Is the serum uric acid (SUA) level and SUA/serum creatinine (Scr) ratio a predictive biomarker for microalbuminuria in patients with diabetes mellitus?

Mercan Taştemur; Çağla Özdemir

doi:10.7197/cmj.1346682

EN

Is the serum uric acid (SUA) level and SUA/serum creatinine (Scr) ratio a predictive biomarker for microalbuminuria in patients with diabetes mellitus?

Abstract

Background: The pathogenesis of diabetic nephropathy (DN) is very complex and is still not well understood. SUA has been associated with metabolic risk in a wide range of diseases. In this study, we aimed to investigate the effect of SUA and SUA/Scr ratio on renal function using glomerular filtration rate (GFR) and microalbuminuria. Methods: A total of 399 patients with diabetes alone, excluding other conditions that affect uric acid levels, were included in the study. Patients were divided into normoalbuminuria (n:247) and microalbuminuria (n:152) groups. SUA, SUA/Scr ratios were compared. Results: Female gender was 53.4% in the normoalbuminuria group and 57.9% in the microalbuminuria group. There was no significant difference in gender between the groups. In the microalbuminuria group, SUA (p=0.032), glucose (p<0.001), GGT (p=0.003), HBA1C (p<0.001), and triglycerides (p<0.001) were significantly higher, while eGFR (p<0.005), HDL (p<0.001), and vitamin D (p=0.017) were significantly lower. There was a significant negative correlation between eGFR and SUA (p<0.001) and albuminuria (p=0.004) and a significant positive correlation between eGFR and SUA/Scr ratio (p<0.001). Conclusion: Serum uric acid (SUA) levels have been found to be associated with renal function in diabetes. Our study confirms this association. The metabolic and microvascular effects of SUA are widely recognized. Nevertheless, further evidence is required to clarify the relationship between SUA/Scr ratio, which accounts for renal function, and DN.

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References

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Details

Primary Language

English

Subjects

Multimorbidity

Journal Section

Research Article

Authors

Mercan Taştemur ^*
0000-0003-0320-4095
Türkiye

Çağla Özdemir
0000-0002-9766-1918
Türkiye

Publication Date

September 30, 2023

Submission Date

August 20, 2023

Acceptance Date

September 26, 2023

Published in Issue

Year 2023 Volume: 45 Number: 3

DOI

https://doi.org/10.7197/cmj.1346682

IZ

https://izlik.org/JA97CM26SE

Cite

RIS / Bibtex

AMA

1.Taştemur M, Özdemir Ç. Is the serum uric acid (SUA) level and SUA/serum creatinine (Scr) ratio a predictive biomarker for microalbuminuria in patients with diabetes mellitus? CMJ. 2023;45(3):57-63. doi:10.7197/cmj.1346682