Antagonism Between Antibiotics Frequently Used in The Treatment of Staphylococcus aureus Infections and The Hypertensive Drug L-Captopril

Rukiye Aslan; Ayşe Hümeyra Taşkın Kafa

doi:10.7197/cmj.1064847

EN

Antagonism Between Antibiotics Frequently Used in The Treatment of Staphylococcus aureus Infections and The Hypertensive Drug L-Captopril

Abstract

Objective: Captopril is a long-acting human angiotensin-converting enzyme (ACE) inhibitor that has been used to treat hypertension and heart failure for many years. In this study, it was aimed to determine the antimicrobial activity of L-captopril on Methicillin-Resistant Staphylococcus aureus MRSA and Methicillin-Sensitive Staphylococcus aureus (MSSA) clinical isolates and, demonstrate the combination activity of captopril with ciprofloxacin (CXP) and gentamicin (GEN), which are among antistaphylococcal chemical agents.
Method: The minimum inhibitor concentration (MIC) and minimum bactericidal concentration (MBC) were determined using the microdilution technique in 96-well microtiter plates. The activity of L-captopril and CXP or GEN combination against MRSA and MSSA clinical isolates was determined by the micro-broth checkerboard assay method.
Results: The captopril MIC value was determined to be 2.5 mg/ml in all bacteria strains tested. The captopril/CXP combination had an indifferent effect in the other strains tested except for one MRSA isolate. The captopril/GEN combination had an antagonistic effect in all strains studied and increased the MIC 2-4 fold. The captopril/GEN combination was found to reduce the bactericidal activity of gentamicin.
Conclusions: The study results suggest that exposure to these drugs may lead to multidrug resistance in S. aureus bacteria. Especially in the hypertensive patient group, the induced resistance in any S. aureus infections should be taken into consideration while using captopril and, it should be considered that this antagonism may cause an increase in S. aureus infections.

Keywords

References

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Details

Primary Language

English

Subjects

Health Care Administration

Journal Section

Research Article

Authors

Rukiye Aslan ^*
0000-0001-5843-626X
Türkiye

Ayşe Hümeyra Taşkın Kafa
0000-0002-7282-4928
Türkiye

Publication Date

March 30, 2022

Submission Date

January 29, 2022

Acceptance Date

March 8, 2022

Published in Issue

Year 1970 Volume: 44 Number: 1

DOI

https://doi.org/10.7197/cmj.1064847

IZ

https://izlik.org/JA67KF46RJ

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RIS / Bibtex

AMA

1.Aslan R, Taşkın Kafa AH. Antagonism Between Antibiotics Frequently Used in The Treatment of Staphylococcus aureus Infections and The Hypertensive Drug L-Captopril. CMJ. 2022;44(1):17-21. doi:10.7197/cmj.1064847

Öz

Antagonism Between Antibiotics Frequently Used in The Treatment of Staphylococcus aureus Infections and The Hypertensive Drug L-Captopril

Abstract

Keywords

References

Details

Primary Language

Subjects

Journal Section

Authors

Publication Date

Submission Date

Acceptance Date

Published in Issue

DOI

IZ

Cite