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Diagnostic value of haematological parameters in neonatal sepsis cases

Yıl 2018, Cilt: 10 Sayı: 3, 252 - 262, 30.09.2018
https://doi.org/10.21601/ortadogutipdergisi.389829

Öz

Aim: In this study, we aimed to
investigate whether haematological parameters could be used in the early
diagnosis of neonatal sepsis in neonates diagnosed with sepsis clinically
.

Material and Method: This study was performed retrospectively from the patient records of 138
newborn infants who were diagnosed with neonatal sepsis whom admitted to Konya
Beyhekim State Hospital Children's Health and Diseases Clinic, Neonatal
Intensive Care Unit, between January 2014 and January 2016. Gender, type of
delivery (normal vaginal delivery or cesarean section), birth weight, body
weight and age at admission, gestational age, length of stay in hospitals,
accompanying complaints/symptoms, risk factors in the noenate mother were
recorded from patient record files.

Results: It was determined that
138 (19.43%)
newborn
infants
of the 710
admitted to our unit were diagnosed with neonatal sepsis diagnosis. Of these
patients, 82 (59.4
%) were male. While 127 patients were diagnosed with
clinical sepsis, 11 (7.97
%) of them were haemoculture-proven. The mean birth
weight of the patients were 3082,14 ± 423,90 grams and 12 (8,69
%) patients
were below 2500 grams. The mean C-reactive protein (CRP) value of the patients
was 19.01±15.30 mg/dl and the mean procalcitonin value was 7.75±6.72 ng/ml. CRP
level was high in 81.88% of the patients. White blood cell (WBC), neutrophil
count, neutrophil/lymphocyte ratio (NLR), mean platelet volume (MPV) and
platelet distrubition width (PDW) were statistically higher in the patient
group than in the control group.

There was no statistically
significant difference between the patient group and the control group
according to platelet/lymphocyte ratio (PLR).

Conclusion: This study revealed that haematological parameters are
still very valuable in the early diagnosis of newborn infants diagnosed with
sepsis.









 

Kaynakça

  • 1. Hofer N, Zacharias E, Müller W, Resch B. An update on the use of c-reactive protein in early-onset neonatal sepsis: current insights and new tasks. Neonatology 2012; 102: 25-36.
  • 2. Polin RA, Parravicini E, Regan JA, Taeusch HW. Bacterial sepsis and meningitis. In: Taeusch HW, Ballard RA, Gleason CA (eds). Avery's Diseases of the Newborn (8th ed) Philadelphia: Elsevier Inc., 2005: 551-7.
  • 3. Ovalı F: Bakteriyel enfeksiyonlar. Editörler; Dağoğlu T, Ovalı F, Samancı N. Neonatoloji (1.baskı) Nobel Tıp Kitabevleri, Istanbul, 2000: 679-707.
  • 4. Yalaz M, Arslanoğlu S, Çetin H ve ark. Üçüncü basamak yenidoğan yoğun bakım merkezinde kanıtlanmış nozokomiyal sepsis etkenlerinin değerlendirilmesi: İki yıllık analiz. ADÜ Tıp Fakültesi Derg 2004; 5: 5-9.
  • 5. World Health Organization, Global Health Observatory Data Repository, 2013. Fromavaliable: http://apps.who.int/gho/data/view.main
  • 6. Liu C, Johnson H, Cousens S, et al. Global, regional and national cause of child mortality: an updated systematic analysis. Lancet 2012; 379: 2151-61.
  • 7. DuPont-Thibodeau G, Joyal JS, Lacroix J. Management of neonatal sepsis in term newborns. F1000 Prime Rep 2014;6:67. doi.org./10.12703/P6-67.
  • 8. Al-Zahrani AK, Ghonaim MM, Hussein YM, et al. Evaluation of recent methods versus conventional methods for diagnosis of early-onset neonatal sepsis. J Infect Dev Ctries 2015; 9: 388-93.
  • 9. Töllner U. Early diagnosis of septicemia in the newborn. Clinical studies and sepsis score. Eur J Pediatr 1982; 138: 331-7.
  • 10. Ovalı F. Yenidoğan enfeksiyonları. 1.baskı. İstanbul: İstanbul Medikal Yayıncılık; 2006: 107-60.
  • 11. Zaidi AKM, Darmstadt GL, Stoll BJ. Neonatal İnfections: A global perspection. In: Wilson CB, Nizet V, Maldonado Y, Remington JS, Klein JO [eds]. Remington and Klein’s Infectious diseases of the fetus and newborn. 7th ed. Philadelphia: Elsevier Saunders, 2011: 25-9.
  • 12. Çoban A. Yenidoğan enfeksiyonları. Neyzi O, Ertuğrul T, editör: Pediatri Nobel Tıp Kitabevleri.3. Baskı İstanbul; 2002: 431-44.
  • 13. Thaver D, Zaidi AKM. Burden of neonatal infections in developing countries: A review of evidence from community-based studies. PIDJ 2009; 28: 3-9.
  • 14. Leonard EG, Dobbs K. Postnatal bacterial infections. In: Martin RJ, Fanaroff AA, Walsh MC, eds. Fanaroff and Martin’s Neonatal-Perinatal Medicine, 10th edn. St. Louis: Elsevier Mosby Inc. 2015: 734-50.
  • 15. Schuchat A, Zywicki SS, Dinsmoor MJ et al. Risk factors and oppotunities for prevention of early-onset neonatal sepsis: A multicenter case-control study. Pediatrics 2000; 105: 21-6.
  • 16. Bhat YR, Lewis LE, Vandana KE. Bacterial isolates of early-onset neonatal sepsis and their antibiotic susceptibility pattern between 1998 and 2004: an audit from a center in India. Ital J Pediatr 2011; 11: 32-7.
  • 17. Kavuncuoğlu S, Kazancı S, Yıldız H ve ark. Yenidoğan Yoğun Bakım Ünitesinde Yatan Kültür Pozitif Sepsisli Olguların Sıklık, Etiyolojik Faktörler, Etken Mikroorganizmalar ve Antibiyotik Direnci Yönünden İncelenmesi. JOPP Derg 2011; 3: 129-38.
  • 18. Dear P. Infection in the newborn. In: Rennie M.J, Roberton NRC, editors: Textbook of Neonatology. Churchill Living; 1999: 1109-39. 19. Aygün C, Oran O, Portakal O. Yenidoğanlarda prokalsitonin düzeyleri ve sepsis tanısındaki yeri. Çocuk Sağlığı ve Hastalıkları Derg 2003; 46: 83-9.
  • 20. Ferrieri P, Wallen LD. Neonatal bacterial sepsis. In: Gleason CA, Devaskar SU, eds. Avery’s Diseases of The Newborn,9th edn. Philadelphia: Saunders, an imprint of Elsevier Inc. 2012: 538-50.
  • 21. Pourcyrous M, Bada US, Korones SB, Baselski V, Wong SP. Significance of serial C-reactive protein responses in neonatal infection and other disorders. Pediatrics 1993; 92: 431-5.
  • 22. Bone RC. The pathogenesis of sepsis. Ann Intern Med 1991; 115: 457-69.
  • 23. Squire E, Favara B, Todd J. Diagnosis of neonatal bacterial infection: hematologic pathologic findings in fatal and non-fatal cases. Pediatrics 1979; 64: 60-4.
  • 24. Stoll J. B. Infections of the neonatal infant. In: Behrman RE, Kliegman RM, Jenson BH, editörs: Nelson Textbook of Pediatrics 17th ed. Saunders, Philadelphia; 2004: 623-40.
  • 25. Bont ESJM, Martens A, Raan VJ, et al. Tumor Necrosis Factör–alfa, interleukin–1ß, Interleukin–6 plasma levels in neonatal sepsis. Pediatric Research 1993; 33: 380-3.
  • 26. Türkmen MK, Telli M, Erisen S, Güzünler M, Eyigör M. Neonatal sepsisli olguların değerlendirilmesi ve antibiyotik duyarlılıklarının belirlenmesi. ADU Tıp Fak Derg 2010; 11: 15-20.
  • 27. Yıldız C. Neonatal Sepsis Erken Tanısında Prokalsitoninin yeri ve önemi. SSK Bakırköy Doğumevi Kadın ve Çocuk Hastalıkları Eğitim Hastanesi Pediatri Kliniği Uzmanlık Tezi İstanbul, 2001.
  • 28. Icagasıoglu D, Caksen H, Sütcü I, Cevit O. Serum Creaktive protein and interleukin 6 levels in neonatal sepsis. Acta Medica 2002; 45: 111-13.
  • 29. Edwards M, Baker C. Sepsis in the newborn. In: Katz S, Gershon A, Hotez P (eds). Krugman’s Infectious Diseases of Children [10th ed]. St.Louis: Mosby Year Book, 1998: 415-28.
  • 30. Gerdes JS. Diagnosis and management of bacterial infections in neonate. Pediatr Clin N Am 2004; 51: 939-59.
  • 31. Bulut MO, Bulut İK, Büyükkayhan D ve ark. Neonatal Sepsisli Olguların Retrospektif Olarak Değerlendirilmesi. C. Ü. Tıp Fakültesi Dergisi 2005; 27: 63-8.
  • 32. Berger C, Uehlinger J, Ghelfi D, Blau N, Fanconi S. Comparison of C-reaktive protein and white blood cell count whith differential in neonates at risk for septicaemia. Eur J Pediatr 1995; 154: 138-44.
  • 33. Forest JC, Lariviere F, Boke P, Masson M, Nadeou L. Creactive protein as biomedical indicator of bacterial infection in neonates. Clin Biochem 1986; 19: 192-4.
  • 34. Meral C, Karademir F, Süleymanoğlu S, Aydınöz S, Tunç T, et al. Neonatal sepsis olgularının ve etkenlerinin retrospektif değerlendirilmesi. TAF Prev Med Bull 2009; 8: 329-32.
  • 35. Carrol ED, Thomson APJ, Hart CA. Procalcitonin as a marker of sepsis International Journal of Antimicrobial Agents 2002; 20: 1-9.
  • 36. Hatherill M, Tibby SM, Sykes K, Turner C, Murdoch IA. Diagnostic markers of infection: comparison of procalcitonin with C-reactive protein and leucocyte count. Arch Dis Child 1999; 81: 417-21.
  • 37. Köksal N, Harmancı R, Çetinkaya M, Hacımustafaoğlu M. Role of procalcitonin and CRP in diagnosis and follow-up of neonatal sepsis. Turk J Pediatr 2007; 49: 21-9.
  • 38. Sütçü İ. Neonatal Sepsisin erken tanısında interleukin–6 ve C-reaktif protein’in kullanımı. Cumhuriyet Üniversitesi Tıp Fak. Çocuk Sağlığı ve Hastalıkları Anabilim Dalı Uzmanlık Tezi Sivas, 1999.
  • 39. Jiang JH, Chiu NC, Huang FY, et al. Neonatal sepsis in the neonatal intensive care unit: characteristics of early versus late onset. J Microbiol Immunol Infect 2004; 37: 301-6.
  • 40. Rodwell RL, Leslie AL, Tudehope Dİ. Early diagnosis of neonatal sepsis using a hematologic scoring sysytem. J Pediatr 1998; 112: 761-7.
  • 41. Van Der Lelie J, Van Dem Barae AK. Increased mean platelet volüme in septicemia. J Clin Patho 1983; 36: 693-6
  • 42. O' Connor TA, Ringerk M, Gaddis ML. MPV during staphylococcal sepsis in neonates. Am J Clin Pathol 1993; 99: 69-71
  • 43. Vagdatli E, Gounari E, Lazaridou E et al. Platelet distribution width: a simple, practical and specific marker of activation of coagulation. Hippokratia 2010; 14: 28-32.
  • 44. Mariani E, Filardo G, Canella V, et al. Platelet-rich plasma affects bacterial growth in vitro. Cytotherapy 2014; 16: 1294-304.
  • 45. Bessman JD, Williams LJ, Gilmer PR. Mean platelet volume: the inverse relation of platelet size and count in normal subjects, and an artifact of other particles. Am J Clin Pathol 1981; 76: 289-93. 46. Wiwanitkit V. Plateletcrit, mean platelet volume, platelet distribution width: its expected values and correlation with parallel red blood cell parameters. Clin Applied Thrombosis/Hemostasis 2004; 10: 175-8.
  • 47. Guclu E, Durmaz Y, Karabay O. Effect of severe sepsis on platelet count and their indices. Afr Health Sci 2013; 13: 333-8.
  • 48. Yilmaz Z, Eralp O, Ilcol YO. Evaluation of platelet count and its association with plateletcrit, mean platelet volume, and platelet size distribution width in a canine model of endotoxemia. Vet Clin Pathol 37: 159–63.
  • 49. Mantovani A, Cassatella MA, Costantini C, Jaillon S. Neutrophils in the activation and regulation of innate and adaptive immunity. Nat Rev Immunol 2011; 11: 519-31.
  • 50. Gibson PH, Cuthbertson BH, Croal BL, et al. Usefulness of neutrophil/lymphocyte ratio as predictor of new-onset atrial fibrillation after coronary artery bypass grafting. Am J Cardiol 2010; 105: 186-91.
  • 51. Bermejo-Martín JF, Tamayo E, Ruiz G, et al. Circulating neutrophil counts and mortality in septic shock. Crit Care 2014; 18: 407.
  • 52. Zahorec R. Ratio of neutrophil to lymphocyte counts--rapid and simple parameter of systemic inflammation and stress in critically ill. Bratisl Lek Listy 2001; 102: 5-14.
  • 53. Loonen AJ, de Jager CP, Tosserams J, Kusters R, Hilbink M, Wever PC and van den Brule AJ: Biomarkers and molecular analysis to improve bloodstream infection diagnostics in an emergency care unit. PLoS One 9: e87315, 2014.
  • 54. De Jager CP, Van Wijk PT, Mathoera RB, et al. Lymphocytopenia and neutrophil lymphocyte count ratio predict bacteremia better than conventional infection markers in an emergency care unit. Crit Care 2010; 14: 192.
  • 55. Zhang HB, Chen J, Lan QF, et al. Diagnostic values of red cell distribution width, platelet distribution width and neutrophil lymphocyte count ratio for sepsis. Experimental Therapeutic Med 2016; 12: 2215-9.
  • 56. Salciccioli JD, Marshall DC, Pimentel MA, et al. The association between the neutrophil-to-lymphocyte ratio and mortality in critical illness: an observational cohort study. Critical Care 2015; 19: 13.
  • 57. Ozer S, Yilmaz R, Sonmezgoz E, et al. Simple markers for subclinical inflammation in patients with Familial Mediterranean Fever. Med Sci Monit 2015; 21: 298-303.
  • 58. Boyraz I, Koc B, Boyaci A, et al. Ratio of neutrophil/lymphocyte and platelet/lymphocyte in patient with ankylosing spondylitis that are treating with anti-TNF. Int J Clin Exp Med 2014; 7: 2912-5.

Yenidoğan sepsis olgularında hematolojik parametrelerin tanısal değeri

Yıl 2018, Cilt: 10 Sayı: 3, 252 - 262, 30.09.2018
https://doi.org/10.21601/ortadogutipdergisi.389829

Öz

Amaç: Bu çalışmada klinik olarak sepsis tanısı
konulan yenidoğanlarda, hematolojik parametrelerin yenidoğan sepsisinin erken
tanısında kullanılıp kullanılamayacağını araştırmayı amaçladık.

Gereç ve Yöntem: Bu
çalışma; Ocak 2014-Ocak 2016 tarihleri arasında Konya Beyhekim Devlet Hastanesi
Çocuk Sağlığı ve Hastalıkları Kliniği, Yenidoğan Yoğun Bakım Ünitesi’ne yenidoğan
sepsisi ön tanısı yatırılmış
olan 138 yenidoğan bebek üzerinde kayıtlarının geriye dönük olarak
incelenmesi sonucu elde edilen verilerle yapıldı.
Hasta
dosyasından; cinsiyet, doğum şekli (normal vajinal doğum, sezaryen), doğum
tartısı, hastaneye yatış tartısı, hastanın kaçıncı gün yatırıldığı,
gestasyon
yaşı,
yattığı gün sayısı, eşlik eden diğer yakınmalar, bebekte ve annede
risk etmenler kaydedildi.

Bulgular: Ünitemize yatırılan
710 yenidoğan bebekten 138’inin (%19,43) neonatal sepsis tanısı ile tedavi
aldığı saptandı. Bu hastaların 82’si (%59,4) erkek idi. Yüz yirmi yedi hastada
klinik sepsis tanısı konulurken hastaların 11’i (%7,97) hemokültür ile
kanıtlanmış sepsis idi. Hastaların ortalama doğum ağırlıkları 3082,14±423,90 gr
olup, 12 (%8,69) hasta 2500 gramın altında idi.
Hastaların ortalama C-reaktif  protein (CRP) değeri
19,01±15,30 mg/dl, ortalama prokalsitonin değeri 7,75±6,72 ng/ml saptandı. CRP
düzeyi hastaların %81,88’inde yüksek idi. Beyaz küre sayısı (WBC), nötrofil
sayısı (Neu), nötrofil/lenfosit oranı (NLO), ortalama
trombosit hacmi (MPV),  trombosit dağılım
genişliği (
PDW) açısından hasta grubunda kontrol grubuna göre
istatistiksel olarak yüksek tespit edildi. Platelet/lenfosit oranı (PLO) düzeyi
açısında hasta grubu ile kontrol grubu arasında istatistiksel olarak anlamlı
fark bulunmadı.







Sonuç: Bu
çalışma klinik olarak sepsis tanısı konulan yenidoğanlarda, hematolojik
parametrelerin yenidoğan sepsisinin erken tanısında
halen
çok kıymetli olduğunu bir kez daha ortaya koymuştur.

Kaynakça

  • 1. Hofer N, Zacharias E, Müller W, Resch B. An update on the use of c-reactive protein in early-onset neonatal sepsis: current insights and new tasks. Neonatology 2012; 102: 25-36.
  • 2. Polin RA, Parravicini E, Regan JA, Taeusch HW. Bacterial sepsis and meningitis. In: Taeusch HW, Ballard RA, Gleason CA (eds). Avery's Diseases of the Newborn (8th ed) Philadelphia: Elsevier Inc., 2005: 551-7.
  • 3. Ovalı F: Bakteriyel enfeksiyonlar. Editörler; Dağoğlu T, Ovalı F, Samancı N. Neonatoloji (1.baskı) Nobel Tıp Kitabevleri, Istanbul, 2000: 679-707.
  • 4. Yalaz M, Arslanoğlu S, Çetin H ve ark. Üçüncü basamak yenidoğan yoğun bakım merkezinde kanıtlanmış nozokomiyal sepsis etkenlerinin değerlendirilmesi: İki yıllık analiz. ADÜ Tıp Fakültesi Derg 2004; 5: 5-9.
  • 5. World Health Organization, Global Health Observatory Data Repository, 2013. Fromavaliable: http://apps.who.int/gho/data/view.main
  • 6. Liu C, Johnson H, Cousens S, et al. Global, regional and national cause of child mortality: an updated systematic analysis. Lancet 2012; 379: 2151-61.
  • 7. DuPont-Thibodeau G, Joyal JS, Lacroix J. Management of neonatal sepsis in term newborns. F1000 Prime Rep 2014;6:67. doi.org./10.12703/P6-67.
  • 8. Al-Zahrani AK, Ghonaim MM, Hussein YM, et al. Evaluation of recent methods versus conventional methods for diagnosis of early-onset neonatal sepsis. J Infect Dev Ctries 2015; 9: 388-93.
  • 9. Töllner U. Early diagnosis of septicemia in the newborn. Clinical studies and sepsis score. Eur J Pediatr 1982; 138: 331-7.
  • 10. Ovalı F. Yenidoğan enfeksiyonları. 1.baskı. İstanbul: İstanbul Medikal Yayıncılık; 2006: 107-60.
  • 11. Zaidi AKM, Darmstadt GL, Stoll BJ. Neonatal İnfections: A global perspection. In: Wilson CB, Nizet V, Maldonado Y, Remington JS, Klein JO [eds]. Remington and Klein’s Infectious diseases of the fetus and newborn. 7th ed. Philadelphia: Elsevier Saunders, 2011: 25-9.
  • 12. Çoban A. Yenidoğan enfeksiyonları. Neyzi O, Ertuğrul T, editör: Pediatri Nobel Tıp Kitabevleri.3. Baskı İstanbul; 2002: 431-44.
  • 13. Thaver D, Zaidi AKM. Burden of neonatal infections in developing countries: A review of evidence from community-based studies. PIDJ 2009; 28: 3-9.
  • 14. Leonard EG, Dobbs K. Postnatal bacterial infections. In: Martin RJ, Fanaroff AA, Walsh MC, eds. Fanaroff and Martin’s Neonatal-Perinatal Medicine, 10th edn. St. Louis: Elsevier Mosby Inc. 2015: 734-50.
  • 15. Schuchat A, Zywicki SS, Dinsmoor MJ et al. Risk factors and oppotunities for prevention of early-onset neonatal sepsis: A multicenter case-control study. Pediatrics 2000; 105: 21-6.
  • 16. Bhat YR, Lewis LE, Vandana KE. Bacterial isolates of early-onset neonatal sepsis and their antibiotic susceptibility pattern between 1998 and 2004: an audit from a center in India. Ital J Pediatr 2011; 11: 32-7.
  • 17. Kavuncuoğlu S, Kazancı S, Yıldız H ve ark. Yenidoğan Yoğun Bakım Ünitesinde Yatan Kültür Pozitif Sepsisli Olguların Sıklık, Etiyolojik Faktörler, Etken Mikroorganizmalar ve Antibiyotik Direnci Yönünden İncelenmesi. JOPP Derg 2011; 3: 129-38.
  • 18. Dear P. Infection in the newborn. In: Rennie M.J, Roberton NRC, editors: Textbook of Neonatology. Churchill Living; 1999: 1109-39. 19. Aygün C, Oran O, Portakal O. Yenidoğanlarda prokalsitonin düzeyleri ve sepsis tanısındaki yeri. Çocuk Sağlığı ve Hastalıkları Derg 2003; 46: 83-9.
  • 20. Ferrieri P, Wallen LD. Neonatal bacterial sepsis. In: Gleason CA, Devaskar SU, eds. Avery’s Diseases of The Newborn,9th edn. Philadelphia: Saunders, an imprint of Elsevier Inc. 2012: 538-50.
  • 21. Pourcyrous M, Bada US, Korones SB, Baselski V, Wong SP. Significance of serial C-reactive protein responses in neonatal infection and other disorders. Pediatrics 1993; 92: 431-5.
  • 22. Bone RC. The pathogenesis of sepsis. Ann Intern Med 1991; 115: 457-69.
  • 23. Squire E, Favara B, Todd J. Diagnosis of neonatal bacterial infection: hematologic pathologic findings in fatal and non-fatal cases. Pediatrics 1979; 64: 60-4.
  • 24. Stoll J. B. Infections of the neonatal infant. In: Behrman RE, Kliegman RM, Jenson BH, editörs: Nelson Textbook of Pediatrics 17th ed. Saunders, Philadelphia; 2004: 623-40.
  • 25. Bont ESJM, Martens A, Raan VJ, et al. Tumor Necrosis Factör–alfa, interleukin–1ß, Interleukin–6 plasma levels in neonatal sepsis. Pediatric Research 1993; 33: 380-3.
  • 26. Türkmen MK, Telli M, Erisen S, Güzünler M, Eyigör M. Neonatal sepsisli olguların değerlendirilmesi ve antibiyotik duyarlılıklarının belirlenmesi. ADU Tıp Fak Derg 2010; 11: 15-20.
  • 27. Yıldız C. Neonatal Sepsis Erken Tanısında Prokalsitoninin yeri ve önemi. SSK Bakırköy Doğumevi Kadın ve Çocuk Hastalıkları Eğitim Hastanesi Pediatri Kliniği Uzmanlık Tezi İstanbul, 2001.
  • 28. Icagasıoglu D, Caksen H, Sütcü I, Cevit O. Serum Creaktive protein and interleukin 6 levels in neonatal sepsis. Acta Medica 2002; 45: 111-13.
  • 29. Edwards M, Baker C. Sepsis in the newborn. In: Katz S, Gershon A, Hotez P (eds). Krugman’s Infectious Diseases of Children [10th ed]. St.Louis: Mosby Year Book, 1998: 415-28.
  • 30. Gerdes JS. Diagnosis and management of bacterial infections in neonate. Pediatr Clin N Am 2004; 51: 939-59.
  • 31. Bulut MO, Bulut İK, Büyükkayhan D ve ark. Neonatal Sepsisli Olguların Retrospektif Olarak Değerlendirilmesi. C. Ü. Tıp Fakültesi Dergisi 2005; 27: 63-8.
  • 32. Berger C, Uehlinger J, Ghelfi D, Blau N, Fanconi S. Comparison of C-reaktive protein and white blood cell count whith differential in neonates at risk for septicaemia. Eur J Pediatr 1995; 154: 138-44.
  • 33. Forest JC, Lariviere F, Boke P, Masson M, Nadeou L. Creactive protein as biomedical indicator of bacterial infection in neonates. Clin Biochem 1986; 19: 192-4.
  • 34. Meral C, Karademir F, Süleymanoğlu S, Aydınöz S, Tunç T, et al. Neonatal sepsis olgularının ve etkenlerinin retrospektif değerlendirilmesi. TAF Prev Med Bull 2009; 8: 329-32.
  • 35. Carrol ED, Thomson APJ, Hart CA. Procalcitonin as a marker of sepsis International Journal of Antimicrobial Agents 2002; 20: 1-9.
  • 36. Hatherill M, Tibby SM, Sykes K, Turner C, Murdoch IA. Diagnostic markers of infection: comparison of procalcitonin with C-reactive protein and leucocyte count. Arch Dis Child 1999; 81: 417-21.
  • 37. Köksal N, Harmancı R, Çetinkaya M, Hacımustafaoğlu M. Role of procalcitonin and CRP in diagnosis and follow-up of neonatal sepsis. Turk J Pediatr 2007; 49: 21-9.
  • 38. Sütçü İ. Neonatal Sepsisin erken tanısında interleukin–6 ve C-reaktif protein’in kullanımı. Cumhuriyet Üniversitesi Tıp Fak. Çocuk Sağlığı ve Hastalıkları Anabilim Dalı Uzmanlık Tezi Sivas, 1999.
  • 39. Jiang JH, Chiu NC, Huang FY, et al. Neonatal sepsis in the neonatal intensive care unit: characteristics of early versus late onset. J Microbiol Immunol Infect 2004; 37: 301-6.
  • 40. Rodwell RL, Leslie AL, Tudehope Dİ. Early diagnosis of neonatal sepsis using a hematologic scoring sysytem. J Pediatr 1998; 112: 761-7.
  • 41. Van Der Lelie J, Van Dem Barae AK. Increased mean platelet volüme in septicemia. J Clin Patho 1983; 36: 693-6
  • 42. O' Connor TA, Ringerk M, Gaddis ML. MPV during staphylococcal sepsis in neonates. Am J Clin Pathol 1993; 99: 69-71
  • 43. Vagdatli E, Gounari E, Lazaridou E et al. Platelet distribution width: a simple, practical and specific marker of activation of coagulation. Hippokratia 2010; 14: 28-32.
  • 44. Mariani E, Filardo G, Canella V, et al. Platelet-rich plasma affects bacterial growth in vitro. Cytotherapy 2014; 16: 1294-304.
  • 45. Bessman JD, Williams LJ, Gilmer PR. Mean platelet volume: the inverse relation of platelet size and count in normal subjects, and an artifact of other particles. Am J Clin Pathol 1981; 76: 289-93. 46. Wiwanitkit V. Plateletcrit, mean platelet volume, platelet distribution width: its expected values and correlation with parallel red blood cell parameters. Clin Applied Thrombosis/Hemostasis 2004; 10: 175-8.
  • 47. Guclu E, Durmaz Y, Karabay O. Effect of severe sepsis on platelet count and their indices. Afr Health Sci 2013; 13: 333-8.
  • 48. Yilmaz Z, Eralp O, Ilcol YO. Evaluation of platelet count and its association with plateletcrit, mean platelet volume, and platelet size distribution width in a canine model of endotoxemia. Vet Clin Pathol 37: 159–63.
  • 49. Mantovani A, Cassatella MA, Costantini C, Jaillon S. Neutrophils in the activation and regulation of innate and adaptive immunity. Nat Rev Immunol 2011; 11: 519-31.
  • 50. Gibson PH, Cuthbertson BH, Croal BL, et al. Usefulness of neutrophil/lymphocyte ratio as predictor of new-onset atrial fibrillation after coronary artery bypass grafting. Am J Cardiol 2010; 105: 186-91.
  • 51. Bermejo-Martín JF, Tamayo E, Ruiz G, et al. Circulating neutrophil counts and mortality in septic shock. Crit Care 2014; 18: 407.
  • 52. Zahorec R. Ratio of neutrophil to lymphocyte counts--rapid and simple parameter of systemic inflammation and stress in critically ill. Bratisl Lek Listy 2001; 102: 5-14.
  • 53. Loonen AJ, de Jager CP, Tosserams J, Kusters R, Hilbink M, Wever PC and van den Brule AJ: Biomarkers and molecular analysis to improve bloodstream infection diagnostics in an emergency care unit. PLoS One 9: e87315, 2014.
  • 54. De Jager CP, Van Wijk PT, Mathoera RB, et al. Lymphocytopenia and neutrophil lymphocyte count ratio predict bacteremia better than conventional infection markers in an emergency care unit. Crit Care 2010; 14: 192.
  • 55. Zhang HB, Chen J, Lan QF, et al. Diagnostic values of red cell distribution width, platelet distribution width and neutrophil lymphocyte count ratio for sepsis. Experimental Therapeutic Med 2016; 12: 2215-9.
  • 56. Salciccioli JD, Marshall DC, Pimentel MA, et al. The association between the neutrophil-to-lymphocyte ratio and mortality in critical illness: an observational cohort study. Critical Care 2015; 19: 13.
  • 57. Ozer S, Yilmaz R, Sonmezgoz E, et al. Simple markers for subclinical inflammation in patients with Familial Mediterranean Fever. Med Sci Monit 2015; 21: 298-303.
  • 58. Boyraz I, Koc B, Boyaci A, et al. Ratio of neutrophil/lymphocyte and platelet/lymphocyte in patient with ankylosing spondylitis that are treating with anti-TNF. Int J Clin Exp Med 2014; 7: 2912-5.
Toplam 56 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular Sağlık Kurumları Yönetimi
Bölüm Araştırma makaleleri
Yazarlar

Alaaddin Yorulmaz 0000-0001-5478-1197

Mehmet Yücel Bu kişi benim

Sadiye Sert Bu kişi benim

Yayımlanma Tarihi 30 Eylül 2018
Yayımlandığı Sayı Yıl 2018 Cilt: 10 Sayı: 3

Kaynak Göster

Vancouver Yorulmaz A, Yücel M, Sert S. Yenidoğan sepsis olgularında hematolojik parametrelerin tanısal değeri. otd. 2018;10(3):252-6.

e-ISSN: 2548-0251

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