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Yıl 2021, Cilt: 5 Sayı: 2, 67 - 71, 15.11.2021

Sevim Çiftçi Yegin Yeter Değer Semiha Dede Fatmagül Yur

https://doi.org/10.47748/tjvr.887175

Öz

Kaynakça

  • Alimoradian A, Changizi-Ashtiyani S, Farahani AG, Kheder L, Rajabi R, Sharifi A. Protective Effects of Pomegranate Juice on Nephrotoxicity Induced By Captopril and Gentamicin in Rats. Iran J Kidney Dis. 2017;11(6):422-9.
  • Anonymous, Hipertansiyonda Korunma ve Tedavi. Available at: https://tkd.org.tr/kilavuz/k03/4_2c93c.htm?wbnum=1107. Accessed Jan 05, 2020.
  • Aygün G. Akılcı Antibiyotik Kullanımı ve Erişkinde Toplumdan Edinilmiş Enfeksiyonlar Sempozyum Dizisi. Cerrahpaşa Tıp Fakültesi Sürekli Tıp Eğitimi Etkinlikleri. 2002;31:39-54.
  • Balcı-Ekmekçi Ö, Donma O, Aydemir A, Özdemir S, Bağrıaçık N. Hipertansif Diyabetik Bireylerin Plazma Anjiotensin Dönüştürücü Enzim Aktivitesi ile Plazma ve Eritrosit Çinko Düzeyleri. Turkiye Klinikleri J Med Sci. 2002;22(6):553-6.
  • Bénéteau-Burnat B1, Baudin B. Angiotensin-Converting Enzyme: Clinical Applications And Laboratory Investigations on Serum and Other Biological Fluids. Crit Rev Clin Lab Sci. 1991;28(5-6):337-56.
  • Burnier M. Angiotensin II Type 1 Receptor Blockers. Circulation. 2001;103:904-12.
  • Caner E, Deger Y. Lipid Peroxidation, Antioxidant Profile And Some Biochemical Parameters in Rat Applied Aminoglycoside. World J Pharm Pharm Sci. 2018;7(1):169-79.
  • Dzau VJ, Bernstein K, Celermajer D, Cohen J, Dahlöf B, Deanfield J, et al. The Relevance of Tissue Angiotensin-Converting Enzyme: Manifestations in Mechanistic And End Point Data. Am J Cardiol. 2001;88(9A):1-20.
  • Ecder T. Renin İnhibisyonu ve Böbrek. Arch Turk Soc Cardiol. 2009;37(7):28-31.
  • Eriguchi M, Lin M, Yamashita M, Zhao TV, Khan Z, Bernstein EA, et al. Renal Tubular ACE-Mediated Tubular İnjury is the Major Contributor to Microalbuminuria in Early Diabetic Nephropathy. Am J Physiol Renal Physiol. 2018;314:531-42.
  • Falkenhahn M, Franke F, Bohle RM, Zyu Y-C, Stauss HM, Bachmann S, et al. Cellular Distribution of Angiotensin-Converting Enzyme After Myocardial Infraction. Hypertension. 1995;25(2):219-26.
  • Fauconneau B, Tallineau C, Huguet F, Piriou A. Gentamicin Induced Kidney Damage and Lipid Peroxidation in Rats. Toxicology Lett. 1995;76:127-34.
  • Humes HD. Aminoglycoside Nephrotoxicity. Kidney Int. 1988;33(4):900-11.
  • Liu M-H, Floten HS, Furnary AP, Yim APC, He G-W. Inhibition of Vasoconstriction by Angiotensin Receptor Antagonist GR117289C in Arterial Grafts. Ann Thorac Surg. 2000;70:2064-69.
  • Ma C, Xin H, Jiang X-Y, Wang Y-X, Zhang Y-S. Relationship Between Renal İnjury and the Antagonistic Roles of Angiotensin-Converting Enzyme (ACE) and ACE2. Genet Mol Res. 2014;13(2):2333-42.
  • Mıstık R. Aminoglikozid Antibiyotikler ve Günde Tek Doz Kullanımları. Klimik Derg. 2000; l:43-5.
  • Moncada S, Palmer RMJ, Higs EA. The Discovery of Nitric oxide As the Endogenous Nitro Vasodilator. Hypertension. 1998;12:365-72.
  • Ozmutlu S, Dede S, Ceylan E. The Effect of Lycopene Treatment on ACE Activity in Rats with Experimental Diabetes. J Renin-Angio-Aldo S. 2012;13(3):328-33.
  • Paller MS. Drug-Induced Nephropaties. Med Clin North America. 1991;74(4):909-1001.
  • Singhal M, Prajapati B. In Vivo Evaluation of Aminoglycoside Induced Nephrotoxicity and Hepatotoxicity in Albino Rats. Pharmacologyonline. 2011;2:451-57.
  • Siragy HM, Carey RM. Role of the Intrarenal Renin-Angiotensin-Aldosterone System in Chronic Kidney Disease. Am J Nephrol. 2010;31(6):541-50.
  • Yanagida C, Ito K, Komiya I, Horie T. Protective Effect of Fosfomycin on Gentamicin-Induced Lipid Peroxidation of Rat Renal Tissue. Chem Biol Interac. 2004;148(3):139-47.
  • Ziai SA, Mooraki A, Mahmoudian M. Gentamicin Reduces Serum Ace Activity in Patients with Normal Kidney Function. Am J Nephrol. 2002;22:487-90.
  • Ziai SA, Salehian P, Mahmoudian M. Study of Serum And Tissues Angiotensin-Converting Enzyme (ACE) Activity in Rat with Gentamicin Induced Renal Toxicity. Ren Fail. 2003;25(6):923-33.

Investigation of The Effect of Aminoglycosides on Angiotensin Converting Enzyme (ACE)

Yıl 2021, Cilt: 5 Sayı: 2, 67 - 71, 15.11.2021

Sevim Çiftçi Yegin Yeter Değer Semiha Dede Fatmagül Yur

https://doi.org/10.47748/tjvr.887175

Öz

Objective: The research attention to nephrotoxicity from antibiotics (as aminoglycosides), non-steroidal anti-inflammatory drugs, and antifungals, angiotensin-converting enzyme (ACE) inhibitors. Several drugs have resulted in produce an adverse effect on kidneys. Angiotensin-converting enzyme (ACE) is a component of the renin-angiotensin system (RAS), which leads to the conversion of angiotensin-I to angiotensin-II in vascular tissues. The present study aimed to determine serum ACE activity in rats with an aminoglycosine.

Material-Method: In this study, two different groups formed, the control group (10 rats/Wistar-albino female) and the experimental group (30 rats/Wistar-albino female) administered aminoglycosine (Amikacin). Aminoglycosine was administered intraperitoneally to the experimental group at a single dose of 15 mg/kg body weight at the same time each day for 14 days. The control group implemented physiological water instead of aminoglycosine at the same rate.

Result: When the groups compared according to the statistic results, it is observed that there was a significant increase in the experimental group according to the control group (p˂0.001).

Conclusion: As a result, it was determined that aminoglycosin administered increased serum ACE activity and it was concluded that it may be useful to investigate the possibilities to evaluate it as a risk factor and indicator in the development of hypertension

Anahtar Kelimeler

Aminoglycosides Angiotensin-Converting Enzyme Antibiotics

Kaynakça

  • Alimoradian A, Changizi-Ashtiyani S, Farahani AG, Kheder L, Rajabi R, Sharifi A. Protective Effects of Pomegranate Juice on Nephrotoxicity Induced By Captopril and Gentamicin in Rats. Iran J Kidney Dis. 2017;11(6):422-9.
  • Anonymous, Hipertansiyonda Korunma ve Tedavi. Available at: https://tkd.org.tr/kilavuz/k03/4_2c93c.htm?wbnum=1107. Accessed Jan 05, 2020.
  • Aygün G. Akılcı Antibiyotik Kullanımı ve Erişkinde Toplumdan Edinilmiş Enfeksiyonlar Sempozyum Dizisi. Cerrahpaşa Tıp Fakültesi Sürekli Tıp Eğitimi Etkinlikleri. 2002;31:39-54.
  • Balcı-Ekmekçi Ö, Donma O, Aydemir A, Özdemir S, Bağrıaçık N. Hipertansif Diyabetik Bireylerin Plazma Anjiotensin Dönüştürücü Enzim Aktivitesi ile Plazma ve Eritrosit Çinko Düzeyleri. Turkiye Klinikleri J Med Sci. 2002;22(6):553-6.
  • Bénéteau-Burnat B1, Baudin B. Angiotensin-Converting Enzyme: Clinical Applications And Laboratory Investigations on Serum and Other Biological Fluids. Crit Rev Clin Lab Sci. 1991;28(5-6):337-56.
  • Burnier M. Angiotensin II Type 1 Receptor Blockers. Circulation. 2001;103:904-12.
  • Caner E, Deger Y. Lipid Peroxidation, Antioxidant Profile And Some Biochemical Parameters in Rat Applied Aminoglycoside. World J Pharm Pharm Sci. 2018;7(1):169-79.
  • Dzau VJ, Bernstein K, Celermajer D, Cohen J, Dahlöf B, Deanfield J, et al. The Relevance of Tissue Angiotensin-Converting Enzyme: Manifestations in Mechanistic And End Point Data. Am J Cardiol. 2001;88(9A):1-20.
  • Ecder T. Renin İnhibisyonu ve Böbrek. Arch Turk Soc Cardiol. 2009;37(7):28-31.
  • Eriguchi M, Lin M, Yamashita M, Zhao TV, Khan Z, Bernstein EA, et al. Renal Tubular ACE-Mediated Tubular İnjury is the Major Contributor to Microalbuminuria in Early Diabetic Nephropathy. Am J Physiol Renal Physiol. 2018;314:531-42.
  • Falkenhahn M, Franke F, Bohle RM, Zyu Y-C, Stauss HM, Bachmann S, et al. Cellular Distribution of Angiotensin-Converting Enzyme After Myocardial Infraction. Hypertension. 1995;25(2):219-26.
  • Fauconneau B, Tallineau C, Huguet F, Piriou A. Gentamicin Induced Kidney Damage and Lipid Peroxidation in Rats. Toxicology Lett. 1995;76:127-34.
  • Humes HD. Aminoglycoside Nephrotoxicity. Kidney Int. 1988;33(4):900-11.
  • Liu M-H, Floten HS, Furnary AP, Yim APC, He G-W. Inhibition of Vasoconstriction by Angiotensin Receptor Antagonist GR117289C in Arterial Grafts. Ann Thorac Surg. 2000;70:2064-69.
  • Ma C, Xin H, Jiang X-Y, Wang Y-X, Zhang Y-S. Relationship Between Renal İnjury and the Antagonistic Roles of Angiotensin-Converting Enzyme (ACE) and ACE2. Genet Mol Res. 2014;13(2):2333-42.
  • Mıstık R. Aminoglikozid Antibiyotikler ve Günde Tek Doz Kullanımları. Klimik Derg. 2000; l:43-5.
  • Moncada S, Palmer RMJ, Higs EA. The Discovery of Nitric oxide As the Endogenous Nitro Vasodilator. Hypertension. 1998;12:365-72.
  • Ozmutlu S, Dede S, Ceylan E. The Effect of Lycopene Treatment on ACE Activity in Rats with Experimental Diabetes. J Renin-Angio-Aldo S. 2012;13(3):328-33.
  • Paller MS. Drug-Induced Nephropaties. Med Clin North America. 1991;74(4):909-1001.
  • Singhal M, Prajapati B. In Vivo Evaluation of Aminoglycoside Induced Nephrotoxicity and Hepatotoxicity in Albino Rats. Pharmacologyonline. 2011;2:451-57.
  • Siragy HM, Carey RM. Role of the Intrarenal Renin-Angiotensin-Aldosterone System in Chronic Kidney Disease. Am J Nephrol. 2010;31(6):541-50.
  • Yanagida C, Ito K, Komiya I, Horie T. Protective Effect of Fosfomycin on Gentamicin-Induced Lipid Peroxidation of Rat Renal Tissue. Chem Biol Interac. 2004;148(3):139-47.
  • Ziai SA, Mooraki A, Mahmoudian M. Gentamicin Reduces Serum Ace Activity in Patients with Normal Kidney Function. Am J Nephrol. 2002;22:487-90.
  • Ziai SA, Salehian P, Mahmoudian M. Study of Serum And Tissues Angiotensin-Converting Enzyme (ACE) Activity in Rat with Gentamicin Induced Renal Toxicity. Ren Fail. 2003;25(6):923-33.
Toplam 24 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Veteriner Cerrahi
Bölüm 2021 Volume 5 Number 2
Yazarlar

Sevim Çiftçi Yegin 0000-0003-3950-4399

Yeter Değer 0000-0002-9023-0699

Semiha Dede 0000-0001-5744-6327

Fatmagül Yur 0000-0002-5536-9169

Yayımlanma Tarihi 15 Kasım 2021
Gönderilme Tarihi 26 Şubat 2021
Yayımlandığı Sayı Yıl 2021 Cilt: 5 Sayı: 2

Kaynak Göster

APA Çiftçi Yegin, S., Değer, Y., Dede, S., Yur, F. (2021). Investigation of The Effect of Aminoglycosides on Angiotensin Converting Enzyme (ACE). Turkish Journal of Veterinary Research, 5(2), 67-71. https://doi.org/10.47748/tjvr.887175
AMA Çiftçi Yegin S, Değer Y, Dede S, Yur F. Investigation of The Effect of Aminoglycosides on Angiotensin Converting Enzyme (ACE). TJVR. Kasım 2021;5(2):67-71. doi:10.47748/tjvr.887175
Chicago Çiftçi Yegin, Sevim, Yeter Değer, Semiha Dede, ve Fatmagül Yur. “Investigation of The Effect of Aminoglycosides on Angiotensin Converting Enzyme (ACE)”. Turkish Journal of Veterinary Research 5, sy. 2 (Kasım 2021): 67-71. https://doi.org/10.47748/tjvr.887175.
EndNote Çiftçi Yegin S, Değer Y, Dede S, Yur F (01 Kasım 2021) Investigation of The Effect of Aminoglycosides on Angiotensin Converting Enzyme (ACE). Turkish Journal of Veterinary Research 5 2 67–71.
IEEE S. Çiftçi Yegin, Y. Değer, S. Dede, ve F. Yur, “Investigation of The Effect of Aminoglycosides on Angiotensin Converting Enzyme (ACE)”, TJVR, c. 5, sy. 2, ss. 67–71, 2021, doi: 10.47748/tjvr.887175.
ISNAD Çiftçi Yegin, Sevim vd. “Investigation of The Effect of Aminoglycosides on Angiotensin Converting Enzyme (ACE)”. Turkish Journal of Veterinary Research 5/2 (Kasım 2021), 67-71. https://doi.org/10.47748/tjvr.887175.
JAMA Çiftçi Yegin S, Değer Y, Dede S, Yur F. Investigation of The Effect of Aminoglycosides on Angiotensin Converting Enzyme (ACE). TJVR. 2021;5:67–71.
MLA Çiftçi Yegin, Sevim vd. “Investigation of The Effect of Aminoglycosides on Angiotensin Converting Enzyme (ACE)”. Turkish Journal of Veterinary Research, c. 5, sy. 2, 2021, ss. 67-71, doi:10.47748/tjvr.887175.
Vancouver Çiftçi Yegin S, Değer Y, Dede S, Yur F. Investigation of The Effect of Aminoglycosides on Angiotensin Converting Enzyme (ACE). TJVR. 2021;5(2):67-71.
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