BibTex RIS Kaynak Göster

Is the flumazenil administration diagnosis or treatment? Two case reports

Yıl 2013, Cilt: 30 Sayı: 4, - , 06.02.2014

Türker Yardan Ethem Acar Hızır Akdemır Ahmet Baydın Latif Duran

Öz

Benzodiazepine has the central nervous system (CNS), cardiac and respiratory side effects when intaked more than therapeutic doses. Acute benzodiazepine poisoning may be manifest taken in the form of dizziness, ataxia, nystagmus, dysarthria, hypoxia, hypothermia, hypotension, bradycardia, apnea, pulmonary aspiration, respiratory depression, coma, cardiopulmonary arrest and death. Alprazolam is the most toxic form of benzodiazepines and unless combined with the other CNS depressants such as barbiturates and alcohol, death is rare. When benzodiazepine intoxication is suspected, the next step is flumazenil administration to reverse the CNS and respiratory system depression. In this case report, we aimed to point to the diagnosis and treatment of benzodiazepine intoxications by representing two intoxicated patients with
coma.

J. Exp. Clin. Med., 2013; 30:395-397

Anahtar Kelimeler

Benzodiazepine; emergency; flumazenil; intoxication

Kaynakça

  • Guadreault, P., Guay, J., Thivierge, R.L., Verdy, L., 1991. Benzodiazepine poisoning: Clinical and pharmacologic considerations and treatment. Drug Safety. 6, 247-265.
  • Güloglu, C., and Söğüt, Ö., 2004. Özkıyım amaçlı yüksek doz alprazolam entoksikasyonu, Dicle Tıp Derg. 31, 69-73.
  • Hung, D.Z., Tsai, W.J., Deng, J.F., 1992. Anterograde amnesia in triazolam overdose despite flumazenil treatment: A case report. Hum. Exp. Toxicol. 11, 289-90.
  • Koski, A., Ojanperä, I., Vuori, E. 2003. Interaction of alcohol and drugs in fatal poisonings. Hum. Exp. Toxicol. 22, 281-287.
  • Michaud, K., Augsburger, M., Giroud, C., Mangin, P. 1999. Fatal overdose of tramadol and alprazolam. Forensic Sci. Int. 105, 185-189. Ramadan, M.I., Werder, S.F., Preskorn, S.H. 2006. Protect against drug-drug interactions with anxiolyticts. Curr. Psychiatr. 5, 16-28.
  • Ritz, R., Zuber, M., Elsasser, S., Scollo-Lavizzari, G., 1990. Use of flumazenil in intoxicated patients with coma. Intensive Care Med. 16, 2422
  • Seger, D.L., 2004. Flumazenil-treatment or toxin. J. Toxicol. Clin. Toxicol. 42, 209-216
  • Tunçok, Y., Kalyoncu, N.I., (ed.) 2007. T.C. Sağlık Bakanlığı Birinci Basamağa Yönelik Zehirlenmeler Tanı ve Tedavi Rehberleri SB, RSHMB. Hıfzısıhha Mektebi Müdürlüğü. 14, 79-82.
  • Weinbroum, A., Rudick, V., Sorkine, P., Nevo, Y., Halpern, P., Geller, E., Niv, D. 1996. Use of flumazenil in the treatment of drug overdose: A double-blind and open clinical study in 110 patients. Crit. Care Med. 24, 199-206.
  • Welch, T.R., Rumack, B.H., Hammond, K., 1977. Clonazepam overdose resulting in cyclic coma. Clin. Toxicol. 10, 433-436.

Yıl 2013, Cilt: 30 Sayı: 4, - , 06.02.2014

Türker Yardan Ethem Acar Hızır Akdemır Ahmet Baydın Latif Duran

Öz

Kaynakça

  • Guadreault, P., Guay, J., Thivierge, R.L., Verdy, L., 1991. Benzodiazepine poisoning: Clinical and pharmacologic considerations and treatment. Drug Safety. 6, 247-265.
  • Güloglu, C., and Söğüt, Ö., 2004. Özkıyım amaçlı yüksek doz alprazolam entoksikasyonu, Dicle Tıp Derg. 31, 69-73.
  • Hung, D.Z., Tsai, W.J., Deng, J.F., 1992. Anterograde amnesia in triazolam overdose despite flumazenil treatment: A case report. Hum. Exp. Toxicol. 11, 289-90.
  • Koski, A., Ojanperä, I., Vuori, E. 2003. Interaction of alcohol and drugs in fatal poisonings. Hum. Exp. Toxicol. 22, 281-287.
  • Michaud, K., Augsburger, M., Giroud, C., Mangin, P. 1999. Fatal overdose of tramadol and alprazolam. Forensic Sci. Int. 105, 185-189. Ramadan, M.I., Werder, S.F., Preskorn, S.H. 2006. Protect against drug-drug interactions with anxiolyticts. Curr. Psychiatr. 5, 16-28.
  • Ritz, R., Zuber, M., Elsasser, S., Scollo-Lavizzari, G., 1990. Use of flumazenil in intoxicated patients with coma. Intensive Care Med. 16, 2422
  • Seger, D.L., 2004. Flumazenil-treatment or toxin. J. Toxicol. Clin. Toxicol. 42, 209-216
  • Tunçok, Y., Kalyoncu, N.I., (ed.) 2007. T.C. Sağlık Bakanlığı Birinci Basamağa Yönelik Zehirlenmeler Tanı ve Tedavi Rehberleri SB, RSHMB. Hıfzısıhha Mektebi Müdürlüğü. 14, 79-82.
  • Weinbroum, A., Rudick, V., Sorkine, P., Nevo, Y., Halpern, P., Geller, E., Niv, D. 1996. Use of flumazenil in the treatment of drug overdose: A double-blind and open clinical study in 110 patients. Crit. Care Med. 24, 199-206.
  • Welch, T.R., Rumack, B.H., Hammond, K., 1977. Clonazepam overdose resulting in cyclic coma. Clin. Toxicol. 10, 433-436.
Toplam 10 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Bölüm Internal Medical Sciences
Yazarlar

Türker Yardan Bu kişi benim

Ethem Acar

Hızır Akdemır Bu kişi benim

Ahmet Baydın

Latif Duran

Yayımlanma Tarihi 6 Şubat 2014
Gönderilme Tarihi 26 Eylül 2013
Yayımlandığı Sayı Yıl 2013 Cilt: 30 Sayı: 4

Kaynak Göster

APA Yardan, T., Acar, E., Akdemır, H., Baydın, A., vd. (2014). Is the flumazenil administration diagnosis or treatment? Two case reports. Journal of Experimental and Clinical Medicine, 30(4). https://doi.org/10.5835/jecm.omu.30.04.026
AMA Yardan T, Acar E, Akdemır H, Baydın A, Duran L. Is the flumazenil administration diagnosis or treatment? Two case reports. J. Exp. Clin. Med. Şubat 2014;30(4). doi:10.5835/jecm.omu.30.04.026
Chicago Yardan, Türker, Ethem Acar, Hızır Akdemır, Ahmet Baydın, ve Latif Duran. “Is the Flumazenil Administration Diagnosis or Treatment? Two Case Reports”. Journal of Experimental and Clinical Medicine 30, sy. 4 (Şubat 2014). https://doi.org/10.5835/jecm.omu.30.04.026.
EndNote Yardan T, Acar E, Akdemır H, Baydın A, Duran L (01 Şubat 2014) Is the flumazenil administration diagnosis or treatment? Two case reports. Journal of Experimental and Clinical Medicine 30 4
IEEE T. Yardan, E. Acar, H. Akdemır, A. Baydın, ve L. Duran, “Is the flumazenil administration diagnosis or treatment? Two case reports”, J. Exp. Clin. Med., c. 30, sy. 4, 2014, doi: 10.5835/jecm.omu.30.04.026.
ISNAD Yardan, Türker vd. “Is the Flumazenil Administration Diagnosis or Treatment? Two Case Reports”. Journal of Experimental and Clinical Medicine 30/4 (Şubat 2014). https://doi.org/10.5835/jecm.omu.30.04.026.
JAMA Yardan T, Acar E, Akdemır H, Baydın A, Duran L. Is the flumazenil administration diagnosis or treatment? Two case reports. J. Exp. Clin. Med. 2014;30. doi:10.5835/jecm.omu.30.04.026.
MLA Yardan, Türker vd. “Is the Flumazenil Administration Diagnosis or Treatment? Two Case Reports”. Journal of Experimental and Clinical Medicine, c. 30, sy. 4, 2014, doi:10.5835/jecm.omu.30.04.026.
Vancouver Yardan T, Acar E, Akdemır H, Baydın A, Duran L. Is the flumazenil administration diagnosis or treatment? Two case reports. J. Exp. Clin. Med. 2014;30(4).
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