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Research Article
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A simple marker in supporting the diagnosis of the incomplete Kawasaki disease: Red cell distribution width

Year 2018, Volume: 40 Issue: 3, 208 - 214, 30.09.2018

Mehmet Küçük , Cem Karadeniz Rahmi Ozdemir Timur Mese

https://doi.org/10.7197/223.vi.420071

Abstract

Aim: To assess whether red cell distribution width (RDW)
would be a useful laboratory marker for Kawasaki disease (KD), particularly its
incomplete form (iKD).



Patients
and Methods: We retrospectively evaluated the medical records of cases
diagnosed with Kawasaki disease.



Results: The number of the cases with KD and controls were 67
and 69, respectively. RDW values were significantly higher in patients with KD
compared to controls.  When clinical and
laboratory findings of complete and incomplete Kawasaki disease patients were
compared, age at diagnosis was significantly lower and RDW values were
significantly higher in patients with iKD.



Conclusion: Our results showed that elevated RDW levels can be
used as a simple, inexpensive laboratory marker in supporting the diagnosis of
iKD.

Keywords

coronary artery lesions children incomplete Kawasaki disese Kawasaki disease red cell distribution width

References

  • 1. Newburger JW, Takahashi M, Gerber MA, et al. Diagnosis, treatment and long-term management of Kawasaki disease: a statement for health professionals from the Committee on Rheumatic Fever, Endocarditis and Kawasaki Disease, Council on Cardiovascular Disease in the Young, American Heart Association. Circulation 2004;110(17), 2747-2771.
  • 2. Huang WC, Huang LM, Chang IS, et al. Epidemiologic features of Kawasaki disease in Taiwan, 2003-2006. Pediatrics 2009;123(3), 401-405.
  • 3. Nakamura Y, Yashiro M, Uehara R, Uehara R, Oki I, Kayaba K, Yanagawa H. Increasing incidence of Kawasaki disease in Japan: nationwide survey. Pediatr Int 2008;50(3), 287-290.
  • 4. Perrin L, Letierce A, Guitton C, Tran TA, Lambert V, Koné-Paut I. Comparative study of complete versus incomplete Kawasaki disease in 59 pediatric patients. Joint Bone Spine 2009;76(5), 481–485.
  • 5. Felker GM, Allen LA, Pocock SJ, et al. Red cell distribution width as a novel prognostic marker in heart failure: data from the CHARM Program and the Duke Databank. J Am Coll Cardiol 2007;50(1), 40–47.
  • 6. Lee JH, Yang DH, Jang SY, et al. Incremental Predictive Value of Red Cell Distribution Width for 12-Month Clinical Outcome After Acute Myocardial Infarction. Clin Cardiol 2013;36(6), 336-341.
  • 7. Ozsu S, Abul Y, Gunaydin S, Orem A, Ozlu T. Prognostic Value of Red Cell Distribution Width in Patients With Pulmonary Embolism. Clin Appl Thromb Hemost 2012;20(4), 365-70.
  • 8. Hampole CV, Mehrotra AK, Thenappan T, Gomberg-Maitland M, Shah SJ. Usefulness of red cell distribution width as a prognostic marker in pulmonary hypertension. Am J Cardiol 2009;104(6), 868-872.
  • 9. Seyhan EC, Ozgul MA, Tutar N, Omür I, Uysal A, Altın S. Red Blood Cell Distribution and Survival in Patients with Chronic Obstructive Pulmonary Disease. COPD 2013;10(4), 416-424.
  • 10. Celikbilek A, Zararsiz G, Atalay T, Tanik N. Red cell distribution width in migraine. Int J Lab Hematol 2013;35(6), 620-8.
  • 11. Jo YH, Kim K, Lee JH, et al. Red cell distribution width is a prognostic factor in severe sepsis and septic shock. Am J Emerg Med 2013;31(3), 545-548.
  • 12. Kato H, Ichinose E, Yoshioka F, et al. Fate of coronary aneurysms in Kawasaki disease: serial coronary angiography and long-term follow-up study. Am J Cardiol 1982;49: 1758 –1766.
  • 13. Newburger JW, Takahashi M, Beiser AS, et al. A single intravenous infusion of gamma globulin as compared with four infusions in the treatment of acute Kawasaki syndrome. N Engl J Med 1991;324(23), 1633-1639.
  • 14. Liu R, Gao F, Huo J, Yi Q. Study on the relationship between mean platelet volume and platelet distribution width with coronary artery lesion in children with Kawasaki disease. Platelets 2012;23(1), 11-16.
  • 15. Collins CE, Rampton DS, Rogers J, Williams NS. Platelet aggregation and neutrophil sequestration in the mesenteric circulation in inflammatory bowel disease. Eur J Gastroenterol Hepatol 1997;9(12), 1213–1217.
  • 16. Kapsoritakis AN, Koukourakis MI, Sfiridaki A, et al. Mean platelet volume: A useful marker of inflammatory bowel disease activity. Am J Gastroenterol 2001;96:776–781.
  • 17. Lee JH, Chung HJ, Kim K, et al. Red cell distribution width as a prognostic marker in patients with community-acquired pneumonia. Am J Emerg Med 2013;31(1):72-79.
  • 18. Massin MM. Relation between red cell distribution width and clinical outcome after surgery for congenital heart disease in children. Pediatr Cardiol 2012;33(7),1021-1025.
  • 19. Scharte M, Fink MP. Red blood cell physiology in critical illness. Crit Care Med 31(12 Suppl), 2003;651-657.
  • 20. Ghaffari S. Oxidative stress in the regulation of normal and neoplastic hematopoiesis. Antioxid Redox Signal 2008;10(11), 1923-1940.
  • 21. Barron K, DeCunto C, Montalvo J, Orson F, Lewis D. Abnormalities of immunoregulation in Kawasaki syndrome. J Rheumatol 1988;15(8):1243-1249.

Year 2018, Volume: 40 Issue: 3, 208 - 214, 30.09.2018

Mehmet Küçük , Cem Karadeniz Rahmi Ozdemir Timur Mese

https://doi.org/10.7197/223.vi.420071

Abstract

References

  • 1. Newburger JW, Takahashi M, Gerber MA, et al. Diagnosis, treatment and long-term management of Kawasaki disease: a statement for health professionals from the Committee on Rheumatic Fever, Endocarditis and Kawasaki Disease, Council on Cardiovascular Disease in the Young, American Heart Association. Circulation 2004;110(17), 2747-2771.
  • 2. Huang WC, Huang LM, Chang IS, et al. Epidemiologic features of Kawasaki disease in Taiwan, 2003-2006. Pediatrics 2009;123(3), 401-405.
  • 3. Nakamura Y, Yashiro M, Uehara R, Uehara R, Oki I, Kayaba K, Yanagawa H. Increasing incidence of Kawasaki disease in Japan: nationwide survey. Pediatr Int 2008;50(3), 287-290.
  • 4. Perrin L, Letierce A, Guitton C, Tran TA, Lambert V, Koné-Paut I. Comparative study of complete versus incomplete Kawasaki disease in 59 pediatric patients. Joint Bone Spine 2009;76(5), 481–485.
  • 5. Felker GM, Allen LA, Pocock SJ, et al. Red cell distribution width as a novel prognostic marker in heart failure: data from the CHARM Program and the Duke Databank. J Am Coll Cardiol 2007;50(1), 40–47.
  • 6. Lee JH, Yang DH, Jang SY, et al. Incremental Predictive Value of Red Cell Distribution Width for 12-Month Clinical Outcome After Acute Myocardial Infarction. Clin Cardiol 2013;36(6), 336-341.
  • 7. Ozsu S, Abul Y, Gunaydin S, Orem A, Ozlu T. Prognostic Value of Red Cell Distribution Width in Patients With Pulmonary Embolism. Clin Appl Thromb Hemost 2012;20(4), 365-70.
  • 8. Hampole CV, Mehrotra AK, Thenappan T, Gomberg-Maitland M, Shah SJ. Usefulness of red cell distribution width as a prognostic marker in pulmonary hypertension. Am J Cardiol 2009;104(6), 868-872.
  • 9. Seyhan EC, Ozgul MA, Tutar N, Omür I, Uysal A, Altın S. Red Blood Cell Distribution and Survival in Patients with Chronic Obstructive Pulmonary Disease. COPD 2013;10(4), 416-424.
  • 10. Celikbilek A, Zararsiz G, Atalay T, Tanik N. Red cell distribution width in migraine. Int J Lab Hematol 2013;35(6), 620-8.
  • 11. Jo YH, Kim K, Lee JH, et al. Red cell distribution width is a prognostic factor in severe sepsis and septic shock. Am J Emerg Med 2013;31(3), 545-548.
  • 12. Kato H, Ichinose E, Yoshioka F, et al. Fate of coronary aneurysms in Kawasaki disease: serial coronary angiography and long-term follow-up study. Am J Cardiol 1982;49: 1758 –1766.
  • 13. Newburger JW, Takahashi M, Beiser AS, et al. A single intravenous infusion of gamma globulin as compared with four infusions in the treatment of acute Kawasaki syndrome. N Engl J Med 1991;324(23), 1633-1639.
  • 14. Liu R, Gao F, Huo J, Yi Q. Study on the relationship between mean platelet volume and platelet distribution width with coronary artery lesion in children with Kawasaki disease. Platelets 2012;23(1), 11-16.
  • 15. Collins CE, Rampton DS, Rogers J, Williams NS. Platelet aggregation and neutrophil sequestration in the mesenteric circulation in inflammatory bowel disease. Eur J Gastroenterol Hepatol 1997;9(12), 1213–1217.
  • 16. Kapsoritakis AN, Koukourakis MI, Sfiridaki A, et al. Mean platelet volume: A useful marker of inflammatory bowel disease activity. Am J Gastroenterol 2001;96:776–781.
  • 17. Lee JH, Chung HJ, Kim K, et al. Red cell distribution width as a prognostic marker in patients with community-acquired pneumonia. Am J Emerg Med 2013;31(1):72-79.
  • 18. Massin MM. Relation between red cell distribution width and clinical outcome after surgery for congenital heart disease in children. Pediatr Cardiol 2012;33(7),1021-1025.
  • 19. Scharte M, Fink MP. Red blood cell physiology in critical illness. Crit Care Med 31(12 Suppl), 2003;651-657.
  • 20. Ghaffari S. Oxidative stress in the regulation of normal and neoplastic hematopoiesis. Antioxid Redox Signal 2008;10(11), 1923-1940.
  • 21. Barron K, DeCunto C, Montalvo J, Orson F, Lewis D. Abnormalities of immunoregulation in Kawasaki syndrome. J Rheumatol 1988;15(8):1243-1249.
There are 21 citations in total.

Details

Primary Language English
Subjects Health Care Administration
Journal Section Medical Science Research Articles
Authors

Mehmet Küçük

Cem Karadeniz

Rahmi Ozdemir

Timur Mese

Publication Date September 30, 2018
Acceptance Date August 2, 2018
Published in Issue Year 2018 Volume: 40 Issue: 3

Cite

AMA Küçük M, Karadeniz C, Ozdemir R, Mese T. A simple marker in supporting the diagnosis of the incomplete Kawasaki disease: Red cell distribution width. CMJ. September 2018;40(3):208-214. doi:10.7197/223.vi.420071