The Relationship between Hospital Mortality and Hematological Parameters in Acute Ischemic Stroke Patients
Öz
In recent years there are many pieces of research about various haematologic parameters that were related to the prognosis of atherosclerosis and thromboembolic events. In our study we searched possible prognostic factors predicting hospital mortality in patients with acute ischemic stroke in neurology intensive care unit. We examined ninety-nine acute ischemic stroke patients which were followed in neurology intensive care unit, between January 01, 2019 and December 31, 2019. History, neurologic examination, computed tomography and diffusion weighted MRI of brain were applied for acute ischemic stroke diagnosis. Age, gender, ischemic lesions' localisation and hematologic parameters, (leukocyte, neutrophil, lymphocyte, monocyte, hemoglobin, platelet, mean platelet volume-MPV, red cell distribution width-RDW, neutrophil/lymphocyte ratio-NLO, platelet/lymphocyte ratio-PLO, lymphocyte / monocyte ratio-LMO) were compared to find possible prognostic factors which could be correlated with hospital mortality. In this study; age, gender, ischemic lesions indicated no difference for hospital mortality. In additional haematologic parameters indicated no significant difference except lymphocyte-to-monocyte ratio (LMR). Lymphocyte-to-monocyte ratio (LMR:2.06±1.46, p=0.011, sensitivity: 61.7%, specificity: 48.1%) was statistically lower in patients who died in the hospital. Based on the study results, lowe rlymphocyte-to-monocyte ratio (LMR) is a haematologic parameter for predicting hospital mortality for acute ischemic stroke patients. However, more detailed and prospective research should be carried out in this field.
Anahtar Kelimeler
Acute Ischemic Stroke Hospital Mortality Lymphocyte-Monocyte Ratio
Kaynakça
- 1. Bennett DA, Krishnamurthi RV, Barker-Collo S, et al. The global burden of ischemic stroke: findings of the GBD2010 study. Glob Heart. 2014;9:107-12.
- 2. Türkiye İstatistik Kurumu. [Internet]. 2018 yılı ölüm nedeni istatistiği, http://tuik.gov.tr/PreTablo.do?alt_id=1083.
- 3. Petrovic-Djergovic D, Goonewardena SN, Pinsky DJ. Inflammatory disequilibrium in stroke. Circ Res. 2016;119:142-58.
- 4. Rodrigues SF, Granger DN. Leukocyte-mediated tissue injury in ischemic stroke. Curr Med Chem, 2014; 21: 2130–7.
- 5. Altintas O, Altintas MO, Tasal A, et al. The relationship of platelet-to-lymphocyte ratio with clinical outcome and final infarct core in acute ischemic stroke patients who have undergone endovascular therapy. Neurol Res. 2016;38(9):759-65.
- 6. Petrone AB, Eisenman RD, Steele KN, et al. Temporal dynamics of peripheral neutrophil and lymphocytes following acute ischemic stroke. Neurol Sci. 2019;40(9):1877-85. 7. Song SY, Hua C, Dornbors D 3rd. et al. Baseline red blood cell distribution width as a predictor of stroke occurrence and outcome: A comprehensive meta-analysis of 31 studies. Front Neurol. 2019;10:1237.
- 8. Herz J, Sabellek P, Lane TE, et al. Role of neutrophils in exacerbation of brain injury after focal cerebral ischemia in hyperlipidemic mice. Stroke. 2015;46:2916–25.
- 9. Zhu JY, Liu CC, Wang L, et al. Peripheral blood lymphocyte-to-monocyte ratio as a prognostic factor in advanced epithelial ovarian cancer: a multicenter retrospective study. J Cancer. 2017;8:737-43.
- 10. Kiris T, Celik A, Varis E, et al. Association of lymphocyte-to-monocyte ratio with the mortality in patients with ST elevation myocardial infarction who underwent primary percutaneous coronary intervention. Angiology. 2017;3319716685480.
- 11. Liesz A, Suri-Payer E, Veltkamp C, et al. Regulatory T cells are key cerebroprotective immunomodulators in acute experimental stroke. Nat Med. 2009;15:192-9.
- 12. Ren H, Liu X, WangL, et al. Lymphocyte-to-monocyte ratio: a novel predictor of the prognosis of acute ischemic stroke. J Stroke Cerebrovasc Dis. 2017; 26(11): 2595–602.
- 13. Bonifacic D, Toplak A, Benjak I, et al. Monocytes and monocyte chemoattractant protein 1 (MCP-1) as early predictors of disease outcome in patients with cerebral ischemic stroke. Wien KlinWochenschr. 2016;128:20-7.
- 14. Kim J, Song TJ, Park JH, et al. Different prognostic value of white blood cell subtypes in patients with acute cerebral infarction. Atherosclerosis. 2012; 222: 464–7.
- 15. Kim JY, Park J, Chang JY, et al. Inflammation after ischemic stroke: the role of leukocytes and glial cells. Exp Neurobiol. 2016;25:241–51.
- 16. Luo Fan, Li Gui, Er-Qing Chai, et al. Routine hematological parameters are associated with short-and long-term prognosis of patients with ischemic stroke. J Clin Lab Anal. 2018;32:e22244.
- 17. Jing Zhang, Qingqing Ren, Yanlin Song, et al. Prognostic role of neutrophil–lymphocyte ratio in patients with acute ischemic stroke. Medicine. 2017; 96(45): e8624.
- 18. Pektezel MY, Yilmaz E, Arsava EM, et al. Neutrophil-to-Lymphocyte Ratio and response to ıntravenous thrombolysis in patients with acute ıschemic stroke. Stroke Cerebrovasc Dis. 2019;28(7):1853-9.
- 19. Xue J, Huang W, Chen X, et al. Neutrophil-to-lymphocyte ratio is a prognostic marker in acute ischemic stroke. J Stroke Cerebrovasc Dis. 2017;26:650–7.
- 20. Kim JY, Kawabori M, Yenari MA. Innate inflammatory responses in stroke: mechanisms and potential therapeutic targets. Curr Med Chem. 2014;21:2076–97.
- 21. Anrather J, Iadecola C. Inflammation ands troke: an overview. Neurother. 2016;13:661-70.
Öz
Anahtar Kelimeler
Akut İskemik İnme Hastane Mortalitesi Lenfosit-Monosit Oranı
Kaynakça
- 1. Bennett DA, Krishnamurthi RV, Barker-Collo S, et al. The global burden of ischemic stroke: findings of the GBD2010 study. Glob Heart. 2014;9:107-12.
- 2. Türkiye İstatistik Kurumu. [Internet]. 2018 yılı ölüm nedeni istatistiği, http://tuik.gov.tr/PreTablo.do?alt_id=1083.
- 3. Petrovic-Djergovic D, Goonewardena SN, Pinsky DJ. Inflammatory disequilibrium in stroke. Circ Res. 2016;119:142-58.
- 4. Rodrigues SF, Granger DN. Leukocyte-mediated tissue injury in ischemic stroke. Curr Med Chem, 2014; 21: 2130–7.
- 5. Altintas O, Altintas MO, Tasal A, et al. The relationship of platelet-to-lymphocyte ratio with clinical outcome and final infarct core in acute ischemic stroke patients who have undergone endovascular therapy. Neurol Res. 2016;38(9):759-65.
- 6. Petrone AB, Eisenman RD, Steele KN, et al. Temporal dynamics of peripheral neutrophil and lymphocytes following acute ischemic stroke. Neurol Sci. 2019;40(9):1877-85. 7. Song SY, Hua C, Dornbors D 3rd. et al. Baseline red blood cell distribution width as a predictor of stroke occurrence and outcome: A comprehensive meta-analysis of 31 studies. Front Neurol. 2019;10:1237.
- 8. Herz J, Sabellek P, Lane TE, et al. Role of neutrophils in exacerbation of brain injury after focal cerebral ischemia in hyperlipidemic mice. Stroke. 2015;46:2916–25.
- 9. Zhu JY, Liu CC, Wang L, et al. Peripheral blood lymphocyte-to-monocyte ratio as a prognostic factor in advanced epithelial ovarian cancer: a multicenter retrospective study. J Cancer. 2017;8:737-43.
- 10. Kiris T, Celik A, Varis E, et al. Association of lymphocyte-to-monocyte ratio with the mortality in patients with ST elevation myocardial infarction who underwent primary percutaneous coronary intervention. Angiology. 2017;3319716685480.
- 11. Liesz A, Suri-Payer E, Veltkamp C, et al. Regulatory T cells are key cerebroprotective immunomodulators in acute experimental stroke. Nat Med. 2009;15:192-9.
- 12. Ren H, Liu X, WangL, et al. Lymphocyte-to-monocyte ratio: a novel predictor of the prognosis of acute ischemic stroke. J Stroke Cerebrovasc Dis. 2017; 26(11): 2595–602.
- 13. Bonifacic D, Toplak A, Benjak I, et al. Monocytes and monocyte chemoattractant protein 1 (MCP-1) as early predictors of disease outcome in patients with cerebral ischemic stroke. Wien KlinWochenschr. 2016;128:20-7.
- 14. Kim J, Song TJ, Park JH, et al. Different prognostic value of white blood cell subtypes in patients with acute cerebral infarction. Atherosclerosis. 2012; 222: 464–7.
- 15. Kim JY, Park J, Chang JY, et al. Inflammation after ischemic stroke: the role of leukocytes and glial cells. Exp Neurobiol. 2016;25:241–51.
- 16. Luo Fan, Li Gui, Er-Qing Chai, et al. Routine hematological parameters are associated with short-and long-term prognosis of patients with ischemic stroke. J Clin Lab Anal. 2018;32:e22244.
- 17. Jing Zhang, Qingqing Ren, Yanlin Song, et al. Prognostic role of neutrophil–lymphocyte ratio in patients with acute ischemic stroke. Medicine. 2017; 96(45): e8624.
- 18. Pektezel MY, Yilmaz E, Arsava EM, et al. Neutrophil-to-Lymphocyte Ratio and response to ıntravenous thrombolysis in patients with acute ıschemic stroke. Stroke Cerebrovasc Dis. 2019;28(7):1853-9.
- 19. Xue J, Huang W, Chen X, et al. Neutrophil-to-lymphocyte ratio is a prognostic marker in acute ischemic stroke. J Stroke Cerebrovasc Dis. 2017;26:650–7.
- 20. Kim JY, Kawabori M, Yenari MA. Innate inflammatory responses in stroke: mechanisms and potential therapeutic targets. Curr Med Chem. 2014;21:2076–97.
- 21. Anrather J, Iadecola C. Inflammation ands troke: an overview. Neurother. 2016;13:661-70.
Ayrıntılar
| Birincil Dil | Türkçe |
|---|---|
| Konular | İç Hastalıkları |
| Bölüm | Araştırma Makalesi |
| Yazarlar | |
| Yayımlanma Tarihi | 28 Nisan 2020 |
| Gönderilme Tarihi | 8 Mart 2020 |
| Yayımlandığı Sayı | Yıl 2020 Cilt: 7 Sayı: 1 |
