Özofagus kanserleri patolojisi

Duygu Kankaya; Işınsu Kuzu

doi:10.5835/jecm.omu.29.s4.005

Araştırma Makalesi

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Kaynak Göster

Pathology of esophageal carcinomas

Yıl 2012, Cilt: 29 Sayı: 4S, 215 - 226, 07.05.2013

Duygu Kankaya Işınsu Kuzu

https://doi.org/10.5835/jecm.omu.29.s4.005

Öz

Özofagus kanserleri, geç dönemde bulgu vermeleri ve anatomik özelliklerin kolaylaştırdığı hızlı yayılımları nedeniyle sıklıkla lokal ilerlemiş hastalık olarak karşımıza çıkmaktadır. Tanı ve tedavi yöntemlerinde sağlanan gelişmelere rağmen bu hastalarda çok düşük sağ kalım izlenmektedir.
Bu hastaların premalign hastalık evresinde saptanabilmesi ve doğru takip ve tedavi yaklaşımlarının belirlenmesinde iyi bir klinisyen - patolog korelasyonu gerekmektedir. Burada özofagus kanserleri ve prekanseröz patolojileri histopatolojik, genetik özellikleri ile ele alınacak, hastaların takip ve tedavisinde yönlendirici olabilecek güncel bilgiler sunulmaya çalışılacaktır.

J. Exp. Clin. Med., 2012; 29:S215-S226

Pathology of esophageal carcinomas

Esophageal carcinomas can usually be detected in locally advanced stages, due to asymptomatic course and the anatomic properties of esophagus which facilitate rapid spread. Despite improvements on the diagnostic and therapeutic techniques, these patients show very poor survival rates. Detection of these patiens on the premalignant disease stage and determining the appropriate follow-up and therapy approaches require good correlation of the pathologist and the clinician. Here, esophageal carcinomas and their premalignant diseases will be reviewed with histopathological and genetical properties and current information required for follow up and treatment procedures are going to be presented.

Anahtar Kelimeler

Barrett esophagus, Adenocarcinoma, Squamous cell carcinoma, Esophagus, Intraepithelial neoplasia, Precursor lesion

Kaynakça

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MANEC’de ise prognozu ekzokrin komponent belirler ve
tümör evresi ve histolojik diferansiasyon gibi özellikler
önemlidir (Chong ve ark., 1979).