Araştırma Makalesi
BibTex RIS Kaynak Göster

Hipertansif Hastalarda Reverse-dipper Kan Basıncı ile Nötrofil Lenfosit Oranı Arasındaki İlişki

Yıl 2019, Cilt: 41 Sayı: 3, 203 - 207, 01.07.2019
https://doi.org/10.20515/otd.410269

Öz

Revers dipper hipertansiyon ve nötrofil/lenfosit
oranı (NLR), kardiyovasküler risk öngördürücüsü olarak araştırılmaktadır. NLR
ve diğer sirkadyen kan basıncı paternleri arasındaki ilişki gösterilmiştir. Bu
çalışmanın amacı hipertansif hastalarda nötrofil lenfosit oranı ile revers
dipper kan basıncı paterni arasındaki ilişkiyi değerlendirmektir. Çalışmaya 144 (66 erkek, 78 kadın)
hipertansif hasta alındı. Kan basıncı paternleri 24 saat ambulatuar kan basıncı
ile değerlendirildi. Nötrofil lenfosit oranı, nötrofil sayısı lenfosit sayısına
bölünerek ölçüldü. Revers dipper hipertansiyonlularda dipper
hipertansiyonlulara göre nötrofil lenfosit oranında anlamlı artış vardı.
(sırasıyla 2.36±1,68 ve 1,81±0,69, p=0,040 ). Nötrofil lenfosit oranı ile
sistolik (r=-0,193;p=0.021 ve diyastolik ( r=-0,160; p=0,057) kan basıncı düşme
oranları arasında negatif korelasyon vardı.
Çalışmamız NLR ve revers dipper patern arasında olası bir ilişki
sunmaktadır ancak nötrofil lenfosit oranını, 
revers dipper paternin  bağımsız
öngörücüsü olarak rapor etmek için daha ileri çalışmalar gereklidir.

Kaynakça

  • 1. Pickering TG, Shimbo D, Haas D. Ambulatory blood-pressure monitoring. N Engl J Med. 2006;354:2368-2374. DOI:10.1056/NEJMra060433. PubMed PMID: 16738273.
  • 2. McAlister FA, Straus SE. Evidence based treatment of hypertension. Measurement of blood pressure : an evidence based review. BMJ 2001 ; 322:908-11. PubMed PMID: 11302909.
  • 3. Verdecchia P, Schillaci G, Borgioni C, et al. Altered circadian blood pressure profile and prognosis. PubMed PMID:10234138.
  • 4. Ohkubo T, Imai Y, Tsuji I, Nagai K,Watanabe N, Minami N, et al. Relation between nocturnal decline in blood pressure and mortality. The Ohasama Study. Am J Hypertens.1997;10:1201-1207. PubMed PMID: 9397237.
  • 5. Yan B, Peng L, Han D, Sun L, Dong Q, Yang P, et al. Reverse –dipper pattern of blood pressure may predict lacunar infarction in patients with essential hypertension. Eur J Neurol 2015;22:1022-5. doi: 10.1111/ene.12659. PubMed PMID: 25614275. Epub 2015 Jan 23.
  • 6. Tamhane UU, Aneja S, Montgomery D, Rogers EK, Eagle KA, Gurm HS. Association between admission neutrophil to lymhocyte ratio and outcomes in patients with acute coranary syndrome. Am J Cardiol 2008;102:653-7. doi: 10.1016/j.amjcard.2008.05.006. PubMed PMID:18773982. Epub 2008 Jun 26.
  • 7. Turak O, Ozcan F, Tok D, Işleyen A, Sökmen E, Taşoğlu I. Serum uric acid, inflammation, and nondipping circadian pattern in essential hypertension. J Clin Hypertens (Greenwich) 2013;15:7-13. doi: 10.1111/jch.12026. Epub 2012 Nov 2. PubMed PMID: 23282120.
  • 8. Verdecchia P, Porcellati C, Schillaci G, Borgioni C, Ciucci A, Battistelli M, et al. Ambulatory blood pressure. an independent predictor of prognosis in essential hypertension. Hypertension. 1994;24:793-801. PubMed PMID: 7995639.
  • 9. Ohkubo T, Hozawa A, Yamaguchi J, Kikuya M, Ohmori K, Michimata M, et al. Prognostic significance of the nocturnal decline in blood pressure in individuals with and without high 24-h blood pressure: the Ohasama study. J Hypertens 2002;20:2183-9. PubMed PMID: 12409956.
  • 10. Boggia J, Li Y, Thijs L, Hansen TW, Kikuya M, Björklund-Bodegård K, et al. Prognostic accuracy of day versus night ambulatory blood pressure: a cohort study. Lancet 2007;370:1219-29. DOI:10.1016/S0140-6736(07)61538-4. PubMed PMID: 17920917.
  • 11. Kario K, Pickering TG, Matsuo T, Hoshide S, Schwartz JE, Shimada K.. Stroke prognosis and abnormal nocturnal blood pressure falls in older hypertensives. Hypertension 38, 852-857 (2001). PubMed PMID: 11641298.
  • 12. Yan B, Peng L, Han D, Sun L, Dong Q, Yang P et al. Blood pressure reverse-dipping is associated with early formation of carotid plaque in senior hypertensive patients. Medicine (Baltimore) 2015; 94:e604. doi: 10.1097/MD.0000000000000604. PubMed PMID:25761180.
  • 13. Wang C, Ye Z, Li Y, Zhang J, Zhang Q, Ma X et al. Prognostic value of reverse dipper blood pressure pattern in chronic kidney disease patients not undergoing dialysis: Prospective cohort study. Sci Rep.2016; 6: 34932. doi: 10.1038/srep34932. PubMed PMID: 27713498.
  • 14. Su D, Guo Q, Gao Y, Han J, Yan B, Peng L, et al. The relationship between red blood cell distribution width and blood pressure abnormal dispping in patients with essential hypertension: a cross-sectional study. BMJ Open 2016;6:e010456. doi: 10.1136/bmjopen-2015-010456. PMID:26908530.

The Relation Between Blood Pressure Reverse-Dipping and Neutrophil to Lymphocyte Ratio in Hypertensive Patients

Yıl 2019, Cilt: 41 Sayı: 3, 203 - 207, 01.07.2019
https://doi.org/10.20515/otd.410269

Öz

Reverse dipper hypertension
and  neutrophil to lymphocyte ratio (NLR)
has been investigated as a predictor for cardiovascular risk. The relationship
between NLR and other circadien blood pressure (BP) patterns has been showed.
The aim of this study was to investigate the relation between NLR and BP
reverse dipper pattern in patients with hypertension. 144 hypertensive patients
(66 males, 78 females) were enrolled the study. BP patterns were evaluated with
24-h ambulatory BP monitoring (ABPM). Baseline NLR was measured by dividing
neutrophil count to lymhocyte count. There was significantly increased NLR in
reverse dippers (2,36±1,68 ) than dippers (1,81±0,69) of hypertension (p=0,040
). NLR was negatively correlated with the decline rate of nocturnal systolic BP(r=-0,193;p=0.021)
and diastolic BP( r=-0,160; p=0,057). Our study provides a possible association
between NLR and reverse dipper pattern, but to report NLR as an independent
predictor of reverse dipper pattern further studies are required.

Kaynakça

  • 1. Pickering TG, Shimbo D, Haas D. Ambulatory blood-pressure monitoring. N Engl J Med. 2006;354:2368-2374. DOI:10.1056/NEJMra060433. PubMed PMID: 16738273.
  • 2. McAlister FA, Straus SE. Evidence based treatment of hypertension. Measurement of blood pressure : an evidence based review. BMJ 2001 ; 322:908-11. PubMed PMID: 11302909.
  • 3. Verdecchia P, Schillaci G, Borgioni C, et al. Altered circadian blood pressure profile and prognosis. PubMed PMID:10234138.
  • 4. Ohkubo T, Imai Y, Tsuji I, Nagai K,Watanabe N, Minami N, et al. Relation between nocturnal decline in blood pressure and mortality. The Ohasama Study. Am J Hypertens.1997;10:1201-1207. PubMed PMID: 9397237.
  • 5. Yan B, Peng L, Han D, Sun L, Dong Q, Yang P, et al. Reverse –dipper pattern of blood pressure may predict lacunar infarction in patients with essential hypertension. Eur J Neurol 2015;22:1022-5. doi: 10.1111/ene.12659. PubMed PMID: 25614275. Epub 2015 Jan 23.
  • 6. Tamhane UU, Aneja S, Montgomery D, Rogers EK, Eagle KA, Gurm HS. Association between admission neutrophil to lymhocyte ratio and outcomes in patients with acute coranary syndrome. Am J Cardiol 2008;102:653-7. doi: 10.1016/j.amjcard.2008.05.006. PubMed PMID:18773982. Epub 2008 Jun 26.
  • 7. Turak O, Ozcan F, Tok D, Işleyen A, Sökmen E, Taşoğlu I. Serum uric acid, inflammation, and nondipping circadian pattern in essential hypertension. J Clin Hypertens (Greenwich) 2013;15:7-13. doi: 10.1111/jch.12026. Epub 2012 Nov 2. PubMed PMID: 23282120.
  • 8. Verdecchia P, Porcellati C, Schillaci G, Borgioni C, Ciucci A, Battistelli M, et al. Ambulatory blood pressure. an independent predictor of prognosis in essential hypertension. Hypertension. 1994;24:793-801. PubMed PMID: 7995639.
  • 9. Ohkubo T, Hozawa A, Yamaguchi J, Kikuya M, Ohmori K, Michimata M, et al. Prognostic significance of the nocturnal decline in blood pressure in individuals with and without high 24-h blood pressure: the Ohasama study. J Hypertens 2002;20:2183-9. PubMed PMID: 12409956.
  • 10. Boggia J, Li Y, Thijs L, Hansen TW, Kikuya M, Björklund-Bodegård K, et al. Prognostic accuracy of day versus night ambulatory blood pressure: a cohort study. Lancet 2007;370:1219-29. DOI:10.1016/S0140-6736(07)61538-4. PubMed PMID: 17920917.
  • 11. Kario K, Pickering TG, Matsuo T, Hoshide S, Schwartz JE, Shimada K.. Stroke prognosis and abnormal nocturnal blood pressure falls in older hypertensives. Hypertension 38, 852-857 (2001). PubMed PMID: 11641298.
  • 12. Yan B, Peng L, Han D, Sun L, Dong Q, Yang P et al. Blood pressure reverse-dipping is associated with early formation of carotid plaque in senior hypertensive patients. Medicine (Baltimore) 2015; 94:e604. doi: 10.1097/MD.0000000000000604. PubMed PMID:25761180.
  • 13. Wang C, Ye Z, Li Y, Zhang J, Zhang Q, Ma X et al. Prognostic value of reverse dipper blood pressure pattern in chronic kidney disease patients not undergoing dialysis: Prospective cohort study. Sci Rep.2016; 6: 34932. doi: 10.1038/srep34932. PubMed PMID: 27713498.
  • 14. Su D, Guo Q, Gao Y, Han J, Yan B, Peng L, et al. The relationship between red blood cell distribution width and blood pressure abnormal dispping in patients with essential hypertension: a cross-sectional study. BMJ Open 2016;6:e010456. doi: 10.1136/bmjopen-2015-010456. PMID:26908530.
Toplam 14 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Sağlık Kurumları Yönetimi
Bölüm ORİJİNAL MAKALELER / ORIGINAL ARTICLES
Yazarlar

Müjgan Tek 0000-0002-1718-1843

Fatma Ayerden Ebinç 0000-0002-7893-3498

Aysun Aybal Kutlugün Bu kişi benim 0000-0001-6350-903X

Fatma Kaplan Efe Bu kişi benim 0000-0001-9896-2459

Serkan Çetin Bu kişi benim 0000-0002-3983-0496

Savaş Çelebi Bu kişi benim 0000-0002-2566-3877

Berkten Berkalp Bu kişi benim 0000-0002-4310-709X

Yayımlanma Tarihi 1 Temmuz 2019
Yayımlandığı Sayı Yıl 2019 Cilt: 41 Sayı: 3

Kaynak Göster

Vancouver Tek M, Ayerden Ebinç F, Aybal Kutlugün A, Kaplan Efe F, Çetin S, Çelebi S, Berkalp B. The Relation Between Blood Pressure Reverse-Dipping and Neutrophil to Lymphocyte Ratio in Hypertensive Patients. Osmangazi Tıp Dergisi. 2019;41(3):203-7.


13299        13308       13306       13305    13307  1330126978