GREEN SYNTHESIS OF ZINC OXIDE NANOPARTICLES USING AQUEOUS EXTRACT OF ACHIELLA MILLEFOLIUM L.: IN VITRO ANTI-CANCER POTENTIAL ON LUNG AND COLON CANCER CELLS

Çiğdem Aydın Acar

Araştırma Makalesi

Yıl 2021, Cilt: 4 Sayı: 1, 40 - 45, 07.04.2021

Çiğdem Aydın Acar

Öz

Kaynakça

1. Albrecht MA, Evans CW, Raston CL. Green chemistry and the health implications of nanoparticles. Green Chem. 2006;8:417–432. doi: 10.1039/b517131h.
2. Osuwa JC, Anusionwu PC. Some advances and prospects in nanotechnology: a review. Asian J Inf Technol 2011;10:96-100.
3. Vadlapudi V, Kaladhar DSVGK. Review: green synthesis of silver and gold nanoparticles. Middle East J Sci Res 2014;19:834-842.
4. Santhoskumar J, Venkat Kumar S, Rajeshkumar S. Synthesis of zinc oxide nanoparticles using plant leaf extract against urinary tract infection pathogen. Resource-Efficient Technologies. 2017;3(4):459-65.
5. Sutradhar P, Saha M. Green synthesis of zinc oxide nanoparticles using tomato (Lycopersicon esculentum) extract and its photovoltaic application. J Exp Nanosci. 2016;11(5):314-27.
6. Khan ST, Musarrat J, Al-Khedhairy AA. Countering drug resistance, infectious diseases, and sepsis using metal and metal oxides nanoparticles: current status. Colloids Surf B Biointerfaces. 2016;146:70-83.
7. Chen J, Liu X, Wang C, Yin SS, Li XL, Hu WJ, et al. Nitric oxide ameliorates zinc oxide nanoparticlesinduced phytotoxicity in rice seedlings. J Hazard Mater. 2016;297:173-82.
8. Nair S, Sasidharan A, Divya Rani VV, Menon D, Nair S, Manzoor K, et al. Role of size scale of ZnO nanoparticles and microparticles on toxicity toward bacteria and osteoblast cancer cells. J Mater Sci Mater Med. 2009;20(Suppl 1):235-41.
9. Hanley C, Layne J, Punnoose A, Reddy KM, Coombs I, Coombs A, et al. Perferential killing of cancer cells anda activated human T cells using ZnO nanoparticles. Nanotecnology. 2008;19(29):295103.
10. Premanathan M, Karthikeyan K, Jeyasubramanian K, Manivannan G. Selective toxicity of ZnO nanoparticles toward Gram-positive bacteria and cancer cells by apoptosis through lipid peroxidation. Nanomedicine. 2011;7(2):184-92.
11. Aksoy B, Atakan N, Aksoy HM, Tezel GG, Renda N, Ozkara HA, et al. Effectiveness of topical zinc oxide application on hypertrophic scar development in rabbits. Burns. 2010;36(7):1027-35.
12. Shokri N, Javar HA. Comparison of calcium phosphate and zinc oxide nanoparticles as dermal penetration enhancers for albumin. Indian J Pharm Sci. 2015;77(6):694-704.
13. Sahdev P, Podaralla S, Kaushik RS, Perumal O. Calcium phosphate nanoparticles fortranscutaneous vaccine delivery. J Biomed Nanotechnol. 2013;9(1):132-41.
14. Parveen K, Banse V, Ledwani L. Green synthesis of nanoparticles: their advantages and disadvantages. AIP Conf Proc. 2016;1724(1):020048.
15. Agarval H, Venkat Kumar S, Rajeshkumar S. A review on green synthesis of zinc oxide nanoparticles - An eco-friendly approach. Resource-Efficient Tecnologies. 2017;3(4):406-13.
16. Abdul Salam H, Sivaraj R, Venckatesh R. Green synthesis and characterization of zinc oxide nanoparticles from Ocimum basilicum L. var. purpurascens Benth.-lamiaceae leaf extract. Mater Lett. 2014;131:16-18.
17. Rajendran SP, Sengodan K. Synthesis and characterization of zinc oxide and iron oxide nanoparticles using Sesbania grandiflora leaf extract as reducing agent. Journal of Nanoscience. 2017;2017:8348507.
18. Yuvakkumar R, Suresh J, Nathanael AJ, Sundrarajan M, Hong SI. Novel green synthetic strategy to prepare ZnO nanocrystals using rambutan (Nephelium lappaceum L.) peel extract and its antibacterial applications. Mater Sci Eng C Mater Biol Appl. 2014;41:17-27.
19. Ramesh P, Rajendran A, Meenakshisundaram M. Green synthesis of zinc oxide nanoparticles using flower extract Cassia Auriculata. J Nanosci Nanotechnol. 2014;2(1):41-45.
20. Iravani S, Korbekandi H, Abbasi S. Production of nanoparticles using organisms. Crit Rev Biotechnol. 2009; 29(4):279–306.
21. Tolaymat TM, El Badawy AM, Genaidy A, Scheckel KG, Luxton TP, Suidan M. An evidence-based environmental perspective of manufactured silver nanoparticle in syntheses and applications: a systematic review and critical appraisal of peer-reviewed scientific papers. Sci Total Environ. 2010;408(5):999-1006. doi: 10.1016/j.scitotenv.2009.11.003.
22. Makarov VV, Love AJ, Sinitsyna OV, Makarova SS, Yaminsky IV, Taliansky ME, Kalinina NO. "Green" nanotechnologies: synthesis of metal nanoparticles using plants. Acta Naturae. 2014;6(1):35-44.
23. Candan F, Unlu M, Tepe B, Daferera D, Polissiou M, Sökmen A, Akpulat HA. Antioxidant and antimicrobial activity of the essential oil and methanol extracts of Achillea millefolium subsp. millefolium Afan. (Asteraceae).J Ethnopharmacol. 2003; 87(2-3):215-20. doi: 10.1016/s0378-8741(03)00149-1.
24. Dall'Acqua S, Bolego C, Cignarella A, Gaion RM, Innocenti G. Vasoprotective activity of standardized Achillea millefolium extract. Phytomedicine. 2011;18(12):1031-6. doi: 10.1016/j.phymed.2011.05.005.
25. Potrich FB, Allemand A, da Silva LM, Dos Santos AC, Baggio CH, Freitas CS, Mendes DA, Andre E, Werner MF, Marques MC. Antiulcerogenic activity of hydroalcoholic extract of Achillea millefolium L.: involvement of the antioxidant system. J Ethnopharmacol. 2010;130(1):85-92. doi: 10.1016/j.jep.2010.04.014.
26. Trumbeckaite S, Benetis R, Bumblauskiene L, Burdulis D, Janulis V, Toleikis A, Viskelis P, Jakstas V. Achillea millefolium L. s.l. herb extract: Antioxidant activity and effect on the rat heart mitochondrial functions. Food Chem 2011;127:1540–1548
27. Aydin Acar C, Pehlivanoglu S. Biosynthesis of silver nanoparticles using Rosa canina extract and its anti-cancer and anti-metastatic activity on human colon adenocarcinoma cell line HT29. MAKU J. Health Sci. Inst. 2019;7(2): 124-131.
28. Donmez S. Green Synthesis of Zinc Oxide Nanoparticles Using Zingiber Officinale Root Extract and Their Applications in Glucose Biosensor. El-Cezerî Journal of Science and Engineering 2020; 7 (3):1191-1200.
29. Safawo T, Sandeep BV, Pola S, Tadesse A. Synthesis and characterization of zinc oxide nanoparticles using tuber extract of anchote (Coccinia abyssinica (Lam.) Cong.) for antimicrobial and antioxidant activity assessment. OpenNano 2018;3:56-63.
30. Rajeshkumar S, Kumar SV, Ramaiah A, Agarwal H, Lakshmi T, Roopan SM. Biosynthesis of zinc oxide nanoparticles using Mangifera indica leaves and evaluation of their antioxidant and cytotoxic properties in lung cancer (A549) cells. Enzyme Microb Technol. 2018;117:91-95. doi: 10.1016/j.enzmictec.2018.06.009.
31. Vijayakumar S, Vaseeharan B, Malaikozhundan B, Shobiya M. Laurus nobilis leaf extract mediated green synthesis of ZnO nanoparticles: Characterization and biomedical applications. Biomed Pharmacother. 2016;84:1213-1222. doi: 10.1016/j.biopha.2016.10.038.
32. Subramaniam VD, Ramachandran M, Marotta F, Banerjee A, Sun XF, Pathak S. Comparative study on anti-proliferative potentials of zinc oxide and aluminium oxide nanoparticles in colon cancer cells. Acta Biomed. 2019;90(2):241-247.
33. Schneider T, Westermann M, Glei M. In vitro uptake and toxicity studies of metal nanoparticles and metal oxide nanoparticles in human HT29 cells. Arch Toxicol 2017;91(11):3517-3527.
34. Bai Aswathanarayan J, Rai Vittal R, Muddegowda U. Anticancer activity of metal nanoparticles and their peptide conjugates against human colon adenorectal carcinoma cells. Artif Cells Nanomed Biotechnol. 2018;46(7):1444-1451.
35. Aswathanarayan JB, Vittal RR. Antimicrobial, Biofilm Inhibitory and Anti-infective Activity of Metallic Nanoparticles Against Pathogens MRSA and Pseudomonas aeruginosa PA01. Pharm Nanotechnol. 2017;5(2):148-153.

GREEN SYNTHESIS OF ZINC OXIDE NANOPARTICLES USING AQUEOUS EXTRACT OF ACHIELLA MILLEFOLIUM L.: IN VITRO ANTI-CANCER POTENTIAL ON LUNG AND COLON CANCER CELLS

Yıl 2021, Cilt: 4 Sayı: 1, 40 - 45, 07.04.2021

Çiğdem Aydın Acar

Öz

In recent years, zinc oxide nanoparticles (ZnONPs) synthesized using plants have become an interesting field especially in nanomedicine applications due to their high biocompatibility and stability. In the present study, ZnONPs were synthesized using aqueous extract of Achiella millefolium L. Characterization of the green synthesized ZnONPs were carried out using UV vis spectroscopy. Cytotoxic activity on A549 lung cancer cells and HT29 colon adenocarcinoma cells was evaluated by MTT Assay. The UV–vis spectroscopy result revealed an absorption peak in the range of 356 nm. The green synthesized ZnONPs showed significant cytotoxic effects on A549 and HT29 cell lines in a dose-dependent manner. The obtained IC50 value of A549 cells were 46.47 while, IC50 value of HT29 cells were 42.82 μg/mL for ZnONPs. ZnONPs had a similar cytotoxic activity on A549 and HT29 cells. In conclusion, ZnONPs were synthesized through a simple, cost effective and eco-friendly green route via the use of Achiella millefolium L. extract. The green synthesized ZnONPs showed strong cytotoxic activity against lung and colon cancer cell lines.

Anahtar Kelimeler

Zinc Oxide Nanoparticles, Green Synthesis, Cytotoxic, antiancer

Kaynakça

1. Albrecht MA, Evans CW, Raston CL. Green chemistry and the health implications of nanoparticles. Green Chem. 2006;8:417–432. doi: 10.1039/b517131h.
2. Osuwa JC, Anusionwu PC. Some advances and prospects in nanotechnology: a review. Asian J Inf Technol 2011;10:96-100.
3. Vadlapudi V, Kaladhar DSVGK. Review: green synthesis of silver and gold nanoparticles. Middle East J Sci Res 2014;19:834-842.
4. Santhoskumar J, Venkat Kumar S, Rajeshkumar S. Synthesis of zinc oxide nanoparticles using plant leaf extract against urinary tract infection pathogen. Resource-Efficient Technologies. 2017;3(4):459-65.
5. Sutradhar P, Saha M. Green synthesis of zinc oxide nanoparticles using tomato (Lycopersicon esculentum) extract and its photovoltaic application. J Exp Nanosci. 2016;11(5):314-27.
6. Khan ST, Musarrat J, Al-Khedhairy AA. Countering drug resistance, infectious diseases, and sepsis using metal and metal oxides nanoparticles: current status. Colloids Surf B Biointerfaces. 2016;146:70-83.
7. Chen J, Liu X, Wang C, Yin SS, Li XL, Hu WJ, et al. Nitric oxide ameliorates zinc oxide nanoparticlesinduced phytotoxicity in rice seedlings. J Hazard Mater. 2016;297:173-82.
8. Nair S, Sasidharan A, Divya Rani VV, Menon D, Nair S, Manzoor K, et al. Role of size scale of ZnO nanoparticles and microparticles on toxicity toward bacteria and osteoblast cancer cells. J Mater Sci Mater Med. 2009;20(Suppl 1):235-41.
9. Hanley C, Layne J, Punnoose A, Reddy KM, Coombs I, Coombs A, et al. Perferential killing of cancer cells anda activated human T cells using ZnO nanoparticles. Nanotecnology. 2008;19(29):295103.
10. Premanathan M, Karthikeyan K, Jeyasubramanian K, Manivannan G. Selective toxicity of ZnO nanoparticles toward Gram-positive bacteria and cancer cells by apoptosis through lipid peroxidation. Nanomedicine. 2011;7(2):184-92.
11. Aksoy B, Atakan N, Aksoy HM, Tezel GG, Renda N, Ozkara HA, et al. Effectiveness of topical zinc oxide application on hypertrophic scar development in rabbits. Burns. 2010;36(7):1027-35.
12. Shokri N, Javar HA. Comparison of calcium phosphate and zinc oxide nanoparticles as dermal penetration enhancers for albumin. Indian J Pharm Sci. 2015;77(6):694-704.
13. Sahdev P, Podaralla S, Kaushik RS, Perumal O. Calcium phosphate nanoparticles fortranscutaneous vaccine delivery. J Biomed Nanotechnol. 2013;9(1):132-41.
14. Parveen K, Banse V, Ledwani L. Green synthesis of nanoparticles: their advantages and disadvantages. AIP Conf Proc. 2016;1724(1):020048.
15. Agarval H, Venkat Kumar S, Rajeshkumar S. A review on green synthesis of zinc oxide nanoparticles - An eco-friendly approach. Resource-Efficient Tecnologies. 2017;3(4):406-13.
16. Abdul Salam H, Sivaraj R, Venckatesh R. Green synthesis and characterization of zinc oxide nanoparticles from Ocimum basilicum L. var. purpurascens Benth.-lamiaceae leaf extract. Mater Lett. 2014;131:16-18.
17. Rajendran SP, Sengodan K. Synthesis and characterization of zinc oxide and iron oxide nanoparticles using Sesbania grandiflora leaf extract as reducing agent. Journal of Nanoscience. 2017;2017:8348507.
18. Yuvakkumar R, Suresh J, Nathanael AJ, Sundrarajan M, Hong SI. Novel green synthetic strategy to prepare ZnO nanocrystals using rambutan (Nephelium lappaceum L.) peel extract and its antibacterial applications. Mater Sci Eng C Mater Biol Appl. 2014;41:17-27.
19. Ramesh P, Rajendran A, Meenakshisundaram M. Green synthesis of zinc oxide nanoparticles using flower extract Cassia Auriculata. J Nanosci Nanotechnol. 2014;2(1):41-45.
20. Iravani S, Korbekandi H, Abbasi S. Production of nanoparticles using organisms. Crit Rev Biotechnol. 2009; 29(4):279–306.
21. Tolaymat TM, El Badawy AM, Genaidy A, Scheckel KG, Luxton TP, Suidan M. An evidence-based environmental perspective of manufactured silver nanoparticle in syntheses and applications: a systematic review and critical appraisal of peer-reviewed scientific papers. Sci Total Environ. 2010;408(5):999-1006. doi: 10.1016/j.scitotenv.2009.11.003.
22. Makarov VV, Love AJ, Sinitsyna OV, Makarova SS, Yaminsky IV, Taliansky ME, Kalinina NO. "Green" nanotechnologies: synthesis of metal nanoparticles using plants. Acta Naturae. 2014;6(1):35-44.
23. Candan F, Unlu M, Tepe B, Daferera D, Polissiou M, Sökmen A, Akpulat HA. Antioxidant and antimicrobial activity of the essential oil and methanol extracts of Achillea millefolium subsp. millefolium Afan. (Asteraceae).J Ethnopharmacol. 2003; 87(2-3):215-20. doi: 10.1016/s0378-8741(03)00149-1.
24. Dall'Acqua S, Bolego C, Cignarella A, Gaion RM, Innocenti G. Vasoprotective activity of standardized Achillea millefolium extract. Phytomedicine. 2011;18(12):1031-6. doi: 10.1016/j.phymed.2011.05.005.
25. Potrich FB, Allemand A, da Silva LM, Dos Santos AC, Baggio CH, Freitas CS, Mendes DA, Andre E, Werner MF, Marques MC. Antiulcerogenic activity of hydroalcoholic extract of Achillea millefolium L.: involvement of the antioxidant system. J Ethnopharmacol. 2010;130(1):85-92. doi: 10.1016/j.jep.2010.04.014.
26. Trumbeckaite S, Benetis R, Bumblauskiene L, Burdulis D, Janulis V, Toleikis A, Viskelis P, Jakstas V. Achillea millefolium L. s.l. herb extract: Antioxidant activity and effect on the rat heart mitochondrial functions. Food Chem 2011;127:1540–1548
27. Aydin Acar C, Pehlivanoglu S. Biosynthesis of silver nanoparticles using Rosa canina extract and its anti-cancer and anti-metastatic activity on human colon adenocarcinoma cell line HT29. MAKU J. Health Sci. Inst. 2019;7(2): 124-131.
28. Donmez S. Green Synthesis of Zinc Oxide Nanoparticles Using Zingiber Officinale Root Extract and Their Applications in Glucose Biosensor. El-Cezerî Journal of Science and Engineering 2020; 7 (3):1191-1200.
29. Safawo T, Sandeep BV, Pola S, Tadesse A. Synthesis and characterization of zinc oxide nanoparticles using tuber extract of anchote (Coccinia abyssinica (Lam.) Cong.) for antimicrobial and antioxidant activity assessment. OpenNano 2018;3:56-63.
30. Rajeshkumar S, Kumar SV, Ramaiah A, Agarwal H, Lakshmi T, Roopan SM. Biosynthesis of zinc oxide nanoparticles using Mangifera indica leaves and evaluation of their antioxidant and cytotoxic properties in lung cancer (A549) cells. Enzyme Microb Technol. 2018;117:91-95. doi: 10.1016/j.enzmictec.2018.06.009.
31. Vijayakumar S, Vaseeharan B, Malaikozhundan B, Shobiya M. Laurus nobilis leaf extract mediated green synthesis of ZnO nanoparticles: Characterization and biomedical applications. Biomed Pharmacother. 2016;84:1213-1222. doi: 10.1016/j.biopha.2016.10.038.
32. Subramaniam VD, Ramachandran M, Marotta F, Banerjee A, Sun XF, Pathak S. Comparative study on anti-proliferative potentials of zinc oxide and aluminium oxide nanoparticles in colon cancer cells. Acta Biomed. 2019;90(2):241-247.
33. Schneider T, Westermann M, Glei M. In vitro uptake and toxicity studies of metal nanoparticles and metal oxide nanoparticles in human HT29 cells. Arch Toxicol 2017;91(11):3517-3527.
34. Bai Aswathanarayan J, Rai Vittal R, Muddegowda U. Anticancer activity of metal nanoparticles and their peptide conjugates against human colon adenorectal carcinoma cells. Artif Cells Nanomed Biotechnol. 2018;46(7):1444-1451.
35. Aswathanarayan JB, Vittal RR. Antimicrobial, Biofilm Inhibitory and Anti-infective Activity of Metallic Nanoparticles Against Pathogens MRSA and Pseudomonas aeruginosa PA01. Pharm Nanotechnol. 2017;5(2):148-153.

Toplam 35 adet kaynakça vardır.

Ayrıntılar

Birincil Dil	İngilizce
Konular	Sağlık Kurumları Yönetimi
Bölüm	Makaleler
Yazarlar	Çiğdem Aydın Acar 0000-0002-1311-2314
Yayımlanma Tarihi	7 Nisan 2021
Yayımlandığı Sayı	Yıl 2021 Cilt: 4 Sayı: 1

Kaynak Göster

APA	Aydın Acar, Ç. (2021). GREEN SYNTHESIS OF ZINC OXIDE NANOPARTICLES USING AQUEOUS EXTRACT OF ACHIELLA MILLEFOLIUM L.: IN VITRO ANTI-CANCER POTENTIAL ON LUNG AND COLON CANCER CELLS. Turkish Journal of Health Science and Life, 4(1), 40-45.

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