Araştırma Makalesi
Can a complete blood count test predict coexisting adenocarcinoma in patients with atypical endometrial hyperplasia?
Öz
To assess the role of inflammatory markers in preoperative prediction of a coexisting endometrial adenocarcinoma (EC) in patients with atypical endometrial hyperplasia (AEH). Patients with a preoperative diagnosis of AEH based on endometrial sampling and who underwent surgical treatment were retrospectively assessed. Ratios of platelet-to-lymphocyte, neutrophil-to-lymphocyte and lymphocyte-to-monocyte, systemic immune-inflammation index and systemic inflammation response index were calculated. Patients were grouped based on the definitive postoperative pathological diagnosis as benign and endometrial adenocarcinoma groups. The cell counts and inflammatory markers were compared between these two groups. ROC curves were constructed for independent predictors of the diagnosis of coexisting endometrial adenocarcinoma to establish diagnostic cut-off values. There were 54 patients. Coexisting EC was detected in 30 patients (55.6%). All of the adenocarcinomas were endometrioid adenocarcinomas in stage 1. Among components of complete blood count (CBC) test monocyte counts, nucleated red blood cell (NRBC) percentage and immature granulocyte (IG) percentage were found to be significantly higher in the adenocarcinoma group. No significant difference was observed with respect to the inflammation indices. ROC curve analysis was performed in order to find cut-off values for monocyte count, NRBC percentage and IG percentage with significant sensitivities and specificities to predict coexisting adenocarcinoma, however, none of these parameters reached a significant area under the curve value. Monocytes, NRBCs and IGs tend to rise in AEH patients with coexisting EH; however, in endometrial biopsy-based AEH diagnosed patients, the prediction of coexisting EC with a simple CBC seems not to be possible.
Anahtar Kelimeler
complete blood count atypical endometrial hyperplasia immature granulocyte monocyte inflammatory index endometrial adenocarcinoma
Kaynakça
- Raglan O, Kalliala I, Markozannes G, Cividini S, Gunter MJ, Nautiyal J, et al. Risk factors for endometrial cancer: An umbrella review of the literature. Int J Cancer. 2019;145(7):1719–30.
- Sanderson PA, Critchley HOD, Williams ARW, Arends MJ, Saunders PTK. New concepts for an old problem: the diagnosis of endometrial hyperplasia. Hum Reprod Update. 2017;23(2):232–54.
- Kurman RJ, Kaminski PF, Norris HJ. The behavior of endometrial hyperplasia. A long‐term study of “untreated” hyperplasia in 170 patients. Cancer. 1985;56(2):403–12.
- Ferenczy A, Gelfand M. The biologic significance of cytologic atypia in progestogen-treated endometrial hyperplasia. Am J Obstet Gynecol. 1989;160(1):126–31.
- Trimble CL, Kauderer J, Zaino R, Silverberg S, Lim PC, Burke JJ, et al. Concurrent endometrial carcinoma in women with a biopsy diagnosis of atypical endometrial hyperplasia: a Gynecologic Oncology Group study. Cancer. 2006;106(4):812–9.
- Travaglino A, Raffone A, Saccone G, Mollo A, De Placido G, Insabato L, et al. Endometrial hyperplasia and the risk of coexistent cancer: WHO versus EIN criteria. Histopathology. 2019;74(5):676–87.
- Kendall BS, Ronnett BM, Isacson C, Cho KR, Hedrick L, Diener-West M, et al. Reproducibility of the diagnosis of endometrial hyperplasia, atypical hyperplasia, and well-differentiated carcinoma. Am J Surg Pathol. 1998;22(8):1012–9.
- Suh-Burgmann E, Hung YY, Armstrong MA. Complex atypical endometrial hyperplasia: the risk of unrecognized adenocarcinoma and value of preoperative dilation and curettage. Obstetrics & Gynecology. 2009;114(3):523–9.
- Gallos ID, Ofinran O, Shehmar M, Coomarasamy A, Gupta JK. Current management of endometrial hyperplasia—a survey of United Kingdom consultant gynaecologists. European Journal of Obstetrics & Gynecology and Reproductive Biology. 2011;158(2):305–7.
- Babu SN, Chetal G, Kumar S. Macrophage migration inhibitory factor: a potential marker for cancer diagnosis and therapy. Asian Pacific Journal of Cancer Prevention. 2012;13(5):1737–44.
- Mantovani A, Allavena P, Sica A, Balkwill F. Cancer-related inflammation. Nature. 2008;454(7203):436–44.
- Takahashi R, Mabuchi S, Kawano M, Sasano T, Matsumoto Y, Kuroda H, et al. Prognostic significance of systemic neutrophil and leukocyte alterations in surgically treated endometrial cancer patients: a monoinstitutional study. Gynecol Oncol. 2015;137(1):112–8.
- Cong R, Kong F, Ma J, Li Q, Wu Q, Ma X. Combination of preoperative neutrophil-lymphocyte ratio, platelet-lymphocyte ratio and monocyte-lymphocyte ratio: a superior prognostic factor of endometrial cancer. BMC Cancer. 2020;20(1):1–11.
- Song H, Jeong MJ, Cha J, Lee JS, Yoo JG, Song MJ, et al. Preoperative neutrophil-to-lymphocyte, platelet-to-lymphocyte and monocyte-to-lymphocyte ratio as a prognostic factor in non-endometrioid endometrial cancer. Int J Med Sci. 2021;18(16):3712.
- Mleko M, Pitynski K, Pluta E, Czerw A, Sygit K, Karakiewicz B, et al. Role of systemic inflammatory reaction in female genital organ malignancies–state of the art. Cancer Manag Res. 2021;5491–508.
- Senthilnayagam B, Kumar T, Sukumaran J, Rao K R. Automated measurement of immature granulocytes: performance characteristics and utility in routine clinical practice. Patholog Res Int. 2012;2012.
- Bourdel N, Chauvet P, Tognazza E, Pereira B, Botchorishvili R, Canis M. Sampling in atypical endometrial hyperplasia: which method results in the lowest underestimation of endometrial cancer? A systematic review and meta-analysis. J Minim Invasive Gynecol. 2016;23(5):692–701.
- Karin M. Nuclear factor-κB in cancer development and progression. Nature. 2006;441(7092):431–6.
- Aggarwal BB, Shishodia S, Sandur SK, Pandey MK, Sethi G. Inflammation and cancer: how hot is the link? Biochem Pharmacol. 2006;72(11):1605–21.
- Singh N, Baby D, Rajguru JP, Patil PB, Thakkannavar SS, Pujari VB. Inflammation and cancer. Ann Afr Med. 2019;18(3):121.
- Cummings M, Merone L, Keeble C, Burland L, Grzelinski M, Sutton K, et al. Preoperative neutrophil: lymphocyte and platelet: lymphocyte ratios predict endometrial cancer survival. Br J Cancer. 2015;113(2):311–20.
- Haruma T, Nakamura K, Nishida T, Ogawa C, Kusumoto T, Seki N, et al. Pre-treatment neutrophil to lymphocyte ratio is a predictor of prognosis in endometrial cancer. Anticancer Res. 2015;35(1):337–43.
- Cakmak B, Gulucu S, Aliyev N, Ozsoy Z, Nacar M, Koseoglu D. Neutrophil-lymphocyte and platelet-lymphocyte ratios in endometrial hyperplasia. Obstet Gynecol Sci. 2015;58(2):157–61.
- Lei H, Xu S, Mao X, Chen X, Chen Y, Sun X, et al. Systemic immune-inflammatory index as a predictor of lymph node metastasis in endometrial cancer. J Inflamm Res. 2021;14:7131.
- Huang Y, Chen Y, Zhu Y, Wu Q, Yao C, Xia H, et al. Postoperative systemic immune-inflammation index (SII): a superior prognostic factor of endometrial cancer. Front Surg. 2021;8:704235.
- Chao B, Ju X, Zhang L, Xu X, Zhao Y. A novel prognostic marker systemic inflammation response index (SIRI) for operable cervical cancer patients. Front Oncol. 2020;10:766.
- Olingy CE, Dinh HQ, Hedrick CC. Monocyte heterogeneity and functions in cancer. J Leukoc Biol. 2019;106(2):309–22.
- Monteiro Júnior JG de M, Torres D de OC, da Silva MCFC, Ramos TM de B, Alves ML, Filho WJN, et al. Nucleated red blood cells as predictors of all-cause mortality in cardiac intensive care unit patients: a prospective cohort study. PLoS One. 2015;10(12):e0144259.
- Menk M, Giebelhäuser L, Vorderwülbecke G, Gassner M, Graw JA, Weiss B, et al. Nucleated red blood cells as predictors of mortality in patients with acute respiratory distress syndrome (ARDS): an observational study. Ann Intensive Care. 2018;8:1–11.
- Desai S, Jones SL, Turner KL, Hall J, Moore LJ. Nucleated red blood cells are associated with a higher mortality rate in patients with surgical sepsis. Surg Infect (Larchmt). 2012;13(6):360–5.
- Phan TT, Vy HT, Ho TT, Tran VT, Tran TT, Pho SP, et al. Emergence role of nucleated red blood cells in molecular response evaluation for chronic myeloid leukemia. Int J Gen Med. 2019;333–41.
- Stachon A, Bolulu O, Holland-Letz T, Krieg M. Association between nucleated red blood cells in blood and the levels of erythropoietin, interleukin 3, interleukin 6, and interleukin 12p70. Shock. 2005;24(1):34–9.
- Cornbleet PJ. Clinical utility of the band count. Clin Lab Med. 2002;22(1):101–36.
- Arneth BM, Ragaller M, Hommel K, Tiebel O, Menschikowski M, Siegert G. Novel parameters of extended complete blood cell count under fluorescence flow cytometry in patients with sepsis. J Clin Lab Anal. 2014;28(2):130–5.
- Ünal Y, Barlas AM. Role of increased immature granulocyte percentage in the early prediction of acute necrotizing pancreatitis. Turkish Journal of Trauma & Emergency Surgery/Ulusal Travma ve Acil Cerrahi Dergisi. 2019;25(2).
Yıl 2024,
Cilt: 41 Sayı: 1, 92 - 96, 29.03.2024
Öz
Kaynakça
- Raglan O, Kalliala I, Markozannes G, Cividini S, Gunter MJ, Nautiyal J, et al. Risk factors for endometrial cancer: An umbrella review of the literature. Int J Cancer. 2019;145(7):1719–30.
- Sanderson PA, Critchley HOD, Williams ARW, Arends MJ, Saunders PTK. New concepts for an old problem: the diagnosis of endometrial hyperplasia. Hum Reprod Update. 2017;23(2):232–54.
- Kurman RJ, Kaminski PF, Norris HJ. The behavior of endometrial hyperplasia. A long‐term study of “untreated” hyperplasia in 170 patients. Cancer. 1985;56(2):403–12.
- Ferenczy A, Gelfand M. The biologic significance of cytologic atypia in progestogen-treated endometrial hyperplasia. Am J Obstet Gynecol. 1989;160(1):126–31.
- Trimble CL, Kauderer J, Zaino R, Silverberg S, Lim PC, Burke JJ, et al. Concurrent endometrial carcinoma in women with a biopsy diagnosis of atypical endometrial hyperplasia: a Gynecologic Oncology Group study. Cancer. 2006;106(4):812–9.
- Travaglino A, Raffone A, Saccone G, Mollo A, De Placido G, Insabato L, et al. Endometrial hyperplasia and the risk of coexistent cancer: WHO versus EIN criteria. Histopathology. 2019;74(5):676–87.
- Kendall BS, Ronnett BM, Isacson C, Cho KR, Hedrick L, Diener-West M, et al. Reproducibility of the diagnosis of endometrial hyperplasia, atypical hyperplasia, and well-differentiated carcinoma. Am J Surg Pathol. 1998;22(8):1012–9.
- Suh-Burgmann E, Hung YY, Armstrong MA. Complex atypical endometrial hyperplasia: the risk of unrecognized adenocarcinoma and value of preoperative dilation and curettage. Obstetrics & Gynecology. 2009;114(3):523–9.
- Gallos ID, Ofinran O, Shehmar M, Coomarasamy A, Gupta JK. Current management of endometrial hyperplasia—a survey of United Kingdom consultant gynaecologists. European Journal of Obstetrics & Gynecology and Reproductive Biology. 2011;158(2):305–7.
- Babu SN, Chetal G, Kumar S. Macrophage migration inhibitory factor: a potential marker for cancer diagnosis and therapy. Asian Pacific Journal of Cancer Prevention. 2012;13(5):1737–44.
- Mantovani A, Allavena P, Sica A, Balkwill F. Cancer-related inflammation. Nature. 2008;454(7203):436–44.
- Takahashi R, Mabuchi S, Kawano M, Sasano T, Matsumoto Y, Kuroda H, et al. Prognostic significance of systemic neutrophil and leukocyte alterations in surgically treated endometrial cancer patients: a monoinstitutional study. Gynecol Oncol. 2015;137(1):112–8.
- Cong R, Kong F, Ma J, Li Q, Wu Q, Ma X. Combination of preoperative neutrophil-lymphocyte ratio, platelet-lymphocyte ratio and monocyte-lymphocyte ratio: a superior prognostic factor of endometrial cancer. BMC Cancer. 2020;20(1):1–11.
- Song H, Jeong MJ, Cha J, Lee JS, Yoo JG, Song MJ, et al. Preoperative neutrophil-to-lymphocyte, platelet-to-lymphocyte and monocyte-to-lymphocyte ratio as a prognostic factor in non-endometrioid endometrial cancer. Int J Med Sci. 2021;18(16):3712.
- Mleko M, Pitynski K, Pluta E, Czerw A, Sygit K, Karakiewicz B, et al. Role of systemic inflammatory reaction in female genital organ malignancies–state of the art. Cancer Manag Res. 2021;5491–508.
- Senthilnayagam B, Kumar T, Sukumaran J, Rao K R. Automated measurement of immature granulocytes: performance characteristics and utility in routine clinical practice. Patholog Res Int. 2012;2012.
- Bourdel N, Chauvet P, Tognazza E, Pereira B, Botchorishvili R, Canis M. Sampling in atypical endometrial hyperplasia: which method results in the lowest underestimation of endometrial cancer? A systematic review and meta-analysis. J Minim Invasive Gynecol. 2016;23(5):692–701.
- Karin M. Nuclear factor-κB in cancer development and progression. Nature. 2006;441(7092):431–6.
- Aggarwal BB, Shishodia S, Sandur SK, Pandey MK, Sethi G. Inflammation and cancer: how hot is the link? Biochem Pharmacol. 2006;72(11):1605–21.
- Singh N, Baby D, Rajguru JP, Patil PB, Thakkannavar SS, Pujari VB. Inflammation and cancer. Ann Afr Med. 2019;18(3):121.
- Cummings M, Merone L, Keeble C, Burland L, Grzelinski M, Sutton K, et al. Preoperative neutrophil: lymphocyte and platelet: lymphocyte ratios predict endometrial cancer survival. Br J Cancer. 2015;113(2):311–20.
- Haruma T, Nakamura K, Nishida T, Ogawa C, Kusumoto T, Seki N, et al. Pre-treatment neutrophil to lymphocyte ratio is a predictor of prognosis in endometrial cancer. Anticancer Res. 2015;35(1):337–43.
- Cakmak B, Gulucu S, Aliyev N, Ozsoy Z, Nacar M, Koseoglu D. Neutrophil-lymphocyte and platelet-lymphocyte ratios in endometrial hyperplasia. Obstet Gynecol Sci. 2015;58(2):157–61.
- Lei H, Xu S, Mao X, Chen X, Chen Y, Sun X, et al. Systemic immune-inflammatory index as a predictor of lymph node metastasis in endometrial cancer. J Inflamm Res. 2021;14:7131.
- Huang Y, Chen Y, Zhu Y, Wu Q, Yao C, Xia H, et al. Postoperative systemic immune-inflammation index (SII): a superior prognostic factor of endometrial cancer. Front Surg. 2021;8:704235.
- Chao B, Ju X, Zhang L, Xu X, Zhao Y. A novel prognostic marker systemic inflammation response index (SIRI) for operable cervical cancer patients. Front Oncol. 2020;10:766.
- Olingy CE, Dinh HQ, Hedrick CC. Monocyte heterogeneity and functions in cancer. J Leukoc Biol. 2019;106(2):309–22.
- Monteiro Júnior JG de M, Torres D de OC, da Silva MCFC, Ramos TM de B, Alves ML, Filho WJN, et al. Nucleated red blood cells as predictors of all-cause mortality in cardiac intensive care unit patients: a prospective cohort study. PLoS One. 2015;10(12):e0144259.
- Menk M, Giebelhäuser L, Vorderwülbecke G, Gassner M, Graw JA, Weiss B, et al. Nucleated red blood cells as predictors of mortality in patients with acute respiratory distress syndrome (ARDS): an observational study. Ann Intensive Care. 2018;8:1–11.
- Desai S, Jones SL, Turner KL, Hall J, Moore LJ. Nucleated red blood cells are associated with a higher mortality rate in patients with surgical sepsis. Surg Infect (Larchmt). 2012;13(6):360–5.
- Phan TT, Vy HT, Ho TT, Tran VT, Tran TT, Pho SP, et al. Emergence role of nucleated red blood cells in molecular response evaluation for chronic myeloid leukemia. Int J Gen Med. 2019;333–41.
- Stachon A, Bolulu O, Holland-Letz T, Krieg M. Association between nucleated red blood cells in blood and the levels of erythropoietin, interleukin 3, interleukin 6, and interleukin 12p70. Shock. 2005;24(1):34–9.
- Cornbleet PJ. Clinical utility of the band count. Clin Lab Med. 2002;22(1):101–36.
- Arneth BM, Ragaller M, Hommel K, Tiebel O, Menschikowski M, Siegert G. Novel parameters of extended complete blood cell count under fluorescence flow cytometry in patients with sepsis. J Clin Lab Anal. 2014;28(2):130–5.
- Ünal Y, Barlas AM. Role of increased immature granulocyte percentage in the early prediction of acute necrotizing pancreatitis. Turkish Journal of Trauma & Emergency Surgery/Ulusal Travma ve Acil Cerrahi Dergisi. 2019;25(2).
Toplam 35 adet kaynakça vardır.
Ayrıntılar
| Birincil Dil | İngilizce |
|---|---|
| Konular | Jinekolojik Onkoloji Cerrahisi |
| Bölüm | Research Article |
| Yazarlar | |
| Yayımlanma Tarihi | 29 Mart 2024 |
| Gönderilme Tarihi | 20 Kasım 2023 |
| Kabul Tarihi | 11 Ocak 2024 |
| Yayımlandığı Sayı | Yıl 2024 Cilt: 41 Sayı: 1 |
Kaynak Göster
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.