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Research Article
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Evaluation of platelet indices in acute, subacute and, chronic phases of deep venous thrombosis

Year 2019, Volume: 41 Issue: 3, 544 - 550, 30.09.2019

Fatih Ada , Vural Polat

https://doi.org/10.7197/cmj.vi.610865
Cited By: 1

Abstract

Objective: The etiology of deep vein thrombosis
disease is multifactorial, and currently it is seen as a public health problem.
Simple, cheap and useful tests that can be used for diagnosis, treatment, and
follow-up is increasingly needed  day by
day because of increasing number of patients. For this purpose, the changes of
platelet indices in routine hemogram tests during DVT follow-up were examined
retrospectively.

Method: This study is a retrospective analysis of
patients who diagnosed with deep venous thrombosis in Sivas Cumhuriyet
University School of Medicine between 01.01.2017-31.12.2018 years. The investigation
started after the decision of Sivas Cumhuriyet University Local Ethics
Committee No. 2019-02/67. The acute, subacute and chronic phase parameters of
patients with deep venous thrombosis were evaluated. The study included 72
patients who developed DVT. Platelet indexes and other hemogram parameters were
analyzed statistically according to the phases of deep vein thrombosis.

Results: 55.6% of the
patients were female, and 44.4% were male. DVT was found most commonly in the
left femoral region (48.6%). PDW and MPV tended to increase rapidly in the
acute phase of deep vein thrombosis and managed to fall in the subacute and
chronic phases. However, there was no statistically significant change in
platelet count and platelet crit.







Conclusions: PDW and MPV appear
to be useful markers in the follow-up of all stages of deep vein thrombosis. It
is evident that with the developing technology, more sensitive and specific
parameters of platelet indices will be obtained.

Keywords

deep venous thrombosis platelet indices complete blood count

Project Number

yok

References

  • 1. Cay N, Unal O, Kartal MG, Ozdemir M, Tola M. Increased level of red blood cell distribution width is associated with deep venous thrombosis. Blood Coagul. Fibrinolysis 2013;24(7):727-31.
  • 2. Han JS, Park TS, Cho SY, Joh JH, Ahn HJ. Increased mean platelet volume and mean platelet volume/platelet count ratio in Korean patients with deep vein thrombosis. Platelets 2013;24(8):590-3.
  • 3. Willans DJ, Mill SC, Ranney EK. Common thrombotic disorders defined by CBC platelet parameters. Clin. Appl. Thromb. Hemost.1995;1(3):188-201.
  • 4. Wiwanitkit, V. Plateletcrit, mean platelet volume, platelet distribution width: its expected values and correlation with parallel red blood cell parameters. Clin. Appl. Thromb. Hemost.2004;10(2):175-8.
  • 5. Wakefield TW, Myers DD, Henke PK. Mechanisms of venous thrombosis and resolution. Arterioscler. Thromb. Vasc. Biol.2008;28(3):387-91.
  • 6. Vagdatli E, Gounari E, Lazaridou E, Katsibourlia E, Tsikopoulou F, Labrianou I. Platelet distribution width: a simple, practical and specific marker of activation of coagulation. Hippokratia 2010;14(1):28-32.
  • 7. Beyan C. Is mean platelet volume a predictive marker in patients with venous thrombosis?. Clin. Appl. Thromb. Hemost. 2012;18(6):670-1.
  • 8. Reddy RS, Khan MI, Phansalkar MD. Platelet Distribution Width (PDW) in Thrombocytopenia. Indian Medical Gazette May 2015;169-174.
  • 9. Van der Lelie J, Von dem Borne AK. Platelet volume analysis for differential diagnosis of thrombocytosis. J. Clin. Pathol. 1986;39(2):129-33.
  • 10. Osselaer JC, Jamart J, Scheiff JM. (1997). Platelet distribution width for differential diagnosis of thrombocytosis. Clin. Chem. 1997;43(6):1072-6.
  • 11. Farias MG, Schunck EG, Dal Bó S, de Castro SM. Definition of reference ranges for the platelet distribution width (PDW): a local need. Clin. Chem. Lab. Med. 2010;48(2):255-7.
  • 12. Aldemir M, Pektaş MB, Parlar Aİ, Akcı Ö, Emren SV, Tecer E,et al. L-carnitine supplementation reduces short-term neutrophil-lymphocyte ratio in patients undergoing coronary artery bypass grafting. Int J Surg 2015;100(7):1160-8.
  • 13. Wang M, Zhang J, Ji Q, Yang Q, Zhao F, Li W, et al. Evaluation of platelet distribution width in chronic obstructive pulmonary disease patients with pulmonary embolism. J Biomark.2016;10(6):587-96.
  • 14. Sarıgül A, Tanyeli Ö. Derin ven trombozunda güncel tedavi yaklaşımları. Turk Gogus Kalp Dama 2007;15(4):316-21.
  • 15. Sevuk U, Bahadir MV, Altindag R, Baysal E, Yaylak B, Ay N, et al. Value of serial platelet indices measurements for the prediction of pulmonary embolism in patients with deep venous thrombosis. Ther Clin Risk Manag2015;11:1243-9.
  • 16. Vatankulu MA, Sonmez O, Ertas G, Bacaksiz A, Turfan M, Erdogan E, et al. A new parameter predicting chronic total occlusion of coronary arteries: platelet distribution width. Angiology2014;65(1):60-4.
  • 17. Adam G, Kocak E, Özkan A, Reşorlu M, Çınar C, Bozkaya H, et al. Evaluation of platelet distribution width and mean platelet volume in patients with carotid artery stenosis. Angiology 2015;66(4):375-8.
  • 18. Li N, Diao Z, Huang X, Niu Y, Liu T, Liu ZP, et al. Increased platelet distribution width predicts poor prognosis in melanoma patients. Scientific reports, 2017;7(1):2970.
  • 19. Bhanukumar M, Ramaswamy PKH, Peddi NK, Menon WB. Mean Platelet Volume and Platelet Distribution Width as Markers of Vascular Thrombosis in Type 2 Diabetes Mellitus. J Postgrad Med Edu Res 2016;50(3):127-131.
  • 20. Sevuk U, Altindag R, Bahadir MV, Ay N, Demirtas E, Ayaz F. Value of platelet indices in identifying complete resolution of thrombus in deep venous thrombosis patients. Indian J Hematol Blood Transfus 2015;31(1):71-6.
  • 21. Bolayır A, Gökçe ŞF. The role of mean platelet volume, platelet distribution width and platelet/lymphocyte ratio in development of cerebral venous thrombosis. Cumhuriyet Med J 2017;39(4):683-91.
  • 22. Kamisli O, Kamisli S, Kablan Y, Gonullu S, Ozcan C. The prognostic value of an increased mean platelet volume and platelet distribution width in the early phase of cerebral venous sinus thrombosis. Clin. Appl. Thromb. Hemost. 2013;19(1):29-32.
  • 23. Fan Z, Pan J, Zhang Y, Wang Z, Zhu M, Yang B, et al. Mean platelet volume and platelet distribution width as markers in the diagnosis of acute gangrenous appendicitis. Dis Markers. 2015;2015:542013.
  • 24. Kaplanoglu M, Yuce T, Bulbul M. (2015). Decreased mean platelet volume is associated with the developing stage of fetoplacental unit in spontaneous abortion. Int J Clin Exp Med2015;8(7):11301-6.
  • 25. Ege MR, Guray U, Guray Y, Acıkgoz S, Demirkan B. Platelet distribution width and saphenous vein disease in patients after CABG. Herz 2013;38(2):197-201.
  • 26. Akbulut N, Yıldız M, Yıldız BŞ, Aktaş S, Yaylacı M. Akut Miyokard İnfarktüslü Hastalarda Ortalama Trombosit Hacmi ve Trombosit Sayısının Değerlendirilmesi. MN kardiyoloji 2006;13(3):180-5.
  • 27. Çil H, Yavuz C, İslamoğlu Y, Tekbaş EÖ, Demirtaş S, Atılgan ZA, et al. Platelet count and mean platelet volume in patients with in-hospital deep venous thrombosis. Clin. Appl. Thromb. Hemost. 2012;18(6):650-3.
  • 28. Huang J, Chen Y, Cai Z, Chen P. Diagnostic value of platelet indexes for pulmonary embolism. Am J Emerg Med2015;33(6):760-3.

Derin venöz trombozun akut, subakut ve kronik fazlarında platelet indekslerinin değerlendirilmesi

Year 2019, Volume: 41 Issue: 3, 544 - 550, 30.09.2019

Fatih Ada , Vural Polat

https://doi.org/10.7197/cmj.vi.610865
Cited By: 1

Abstract

Amaç: Derin ven trombozu etiyolojisi multifaktöriyel bir hastalık olup günümüzde bir halk sağlığı problemi olarak görülmektedir. Artan hasta sayısıyla birlikte tanı, tedavi ve takipte kullanılabilecek basit, ucuz ve kullanışlı testlere ihtiyaç her geçen gün artmaktadır. Bu amaçla rutin hemogram testlerinde yer alan platelet indekslerinin DVT takibinde ki değişimleri retrospektif olarak incelenmiştir. Yöntem: Bu çalışma, 01.01.2017-31.12.2018 tarihleri arasında Sivas Cumhuriyet Üniversitesi Tıp Fakültesinde, tanı konulmuş derin venöz trombozlu hastaların retrospektif bir analizidir. Çalışmaya, Sivas Cumhuriyet Üniversitesi Yerel Etik Kurulunun 2019-02/67sayılı kararı sonrası başlandı. Derin venöz trombozlu hastaların akut, subakut ve kronik faz parametreleri değerlendirildi. Çalışmaya DVT gelişen 72 hasta dâhil edildi. Trombosit indeksleri ve diğer hemogram parametreleri derin ven trombozunun evrelerine göre istatistiksel olarak analiz edildi. Bulgular: DVT görülen hastaların %55,6’sı kadın ve %44,4’ü erkek idi. En sık sol femoral bölgede (%48,6) DVT saptanmıştır. PDW ve MPV,derin venöz trombozun akut fazında hızlı bir yükselişe geçerken subakut ve kronik fazlarda düşme eğiliminde idi. Bununla birlikte platelet sayısı ve plateletkritin istatistiksel olarak anlamlı bir değişimi yoktu. Sonuç: Derin ven trombozun tüm evrelerinin takibinde PDW ve MPV iyi birer marker olarak görünmektedir. Gelişen teknoloji ile birlikte platelet indekslerine ait çok daha hassas ve özgül parametrelerin elde edileceği de aşikârdır. 

Keywords

Derin venöz tromboz hemogram parametreleri trombosit indeksleri ortalama trombosit hacmi trombosit dağılım genişliği

Supporting Institution

yok

Project Number

yok

Thanks

yok

References

  • 1. Cay N, Unal O, Kartal MG, Ozdemir M, Tola M. Increased level of red blood cell distribution width is associated with deep venous thrombosis. Blood Coagul. Fibrinolysis 2013;24(7):727-31.
  • 2. Han JS, Park TS, Cho SY, Joh JH, Ahn HJ. Increased mean platelet volume and mean platelet volume/platelet count ratio in Korean patients with deep vein thrombosis. Platelets 2013;24(8):590-3.
  • 3. Willans DJ, Mill SC, Ranney EK. Common thrombotic disorders defined by CBC platelet parameters. Clin. Appl. Thromb. Hemost.1995;1(3):188-201.
  • 4. Wiwanitkit, V. Plateletcrit, mean platelet volume, platelet distribution width: its expected values and correlation with parallel red blood cell parameters. Clin. Appl. Thromb. Hemost.2004;10(2):175-8.
  • 5. Wakefield TW, Myers DD, Henke PK. Mechanisms of venous thrombosis and resolution. Arterioscler. Thromb. Vasc. Biol.2008;28(3):387-91.
  • 6. Vagdatli E, Gounari E, Lazaridou E, Katsibourlia E, Tsikopoulou F, Labrianou I. Platelet distribution width: a simple, practical and specific marker of activation of coagulation. Hippokratia 2010;14(1):28-32.
  • 7. Beyan C. Is mean platelet volume a predictive marker in patients with venous thrombosis?. Clin. Appl. Thromb. Hemost. 2012;18(6):670-1.
  • 8. Reddy RS, Khan MI, Phansalkar MD. Platelet Distribution Width (PDW) in Thrombocytopenia. Indian Medical Gazette May 2015;169-174.
  • 9. Van der Lelie J, Von dem Borne AK. Platelet volume analysis for differential diagnosis of thrombocytosis. J. Clin. Pathol. 1986;39(2):129-33.
  • 10. Osselaer JC, Jamart J, Scheiff JM. (1997). Platelet distribution width for differential diagnosis of thrombocytosis. Clin. Chem. 1997;43(6):1072-6.
  • 11. Farias MG, Schunck EG, Dal Bó S, de Castro SM. Definition of reference ranges for the platelet distribution width (PDW): a local need. Clin. Chem. Lab. Med. 2010;48(2):255-7.
  • 12. Aldemir M, Pektaş MB, Parlar Aİ, Akcı Ö, Emren SV, Tecer E,et al. L-carnitine supplementation reduces short-term neutrophil-lymphocyte ratio in patients undergoing coronary artery bypass grafting. Int J Surg 2015;100(7):1160-8.
  • 13. Wang M, Zhang J, Ji Q, Yang Q, Zhao F, Li W, et al. Evaluation of platelet distribution width in chronic obstructive pulmonary disease patients with pulmonary embolism. J Biomark.2016;10(6):587-96.
  • 14. Sarıgül A, Tanyeli Ö. Derin ven trombozunda güncel tedavi yaklaşımları. Turk Gogus Kalp Dama 2007;15(4):316-21.
  • 15. Sevuk U, Bahadir MV, Altindag R, Baysal E, Yaylak B, Ay N, et al. Value of serial platelet indices measurements for the prediction of pulmonary embolism in patients with deep venous thrombosis. Ther Clin Risk Manag2015;11:1243-9.
  • 16. Vatankulu MA, Sonmez O, Ertas G, Bacaksiz A, Turfan M, Erdogan E, et al. A new parameter predicting chronic total occlusion of coronary arteries: platelet distribution width. Angiology2014;65(1):60-4.
  • 17. Adam G, Kocak E, Özkan A, Reşorlu M, Çınar C, Bozkaya H, et al. Evaluation of platelet distribution width and mean platelet volume in patients with carotid artery stenosis. Angiology 2015;66(4):375-8.
  • 18. Li N, Diao Z, Huang X, Niu Y, Liu T, Liu ZP, et al. Increased platelet distribution width predicts poor prognosis in melanoma patients. Scientific reports, 2017;7(1):2970.
  • 19. Bhanukumar M, Ramaswamy PKH, Peddi NK, Menon WB. Mean Platelet Volume and Platelet Distribution Width as Markers of Vascular Thrombosis in Type 2 Diabetes Mellitus. J Postgrad Med Edu Res 2016;50(3):127-131.
  • 20. Sevuk U, Altindag R, Bahadir MV, Ay N, Demirtas E, Ayaz F. Value of platelet indices in identifying complete resolution of thrombus in deep venous thrombosis patients. Indian J Hematol Blood Transfus 2015;31(1):71-6.
  • 21. Bolayır A, Gökçe ŞF. The role of mean platelet volume, platelet distribution width and platelet/lymphocyte ratio in development of cerebral venous thrombosis. Cumhuriyet Med J 2017;39(4):683-91.
  • 22. Kamisli O, Kamisli S, Kablan Y, Gonullu S, Ozcan C. The prognostic value of an increased mean platelet volume and platelet distribution width in the early phase of cerebral venous sinus thrombosis. Clin. Appl. Thromb. Hemost. 2013;19(1):29-32.
  • 23. Fan Z, Pan J, Zhang Y, Wang Z, Zhu M, Yang B, et al. Mean platelet volume and platelet distribution width as markers in the diagnosis of acute gangrenous appendicitis. Dis Markers. 2015;2015:542013.
  • 24. Kaplanoglu M, Yuce T, Bulbul M. (2015). Decreased mean platelet volume is associated with the developing stage of fetoplacental unit in spontaneous abortion. Int J Clin Exp Med2015;8(7):11301-6.
  • 25. Ege MR, Guray U, Guray Y, Acıkgoz S, Demirkan B. Platelet distribution width and saphenous vein disease in patients after CABG. Herz 2013;38(2):197-201.
  • 26. Akbulut N, Yıldız M, Yıldız BŞ, Aktaş S, Yaylacı M. Akut Miyokard İnfarktüslü Hastalarda Ortalama Trombosit Hacmi ve Trombosit Sayısının Değerlendirilmesi. MN kardiyoloji 2006;13(3):180-5.
  • 27. Çil H, Yavuz C, İslamoğlu Y, Tekbaş EÖ, Demirtaş S, Atılgan ZA, et al. Platelet count and mean platelet volume in patients with in-hospital deep venous thrombosis. Clin. Appl. Thromb. Hemost. 2012;18(6):650-3.
  • 28. Huang J, Chen Y, Cai Z, Chen P. Diagnostic value of platelet indexes for pulmonary embolism. Am J Emerg Med2015;33(6):760-3.
There are 28 citations in total.

Details

Primary Language English
Subjects Health Care Administration
Journal Section Medical Science Research Articles
Authors

Fatih Ada 0000-0002-6953-5906

Vural Polat 0000-0001-9553-3990

Project Number yok
Publication Date September 30, 2019
Acceptance Date September 28, 2019
Published in Issue Year 2019 Volume: 41 Issue: 3

Cite

AMA Ada F, Polat V. Evaluation of platelet indices in acute, subacute and, chronic phases of deep venous thrombosis. CMJ. September 2019;41(3):544-550. doi:10.7197/cmj.vi.610865

Cited By

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