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Epidemiology of acute respiratory viral infections of children with cancer before the COVID-19 pandemic

Yıl 2023, Cilt: 45 Sayı: 6, 909 - 915, 24.10.2023
https://doi.org/10.20515/otd.1315573

Öz

Children with cancer became a major high-risk group during the COVID-19 pandemic. It has become difficult for patients to reach practical and safe care and treatment all over the world. The late diagnosis of many childhood cancers was driven by limited access to healthcare due to the pandemic and fears of COVID-19 that prevented parents from making an early medical assessment of their child's symptoms. Acute respiratory diseases are an important cause of morbidity and mortality in children with cancer, regardless of the COVID-19 pandemic and were seen less frequently in the pandemic during the lockdown and distant education period in comparison to the time before the pandemic in children with cancer. Acute respiratory viral infections frequently cause febrile neutropenia attacks in children under five years of age. A three year retrospective cross-sectional study was performed in a tertiary care university hospital. Children with cancer who presented to the Department of Pediatric Hematology and Oncology with the diagnosis of acute respiratory viral infection were included in the study if they had available results of multiplex polymerase chain reaction (PCR) of nasopharyngeal aspirate samples. The qualitative detection of 18 respiratory viruses and four bacterias were detected by the real-time multiplex polymerase chain reaction. Sixty-six patients with 93 acute respiratory viral infection were included in this study. Seventy of 93 (75%) samples were positive for at least one pathogen. The most common three viruses were HRV, Influenza H1N1, and Influenza H1N3, respectively. Other than COVID-19, the risk of severe acute respiratory viral infections are always important in children with cancer and during the pandemic, hygiene measures and social restrictions caused a reduction in the number of acute respiratory viral infection. This study is critical because it shows the distribution of agents in children with cancer who had acute viral upper respiratory tract infections in the near term before the pandemic.

Kaynakça

  • 1. Sullivan M, Bouffet E, Rodriguez-Galindo C, et al. The COVID-19 pandemic: A rapid global response for children with cancer from SIOP, COG, SIOP-E, SIOP-PODC, IPSO, PROS, CCI, and St Jude Global. Pediatr Blood Cancer. 2020 Jul;67(7): e28409.
  • 2. Kebudi R, Chantada G, Kurucu N, et al. COVID-19: Consequences for Children With Cancer in Turkey and Globally. Turk Arch Pediatr. 2021 Jul 1;56(4):295-299.
  • 3. El-Qushayri AE, Benmelouka AY, Dahy A, Hashan MR. COVID-19 outcomes in paediatric cancer: A large scale pooled meta-analysis of 984 cancer patients. Rev Med Virol. 2022 Sep;32(5): e2344.
  • 4. Kebudi R, Kacar D, Ozyoruk D, et al. Non-COVID-19 viral respiratory infections in children with cancer during the COVID-19 pandemic: a multicenter observational study. Pediatr Blood Cancer. 2022 September; 69(5): ep453.
  • 5. Benites EC, Cabrini DP, Silva AC, et al. Acute respiratory viral infections in pediatric cancer patients undergoing chemotherapy. J Pediatr (Rio J). 2014 Jul-Aug;90(4):370-6.
  • 6. Alali M, David MZ, Ham SA, Danziger-Isakov L, Pisano J. Febrile Neutropenia Syndromes in Children: Risk Factors and Outcomes of Primary, Prolonged, and Recurrent Fever. J Pediatr Hematol Oncol. 2021;43(7):e962-e971.
  • 7. Alali M, David MZ, Danziger-Isakov LA, et al. Pediatric Febrile Neutropenia: Change in Etiology of Bacteremia, Empiric Choice of Therapy and Clinical Outcomes. J Pediatr Hematol Oncol. 2020 Aug;42(6):e445-e451.
  • 8. Alali M, David MZ, Danziger-Isakov LA, et al. Association Between Depth of Neutropenia and Clinical Outcomes in Febrile Pediatric Cancer and/or Patients Undergoing Hematopoietic Stem-cell Transplantation. Pediatr Infect Dis J. 2020 Jul;39(7):628-633.
  • 9. Kebudi R, Kacar D, Ozyoruk D, et al. Non-COVID-19 viral respiratory infections in children with cancer during the COVID-19 pandemic: a multicenter observational study. Pediatr Blood Cancer. 2022 September; 69(5): ep453.
  • 10. Onyeaka H, Anumudu CK, Al-Sharify ZT, Egele-Godswill E, Mbaegbu P. COVID-19 pandemic: A review of the global lockdown and its far-reaching effects. Sci Prog. 2021 Apr-Jun;104(2): 368504211019854.
  • 11. Mazzoleni S, Turchetti G, Ambrosino N. The COVID-19 outbreak: From "black swan" to global challenges and opportunities. Pulmonology. 2020 May-Jun;26(3): 117-8.
  • 12. Kebudi R, Kizilocak H. Febrile Neutropenia in Children with Cancer: Approach to Diagnosis and Treatment. Curr Pediatr Rev. 2018;14(3):204-209.
  • 13. Lehrnbecher T, Robinson P, Fisher B, et al. Guideline for the Management of Fever and Neutropenia in Children With Cancer and Hematopoietic Stem-Cell Transplantation Recipients: 2017 Update. J Clin Oncol. 2017 Jun 20;35(18): 2082-94.
  • 14. Marcone DN, Ellis A, Videla C, Ekstrom J, Ricarte C, Carballal G, Vidaurreta SM, Echavarría M. Viral etiology of acute respiratory infections in hospitalized and outpatient children in Buenos Aires, Argentina. Pediatr Infect Dis J. 2013 Mar;32(3):e105-10.
  • 15. Aydin Köker S, Demirağ B, Tahta N, Bayram N, Oymak Y, Karapinar TH, Gözmen S, Düzgöl M, Erçan Bozyer H, Vergin C, Devrim İ. A 3-Year Retrospective Study of the Epidemiology of Acute Respiratory Viral Infections in Pediatric Patients With Cancer Undergoing Chemotherapy. J Pediatr Hematol Oncol. 2019 May;41(4):e242-e246
  • 16. Li YT, Liang Y, Ling YS, Duan MQ, Pan L, Chen ZG. The spectrum of viral pathogens in children with severe acute lower respiratory tract infection: A 3-year prospective study in the pediatric intensive care unit. J Med Virol. 2019 Sep;91(9):1633-1642.
  • 17. Çiçek C, Arslan A, Karakuş HS, Yalaz M, Saz EU, Pullukçu H, Çok G. Akut solunum yolu enfeksiyonu olan hastalarda solunum viruslarının prevalansı ve mevsimsel dağılımı, 2002-2014 [Prevalence and seasonal distribution of respiratory viruses in patients with acute respiratory tract infections, 2002-2014]. Mikrobiyol Bul. 2015 Apr;49(2):188-200.
  • 18. Moscona A. Neuraminidase inhibitors for influenza. N Engl J Med. 2005 Sep 29;353(13):1363-73.
  • 19. Hijano DR, Maron G, Hayden RT. Respiratory Viral Infections in Patients With Cancer or Undergoing Hematopoietic Cell Transplant. Front Microbiol. 2018 Dec 12;9: 3097.
  • 20. Kobayashi R, Hori D, Sano H, Suzuki D, Kishimoto K, Kobayashi K. Meropenem versus piperacillin/tazobactam with or without immunoglobulin as second-line therapy for febrile neutropenia in pediatric patients. J Microbiol Immunol Infect. 2018 Aug;51(4): 473-7.

COVID-19 pandemisi öncesi kanserli çocukların akut solunum yolu viral enfeksiyonlarının epidemiyolojisi

Yıl 2023, Cilt: 45 Sayı: 6, 909 - 915, 24.10.2023
https://doi.org/10.20515/otd.1315573

Öz

COVID-19 pandemisi sırasında kanserli çocuklar yüksek riskli gruplardan biri oldular. Hastaların kolay vegüvenli hasta bakımına, daha önemlisi tedaviye ulaşması tüm dünyada zorlaştı. Pandemi nedeniyle sağlık hizmetlerine sınırlı erişim ve ebeveynlerin çocuklarındaki semptomların erken tıbbi değerlendirilmesini engelleyen COVID-19 korkusu birçok çocukluk çağı kanserinin geç teşhisine neden oldu. Akut solunum yolu enfeksiyonları, COVID-19 pandemisinden bağımsız olarak kanserli çocuklarda önemli bir hastalık ve ölüm nedenidir. Bu enfeksiyonlar, pandemi öncesine göre pandemi döneminde sokağa çıkma yasağı ve uzaktan eğitim nedeniyle daha az görüldü. Akut solunum yolu viral enfeksiyonları beş yaşın altındaki çocuklarda sıklıkla febril nötropeni ataklarına neden olur. Üç yıllık retrospektif kesitsel nitelikte olan bu çalışma üçüncü basamak bir üniversite hastanesinde yapıldı. Çocuk Hematoloji ve Onkoloji Bilim Dalı'nda akut solunum yolu viral enfeksiyonu tanısı alan kanserli çocuklar, nazofaringeal aspirat örneklerinde multipleks polimeraz zincir reaksiyonu (PCR) ile etken saptandıysa çalışmaya dahil edildi. Multipleks polimeraz zincir reaksiyonu ile on sekiz solunum virüsünün ve dört bakterinin kalitatif tespiti için test çalışıldı. Akut viral üst solunum yolu atağı geçiren 66 hasta bu çalışma dahil edildi. Doksan üç örneğin 70’i (%75) en az bir patojen için pozitifti. En yaygın üç virüs sırasıyla HRV, Influenza H1N1 ve Influenza H1N3’dü. COVID-19 dışında, kanserli çocuklarda ciddi akut solunum yolu viral enfeksiyonu riski her zaman önemlidir ve pandemi sırasında hijyen önlemleri ve sosyal kısıtlamalar, akut solunum yolu viral enfeksiyonu sayısında azalmaya neden olmuştur. Bu çalışma pandemi öncesi yakın dönemin akut viral üst solunum yolu enfeksiyonu geçiren kanserli çocuklarda etken dağılımı göstermesi nedeniyle önemlidir.

Kaynakça

  • 1. Sullivan M, Bouffet E, Rodriguez-Galindo C, et al. The COVID-19 pandemic: A rapid global response for children with cancer from SIOP, COG, SIOP-E, SIOP-PODC, IPSO, PROS, CCI, and St Jude Global. Pediatr Blood Cancer. 2020 Jul;67(7): e28409.
  • 2. Kebudi R, Chantada G, Kurucu N, et al. COVID-19: Consequences for Children With Cancer in Turkey and Globally. Turk Arch Pediatr. 2021 Jul 1;56(4):295-299.
  • 3. El-Qushayri AE, Benmelouka AY, Dahy A, Hashan MR. COVID-19 outcomes in paediatric cancer: A large scale pooled meta-analysis of 984 cancer patients. Rev Med Virol. 2022 Sep;32(5): e2344.
  • 4. Kebudi R, Kacar D, Ozyoruk D, et al. Non-COVID-19 viral respiratory infections in children with cancer during the COVID-19 pandemic: a multicenter observational study. Pediatr Blood Cancer. 2022 September; 69(5): ep453.
  • 5. Benites EC, Cabrini DP, Silva AC, et al. Acute respiratory viral infections in pediatric cancer patients undergoing chemotherapy. J Pediatr (Rio J). 2014 Jul-Aug;90(4):370-6.
  • 6. Alali M, David MZ, Ham SA, Danziger-Isakov L, Pisano J. Febrile Neutropenia Syndromes in Children: Risk Factors and Outcomes of Primary, Prolonged, and Recurrent Fever. J Pediatr Hematol Oncol. 2021;43(7):e962-e971.
  • 7. Alali M, David MZ, Danziger-Isakov LA, et al. Pediatric Febrile Neutropenia: Change in Etiology of Bacteremia, Empiric Choice of Therapy and Clinical Outcomes. J Pediatr Hematol Oncol. 2020 Aug;42(6):e445-e451.
  • 8. Alali M, David MZ, Danziger-Isakov LA, et al. Association Between Depth of Neutropenia and Clinical Outcomes in Febrile Pediatric Cancer and/or Patients Undergoing Hematopoietic Stem-cell Transplantation. Pediatr Infect Dis J. 2020 Jul;39(7):628-633.
  • 9. Kebudi R, Kacar D, Ozyoruk D, et al. Non-COVID-19 viral respiratory infections in children with cancer during the COVID-19 pandemic: a multicenter observational study. Pediatr Blood Cancer. 2022 September; 69(5): ep453.
  • 10. Onyeaka H, Anumudu CK, Al-Sharify ZT, Egele-Godswill E, Mbaegbu P. COVID-19 pandemic: A review of the global lockdown and its far-reaching effects. Sci Prog. 2021 Apr-Jun;104(2): 368504211019854.
  • 11. Mazzoleni S, Turchetti G, Ambrosino N. The COVID-19 outbreak: From "black swan" to global challenges and opportunities. Pulmonology. 2020 May-Jun;26(3): 117-8.
  • 12. Kebudi R, Kizilocak H. Febrile Neutropenia in Children with Cancer: Approach to Diagnosis and Treatment. Curr Pediatr Rev. 2018;14(3):204-209.
  • 13. Lehrnbecher T, Robinson P, Fisher B, et al. Guideline for the Management of Fever and Neutropenia in Children With Cancer and Hematopoietic Stem-Cell Transplantation Recipients: 2017 Update. J Clin Oncol. 2017 Jun 20;35(18): 2082-94.
  • 14. Marcone DN, Ellis A, Videla C, Ekstrom J, Ricarte C, Carballal G, Vidaurreta SM, Echavarría M. Viral etiology of acute respiratory infections in hospitalized and outpatient children in Buenos Aires, Argentina. Pediatr Infect Dis J. 2013 Mar;32(3):e105-10.
  • 15. Aydin Köker S, Demirağ B, Tahta N, Bayram N, Oymak Y, Karapinar TH, Gözmen S, Düzgöl M, Erçan Bozyer H, Vergin C, Devrim İ. A 3-Year Retrospective Study of the Epidemiology of Acute Respiratory Viral Infections in Pediatric Patients With Cancer Undergoing Chemotherapy. J Pediatr Hematol Oncol. 2019 May;41(4):e242-e246
  • 16. Li YT, Liang Y, Ling YS, Duan MQ, Pan L, Chen ZG. The spectrum of viral pathogens in children with severe acute lower respiratory tract infection: A 3-year prospective study in the pediatric intensive care unit. J Med Virol. 2019 Sep;91(9):1633-1642.
  • 17. Çiçek C, Arslan A, Karakuş HS, Yalaz M, Saz EU, Pullukçu H, Çok G. Akut solunum yolu enfeksiyonu olan hastalarda solunum viruslarının prevalansı ve mevsimsel dağılımı, 2002-2014 [Prevalence and seasonal distribution of respiratory viruses in patients with acute respiratory tract infections, 2002-2014]. Mikrobiyol Bul. 2015 Apr;49(2):188-200.
  • 18. Moscona A. Neuraminidase inhibitors for influenza. N Engl J Med. 2005 Sep 29;353(13):1363-73.
  • 19. Hijano DR, Maron G, Hayden RT. Respiratory Viral Infections in Patients With Cancer or Undergoing Hematopoietic Cell Transplant. Front Microbiol. 2018 Dec 12;9: 3097.
  • 20. Kobayashi R, Hori D, Sano H, Suzuki D, Kishimoto K, Kobayashi K. Meropenem versus piperacillin/tazobactam with or without immunoglobulin as second-line therapy for febrile neutropenia in pediatric patients. J Microbiol Immunol Infect. 2018 Aug;51(4): 473-7.
Toplam 20 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Çocuk Hematolojisi ve Onkolojisi, Çocuk Sağlığı ve Hastalıkları (Diğer)
Bölüm ORİJİNAL MAKALELER / ORIGINAL ARTICLES
Yazarlar

Ersin Töret 0000-0002-6379-8326

Uğur Tokdemir 0000-0002-8500-4304

Zeynep Canan Özdemir 0000-0002-9172-9627

Berra Nur Aksakal Bu kişi benim 0000-0002-3703-2474

Ömer Kılıç 0000-0003-0168-4080

Tercan Us 0000-0002-9772-6777

Gül Durmaz 0000-0002-2002-8380

Ozcan Bor 0000-0002-1662-3259

Yayımlanma Tarihi 24 Ekim 2023
Yayımlandığı Sayı Yıl 2023 Cilt: 45 Sayı: 6

Kaynak Göster

Vancouver Töret E, Tokdemir U, Özdemir ZC, Aksakal BN, Kılıç Ö, Us T, Durmaz G, Bor O. Epidemiology of acute respiratory viral infections of children with cancer before the COVID-19 pandemic. Osmangazi Tıp Dergisi. 2023;45(6):909-15.


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