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Endometrium kanserinde nötrofil/lenfosit oranının ve platelet endekslerinin değerlendirilmesi

Yıl 2018, Cilt: 10 Sayı: 3, 307 - 311, 30.09.2018
https://doi.org/10.21601/ortadogutipdergisi.445159

Öz

Amaç:
Jinekolojik kanserler arasında en sık görüleni endometrium
kanseridir. Tüm kanserlerde olduğu gibi, endometrium kanserinde de kronik
inflamasyon etyolojik faktör olarak rol oynamaktadır.

Gereç
ve Yöntem:
Çalışmamıza her grupta 35 olmak üzere üç
grup ve toplam 105 hasta dahil edildi. Endometrial örnekleme sonuçlarına göre
gruplar; benign grup, hiperplazi grubu ve malign grup olarak isimlendirildi.
Gruplar arasında hematolojik parametrelerde anlamlı fark olup olmadığı
araştırıldı.

Bulgular:
Nötrofil sayısı, lenfosit sayısı, platelet sayısı, nötrofil/lenfosit
oranı ve platelet/lenfosit oranı bakımından gruplar arasında istatistiksel
olarak anlamlı bir fark saptanmadı (p>0,05). Hemoglobin, ortalama platelet
volümü ve Platelet dağılım genişliği değerleri malign grupta istatistiksel
olarak anlamlı derecede yüksek saptandı (p<0,05).







Sonuç: Çalışmamızda elde ettiğimiz sonuçlar bize; inflamasyonun,
platelet aktivitesini arttırarak endometrium kanserine zemin hazırlayabileceğini
düşündürdü.

Kaynakça

  • Referans1. Elit LM, Pond G, Seow H. Time interval between endometrial biopsy and surgical staging for type I endometrial cancer: association between tumor characteristics and survival outcome. Obstet Gynecol. 2015;125:1497-1498.
  • Referans2. Kim MK, Seong SJ, Kim JW ve ark. Management of Endometrial Hyperplasia: A Survey of Members of the Korean Gynecologic Oncology Group. Int J Gynecol Cancer. 2015;25:1277-1284.
  • Referans3. Kim DK, Oh SY, Kwon HC ve ark. Clinical significances of preoperative serum interleukin-6 and C-reactive protein level inoperable gastric cancer. BMC Cancer. 2009;9:155.
  • Referans4. Mangalpally KK, Siqueiros-Garcia A, Vaduganathan M, Dong JF, Kleiman NS, Guthikonda S. Platelet activation patterns in platelet size sub-populations: differential responses to aspirin in vitro. Journal of Thrombosis and Thrombolysis. 2010;30:251–262.
  • Referans5. Talhouk A, McConechy MK, Leung S ve ark. A clinically applicable molecular-based classification for endometrial cancers. Br J Cancer. 2015;113:299-310.
  • Referans6. D. W. Kamp, E. Shacter, and S. A. Weitzman, Chronic inflammation and cancer: the role of the mitochondria. Oncology. 2011;400–413.
  • Referans7. Arango HA, Icely S, Roberts WS, Cavanagh D, Becker JL. Aspirin effects on endometrial cancer cell growth. Obstet Gynecol 2001;423–427.
  • Referans8. L. Dossus, S. Rinaldi, S. Becker ve ark. Obesity, inflammatory markers, and endometrial cancer risk: a prospective Case-Control Study. Endocrine-Related Cancer. 2010;1007–1019.
  • Referans9. Vagdatli E, Gounari E, Lazaridou E, Katsibourlia E, Tsikopoulou F, Labrianou I. Platelet distribution width: a simple, practical and specific marker of activation of coagulation. Hippokratia. 2010;14:28-32.
  • Referans10. Tuszynski GP, Nicosia RF. The role of thrombospondin-1 in tumor progression and angiogenesis. Bioessays, 1996; 71-76.
  • Referans11. Oge T, Yalcin OT, Ozalp SS, Isikci T. Platelet volume as a parameter for platelet activation in patients with endometrial cancer. J Obstet Gynaecol. 2013;33:301-304.
  • Referans12. Ercan Yılmaz, Ebru İnci Coşkun, Nurhan Şahin, Tamer Elkıran, Barış Cıplak, Yavuz Şimşek. The sıgnıfıcance of MPV and N/L value ın dıagnosıs of endometrıal cancer. Türk Jinekolojik Onkoloji Dergisi. 2015;33-36.
  • Referans13. Karateke A, Kaplanoglu M, Baloglu A. Relations of Platelet Indices with Endometrial Hyperplasia and Endometrial Cancer. Asian Pac J Cancer Prev. 2015;16:4905-4908.
  • Referans14. Yıldırım MA, Seckin KD, Togrul C ve ark. Roles of neutrophil/lymphocyte and platelet/lymphocyte ratios in the early diagnosis of malignant ovarian masses. Asian Pac J Cancer Prev. 2014;15:6881-6885.
  • Referans15. Kokcu A, Kurtoglu E, Celik H, Tosun M, Malatyalıoglu E, Ozdemir AZ. May the platelet to lymphocyte ratio be a prognostic factor for epithelial ovarian cancer? Asian Pac J Cancer Prev. 2014;15:9781-9784.

Evaluation of neutrophil / lymphocyte ratio and platelet indexes in endometrium cancer

Yıl 2018, Cilt: 10 Sayı: 3, 307 - 311, 30.09.2018
https://doi.org/10.21601/ortadogutipdergisi.445159

Öz

Aim:
Endometrium cancer is the most common
ly seen
gynecologic cancer.
As in all the cancer processes,
chronic inflammation plays an etiological role.

Material
and Method:
The study included a total of 105 patients. Three
groups
each
consisting
35 patients are formed. Based
on the results of endometrial sampling, the
patients are groped as benign,
hyperplasia and malignant
. Differences of
hematologic parameters between the groups w
ere
investigated.

Results: There
was no statistically significant difference between
the groups
in terms of neutrophil, lymphocyte,
and platelet count,
neutrophil/lymphocyte
ratio and
platelet/lymphocyte ratio
(p>0.05).
Hemoglobin, mean platelet volume and platelet distribution width values
​​were
found statistically significantly higher in the malignant group (p<0.05).







Conclusion: As a result; inflammation may increase platelet
activity and provide
a basis for endometrial cancer.

Kaynakça

  • Referans1. Elit LM, Pond G, Seow H. Time interval between endometrial biopsy and surgical staging for type I endometrial cancer: association between tumor characteristics and survival outcome. Obstet Gynecol. 2015;125:1497-1498.
  • Referans2. Kim MK, Seong SJ, Kim JW ve ark. Management of Endometrial Hyperplasia: A Survey of Members of the Korean Gynecologic Oncology Group. Int J Gynecol Cancer. 2015;25:1277-1284.
  • Referans3. Kim DK, Oh SY, Kwon HC ve ark. Clinical significances of preoperative serum interleukin-6 and C-reactive protein level inoperable gastric cancer. BMC Cancer. 2009;9:155.
  • Referans4. Mangalpally KK, Siqueiros-Garcia A, Vaduganathan M, Dong JF, Kleiman NS, Guthikonda S. Platelet activation patterns in platelet size sub-populations: differential responses to aspirin in vitro. Journal of Thrombosis and Thrombolysis. 2010;30:251–262.
  • Referans5. Talhouk A, McConechy MK, Leung S ve ark. A clinically applicable molecular-based classification for endometrial cancers. Br J Cancer. 2015;113:299-310.
  • Referans6. D. W. Kamp, E. Shacter, and S. A. Weitzman, Chronic inflammation and cancer: the role of the mitochondria. Oncology. 2011;400–413.
  • Referans7. Arango HA, Icely S, Roberts WS, Cavanagh D, Becker JL. Aspirin effects on endometrial cancer cell growth. Obstet Gynecol 2001;423–427.
  • Referans8. L. Dossus, S. Rinaldi, S. Becker ve ark. Obesity, inflammatory markers, and endometrial cancer risk: a prospective Case-Control Study. Endocrine-Related Cancer. 2010;1007–1019.
  • Referans9. Vagdatli E, Gounari E, Lazaridou E, Katsibourlia E, Tsikopoulou F, Labrianou I. Platelet distribution width: a simple, practical and specific marker of activation of coagulation. Hippokratia. 2010;14:28-32.
  • Referans10. Tuszynski GP, Nicosia RF. The role of thrombospondin-1 in tumor progression and angiogenesis. Bioessays, 1996; 71-76.
  • Referans11. Oge T, Yalcin OT, Ozalp SS, Isikci T. Platelet volume as a parameter for platelet activation in patients with endometrial cancer. J Obstet Gynaecol. 2013;33:301-304.
  • Referans12. Ercan Yılmaz, Ebru İnci Coşkun, Nurhan Şahin, Tamer Elkıran, Barış Cıplak, Yavuz Şimşek. The sıgnıfıcance of MPV and N/L value ın dıagnosıs of endometrıal cancer. Türk Jinekolojik Onkoloji Dergisi. 2015;33-36.
  • Referans13. Karateke A, Kaplanoglu M, Baloglu A. Relations of Platelet Indices with Endometrial Hyperplasia and Endometrial Cancer. Asian Pac J Cancer Prev. 2015;16:4905-4908.
  • Referans14. Yıldırım MA, Seckin KD, Togrul C ve ark. Roles of neutrophil/lymphocyte and platelet/lymphocyte ratios in the early diagnosis of malignant ovarian masses. Asian Pac J Cancer Prev. 2014;15:6881-6885.
  • Referans15. Kokcu A, Kurtoglu E, Celik H, Tosun M, Malatyalıoglu E, Ozdemir AZ. May the platelet to lymphocyte ratio be a prognostic factor for epithelial ovarian cancer? Asian Pac J Cancer Prev. 2014;15:9781-9784.
Toplam 15 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Konular Sağlık Kurumları Yönetimi
Bölüm Araştırma makaleleri
Yazarlar

İlkin Yeral 0000-0001-8987-1336

Cemile Dayangan Sayan

Yayımlanma Tarihi 30 Eylül 2018
Yayımlandığı Sayı Yıl 2018 Cilt: 10 Sayı: 3

Kaynak Göster

Vancouver Yeral İ, Dayangan Sayan C. Endometrium kanserinde nötrofil/lenfosit oranının ve platelet endekslerinin değerlendirilmesi. otd. 2018;10(3):307-11.

e-ISSN: 2548-0251

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