Deniz Kabuklularında Bulunan İndigoid Boyarmaddelerin Metal Etkileşimlerinin Spektrofotometrik Yöntemle İncelenmesi
Öz
Renklendiriciler gündelik hayatımızda önemli bir yer tutmaktadırlar. Tekstil, gıda, ilaç ve kozmetik endüstrisinde yaygın olarak kullanılan sentetik boyarmaddelerin insan ve çevre sağlığı üzerine olan zararlı etkilerinden dolayı, günümüzde doğal boyarmaddelerin kullanımı giderek artmaktadır. Deniz kabuklularından elde edilen indirubin, 6-bromo indirubin, 6’-bromo indirubin, 6,6’-dibromo indirubin, indigotin, 6-bromo indigotin ve 6,6’-dibromo indigotin boyarmaddeleri tarihte ilk kullanılan renklendiricilerdendir (1). Objeleri renklendirmenin dışında birçok geleneksel tıp reçetesinde de kullanılmışlardır. Günümüzde bu maddelerin kanser, diyabet gibi hastalıkların tedavisinde kullanılabilecek yeni analogları da sentezlenmektedir (2). Boyama sırasında metalle mordanlama işlemi çok önemlidir. Mordanlamada kullanılan metalle boyarmadde arasındaki etkileşim boyamanın kalitesini etkileyen en önemli faktördür. Bu çalışmada deniz kabuklularından elde edilen indigo analoğu yedi tane boyarmaddenin alüminyum(III) ve kalay(II) metalleri ile olan etkileşimleri spektrofotometrik yöntemle incelenmiştir.
Anahtar Kelimeler
doğal boyarmadde kalay (II) alüminyum (III) UV-VIS spektrofotometri İndigo
Kaynakça
- Cardon D. Natural Dyes Sources, Tradition, Technology and Science. Archetype Publications Ltd, London. 2007. p. 607 – 710.
- Hoessel R, Leclerc S, Endicott JA, Nobel MEM, Lawrie A, Tunnah P, Leost M, Damiens E, Marie D, Marko D. Niederberger E. Tang W. Eisenbrand G. Meijer L. Indirubin, the active constituent of a Chinese antileukaemia medicine, inhibits cyclin-dependent kinases. Nat Cell Biol 1999;1:60-67.
- Perkin AG. Everest AE. The Natural Organic Colouring Matters. Longmans, Green and Co, London. 1918.
- Balfour-Paul J. Indigo. British Museum Press, London. 2000.
- In Meijer L. Guyard N. Skaltsounis L. Eisenbrand G. Indirubin, the red shade of indigo. Life in Progress Editions, Roscoff, France. 2006. p. 45-53.
- Cooksey CJ. Tyrian purple: 6,6’-Dibromoindigo and related compounds. Molecules 2001; 6:736-769.
- Noble MEM. Protein kinase inhibitors: Insights into drug design from structure. Science 2004;303:1800-1805.
- Nam S, Buettner R, Turkson J, Kim D, Cheng JQ, Muehlbeyer S, Hippe F, Vatter S, Merz KH, Eisenbrand G, Jove R, Vogt PK. Indirubin derivatives inhibit stat-3 signaling and induce apoptosis in human cancer cells. P Natl Acad Sci USA 2005;102:17:5998-6003.
- Hoessel R, Leclerc S, Endicott JA, Nobel MEM, Lawrie A, Tunnah P, Leost M, Damiens E, Marie D, Marko D, Niederberger E, Tang W, Eisenbrand G, Meijer L. Indirubin, the active constituent of a Chinese antileukaemia medicine, inhibits cyclin-dependent kinases. Nat Cell Biol 1999;1:60–67.
- Moon MJ, Lee SK, Lee JW, Song WK, Kim SW, Kim JI, Cho C, Choia SJ, Kima YC. Synthesis and structure-activity relationships of novel indirubin derivatives as potent anti-proliferative agents with CDK2 inhibitory activities. Bioorgan Med Chem 2006;14:237-246.
- Meijer L, Skaltsounis AL, Magiatis P, Polychronopoulos P, Knockaert M, Leost M, Ryan XP, Vonica CA, Brivanlou A, Dajani R, Crovace C, Tarricone C, Musacchio A, Roe SM, Pearl L, Greengard P. GSK-3-Selective Inhibitors Derived from Tyrian Purple Indirubins. Chem Biol 2003;10:1255–1266.
- Chavan, R.B. Environment-friendly dyeing processes for cotton. Indian J Fibre Text 2001;26:93-100.
- Ryberg K, Isaksson M, Gruberger B, Hindsen M, Zimerson E, Bruze M. Contact allergy to textile dyes in southern sweden. Contact Dermatitis 2006;54(6) 313-321.
- Seesuriyachana P, Takenakab S, Kuntiyaa A, Klayraungc S, Murakamib S, Aokib K. Metabolism of azo dyes by Lactobacillus casei TISTR 1500 and effects of various factors on decolorization. Water Res 2007;41: 985 – 992.
Öz
Synthetic dyes are widely used in textile, food, pharmaceutical and cosmetic industries and they have an important place in our daily lives. In recent years toxic effects of synthetic dyes on environment and human health have been reported and natural dyes have been proposed as an alternative colorants.Indirubin, 6-bromo indirubin, 6’-bromo indirubin, 6,6’-dibromo indirubin, indigotin, 6-bromo indigotin and
Anahtar Kelimeler
Indigo Natural dye Tin (II) Aluminium (III) UV-VIS spectrophotometry
Kaynakça
- Cardon D. Natural Dyes Sources, Tradition, Technology and Science. Archetype Publications Ltd, London. 2007. p. 607 – 710.
- Hoessel R, Leclerc S, Endicott JA, Nobel MEM, Lawrie A, Tunnah P, Leost M, Damiens E, Marie D, Marko D. Niederberger E. Tang W. Eisenbrand G. Meijer L. Indirubin, the active constituent of a Chinese antileukaemia medicine, inhibits cyclin-dependent kinases. Nat Cell Biol 1999;1:60-67.
- Perkin AG. Everest AE. The Natural Organic Colouring Matters. Longmans, Green and Co, London. 1918.
- Balfour-Paul J. Indigo. British Museum Press, London. 2000.
- In Meijer L. Guyard N. Skaltsounis L. Eisenbrand G. Indirubin, the red shade of indigo. Life in Progress Editions, Roscoff, France. 2006. p. 45-53.
- Cooksey CJ. Tyrian purple: 6,6’-Dibromoindigo and related compounds. Molecules 2001; 6:736-769.
- Noble MEM. Protein kinase inhibitors: Insights into drug design from structure. Science 2004;303:1800-1805.
- Nam S, Buettner R, Turkson J, Kim D, Cheng JQ, Muehlbeyer S, Hippe F, Vatter S, Merz KH, Eisenbrand G, Jove R, Vogt PK. Indirubin derivatives inhibit stat-3 signaling and induce apoptosis in human cancer cells. P Natl Acad Sci USA 2005;102:17:5998-6003.
- Hoessel R, Leclerc S, Endicott JA, Nobel MEM, Lawrie A, Tunnah P, Leost M, Damiens E, Marie D, Marko D, Niederberger E, Tang W, Eisenbrand G, Meijer L. Indirubin, the active constituent of a Chinese antileukaemia medicine, inhibits cyclin-dependent kinases. Nat Cell Biol 1999;1:60–67.
- Moon MJ, Lee SK, Lee JW, Song WK, Kim SW, Kim JI, Cho C, Choia SJ, Kima YC. Synthesis and structure-activity relationships of novel indirubin derivatives as potent anti-proliferative agents with CDK2 inhibitory activities. Bioorgan Med Chem 2006;14:237-246.
- Meijer L, Skaltsounis AL, Magiatis P, Polychronopoulos P, Knockaert M, Leost M, Ryan XP, Vonica CA, Brivanlou A, Dajani R, Crovace C, Tarricone C, Musacchio A, Roe SM, Pearl L, Greengard P. GSK-3-Selective Inhibitors Derived from Tyrian Purple Indirubins. Chem Biol 2003;10:1255–1266.
- Chavan, R.B. Environment-friendly dyeing processes for cotton. Indian J Fibre Text 2001;26:93-100.
- Ryberg K, Isaksson M, Gruberger B, Hindsen M, Zimerson E, Bruze M. Contact allergy to textile dyes in southern sweden. Contact Dermatitis 2006;54(6) 313-321.
- Seesuriyachana P, Takenakab S, Kuntiyaa A, Klayraungc S, Murakamib S, Aokib K. Metabolism of azo dyes by Lactobacillus casei TISTR 1500 and effects of various factors on decolorization. Water Res 2007;41: 985 – 992.
Ayrıntılar
| Birincil Dil | Türkçe |
|---|---|
| Konular | Sağlık Kurumları Yönetimi |
| Bölüm | Makaleler |
| Yazarlar | |
| Yayımlanma Tarihi | 10 Nisan 2015 |
| Yayımlandığı Sayı | Yıl 2015 Cilt: 19 Sayı: 2 |