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VULVAR PARAURETRAL EKSTRAGASTROINTESTİNAL STROMAL TUMOR; A CASE REPORT

Yıl 2017, Cilt: 48 Sayı: 4, 168 - 172, 07.12.2017
https://doi.org/10.16948/zktipb.290910

Öz

SUMMARY



Gastrointestinal
Stromal Tumors (GISTs) are mesenchymal tumors that are arises from the wall of
the gastrointestinal tract and is throught to originate from the Interstitial
Cells of Cajal (ICC), which regulate the motility of the gastrointestinal
tract. More rarely neoplasms with histology and immunohistochemistry similar to
gastrointestinal stromal tumors may ocur outside the gastrointestinal tract and
are so-called Extra-gastrointestinal Stromal Tumors (EGISTs). Surgical removal  is the gold standard treatment for
non-metastatic Extragastrointestinal stromal tumors. We reported a very rare
case of ekstragastrointestinal stromal tumor arising from the vulva in this
article.

Kaynakça

  • 1. Gold JS,Dematteo RP. Combined surgıcal and molecular therapy: the gastrointestinal stromal tumor model. Ann Surg 2006;244:176-84.
  • 2. Kindblom LG, Remotti HE, Aldenborg F. Gastrointestinal pacemaker cell tumor (GIPACT). Gastrointestinal stromal tumors show phenotypic characteristics of intestinal cell of Cajal. Am J Pathol. 1998:152(5):1259-69.
  • 3. Heinrich MC, Corless CL, Duensing A, Chen CJ, Joseph N, et al. PDGFRA activating mutations in gastrointestinal stromal tumors. Science. 2003;299:708-10.
  • 4. Hirota S, Ohashi A, Nishida T, Isozaki K, Kinoshita K, Shinomura Y, et al. Gain-of-function mutations of platelet-derived growht factor receptor alpha gene in gastrointestinal stromal tumors. Gastroenterology. 2003;125:660-7.
  • 5. Mortensen MB, Larsen KE, Fristrup CW, Nielsen HO. Gastrointestinal stromal tumor: clinical and pathological presentation. Ungeskr Laeger. 2007;169:2776-9.
  • 6. Yamamoto H, Oda Y, Kawaguchi K, et al. C-kit and PDGFRA mutations in extragastrointestinal stromal tumor (gastrointestinal stromal tumor of the soft tissue) Am J Surg Pathol, 2004;28(4):479-88.
  • 7. Gun BD, Gun MO, Karamanoglu Z. Primary stromal tumor of the omentum: report of a case. Surg Today 2006:36:994-6.
  • 8. Li J, Gong JF, Wu AW, Shen L. Post-operative imatinib in patients with intermediate or high risk gastrointestinal stromal tumor. Eur J Cancer Surg 2001:37:319-24.
  • 9. Nilsson B, Sjölund K, Kindblom LG, Meis-Kindblom JM, Bümming P, Nilsson O, Anderson J and Ahlman H: Adjuvant imatinib treatment improves recurrence-free survival in patients with high-risk gastrointestinal stromal tumors (GIST). Br J Cancer 96: 1656-1658, 2007.
  • 10. De Matteo RP, Ballman KV, Antonescu CR, Maki RG, Pisters PW, Demetri GD et al. Adjuvant imatinib mesylate after resection of localized primary gastrointestinal stromal tumour: a randomized, double-blind, placebo-controlled trial. Lancet. 2009;373;1097-104.
  • 11. Hirota S, Isozaki K, Moriyama Y, Hashimato K, Nishida T, Ishiguro S et al. Gain of function mutations of c-kit in human gastrointestinal stromal tumors. Science. 1998:279(5350):577-80.
  • 12. Fletcher CDM, Berman JJ, Corless C, Gorstein F, Lasota J, Longley BJ et al. Diagnosis of gastrointestinal stromal tumors: a consensus approach. Hum Pathol. 2002:33:459-65.
  • 13. Connoly EM, Gaffney E, Reynolds JV. Gastrointestinal stromal tumors. Br J Surg. 2003:90:1178-86.
  • 14. Miettinen M, Lasota J. Gastrointestinal stromal tumors: definition, clinical, histological, immunohistochemical and molecular genetic features and differential diagnosis. Virchows Arch. 2001:438:1-12.
  • 15. Reith JD, Goldblum JR, Lyles RH, Weiss SW. Extragastrointestinal (soft-tissue) stromal tumors: an analysis of 48 cases with emphasis on histologic predictors of outcome. Mod Pathol. 2000:13(5):577-85.
  • 16. Park SS, Min BW, Kim WB, Choi JW, Lee JH, Chae YS, et al. Malignant extragastrointestinal stromal tumors of retroperitoneum. Acta Oncol. 2005;44(5):497-9.
  • 17. Lognoro R, Jones DV, Faruqi S, Bhutani MS. Recent advances in cell biology, diagnosis and therapy of gastrointestinal stromal tumor (GIST) . Cancer Biol Ther. 2004;3:251-8.
  • 18. Barreda-Bolanos F, Liu Bejarano H, Sanchez Lihon J, Landeo Aliaga I, Sanchez Rodriguez Z. Survival factors in 152 patients with gastrointestinal stromal tumor . Rev Gastroenterol Peru. 2010;30:305-23.
  • 19. Barros A, Linhares E, Valadao M, et al. Extragastrointestinal stromal tumor (EGIST) : a series of case reports. Hepatogastroenterology 2011:58:865-868.
  • 20. Yamamato H, Kojima A, Nagata S, Tomita Y, Takahashi S, Oda Y. KIT negative gastrointestinal stromal tumor of the abdominal soft tissue : a clinicopathologic and genetic study of 10 cases. Am J Surg Pathol. 2011;35:1287-1295.
  • 21. Sakurai S, Hishima T, Takazawa Y, Sano T, Nakajima T, Saito K, et al. Gastrointestinal stromal tumors and KIT-positive mesenchymal cells in the omentum. Pathol Int. 2001:51:524-31.
  • 22. Ruiz-Tovar J, Diez-Tabernilla M, Housari G, Martinez-Molina E, Sanjuanbenito A. Gastrointestinal stromal tumor: actin expression, a new prognostic factors? Am Surg. 2010:76:1244-9.

VULVADA PARAÜRETRAL EKSTRAGASTROİNTESTİNAL STROMAL TÜMÖR; OLGU SUNUMU

Yıl 2017, Cilt: 48 Sayı: 4, 168 - 172, 07.12.2017
https://doi.org/10.16948/zktipb.290910

Öz

ÖZET



Gastrointestinal
Stromal Tümörler (GİST), gastrointestinal sistem duvarı peristaltizmini düzenleyen
İnterstisyel Cajal Hücreleri’nden (İCH) kaynaklandığı düşünülen mezenkimal
tümörlerdir. Ekstragastrointestinal  Stromal
Tümörler (EGİST) daha nadir görülen, histoloji ve immünohistokimlyasal açıdan
gastrointestinal stromal tümörler ile benzer ancak gastro intestinal yolak
dışında oluşan tümörlerdir. Metastatik olmayan ekstragastrointestinal stromal
tümörlerin cerrahi olarak çıkarılması altın standart tedavidir. Bu makalede,
nadiren vulvadan köken alan ekstragastrointestinal stromal tümörlü bir olgu
sunduk.

Kaynakça

  • 1. Gold JS,Dematteo RP. Combined surgıcal and molecular therapy: the gastrointestinal stromal tumor model. Ann Surg 2006;244:176-84.
  • 2. Kindblom LG, Remotti HE, Aldenborg F. Gastrointestinal pacemaker cell tumor (GIPACT). Gastrointestinal stromal tumors show phenotypic characteristics of intestinal cell of Cajal. Am J Pathol. 1998:152(5):1259-69.
  • 3. Heinrich MC, Corless CL, Duensing A, Chen CJ, Joseph N, et al. PDGFRA activating mutations in gastrointestinal stromal tumors. Science. 2003;299:708-10.
  • 4. Hirota S, Ohashi A, Nishida T, Isozaki K, Kinoshita K, Shinomura Y, et al. Gain-of-function mutations of platelet-derived growht factor receptor alpha gene in gastrointestinal stromal tumors. Gastroenterology. 2003;125:660-7.
  • 5. Mortensen MB, Larsen KE, Fristrup CW, Nielsen HO. Gastrointestinal stromal tumor: clinical and pathological presentation. Ungeskr Laeger. 2007;169:2776-9.
  • 6. Yamamoto H, Oda Y, Kawaguchi K, et al. C-kit and PDGFRA mutations in extragastrointestinal stromal tumor (gastrointestinal stromal tumor of the soft tissue) Am J Surg Pathol, 2004;28(4):479-88.
  • 7. Gun BD, Gun MO, Karamanoglu Z. Primary stromal tumor of the omentum: report of a case. Surg Today 2006:36:994-6.
  • 8. Li J, Gong JF, Wu AW, Shen L. Post-operative imatinib in patients with intermediate or high risk gastrointestinal stromal tumor. Eur J Cancer Surg 2001:37:319-24.
  • 9. Nilsson B, Sjölund K, Kindblom LG, Meis-Kindblom JM, Bümming P, Nilsson O, Anderson J and Ahlman H: Adjuvant imatinib treatment improves recurrence-free survival in patients with high-risk gastrointestinal stromal tumors (GIST). Br J Cancer 96: 1656-1658, 2007.
  • 10. De Matteo RP, Ballman KV, Antonescu CR, Maki RG, Pisters PW, Demetri GD et al. Adjuvant imatinib mesylate after resection of localized primary gastrointestinal stromal tumour: a randomized, double-blind, placebo-controlled trial. Lancet. 2009;373;1097-104.
  • 11. Hirota S, Isozaki K, Moriyama Y, Hashimato K, Nishida T, Ishiguro S et al. Gain of function mutations of c-kit in human gastrointestinal stromal tumors. Science. 1998:279(5350):577-80.
  • 12. Fletcher CDM, Berman JJ, Corless C, Gorstein F, Lasota J, Longley BJ et al. Diagnosis of gastrointestinal stromal tumors: a consensus approach. Hum Pathol. 2002:33:459-65.
  • 13. Connoly EM, Gaffney E, Reynolds JV. Gastrointestinal stromal tumors. Br J Surg. 2003:90:1178-86.
  • 14. Miettinen M, Lasota J. Gastrointestinal stromal tumors: definition, clinical, histological, immunohistochemical and molecular genetic features and differential diagnosis. Virchows Arch. 2001:438:1-12.
  • 15. Reith JD, Goldblum JR, Lyles RH, Weiss SW. Extragastrointestinal (soft-tissue) stromal tumors: an analysis of 48 cases with emphasis on histologic predictors of outcome. Mod Pathol. 2000:13(5):577-85.
  • 16. Park SS, Min BW, Kim WB, Choi JW, Lee JH, Chae YS, et al. Malignant extragastrointestinal stromal tumors of retroperitoneum. Acta Oncol. 2005;44(5):497-9.
  • 17. Lognoro R, Jones DV, Faruqi S, Bhutani MS. Recent advances in cell biology, diagnosis and therapy of gastrointestinal stromal tumor (GIST) . Cancer Biol Ther. 2004;3:251-8.
  • 18. Barreda-Bolanos F, Liu Bejarano H, Sanchez Lihon J, Landeo Aliaga I, Sanchez Rodriguez Z. Survival factors in 152 patients with gastrointestinal stromal tumor . Rev Gastroenterol Peru. 2010;30:305-23.
  • 19. Barros A, Linhares E, Valadao M, et al. Extragastrointestinal stromal tumor (EGIST) : a series of case reports. Hepatogastroenterology 2011:58:865-868.
  • 20. Yamamato H, Kojima A, Nagata S, Tomita Y, Takahashi S, Oda Y. KIT negative gastrointestinal stromal tumor of the abdominal soft tissue : a clinicopathologic and genetic study of 10 cases. Am J Surg Pathol. 2011;35:1287-1295.
  • 21. Sakurai S, Hishima T, Takazawa Y, Sano T, Nakajima T, Saito K, et al. Gastrointestinal stromal tumors and KIT-positive mesenchymal cells in the omentum. Pathol Int. 2001:51:524-31.
  • 22. Ruiz-Tovar J, Diez-Tabernilla M, Housari G, Martinez-Molina E, Sanjuanbenito A. Gastrointestinal stromal tumor: actin expression, a new prognostic factors? Am Surg. 2010:76:1244-9.
Toplam 22 adet kaynakça vardır.

Ayrıntılar

Konular Sağlık Kurumları Yönetimi
Bölüm Olgu Sunumu
Yazarlar

Mesut Tek

İdris Aydın Bu kişi benim

Yasemin Yuyucu Karabulut Bu kişi benim

Mürşide Çevikoğlu Kıllı

Yayımlanma Tarihi 7 Aralık 2017
Yayımlandığı Sayı Yıl 2017 Cilt: 48 Sayı: 4

Kaynak Göster

APA Tek, M., Aydın, İ., Yuyucu Karabulut, Y., Çevikoğlu Kıllı, M. (2017). VULVADA PARAÜRETRAL EKSTRAGASTROİNTESTİNAL STROMAL TÜMÖR; OLGU SUNUMU. Zeynep Kamil Tıp Bülteni, 48(4), 168-172. https://doi.org/10.16948/zktipb.290910
AMA Tek M, Aydın İ, Yuyucu Karabulut Y, Çevikoğlu Kıllı M. VULVADA PARAÜRETRAL EKSTRAGASTROİNTESTİNAL STROMAL TÜMÖR; OLGU SUNUMU. Zeynep Kamil Tıp Bülteni. Aralık 2017;48(4):168-172. doi:10.16948/zktipb.290910
Chicago Tek, Mesut, İdris Aydın, Yasemin Yuyucu Karabulut, ve Mürşide Çevikoğlu Kıllı. “VULVADA PARAÜRETRAL EKSTRAGASTROİNTESTİNAL STROMAL TÜMÖR; OLGU SUNUMU”. Zeynep Kamil Tıp Bülteni 48, sy. 4 (Aralık 2017): 168-72. https://doi.org/10.16948/zktipb.290910.
EndNote Tek M, Aydın İ, Yuyucu Karabulut Y, Çevikoğlu Kıllı M (01 Aralık 2017) VULVADA PARAÜRETRAL EKSTRAGASTROİNTESTİNAL STROMAL TÜMÖR; OLGU SUNUMU. Zeynep Kamil Tıp Bülteni 48 4 168–172.
IEEE M. Tek, İ. Aydın, Y. Yuyucu Karabulut, ve M. Çevikoğlu Kıllı, “VULVADA PARAÜRETRAL EKSTRAGASTROİNTESTİNAL STROMAL TÜMÖR; OLGU SUNUMU”, Zeynep Kamil Tıp Bülteni, c. 48, sy. 4, ss. 168–172, 2017, doi: 10.16948/zktipb.290910.
ISNAD Tek, Mesut vd. “VULVADA PARAÜRETRAL EKSTRAGASTROİNTESTİNAL STROMAL TÜMÖR; OLGU SUNUMU”. Zeynep Kamil Tıp Bülteni 48/4 (Aralık 2017), 168-172. https://doi.org/10.16948/zktipb.290910.
JAMA Tek M, Aydın İ, Yuyucu Karabulut Y, Çevikoğlu Kıllı M. VULVADA PARAÜRETRAL EKSTRAGASTROİNTESTİNAL STROMAL TÜMÖR; OLGU SUNUMU. Zeynep Kamil Tıp Bülteni. 2017;48:168–172.
MLA Tek, Mesut vd. “VULVADA PARAÜRETRAL EKSTRAGASTROİNTESTİNAL STROMAL TÜMÖR; OLGU SUNUMU”. Zeynep Kamil Tıp Bülteni, c. 48, sy. 4, 2017, ss. 168-72, doi:10.16948/zktipb.290910.
Vancouver Tek M, Aydın İ, Yuyucu Karabulut Y, Çevikoğlu Kıllı M. VULVADA PARAÜRETRAL EKSTRAGASTROİNTESTİNAL STROMAL TÜMÖR; OLGU SUNUMU. Zeynep Kamil Tıp Bülteni. 2017;48(4):168-72.