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Recurrent abortions and postnatal loses in two cases including G-negative band within Chromosome 1qh region

Yıl 2011, Cilt: 28 Sayı: 3, 117 - 119, 09.02.2012

Nurten Kara Gülsen Ökten Şengül Tural Nevin Karakuş İdris Koçak

Öz

ABSTRACT
Morphological variations due to heterochromatic DNA of the secondary constriction re¬gion (qh) of human chromosome 1 are considered normal. The presence of a G-negative band within the qh region of chromosome 1 has been considered as a rare or unusual variant. The aim of the present study was investigated the role of G-negative band that embedded within the secondary constriction region of chromosome 1 in two cases. Both cases were unrelated and two different family. First family history was three postna¬tal loses-one stillborn and second family had three recurrent abortions. There were no risk factors for fetal losses. Clinical assessment and cytogenetic studies were evaluated. Chromosomal analysis was performed with conventional methods from lymphocytes and karyotyped using G and C banding techniques. Male in the first family (case I) was 46,XY,1qh G-negative band in all metaphases and his wife was normal 46, XX chromo¬some structure. Female in the second family (case II) was 46,XX,1qh G-negative band and her husband was normal 46, XY chromosome. Both cases were phenotypicaly nor¬mal and they have one healthy child. We presented that those families for interesting although clinical consequences of heterochromatic variants remain obscure. Our study is important by virtue a rare study to investigate relationship between fetal loses and G-negative band in chromosome1qh.
J. Exp. Clin. Med., 2011; 28:117-119

Anahtar Kelimeler

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Kaynakça

  • Ashley, T., 1988. G-band position effects on meiotic synapses and crossing over. Genetics, 118, 307-317.
  • Bernardi, G., Bernardi, G., 1986. Compositional constraints and genomic evolution. J. Molec. Evol. 24, 1-11.
  • Imai, A., Misao, R., Tamaya, T., 1995. Recurrent abortion associated with 1qh+. J. Med. 26, 343-345.
  • Knight, L.A., Soon, G.M., Tan, M., 1993. Extra G positive band on the long arm of chromosome 9. J. Med. Genet. 30, 613.
  • Luke, S., Verma, R.S., Conte, R.A., Mathews, T., 1992. Molecular characterization of secondary constriction region (qh) of human chromosome with pericentric inversion. J. Cell. Sci. 103, 919-923.

Yıl 2011, Cilt: 28 Sayı: 3, 117 - 119, 09.02.2012

Nurten Kara Gülsen Ökten Şengül Tural Nevin Karakuş İdris Koçak

Öz

Kaynakça

  • Ashley, T., 1988. G-band position effects on meiotic synapses and crossing over. Genetics, 118, 307-317.
  • Bernardi, G., Bernardi, G., 1986. Compositional constraints and genomic evolution. J. Molec. Evol. 24, 1-11.
  • Imai, A., Misao, R., Tamaya, T., 1995. Recurrent abortion associated with 1qh+. J. Med. 26, 343-345.
  • Knight, L.A., Soon, G.M., Tan, M., 1993. Extra G positive band on the long arm of chromosome 9. J. Med. Genet. 30, 613.
  • Luke, S., Verma, R.S., Conte, R.A., Mathews, T., 1992. Molecular characterization of secondary constriction region (qh) of human chromosome with pericentric inversion. J. Cell. Sci. 103, 919-923.
Toplam 5 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Bölüm Basic Medical Sciences
Yazarlar

Nurten Kara

Gülsen Ökten Bu kişi benim

Şengül Tural Bu kişi benim

Nevin Karakuş Bu kişi benim

İdris Koçak Bu kişi benim

Yayımlanma Tarihi 9 Şubat 2012
Gönderilme Tarihi 20 Ekim 2011
Yayımlandığı Sayı Yıl 2011 Cilt: 28 Sayı: 3

Kaynak Göster

APA Kara, N., Ökten, G., Tural, Ş., Karakuş, N., vd. (2012). Recurrent abortions and postnatal loses in two cases including G-negative band within Chromosome 1qh region. Journal of Experimental and Clinical Medicine, 28(3), 117-119. https://doi.org/10.5835/jecm.omu.28.03.004
AMA Kara N, Ökten G, Tural Ş, Karakuş N, Koçak İ. Recurrent abortions and postnatal loses in two cases including G-negative band within Chromosome 1qh region. J. Exp. Clin. Med. Şubat 2012;28(3):117-119. doi:10.5835/jecm.omu.28.03.004
Chicago Kara, Nurten, Gülsen Ökten, Şengül Tural, Nevin Karakuş, ve İdris Koçak. “Recurrent Abortions and Postnatal Loses in Two Cases Including G-Negative Band Within Chromosome 1qh Region”. Journal of Experimental and Clinical Medicine 28, sy. 3 (Şubat 2012): 117-19. https://doi.org/10.5835/jecm.omu.28.03.004.
EndNote Kara N, Ökten G, Tural Ş, Karakuş N, Koçak İ (01 Şubat 2012) Recurrent abortions and postnatal loses in two cases including G-negative band within Chromosome 1qh region. Journal of Experimental and Clinical Medicine 28 3 117–119.
IEEE N. Kara, G. Ökten, Ş. Tural, N. Karakuş, ve İ. Koçak, “Recurrent abortions and postnatal loses in two cases including G-negative band within Chromosome 1qh region”, J. Exp. Clin. Med., c. 28, sy. 3, ss. 117–119, 2012, doi: 10.5835/jecm.omu.28.03.004.
ISNAD Kara, Nurten vd. “Recurrent Abortions and Postnatal Loses in Two Cases Including G-Negative Band Within Chromosome 1qh Region”. Journal of Experimental and Clinical Medicine 28/3 (Şubat 2012), 117-119. https://doi.org/10.5835/jecm.omu.28.03.004.
JAMA Kara N, Ökten G, Tural Ş, Karakuş N, Koçak İ. Recurrent abortions and postnatal loses in two cases including G-negative band within Chromosome 1qh region. J. Exp. Clin. Med. 2012;28:117–119.
MLA Kara, Nurten vd. “Recurrent Abortions and Postnatal Loses in Two Cases Including G-Negative Band Within Chromosome 1qh Region”. Journal of Experimental and Clinical Medicine, c. 28, sy. 3, 2012, ss. 117-9, doi:10.5835/jecm.omu.28.03.004.
Vancouver Kara N, Ökten G, Tural Ş, Karakuş N, Koçak İ. Recurrent abortions and postnatal loses in two cases including G-negative band within Chromosome 1qh region. J. Exp. Clin. Med. 2012;28(3):117-9.
 Kapak Resmi İndir

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