Evaluation of QT Interval of Patients Using Muscle Relaxants Under General Anesthesia, Randomized Clinical Trial

Bekir Kurt; Oğuz Gündoğdu; Onur Avcı; Sinan Gürsoy; İclal Özdemir Kol; Kenan Kaygusuz; Cemil İsbir

doi:10.7197/cmj.1056331

EN

Evaluation of QT Interval of Patients Using Muscle Relaxants Under General Anesthesia, Randomized Clinical Trial

Abstract

Objective: The aim of the study was to investigate the effects of rocuronium, mivacurium, and atracurium on arrhythmia markers, QT interval, and QT dispersion (QTd).
Method: Ninety patients scheduled for septorhinoplasty were randomly assigned to one of three groups of 30. During the induction of anesthesia, muscle relaxants of 0.6 mg/kg rocuronium in Group R, 0.2 mg/kg mivacurium in Group M, and 0.5 mg/kg atracurium in Group A were employed. Mean blood pressure (MAP), heart rate (HR), and electrocardiogram (ECG) values were measured before induction of anesthesia (T0), immediately after induction of anesthesia (T1), at 1 minute (T2), 5 minutes (T3), 10 minutes (T4) and 15 minutes (T5) after muscle relaxant administration, and QT, corrected QT (QTc), QTd and corrected QTd (QTcd) intervals were recorded.
Results: When the groups were compared in terms of QTcd values, the difference between mivacurium and atracurium was significant in terms of T5 values, and atracurium (T5) QTcd was found to be shorter (p<0.05). Group M had 5 of the 6 measures with pathological QTc prolongation.
Conclusions: Because the prevalence of pathological QTc is greater in mivacurium, further clinical trials should be conducted to challenge the use of mivacurium in individuals with a long QT interval.

Keywords

References

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Details

Primary Language

English

Subjects

Health Care Administration

Journal Section

Research Article

Authors

Bekir Kurt
0000-0003-4002-9732
Türkiye

Oğuz Gündoğdu ^*
0000-0002-8864-0015
Türkiye

Onur Avcı
0000-0003-0743-754X
Türkiye

Sinan Gürsoy
0000-0003-0259-9750
Türkiye

İclal Özdemir Kol
0000-0001-8247-440X
Türkiye

Kenan Kaygusuz
0000-0002-0745-4633
Türkiye

Cemil İsbir
0000-0003-4094-7584
Türkiye

Publication Date

March 30, 2022

Submission Date

January 11, 2022

Acceptance Date

March 21, 2022

Published in Issue

Year 2022 Volume: 44 Number: 1

DOI

https://doi.org/10.7197/cmj.1056331

IZ

https://izlik.org/JA72EW98LD

Cite

RIS / Bibtex

AMA

1.Kurt B, Gündoğdu O, Avcı O, et al. Evaluation of QT Interval of Patients Using Muscle Relaxants Under General Anesthesia, Randomized Clinical Trial. CMJ. 2022;44(1):80-86. doi:10.7197/cmj.1056331