The predictive role of CA- 125 value in early stage endometrioid endometrial cancer

Begüm Kurt; İrem Küçükyıldız; Ali Yanık

doi:10.7197/cmj.1299893

Research Article

Year 2023, Volume: 45 Issue: 2, 31 - 37, 30.06.2023

Begüm Kurt , İrem Küçükyıldız , Ali Yanık

https://doi.org/10.7197/cmj.1299893

Cited By: 1

Abstract

References

1. Miller KD Nogueira L Mariotto AB Rowland JH Yabroff KR Cancer treatment and survival statistics 2019. CA:A Cancer Journal for Clinicians . 2019; 69:363–385.
2. Pearson-Stuttard J, Zhou B, Kontis V, Bentham J, Gunter MJ, Ezzati M. Worldwide cancer burden attributable to diabetes and high body mass index: a comparative risk assessment. Lancet Diabetes Endocrinol. 2018; 6:e6–e15.
3 Reijnen, C., Visser, N. C., Kasius, J. C., Boll, D., Geomini, P. M., Ngo, H., Van Hamont, D., Pijlman, B. M., Vos, M. C., Bulten, J., Snijders, M. P., Massuger, L. F., & Pijnenborg, J. M. (2019). Improved preoperative risk stratification with CA-125 in low-grade endometrial cancer: a multicenter prospective cohort study. Journal of gynecologic oncology, 30(5), e70. https://doi.org/10.3802/jgo.2019.30.e70
4. Pinar Cilesiz Goksedef, B., Gorgen, H., Baran, S. Y., Api, M., & Cetin, A. (2011). Preoperative serum CA 125 level as a predictor for metastasis and survival in endometrioid endometrial cancer. Journal of obstetrics and gynaecology Canada: JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC, 33(8), 844–850. https://doi.org/10.1016/S1701-2163(16)34988-X
5. Preoperative evaluation of Soper JT Berchuck A Olt GJ Soisson AP Clarke-Pearson DL Bast RC Serum CA 125. American Journal of Obstetrics & Gynecology. 1990; 163 :1204–1209. [ PubMed ] [ Google Scholar ] 6. Chao A Tang YH Lai. CH Chang Chang SC The potential for age-stratified CA125 cutoff to improve the prognostic classification of patients with endometrial cancer. Gynecological Oncology. 2013; 129 :500–504. [ PubMed ] [ Google Scholar ]
7. Patsner B Yim GW Estimated value of preoperative serum CA-125 levels in patients with uterine cancer: Asian experience 2000 to 2012. Science of Obstetrics and Gynecology. 2013; 56 :281–281. [ PMC free article ] [ PubMed ] [ Google Scholar ]
8. Chen YL Huang CY Chien TY Huang SH Wu Ho C Value of preoperative serum CA125 level for prognosis prediction in patients with endometrial cancer. Australian and New Zealand Journal of Obstetrics and Gynecology. 2011; 51 :397-402. [ PubMed ] [ Google Scholar ]
9. Ebina Y Sakuragi N Hareyama H Todo Y Nomura E Serum CA 125 levels in endometrial carcinoma and para-aortic lymph node metastasis in relation to nuclear grade. Acta Obstetricia et Gynecologica Scandinavica. 2002; 81 :458–465. [ PubMed ] [ Google Scholar ]
10. Modarres-Gilani M Vaezi M Shariat M Zamani N Nourizadeh R. The prognostic role of preoperative serum CA125 levels in patients with advanced endometrial carcinoma. Cancer Biomarkers. 2017; 20 :135–141. [ PubMed ] [ Google Scholar ]
11. Colombo N, Creutzberg C, Amant F, Bosse T, González-Martín A, Ledermann J. ESMO-ESGO-ESTRO consensus conference on endometrial cancer: diagnosis, treatment and follow-up. Radioter Oncol. 2015; 117 :559-581.
12. Alcazar JL, Dominguez-Piriz J, Juez L, Caparros M, Jurado M. Intraoperative gross examination and intraoperative frozen section in patients with endometrial cancer for detection of deep myometrial invasion: a systematic review and meta-analysis. Int J Gynecol Cancer. 2016; 26 :407–415.
13. Creasman, W. (2009), Revised FIGO staging for carcinoma of the endometrium. International Journal of Gynecology & Obstetrics, 105: 109-109. https://doi.org/10.1016/j.ijgo.2009.02.010
14. International Agency for Reseach on Cancer, GLOBOCAN 2008 v, IARC, European age-standardised rates calculated by the Statistical Information Team at Cancer Research UK, 2011.
15.Beesley VL, Rowlands IJ, Hayes SC, Janda M, O’Rourke P, Marquart L. Incidence, risk factors and estimates of a woman’s risk of developing secondary lower limb lymphedema and lymphedema-specific supportive care needs in women treated for endometrial cancer. Gynecol Oncol. 2015;136:87–93.
16.Salani R, Preston MM, Hade EM, Johns J, Fowler JM, Paskett EP. Swelling among women who need education about leg lymphedema: a descriptive study of lymphedema in women undergoing surgery for endometrial cancer. Int J Gynecol Cancer. 2014;24:1507–12.
17. Bağcı, M., Gülhan, İ., M., Saygılı, U., & Demir, N. (2005). The Diagnostic Accuracy Of Magnetic Resonance Imaging In The Prediction Of Myometrial Invasion And Correlation Between Serum Ca - 125 Level And Myometrial Invasion In Endometrial Cancer. J Clin Obstet Gynecol, 15(6), 296-303.
18. Atguden Z, Yildiz A, Aksut H, Yalcin SE, Yalcin Y, Uysal D, Yetimalar H. The Value of Preoperative CA 125 Levels in Prediction of Myometrial Invasion in Patients with Early-stage Endometrioid- type Endometrial Cancer. Asian Pac J Cancer Prev. 2016;17(2):497-501. doi: 10.7314/apjcp.2016.17.2.497. PMID: 26925634.
19. Hsieh CH, Chang Chien CC, Lin H. Can a preoperative CA-125 level he a criterion for full pelviclymphadenectomy in surgical staging of endometrial cancer’? Gynecol Oncol 2002: 86: 28-33.
20. Dotters D. Preoperative Ca-125 in endometrial cancer: is it useful. Am J Obstet Gynecol 2000; 182: 1328-35.
21. Jiang T Huang L Zhang S. Preoperative serum CA125: a useful marker for surgical treatment of endometrial cancer. BMC Cancer. 2015; 15 :396–396. [ PMC free article ] [ PubMed ] [ Google Scholar ]
22. Kim HS Park CY Lee JM Lee JK Evaluation of serum CA-125 levels for preoperative counseling in endometrioid endometrial cancer: A multicenter study. Gynecological Oncology. 2010; 118 :283-288. [ PubMed ] [ Google Scholar ]
23. Unsal M., Kimyon Comert G., Karalok A., Baaran D., Turkmen O. Preoperative serum CA125 can predict lymph node metastasis in endometrioid type endometrial cancer. Ginecologia Polska. 2018; 89 :599–606.
24. Zhong, W., Zhou, C., Chen, L., Wang, Z., Lin, H., Wu, K., & Zhang, S. (2021). The Coefficient of Variation of Red Blood Cell Distribution Width Combined with Cancer Antigen 125 Predicts Postoperative Overall Survival in Endometrial Cancer. International journal of general medicine, 14, 5903–5910. https://doi.org/10.2147/IJGM.S323136.
25. Yilmaz Baran Ş, Alemdaroğlu S, Doğan Durdağ G, Yüksel Şimşek S, Bolat F, Köse F, Çelik H. What is the predictive value of preoperative CA 125 level on the survival rate of type 1 endometrial cancer? Turk J Med Sci. 2021 Feb 26;51(1):335-341. doi: 10.3906/sag-2005-331. PMID: 32979897; PMCID: PMC7991883.

The predictive role of CA- 125 value in early stage endometrioid endometrial cancer

Year 2023, Volume: 45 Issue: 2, 31 - 37, 30.06.2023

Begüm Kurt , İrem Küçükyıldız , Ali Yanık

https://doi.org/10.7197/cmj.1299893

Cited By: 1

Abstract

Objective: We aimed to evaluate the prognostic role of preoperative serum cancer antigen 125 (CA-125) in endometrioid endometrial cancer for determining the cut-off values for clinicopathological factors.
Study design: 161 patients were included in the study. The inclusion criteria were histopathological confirmation of endometrioid endometrial cancer and patients with CA-125 levels measured at most ten days before surgery. The association between CA-125 value and clinicopathological variables were analyzed. Receiver operating characteristic curve statistical tests with clinicopathological factors were used to determine the cut-off values and the prognostic role of CA-125.
Results: The median value of CA-125 level was 15.4 (3, 2-577) IU/L. These CA-125 cut-off values ranged from 14.30 to 18.67 IU/L (sensitivity 53%– 100%, specificity 30%–59%). The statistical analysis showed a significant relation between CA-125 value and stage and pelvic-paraaortic lymph nodes metastasis. The average life expectancy of patients with CA-125 ≥15.4 was 102.8±5.9 months, whereas that of patients with CA-125 <15.4 was 120.1±3.4 months.
Conclusion: Serum CA-125 levels with endometrioid endometrial cancer are related to the stage of the disease. Lower cut-off values compared to the traditional 35 IU/ml value used in ovarian cancer can be a prognostic factor in patients with endometrioid endometrial cancer.

Keywords

CA-125 antigen , cut-off value , endometrial carcinoma , prognosis , ; survival

References

1. Miller KD Nogueira L Mariotto AB Rowland JH Yabroff KR Cancer treatment and survival statistics 2019. CA:A Cancer Journal for Clinicians . 2019; 69:363–385.
2. Pearson-Stuttard J, Zhou B, Kontis V, Bentham J, Gunter MJ, Ezzati M. Worldwide cancer burden attributable to diabetes and high body mass index: a comparative risk assessment. Lancet Diabetes Endocrinol. 2018; 6:e6–e15.
3 Reijnen, C., Visser, N. C., Kasius, J. C., Boll, D., Geomini, P. M., Ngo, H., Van Hamont, D., Pijlman, B. M., Vos, M. C., Bulten, J., Snijders, M. P., Massuger, L. F., & Pijnenborg, J. M. (2019). Improved preoperative risk stratification with CA-125 in low-grade endometrial cancer: a multicenter prospective cohort study. Journal of gynecologic oncology, 30(5), e70. https://doi.org/10.3802/jgo.2019.30.e70
4. Pinar Cilesiz Goksedef, B., Gorgen, H., Baran, S. Y., Api, M., & Cetin, A. (2011). Preoperative serum CA 125 level as a predictor for metastasis and survival in endometrioid endometrial cancer. Journal of obstetrics and gynaecology Canada: JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC, 33(8), 844–850. https://doi.org/10.1016/S1701-2163(16)34988-X
5. Preoperative evaluation of Soper JT Berchuck A Olt GJ Soisson AP Clarke-Pearson DL Bast RC Serum CA 125. American Journal of Obstetrics & Gynecology. 1990; 163 :1204–1209. [ PubMed ] [ Google Scholar ] 6. Chao A Tang YH Lai. CH Chang Chang SC The potential for age-stratified CA125 cutoff to improve the prognostic classification of patients with endometrial cancer. Gynecological Oncology. 2013; 129 :500–504. [ PubMed ] [ Google Scholar ]
7. Patsner B Yim GW Estimated value of preoperative serum CA-125 levels in patients with uterine cancer: Asian experience 2000 to 2012. Science of Obstetrics and Gynecology. 2013; 56 :281–281. [ PMC free article ] [ PubMed ] [ Google Scholar ]
8. Chen YL Huang CY Chien TY Huang SH Wu Ho C Value of preoperative serum CA125 level for prognosis prediction in patients with endometrial cancer. Australian and New Zealand Journal of Obstetrics and Gynecology. 2011; 51 :397-402. [ PubMed ] [ Google Scholar ]
9. Ebina Y Sakuragi N Hareyama H Todo Y Nomura E Serum CA 125 levels in endometrial carcinoma and para-aortic lymph node metastasis in relation to nuclear grade. Acta Obstetricia et Gynecologica Scandinavica. 2002; 81 :458–465. [ PubMed ] [ Google Scholar ]
10. Modarres-Gilani M Vaezi M Shariat M Zamani N Nourizadeh R. The prognostic role of preoperative serum CA125 levels in patients with advanced endometrial carcinoma. Cancer Biomarkers. 2017; 20 :135–141. [ PubMed ] [ Google Scholar ]
11. Colombo N, Creutzberg C, Amant F, Bosse T, González-Martín A, Ledermann J. ESMO-ESGO-ESTRO consensus conference on endometrial cancer: diagnosis, treatment and follow-up. Radioter Oncol. 2015; 117 :559-581.
12. Alcazar JL, Dominguez-Piriz J, Juez L, Caparros M, Jurado M. Intraoperative gross examination and intraoperative frozen section in patients with endometrial cancer for detection of deep myometrial invasion: a systematic review and meta-analysis. Int J Gynecol Cancer. 2016; 26 :407–415.
13. Creasman, W. (2009), Revised FIGO staging for carcinoma of the endometrium. International Journal of Gynecology & Obstetrics, 105: 109-109. https://doi.org/10.1016/j.ijgo.2009.02.010
14. International Agency for Reseach on Cancer, GLOBOCAN 2008 v, IARC, European age-standardised rates calculated by the Statistical Information Team at Cancer Research UK, 2011.
15.Beesley VL, Rowlands IJ, Hayes SC, Janda M, O’Rourke P, Marquart L. Incidence, risk factors and estimates of a woman’s risk of developing secondary lower limb lymphedema and lymphedema-specific supportive care needs in women treated for endometrial cancer. Gynecol Oncol. 2015;136:87–93.
16.Salani R, Preston MM, Hade EM, Johns J, Fowler JM, Paskett EP. Swelling among women who need education about leg lymphedema: a descriptive study of lymphedema in women undergoing surgery for endometrial cancer. Int J Gynecol Cancer. 2014;24:1507–12.
17. Bağcı, M., Gülhan, İ., M., Saygılı, U., & Demir, N. (2005). The Diagnostic Accuracy Of Magnetic Resonance Imaging In The Prediction Of Myometrial Invasion And Correlation Between Serum Ca - 125 Level And Myometrial Invasion In Endometrial Cancer. J Clin Obstet Gynecol, 15(6), 296-303.
18. Atguden Z, Yildiz A, Aksut H, Yalcin SE, Yalcin Y, Uysal D, Yetimalar H. The Value of Preoperative CA 125 Levels in Prediction of Myometrial Invasion in Patients with Early-stage Endometrioid- type Endometrial Cancer. Asian Pac J Cancer Prev. 2016;17(2):497-501. doi: 10.7314/apjcp.2016.17.2.497. PMID: 26925634.
19. Hsieh CH, Chang Chien CC, Lin H. Can a preoperative CA-125 level he a criterion for full pelviclymphadenectomy in surgical staging of endometrial cancer’? Gynecol Oncol 2002: 86: 28-33.
20. Dotters D. Preoperative Ca-125 in endometrial cancer: is it useful. Am J Obstet Gynecol 2000; 182: 1328-35.
21. Jiang T Huang L Zhang S. Preoperative serum CA125: a useful marker for surgical treatment of endometrial cancer. BMC Cancer. 2015; 15 :396–396. [ PMC free article ] [ PubMed ] [ Google Scholar ]
22. Kim HS Park CY Lee JM Lee JK Evaluation of serum CA-125 levels for preoperative counseling in endometrioid endometrial cancer: A multicenter study. Gynecological Oncology. 2010; 118 :283-288. [ PubMed ] [ Google Scholar ]
23. Unsal M., Kimyon Comert G., Karalok A., Baaran D., Turkmen O. Preoperative serum CA125 can predict lymph node metastasis in endometrioid type endometrial cancer. Ginecologia Polska. 2018; 89 :599–606.
24. Zhong, W., Zhou, C., Chen, L., Wang, Z., Lin, H., Wu, K., & Zhang, S. (2021). The Coefficient of Variation of Red Blood Cell Distribution Width Combined with Cancer Antigen 125 Predicts Postoperative Overall Survival in Endometrial Cancer. International journal of general medicine, 14, 5903–5910. https://doi.org/10.2147/IJGM.S323136.
25. Yilmaz Baran Ş, Alemdaroğlu S, Doğan Durdağ G, Yüksel Şimşek S, Bolat F, Köse F, Çelik H. What is the predictive value of preoperative CA 125 level on the survival rate of type 1 endometrial cancer? Turk J Med Sci. 2021 Feb 26;51(1):335-341. doi: 10.3906/sag-2005-331. PMID: 32979897; PMCID: PMC7991883.

There are 24 citations in total.

Details

Primary Language	English
Subjects	Health Care Administration
Journal Section	Surgical Science Research Articles
Authors	Begüm Kurt 0000-0002-7166-3130 İrem Küçükyıldız 0000-0002-6604-0713 Ali Yanık 0000-0001-9634-2117
Early Pub Date	June 30, 2023
Publication Date	June 30, 2023
Acceptance Date	June 24, 2023
Published in Issue	Year 2023 Volume: 45 Issue: 2

Cite

AMA	Kurt B, Küçükyıldız İ, Yanık A. The predictive role of CA- 125 value in early stage endometrioid endometrial cancer. CMJ. June 2023;45(2):31-37. doi:10.7197/cmj.1299893

Cited By

The role of preoperative serum CA-125 levels in predicting lymph node metastasis in patients undergoing treatment for endometrial cancer

Journal of Health Sciences and Medicine

https://doi.org/10.32322/jhsm.1403151

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