi: 10.5472/MMJcr.2802.12.
ISNAD Biçer, Suat vd. “Seizure Worsening Caused by Low Serum Valproate Levels from an Interaction Between Valproate and Meropenem”. Marmara Medical Journal 28/2 (Eylül 2015), 116-119. https://doi.org/10.5472/MMJcr.2802.12.
JAMA Biçer S, Çiler Erdağ G, Kocaman Yıldırım C, Giray T, Çöl D, Küçük Ö, Yalvaç Z, Vitrinel A. Seizure worsening caused by low serum valproate levels from an interaction between valproate and meropenem. Marmara Med J. 2015;28:116–119.
MLA Biçer, Suat vd. “Seizure Worsening Caused by Low Serum Valproate Levels from an Interaction Between Valproate and Meropenem”. Marmara Medical Journal, c. 28, sy. 2, 2015, ss. 116-9, doi:10.5472/MMJcr.2802.12.
Vancouver Biçer S, Çiler Erdağ G, Kocaman Yıldırım C, Giray T, Çöl D, Küçük Ö, Yalvaç Z, Vitrinel A. Seizure worsening caused by low serum valproate levels from an interaction between valproate and meropenem. Marmara Med J. 2015;28(2):116-9.

Cited By

Meropenem/valproate interaction
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