Araştırma Makalesi
BibTex RIS Kaynak Göster
Yıl 2021, Cilt: 7 Sayı: 2, 262 - 268, 31.08.2021
https://doi.org/10.19127/mbsjohs.953166

Öz

Kaynakça

  • 1. Sadock BJ, Sadoc/k VA. Çeviri editörü Bozkurt A. Kaplan & Sadock Klinik Psikiyatri. 4.baskı: İstanbul, Güneş Tıp Kitapevleri, 2009.
  • 2. Ertuğrul A. Şizofreninin Nörobiyolojisi, Temel Psikofarmakoloji. Ankara, 2010; 1:354.
  • 3. Doğan O. Şizofrenik bozuklukların epidemiyolojisi. Doğan O (ed.): Psikiyatrik Epidemiyoloji’de. Ege Psikiyatri Yayınları, İzmir, 2002; s.15-34.
  • 4. Karakuş G , Kocal Y, Sert D. Şizofreni: Etyoloji, Klinik Özellikler ve Tedavi. Arşiv Kaynak Tarama Dergisi, 2017; 26(2): 251-267.
  • 5. Yavaşcı ÖE, Akkaya C. Şizofrenide serotoninin rolü. Psikiyatride Güncel Yaklaşımlar, 2012; 4(2):237-259.
  • 6. Kim Y, Zerwas S, Trace SE, Sullivan PF. Schizophrenia genetics: Where next? Schizophr Bull., 2011; 37:456-63.
  • 7. Prasad S, Bhatia T, Kukshal P, Nimgaonkar VL, Deshpande SN, et al. Attempts to replicate genetic associations with schizophrenia in a cohort from north India. NPJ Schizophr, 2017 Aug 30;3(1):28. 8. Hilker R, Helenius D, Fagerlund B, Skytthe A, Christensen K, et al. Heritability of Schizophrenia and Schizophrenia Spectrum Based on the Nationwide Danish Twin Register. Biol Psychiatry, 2018; 15;83(6):492-498.
  • 9. Kantrowitz JT. Targeting Serotonin 5-HT2A Receptors to Better Treat Schizophrenia: Rationale and Current Approaches. CNS Drugs, 2020; 34(9):947-959.
  • 10. Tsai S-J, Ouyang W-C, Hong C-J. Association for serotonin transporter gene variable number tandem repeat polymorphism and schizophrenic disorders. Neuropsychobiology. 2002; 45:131-133.
  • 11. Fan J, Sklar P. Meta-analysis reveals association between serotonin transporter gene STin2 VNTR polymorphism and schizophrenia. Mol Psychiatry, 2005; 10, 928–938.
  • 12. Kaiser R, Tremblay P-B, Schmider J, Henneken M, Dettling M, et al. Serotonin transporter polymorphisms: no association with response to antipsychotic treatment, but associations with the schizoparanoid and residual subtypes of schizophrenia. Mol Psychiatry, 2001; 6:179-185.
  • 13. Vijayan NN, Iwayama Y, Koshy LV, Natarajan C, Nair C, et al. Evidence of association of serotonin transporter gene polymorphisms with schizophrenia in a South Indian population. J Hum Genet., 2009; 54(9):538-42.
  • 14. Herken H, Erdal ME, Aynacıoğlu AS, Barlas O, Cataloluk O ve ark. Frequency of the 17-bp variable number of tandem repeat polymorphism in Turkish schizophrenic patients. Schizophr Res., 2002; 58:99-100.
  • 15. Sáiz PA, García-Portilla MP, Arango C, Morales B, Alvarez V, et al. Association study of serotonin 2A receptor (5-HT2A) and serotonin transporter (5-HTT) gene polymorphisms with schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry, 2007; 13;31(3):741-5.
  • 16. Culej J, Štefanović M, Ćelap I, Nikolac N, Karlović D. Serotonin transporter polymorphism (5-HTTLPR) in Croatian population. Mol Biol Rep., 2015 Feb 42;(2):553-8.
  • 17. American Psychiatric Association (APA). Diagnostic and Statistical Manual of Mental Disorders, 4th edition, text revision (DSM-IV-TR). Washington, DC. 2000.
  • 18. Keshevan MS, Diwadkar VA, Montrose DM, Rajarethinam R, Sweeney JA. Premorbid İndicators And Risk For Schizophrenia. Schizophrenia Res., 2005; 79: 45-57. 19. Herken H, Ceylan ME. Genetik. In: Ceylan ME, Çetin M (ed). Şizofreni. İstanbul: İncekara: 2009; s. 319-353.
  • 20. Hranilovic D, Stefulj J, Schwab S, Borrmann-Hassenbach M, Albus M, et al. Serotonin transporter promoter and intron 2 polymorphisms: relationship between allelic variants and gene expression. Biol Psychiatry, 2004; 1;55(11):1090.
  • 21. Lindholm Carlström E, Saetre P, Rosengren A, Thygesen JH, Djurovic S, et al. Association between a genetic variant in the serotonin transporter gene (SLC6A4) and suicidal behavior in patients with schizophrenia. Behav Brain Funct., 2012 May 17;8:24.
  • 22. Herken H, Erdal ME, Esgi K, Barlas Ö, Erdal N, Ayancıoğlu Ş. Şizofrenili Hastalarda Serotonin Taşıyıcı Gen Polimorfizmi. Klinik Psikofarmakoloji Bülteni. 2001; 11:4.
  • 23. Pae CU, Kim TS, Kim JJ, Lee CU, Lee SJ et al. The Serotonin Transporter Gene Polymorphism may not be Associated with Antipsychotic Treatment Response in Patients with Schizophrenia. Psychiatr Invest., 2005; 2 (2):98-103.
  • 24. Golimbet V, Korovaitseva G, Lezheiko T, Abramova LI., Kaleda VG. The serotonin transporter gene 5-HTTLPR polymorphism is associated with affective psychoses but not with schizophrenia: A large-scale study in the Russian population. Journal of Affective Disorders, 2017; 208, 604-609.
  • 25. Contreras J, Hernández S, Quezada P, Dassori A, Walss-Bass C,et al. Association of Serotonin Transporter Promoter Gene Polymorphism (5-HTTLPR) With Depression in Costa Rican Schizophrenic Patients, Journal of Neurogenetics, 2010; 24:2, 83-89.

Serotonin Transporter Gene Polymorphism in Patients with Schizophrenic Disorders

Yıl 2021, Cilt: 7 Sayı: 2, 262 - 268, 31.08.2021
https://doi.org/10.19127/mbsjohs.953166

Öz

Objective: Studies performed to solve the genetic basis of schizophrenia have focused on the role of serotonin in the etiology of schizophrenia and the function of serotonin transporter gene. This study aimed to investigate whether there was a relationship between schizophrenia and polymorphism of the Variable Number of Tandem Repeats (VTNR) and 5-HTT Gene-Linked Polymorphic Region (5-HTTLPR) variants in the transcriptional control region of the serotonin transporter gene or not.

Method: A total of 55 schizophrenia patients who were diagnosed according to the diagnostic criteria of DSM-IV-TR and 32 healthy volunteers (the control group) were included in the study. DNAs were extracted from the bloods collected from the patient and control groups with the salting-out method. Alleles of the serotonin transporter gene polymorphism were determined with the polymerase chain reaction (PCR) method.

Results: Based on the serotonin transporter gene intron 2 VNTR polymorphism, the distribution of 12/12, 12/10, 10/10, and 12/9 genotypes was 47.3%, 47.3%, 3.6%, and 1.8% in the patients and 46.9%, 46.9% and 6.3% respectively in the control group. There was no 12/9 genotype in the control group. The distribution of L/L, L/S and S/S genotypes according to the 5-HTTLPR polymorphism was 30.9%, 41.8% and 27.3% in the patients and 28.1%, 50.0% and 21.9% respectively in the control group.

Conclusion: Although the allele and genotype distributions of the serotonin transporter gene polymorphism relatively differed between the patient and control groups this difference was not statistically significant.

Kaynakça

  • 1. Sadock BJ, Sadoc/k VA. Çeviri editörü Bozkurt A. Kaplan & Sadock Klinik Psikiyatri. 4.baskı: İstanbul, Güneş Tıp Kitapevleri, 2009.
  • 2. Ertuğrul A. Şizofreninin Nörobiyolojisi, Temel Psikofarmakoloji. Ankara, 2010; 1:354.
  • 3. Doğan O. Şizofrenik bozuklukların epidemiyolojisi. Doğan O (ed.): Psikiyatrik Epidemiyoloji’de. Ege Psikiyatri Yayınları, İzmir, 2002; s.15-34.
  • 4. Karakuş G , Kocal Y, Sert D. Şizofreni: Etyoloji, Klinik Özellikler ve Tedavi. Arşiv Kaynak Tarama Dergisi, 2017; 26(2): 251-267.
  • 5. Yavaşcı ÖE, Akkaya C. Şizofrenide serotoninin rolü. Psikiyatride Güncel Yaklaşımlar, 2012; 4(2):237-259.
  • 6. Kim Y, Zerwas S, Trace SE, Sullivan PF. Schizophrenia genetics: Where next? Schizophr Bull., 2011; 37:456-63.
  • 7. Prasad S, Bhatia T, Kukshal P, Nimgaonkar VL, Deshpande SN, et al. Attempts to replicate genetic associations with schizophrenia in a cohort from north India. NPJ Schizophr, 2017 Aug 30;3(1):28. 8. Hilker R, Helenius D, Fagerlund B, Skytthe A, Christensen K, et al. Heritability of Schizophrenia and Schizophrenia Spectrum Based on the Nationwide Danish Twin Register. Biol Psychiatry, 2018; 15;83(6):492-498.
  • 9. Kantrowitz JT. Targeting Serotonin 5-HT2A Receptors to Better Treat Schizophrenia: Rationale and Current Approaches. CNS Drugs, 2020; 34(9):947-959.
  • 10. Tsai S-J, Ouyang W-C, Hong C-J. Association for serotonin transporter gene variable number tandem repeat polymorphism and schizophrenic disorders. Neuropsychobiology. 2002; 45:131-133.
  • 11. Fan J, Sklar P. Meta-analysis reveals association between serotonin transporter gene STin2 VNTR polymorphism and schizophrenia. Mol Psychiatry, 2005; 10, 928–938.
  • 12. Kaiser R, Tremblay P-B, Schmider J, Henneken M, Dettling M, et al. Serotonin transporter polymorphisms: no association with response to antipsychotic treatment, but associations with the schizoparanoid and residual subtypes of schizophrenia. Mol Psychiatry, 2001; 6:179-185.
  • 13. Vijayan NN, Iwayama Y, Koshy LV, Natarajan C, Nair C, et al. Evidence of association of serotonin transporter gene polymorphisms with schizophrenia in a South Indian population. J Hum Genet., 2009; 54(9):538-42.
  • 14. Herken H, Erdal ME, Aynacıoğlu AS, Barlas O, Cataloluk O ve ark. Frequency of the 17-bp variable number of tandem repeat polymorphism in Turkish schizophrenic patients. Schizophr Res., 2002; 58:99-100.
  • 15. Sáiz PA, García-Portilla MP, Arango C, Morales B, Alvarez V, et al. Association study of serotonin 2A receptor (5-HT2A) and serotonin transporter (5-HTT) gene polymorphisms with schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry, 2007; 13;31(3):741-5.
  • 16. Culej J, Štefanović M, Ćelap I, Nikolac N, Karlović D. Serotonin transporter polymorphism (5-HTTLPR) in Croatian population. Mol Biol Rep., 2015 Feb 42;(2):553-8.
  • 17. American Psychiatric Association (APA). Diagnostic and Statistical Manual of Mental Disorders, 4th edition, text revision (DSM-IV-TR). Washington, DC. 2000.
  • 18. Keshevan MS, Diwadkar VA, Montrose DM, Rajarethinam R, Sweeney JA. Premorbid İndicators And Risk For Schizophrenia. Schizophrenia Res., 2005; 79: 45-57. 19. Herken H, Ceylan ME. Genetik. In: Ceylan ME, Çetin M (ed). Şizofreni. İstanbul: İncekara: 2009; s. 319-353.
  • 20. Hranilovic D, Stefulj J, Schwab S, Borrmann-Hassenbach M, Albus M, et al. Serotonin transporter promoter and intron 2 polymorphisms: relationship between allelic variants and gene expression. Biol Psychiatry, 2004; 1;55(11):1090.
  • 21. Lindholm Carlström E, Saetre P, Rosengren A, Thygesen JH, Djurovic S, et al. Association between a genetic variant in the serotonin transporter gene (SLC6A4) and suicidal behavior in patients with schizophrenia. Behav Brain Funct., 2012 May 17;8:24.
  • 22. Herken H, Erdal ME, Esgi K, Barlas Ö, Erdal N, Ayancıoğlu Ş. Şizofrenili Hastalarda Serotonin Taşıyıcı Gen Polimorfizmi. Klinik Psikofarmakoloji Bülteni. 2001; 11:4.
  • 23. Pae CU, Kim TS, Kim JJ, Lee CU, Lee SJ et al. The Serotonin Transporter Gene Polymorphism may not be Associated with Antipsychotic Treatment Response in Patients with Schizophrenia. Psychiatr Invest., 2005; 2 (2):98-103.
  • 24. Golimbet V, Korovaitseva G, Lezheiko T, Abramova LI., Kaleda VG. The serotonin transporter gene 5-HTTLPR polymorphism is associated with affective psychoses but not with schizophrenia: A large-scale study in the Russian population. Journal of Affective Disorders, 2017; 208, 604-609.
  • 25. Contreras J, Hernández S, Quezada P, Dassori A, Walss-Bass C,et al. Association of Serotonin Transporter Promoter Gene Polymorphism (5-HTTLPR) With Depression in Costa Rican Schizophrenic Patients, Journal of Neurogenetics, 2010; 24:2, 83-89.
Toplam 23 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Sağlık Kurumları Yönetimi
Bölüm Araştırma Makaleleri
Yazarlar

Fatma Çoker 0000-0002-3818-8796

Orhan Dogan 0000-0002-0161-3584

Yayımlanma Tarihi 31 Ağustos 2021
Yayımlandığı Sayı Yıl 2021 Cilt: 7 Sayı: 2

Kaynak Göster

Vancouver Çoker F, Dogan O. Serotonin Transporter Gene Polymorphism in Patients with Schizophrenic Disorders. Middle Black Sea Journal of Health Science. 2021;7(2):262-8.

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