Evaluation of Cognitive Functions of Patients with Anemia

Duygu Felek

doi:10.7197/cmj.1223208

Research Article

Evaluation of Cognitive Functions of Patients with Anemia

Year 2023, Volume: 45 Issue: 1, 62 - 65, 31.03.2023

Duygu Felek

https://doi.org/10.7197/cmj.1223208

Abstract

Iron deficiency anemia is the most common anemia type in the population. It causes many systemic clinical symptoms, including the effects on cognitive functions. Therefore, this study aimed to observe individuals' cognitive changes resulting from iron deficiency, a preventable cause.
Method: Cognitive scores of 112 individuals (56 with iron deficiency anemia-test group and 56 healthy individuals-control group) from the Montreal Cognitive Assessment (MoCA) were recorded. In addition, hemoglobin levels and recurrent anemia histories of individuals with iron deficiency anemia were also considered.
Results: Cognitive functions were lower in the test group (individuals with iron deficiency anemia) compared to the control group. The mean MoCA score of the test and control groups were 19.80±3.46 and 22.98±3.59, respectively, and the difference was significant (p<0.05). In addition, a direct relationship (R=0.22) was found between the hemoglobin level and the MoCA score in individuals with anemia.
Conclusion: Cognitive functions and B12 deficiency come to the fore in these patients whose cognitive functions are also affected by iron deficiency. Therefore, besides examining cardiovascular and gastrointestinal systems, these patients' neurological system should also be evaluated in terms of cognitive functions.

Keywords

Anemia , iron defiency anemia , montreal cognitive assessment scala , cognitive functions

References

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2.Akarsu S, Kilic M, Yilmaz E, Aydin M, Taskin E, AygunAD. Frequency of hypoferritinemia, iron deficiency andiron deficiency anemia in outpatients. Acta Haematol2006; 116: 46-50.
3. Fourn L, Salami L. Diagnostic value of tegument pallorin anemia in pregnant women in Benin. Sante publique(Vandoeuvre-les-Nancy, France). 2004;16(1):123.
4. Matteson KA, Raker CA, Pinto SB, Scott DM, FrishmanGN. Women presenting to an emergency facility withabnormal uterine bleeding: patient characteristics andprevalence of anemia. The Journal of reproductivemedicine. 2012;57:17.
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7.Selekler K, Cangoz B, Uluc S. Montreal BilisselDeğerlendirme Olceği (MOBİD)’nin Hafif BilisselBozukluk ve Alzheimer Hastalığını Ayırt EdebilmeGucunun İncelenmesi. Turkish Journal of Geriatrics2010; 13:166-71. 64
8.Brayne C, Calloway P.Normal ageing, impairedcognitive function, and senile dementia of theAlzheimer 's type:A continuum.Lancet 1988; 4: 1265-1268.
9.Crook T, Bartus RT, Ferris SH, Whitehouse P, CohenGD.Age associated memory impairment. Proposeddiagnostic criteria .. and measures of clinical change-report ofa National lnstitute of Mental Health WorkGroup . Dev Neuropsychol 1986;4:261-276.
10.Ozdilek B, Kenangil G. Validation of the TurkishVersion of the Montreal Cognitive Assessment Scale(MoCA-TR) in patients with Parkinson's disease. ClinNeuropsychol 2014;28:333-343.
11.Kaya Y, Aki OE, Can UA, et al. Validation of montrealcognitive assessment and discriminant power ofmontreal cognitive assessment subtests in patientswith mild cognitive impairment and alzheimerdementia in Turkish population. J Geriatr PsychiatryNeurol 2014;27:103-109.
12.Charest K, Tremblay A, Langlois R, Roger É,Duquette P, Rouleau I. Detecting subtle cognitiveimpairment in multiple sclerosis with the montrealcognitive assessment. Can J Neurol Sci 2020;47:620-626.
13.Paez-Venegas N, Jordan-Estrada B, Chavarria-AvilaE, et al. The montreal cognitive assessment test: auseful tool in screening of cognitive impairment inpatients with systemic lupus erythematosus. J ClinRheumatol 2019;25:325-328.
14.Cameron J, Worrall-Carter L, Page K, et al. Doescognitive impairment predict poor self-care in patientswith heart failure? Eur J Heart Fail 2010;12:508-515.
15.Alagiakrishnan K, Zhao N, Mereu L, Senior P,Senthilselvan A. Montreal cognitive assessment issuperior to standardized mini-mental status exam indetecting mild cognitive impairment in the middle-agedand elderly patients with type 2 diabetes mellitus.Biomed Res Int 2013:186106.
16.Erdem N, Erdem R, Kurtoglu E, Oktay G. Screeningof Cosnitive Dysfunction Using the Montreal CognitiveAssessment Test and Evaluation of NeurologicComplications in Turkish Adults With Sickle CellAnemia. Turk J Neurol, 2021; 27(2) : 158-163
17.Ünal F. 0-12 Yaş arası çocuklarda dengelibeslenmenin önemi. Klinik Tıp Pediatri Dergisi, 2017,9.6: 17-27.
18.Yılmaz N. İnflamatuar Barsak HastalığındaAdalimumab Tedavisinin Demir Parametreleri ve AnemiÜzerindeki Etkileri. Harran Üniversitesi Tıp FakültesiDergisi, 2021, 18.1: 109-114.
19.Evrensel A, Ceylan Mehmet Emin. Bağırsak beyinekseni: Psikiyatrik bozukluklarda bağırsakmikrobiyotasının rolü. Psikiyatride güncel yaklaşımlar,2015, 7.4: 461-472
20.Ak Recep, Üstündağ Sedat. Kronik böbrekhastalarında kognitif fonksiyonların değerlendirilmesi.Trakya Üniversitesi. Yayınlanmamış uzmanlık tezi.2012.

Year 2023, Volume: 45 Issue: 1, 62 - 65, 31.03.2023

Duygu Felek

https://doi.org/10.7197/cmj.1223208

Abstract

Keywords

Anemia , iron defiency anemia , montreal cognitive assessment scala , cognitive functions

Thanks

Makalede istatistiksel alandaki desteklerinden dolayı Ziynet Çınar'a teşekkürler.

References

1.Çıpıl H, Demırcıoğlu S. Demir eksikliğianemisi. Turkiye Klinikleri Journal of Family MedicineSpecial Topics, 2016, 7.3: 34-37.
2.Akarsu S, Kilic M, Yilmaz E, Aydin M, Taskin E, AygunAD. Frequency of hypoferritinemia, iron deficiency andiron deficiency anemia in outpatients. Acta Haematol2006; 116: 46-50.
3. Fourn L, Salami L. Diagnostic value of tegument pallorin anemia in pregnant women in Benin. Sante publique(Vandoeuvre-les-Nancy, France). 2004;16(1):123.
4. Matteson KA, Raker CA, Pinto SB, Scott DM, FrishmanGN. Women presenting to an emergency facility withabnormal uterine bleeding: patient characteristics andprevalence of anemia. The Journal of reproductivemedicine. 2012;57:17.
5.Lopez A, Cacoub P, Macdougall IC, Peyrin-Biroulet L.Iron deficiency anaemia. The Lancet.2016;387(10021):907-16.
6.Nasreddine ZS, Phillips NA, Bedirian V, CharbonneauS, Whitehead V, Collin I, et al. Montreal CognitiveAssessment, MOBİD: a brief screening tool for mildcognitive impairment. J Am Geriatr Soc 2005; 53: 695-9.
7.Selekler K, Cangoz B, Uluc S. Montreal BilisselDeğerlendirme Olceği (MOBİD)’nin Hafif BilisselBozukluk ve Alzheimer Hastalığını Ayırt EdebilmeGucunun İncelenmesi. Turkish Journal of Geriatrics2010; 13:166-71. 64
8.Brayne C, Calloway P.Normal ageing, impairedcognitive function, and senile dementia of theAlzheimer 's type:A continuum.Lancet 1988; 4: 1265-1268.
9.Crook T, Bartus RT, Ferris SH, Whitehouse P, CohenGD.Age associated memory impairment. Proposeddiagnostic criteria .. and measures of clinical change-report ofa National lnstitute of Mental Health WorkGroup . Dev Neuropsychol 1986;4:261-276.
10.Ozdilek B, Kenangil G. Validation of the TurkishVersion of the Montreal Cognitive Assessment Scale(MoCA-TR) in patients with Parkinson's disease. ClinNeuropsychol 2014;28:333-343.
11.Kaya Y, Aki OE, Can UA, et al. Validation of montrealcognitive assessment and discriminant power ofmontreal cognitive assessment subtests in patientswith mild cognitive impairment and alzheimerdementia in Turkish population. J Geriatr PsychiatryNeurol 2014;27:103-109.
12.Charest K, Tremblay A, Langlois R, Roger É,Duquette P, Rouleau I. Detecting subtle cognitiveimpairment in multiple sclerosis with the montrealcognitive assessment. Can J Neurol Sci 2020;47:620-626.
13.Paez-Venegas N, Jordan-Estrada B, Chavarria-AvilaE, et al. The montreal cognitive assessment test: auseful tool in screening of cognitive impairment inpatients with systemic lupus erythematosus. J ClinRheumatol 2019;25:325-328.
14.Cameron J, Worrall-Carter L, Page K, et al. Doescognitive impairment predict poor self-care in patientswith heart failure? Eur J Heart Fail 2010;12:508-515.
15.Alagiakrishnan K, Zhao N, Mereu L, Senior P,Senthilselvan A. Montreal cognitive assessment issuperior to standardized mini-mental status exam indetecting mild cognitive impairment in the middle-agedand elderly patients with type 2 diabetes mellitus.Biomed Res Int 2013:186106.
16.Erdem N, Erdem R, Kurtoglu E, Oktay G. Screeningof Cosnitive Dysfunction Using the Montreal CognitiveAssessment Test and Evaluation of NeurologicComplications in Turkish Adults With Sickle CellAnemia. Turk J Neurol, 2021; 27(2) : 158-163
17.Ünal F. 0-12 Yaş arası çocuklarda dengelibeslenmenin önemi. Klinik Tıp Pediatri Dergisi, 2017,9.6: 17-27.
18.Yılmaz N. İnflamatuar Barsak HastalığındaAdalimumab Tedavisinin Demir Parametreleri ve AnemiÜzerindeki Etkileri. Harran Üniversitesi Tıp FakültesiDergisi, 2021, 18.1: 109-114.
19.Evrensel A, Ceylan Mehmet Emin. Bağırsak beyinekseni: Psikiyatrik bozukluklarda bağırsakmikrobiyotasının rolü. Psikiyatride güncel yaklaşımlar,2015, 7.4: 461-472
20.Ak Recep, Üstündağ Sedat. Kronik böbrekhastalarında kognitif fonksiyonların değerlendirilmesi.Trakya Üniversitesi. Yayınlanmamış uzmanlık tezi.2012.

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Details

Primary Language	English
Subjects	Health Care Administration
Journal Section	Medical Science Research Articles
Authors	Duygu Felek 0000-0002-7689-4552
Publication Date	March 31, 2023
Acceptance Date	March 26, 2023
Published in Issue	Year 2023 Volume: 45 Issue: 1

Cite

AMA	Felek D. Evaluation of Cognitive Functions of Patients with Anemia. CMJ. March 2023;45(1):62-65. doi:10.7197/cmj.1223208

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