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THE EFFECTS OF THIOSEMICARBAZONE DERIVATIVE SCHIFF BASE 1-(1-PHENIL-1-METHYLCYCLOBUTANE-3-YL)-2-SUKSINIMIDO ETANON THIOSEMICARBAZONE ON ANTIOXIDAN VITAMINS IN LIVER, KIDNEY AND SERUM OF RABBITS

Yıl 2018, Cilt: 13 Sayı: 1, 1 - 6, 20.01.2018

Öz

Thiosemicarbazones
(TSC) are a class of compounds very promising in the treatment of many
diseases, cancer in particular, and its development is still in progress.
The purpose of
the present study was to evaluate the effect of
1-(1-phenil-1-methylcyclobutane-3-yl)-2-suksinimido
etanonthiosemicarbazone (
FSTSC) on antioxidan vitamins (A,
E, C) in liver, kidney and serum of rabbits.
Twenty male rabbits were randomly divided into two groups. The
first group was used as a control
which injected
subcutaneously

of 250µl, 10% dimethylsulphoxide was given to the control group every otherday.
FSTSC compound (25mgkg–1, dissolved in 250µl, 10%
dimethylsulphoxide) was administered to the other group of rabbits.
This
administration was done for a period of 32days.
The vitamin levels (A, E and C) were
determined by high performance liquid chromatography (HPLC). The liver tissue and
serum vitamin C levels were significantly decreased compared to control group
(P<0.05). Levels of vitamins A in kidney was significantly decreased
compared to control group (P<0.05). In addition to many pharmacological
properties of the TSC derivatives examined, it will contribute to the knowledge
of the literature.

Kaynakça

  • 1. Liberta, A.E. and West, D.X., (1992). Antifungal and Antitumour Activity of Heterocyclic Thiosemicarbazones and Their Metal Complexes. Biometals 5:121–126.
  • 2. Padhy, S. and Kauffman, G.B., (1985). Transition Metal Complexes of Semicarbazones and Thiosemicarbazones. Coord ChemRev 63:127–160.
  • 3. Richardson, D.R., (2002). Iron Chelators as Therapeutic Agents for the Treatment of Cancer, Crit. Rev. Oncol. Hematol. 42:267–281.
  • 4. Belicchi-Ferrari, M., Isceglie, F., Casoli, C., Durot, S., Morgenstern-Badarau, I., Pelosi, G., Pilotti, E., Pinelli, S., and Tarasconi, P., (2005). Copper (II) and Co-balt (III) Pyridoxalthiosemicarbazone Complexes with Nitroprusside as Counterion: Syntheses, Electronic Properties, and Antileukemic Activity, J. Med. Chem. 48:1671–1675.
  • 5. Greenbaum, D.C., Mackey, Z., Hansell, E., Doyle, P., Gut, J., Caffrey, C.R., Lehrman, J., Rosenthal, P.J., McKerrow, J.H., and Chibale, K., (2004). Synthesis and Structure-activity Relationships of Parasiticidalthiosemicarbazone Cysteine Protease Inhibitors against Plasmodium Falciparum, Trypanosomabrucei, and Trypanosomacruzi, J. Med. Chem. 47:3212–3219.
  • 6. Pirrung, M.C., Pansare, S.V., Sarma, K.D., Keith, K.A., and Kern, E.R., (2005). Combi-natorial Optimization of Isatin-â -thiosemicarbazones as Anti-poxvirus Agents, J. Med. Chem. 48:3045–3050.
  • 7. Shih, M.H. and Ke, F.Y., (2004). Syntheses and Evaluation of Antioxidant Activity of Sydnonyl Substituted Thiazolidinone and Thiazoline Derivatives. Bioorg Med Chem. Sep 17:4633-43.
  • 8. Moon, R.C., McCormick, D.L., and Mehta, R.G., (1983). Inhibition of Carcinogenesis by Retinoids, Cancer Res. 43:2469-2475.
  • 9. Laila G, Yues A, Bernard H, Claude J, Gerard C, Gerard S (1991) Biological variability of superoxide dismutase glutathione peroxidase and catalase in blood, Clin. Chem. 37:1932-1937.
  • 10. Halliwell, B., (1994). Free Radical Antioxidants in Human Disease. Curiosity, cause or consequence, Lancet. 344:721-724.
  • 11. Cukurovali, A. and Yilmaz, I., (2000). Synthesis and Characterization of a Newcyclobutane Substituted Schiff Base Ligand and its Cd(II), Co(II), Ni(II) and Zn(II) complexes. Polish J Chem 74:147–151.
  • 12. Miller, K.W., Lorr, N.A., and Yang, C.S., (1984). Simultaneous Determination of Plasma Retinol, á -tocopherol, lycopene, á -carotene, and â -carotene by high performance liquid- chromatography, Anal. Biochem. 138:340–345.
  • 13. Cerhata, D., Bauerova, A., and Ginter, B., (1994). Determination of Ascorbic Acid in Serum Using High Performance Liquid-Chromatography and its Correlation with Spectrophometric (Colorimetric) Determination, CeskaSlov. Farm. 43:166–168.
  • 14. Tavazzi, B., Lazzarino, G., Di-Piero, D., and Giardina, B., (1992). Malondialdehyde Production and Ascorbate Decrease are Associated to the Reperfusion of the Isolated Postischemic Rat Heart, Free Radic. Biol. Med. 13:75–78.
  • 15. Freeman, B.A. and Crapo, J.D., (1982). Biology of Disease: Free Radicals and Tissue Injury, Lab. Invest. 47:412–426. 16. Kojos, I.H., (1997). Interaction between Vitamin C and Vitamin E are Observed in Tissues of Interactually Scorbutic Rats, J. Nutr. 27:12060–12064.
  • 17. Ognjanovic, B.J., Pavlovic, S.Z., Maletic, S.D., Zikic, R.V., Stajn, A.S., Radojicic, R.M., Saicic, Z.S., and Petrovic, V.M., (2003). Protective Influence of Vitamin E on Antioxidant Defense System in the Blood of Rats Treated with Cadmium, Physiol. Res. 52:563–570.
  • 18. Lu, S.H., Ohshima, H., Fu, H.M., Tian, Y., Li, F.M., Blettner, M., Wah-rendorf, J., and Bartsch, H., (1986). Urinary Excretion of n-nitrosamino Acids and Nitrate by Inhabitants of High-and Low-risk Areas for Esophageal Cancer in Northern China: Endogenous Formation of Nitrosoproline and its inhibi-tion by vitamin C, Cancer Res. 46:1485–1491.
  • 19. Maramag, C., Menon, M., Balaji, K.C., Reddy, P.G., and Laxmanan, S., (1997). Effect of Vitamin C on Prostate Cancer Cells in vitro: Effect on Cell Number, via-bility, and DNA synthesis, Prostate 32:188–195.
  • 20. Niki, E., (1991). Vitamin C as an Antioxidant, World. Rew. Nutr. Diet, 64:3-30.
  • 21. Sogawa, S., Nihro, Y., Ueda, H., Miki, T., Matsomota, H., and Satoh, T., (1994). Protec-tive Effects of Hydroxychalcones on Free Radical-Induced Cell Damage, Biol. Pharm. Bull. 17:251–256.
Yıl 2018, Cilt: 13 Sayı: 1, 1 - 6, 20.01.2018

Öz

Kaynakça

  • 1. Liberta, A.E. and West, D.X., (1992). Antifungal and Antitumour Activity of Heterocyclic Thiosemicarbazones and Their Metal Complexes. Biometals 5:121–126.
  • 2. Padhy, S. and Kauffman, G.B., (1985). Transition Metal Complexes of Semicarbazones and Thiosemicarbazones. Coord ChemRev 63:127–160.
  • 3. Richardson, D.R., (2002). Iron Chelators as Therapeutic Agents for the Treatment of Cancer, Crit. Rev. Oncol. Hematol. 42:267–281.
  • 4. Belicchi-Ferrari, M., Isceglie, F., Casoli, C., Durot, S., Morgenstern-Badarau, I., Pelosi, G., Pilotti, E., Pinelli, S., and Tarasconi, P., (2005). Copper (II) and Co-balt (III) Pyridoxalthiosemicarbazone Complexes with Nitroprusside as Counterion: Syntheses, Electronic Properties, and Antileukemic Activity, J. Med. Chem. 48:1671–1675.
  • 5. Greenbaum, D.C., Mackey, Z., Hansell, E., Doyle, P., Gut, J., Caffrey, C.R., Lehrman, J., Rosenthal, P.J., McKerrow, J.H., and Chibale, K., (2004). Synthesis and Structure-activity Relationships of Parasiticidalthiosemicarbazone Cysteine Protease Inhibitors against Plasmodium Falciparum, Trypanosomabrucei, and Trypanosomacruzi, J. Med. Chem. 47:3212–3219.
  • 6. Pirrung, M.C., Pansare, S.V., Sarma, K.D., Keith, K.A., and Kern, E.R., (2005). Combi-natorial Optimization of Isatin-â -thiosemicarbazones as Anti-poxvirus Agents, J. Med. Chem. 48:3045–3050.
  • 7. Shih, M.H. and Ke, F.Y., (2004). Syntheses and Evaluation of Antioxidant Activity of Sydnonyl Substituted Thiazolidinone and Thiazoline Derivatives. Bioorg Med Chem. Sep 17:4633-43.
  • 8. Moon, R.C., McCormick, D.L., and Mehta, R.G., (1983). Inhibition of Carcinogenesis by Retinoids, Cancer Res. 43:2469-2475.
  • 9. Laila G, Yues A, Bernard H, Claude J, Gerard C, Gerard S (1991) Biological variability of superoxide dismutase glutathione peroxidase and catalase in blood, Clin. Chem. 37:1932-1937.
  • 10. Halliwell, B., (1994). Free Radical Antioxidants in Human Disease. Curiosity, cause or consequence, Lancet. 344:721-724.
  • 11. Cukurovali, A. and Yilmaz, I., (2000). Synthesis and Characterization of a Newcyclobutane Substituted Schiff Base Ligand and its Cd(II), Co(II), Ni(II) and Zn(II) complexes. Polish J Chem 74:147–151.
  • 12. Miller, K.W., Lorr, N.A., and Yang, C.S., (1984). Simultaneous Determination of Plasma Retinol, á -tocopherol, lycopene, á -carotene, and â -carotene by high performance liquid- chromatography, Anal. Biochem. 138:340–345.
  • 13. Cerhata, D., Bauerova, A., and Ginter, B., (1994). Determination of Ascorbic Acid in Serum Using High Performance Liquid-Chromatography and its Correlation with Spectrophometric (Colorimetric) Determination, CeskaSlov. Farm. 43:166–168.
  • 14. Tavazzi, B., Lazzarino, G., Di-Piero, D., and Giardina, B., (1992). Malondialdehyde Production and Ascorbate Decrease are Associated to the Reperfusion of the Isolated Postischemic Rat Heart, Free Radic. Biol. Med. 13:75–78.
  • 15. Freeman, B.A. and Crapo, J.D., (1982). Biology of Disease: Free Radicals and Tissue Injury, Lab. Invest. 47:412–426. 16. Kojos, I.H., (1997). Interaction between Vitamin C and Vitamin E are Observed in Tissues of Interactually Scorbutic Rats, J. Nutr. 27:12060–12064.
  • 17. Ognjanovic, B.J., Pavlovic, S.Z., Maletic, S.D., Zikic, R.V., Stajn, A.S., Radojicic, R.M., Saicic, Z.S., and Petrovic, V.M., (2003). Protective Influence of Vitamin E on Antioxidant Defense System in the Blood of Rats Treated with Cadmium, Physiol. Res. 52:563–570.
  • 18. Lu, S.H., Ohshima, H., Fu, H.M., Tian, Y., Li, F.M., Blettner, M., Wah-rendorf, J., and Bartsch, H., (1986). Urinary Excretion of n-nitrosamino Acids and Nitrate by Inhabitants of High-and Low-risk Areas for Esophageal Cancer in Northern China: Endogenous Formation of Nitrosoproline and its inhibi-tion by vitamin C, Cancer Res. 46:1485–1491.
  • 19. Maramag, C., Menon, M., Balaji, K.C., Reddy, P.G., and Laxmanan, S., (1997). Effect of Vitamin C on Prostate Cancer Cells in vitro: Effect on Cell Number, via-bility, and DNA synthesis, Prostate 32:188–195.
  • 20. Niki, E., (1991). Vitamin C as an Antioxidant, World. Rew. Nutr. Diet, 64:3-30.
  • 21. Sogawa, S., Nihro, Y., Ueda, H., Miki, T., Matsomota, H., and Satoh, T., (1994). Protec-tive Effects of Hydroxychalcones on Free Radical-Induced Cell Damage, Biol. Pharm. Bull. 17:251–256.
Toplam 20 adet kaynakça vardır.

Ayrıntılar

Konular Mühendislik
Bölüm Kimya
Yazarlar

Aysel Sarı

Alaaddin Çukurovalı

Yayımlanma Tarihi 20 Ocak 2018
Yayımlandığı Sayı Yıl 2018 Cilt: 13 Sayı: 1

Kaynak Göster

APA Sarı, A., & Çukurovalı, A. (2018). THE EFFECTS OF THIOSEMICARBAZONE DERIVATIVE SCHIFF BASE 1-(1-PHENIL-1-METHYLCYCLOBUTANE-3-YL)-2-SUKSINIMIDO ETANON THIOSEMICARBAZONE ON ANTIOXIDAN VITAMINS IN LIVER, KIDNEY AND SERUM OF RABBITS. Physical Sciences, 13(1), 1-6.
AMA Sarı A, Çukurovalı A. THE EFFECTS OF THIOSEMICARBAZONE DERIVATIVE SCHIFF BASE 1-(1-PHENIL-1-METHYLCYCLOBUTANE-3-YL)-2-SUKSINIMIDO ETANON THIOSEMICARBAZONE ON ANTIOXIDAN VITAMINS IN LIVER, KIDNEY AND SERUM OF RABBITS. Physical Sciences. Ocak 2018;13(1):1-6.
Chicago Sarı, Aysel, ve Alaaddin Çukurovalı. “THE EFFECTS OF THIOSEMICARBAZONE DERIVATIVE SCHIFF BASE 1-(1-PHENIL-1-METHYLCYCLOBUTANE-3-YL)-2-SUKSINIMIDO ETANON THIOSEMICARBAZONE ON ANTIOXIDAN VITAMINS IN LIVER, KIDNEY AND SERUM OF RABBITS”. Physical Sciences 13, sy. 1 (Ocak 2018): 1-6.
EndNote Sarı A, Çukurovalı A (01 Ocak 2018) THE EFFECTS OF THIOSEMICARBAZONE DERIVATIVE SCHIFF BASE 1-(1-PHENIL-1-METHYLCYCLOBUTANE-3-YL)-2-SUKSINIMIDO ETANON THIOSEMICARBAZONE ON ANTIOXIDAN VITAMINS IN LIVER, KIDNEY AND SERUM OF RABBITS. Physical Sciences 13 1 1–6.
IEEE A. Sarı ve A. Çukurovalı, “THE EFFECTS OF THIOSEMICARBAZONE DERIVATIVE SCHIFF BASE 1-(1-PHENIL-1-METHYLCYCLOBUTANE-3-YL)-2-SUKSINIMIDO ETANON THIOSEMICARBAZONE ON ANTIOXIDAN VITAMINS IN LIVER, KIDNEY AND SERUM OF RABBITS”, Physical Sciences, c. 13, sy. 1, ss. 1–6, 2018.
ISNAD Sarı, Aysel - Çukurovalı, Alaaddin. “THE EFFECTS OF THIOSEMICARBAZONE DERIVATIVE SCHIFF BASE 1-(1-PHENIL-1-METHYLCYCLOBUTANE-3-YL)-2-SUKSINIMIDO ETANON THIOSEMICARBAZONE ON ANTIOXIDAN VITAMINS IN LIVER, KIDNEY AND SERUM OF RABBITS”. Physical Sciences 13/1 (Ocak 2018), 1-6.
JAMA Sarı A, Çukurovalı A. THE EFFECTS OF THIOSEMICARBAZONE DERIVATIVE SCHIFF BASE 1-(1-PHENIL-1-METHYLCYCLOBUTANE-3-YL)-2-SUKSINIMIDO ETANON THIOSEMICARBAZONE ON ANTIOXIDAN VITAMINS IN LIVER, KIDNEY AND SERUM OF RABBITS. Physical Sciences. 2018;13:1–6.
MLA Sarı, Aysel ve Alaaddin Çukurovalı. “THE EFFECTS OF THIOSEMICARBAZONE DERIVATIVE SCHIFF BASE 1-(1-PHENIL-1-METHYLCYCLOBUTANE-3-YL)-2-SUKSINIMIDO ETANON THIOSEMICARBAZONE ON ANTIOXIDAN VITAMINS IN LIVER, KIDNEY AND SERUM OF RABBITS”. Physical Sciences, c. 13, sy. 1, 2018, ss. 1-6.
Vancouver Sarı A, Çukurovalı A. THE EFFECTS OF THIOSEMICARBAZONE DERIVATIVE SCHIFF BASE 1-(1-PHENIL-1-METHYLCYCLOBUTANE-3-YL)-2-SUKSINIMIDO ETANON THIOSEMICARBAZONE ON ANTIOXIDAN VITAMINS IN LIVER, KIDNEY AND SERUM OF RABBITS. Physical Sciences. 2018;13(1):1-6.