Evaluation of Antibody Response After COVID-19 Vaccination in Healthcare Workers: A Turkish Tertiary Hospital Experience

Fatih Çubuk; Rukiye Aslan; Mürşit Hasbek; Ayşe Hümeyra Taşkın Kafa

doi:10.7197/cmj.1382874

EN TR

Evaluation of Antibody Response After COVID-19 Vaccination in Healthcare Workers: A Turkish Tertiary Hospital Experience

Abstract

Objective: It was aimed to explore the correlation between demographic characteristics and the presence of comorbidity in the antibody response after the second dose of vaccination in healthcare workers in this study. In addition, the third and fourth dose approaches of the participants and the protection of the antibody levels formed by the two doses of vaccine against COVID-19 were examined observationally. Methods: Health workers, whose NCP and S protein antibody levels were detected on the 30th day after the second dose of the CoronaVac vaccine, were followed up in terms of being vaccinated for the third and fourth doses and having COVID-19. Results: Higher levels of S antibodies were detected in women after two doses of vaccination (p=0.001). It was pointed out that smoking has a negative effect on the antibody response after vaccination (p=0.008). People who had pre-vaccine COVID-19 had higher NCP antibody levels after two doses of vaccination (p=0.013). Of the participants, 152 (97.4%) were vaccinated with the third dose and 110 (70.5%) with the fourth dose. Conclusion: The antibody response after two doses of inactivated CoronaVac® vaccination probe is significantly higher in women, younger people, non-smokers, and people who have not been previously infected with the SARS-CoV-2.

Keywords

Sağlık Çalışanlarında COVID-19 Aşısı Sonrası Antikor Yanıtının Değerlendirilmesi: Türkiye’de Üçüncü Basamak Bir Hastane Deneyimi

Öz

Amaç: Bu çalışmada sağlık çalışanlarında ikinci doz aşılama sonrası antikor yanıtında komorbidite varlığı ile demografik özellikler arasındaki ilişkinin araştırılması amaçlanmıştır. Ayrıca katılımcıların üçüncü ve dördüncü doz yaklaşımları ile iki doz aşının COVID-19'a karşı oluşturduğu antikor düzeylerinin koruyuculuğu gözlemsel olarak incelenmiştir. Yöntem: CoronaVac aşısının ikinci dozundan sonraki 30. günde NCP ve S protein antikor düzeyleri saptanan sağlık çalışanları, üçüncü ve dördüncü doz aşılarını yaptırmaları ve COVID-19'a sahip olmaları açısından takibe alınmıştır. Bulgular: İki doz aşılamadan sonra kadınlarda daha yüksek S antikorları saptanmıştır (p=0.001). Sigaranın aşılama sonrası antikor cevabını olumsuz etkilediğine dikkat çekilmiştir (p=0,008). Aşı öncesi COVID-19 enfeksiyonu olan kişilerin, iki doz aşılamadan sonra daha yüksek NCP antikor seviyelerine sahipolduğu belirlendi (p=0.013). Katılımcıların 152'si (%97,4) üçüncü doz, 110'u (%70,5) dördüncü doz ile aşılanmştır. Sonuç: İki doz inaktif CoronaVac® aşılama probu sonrası antikor yanıtı, kadınlarda, gençlerde, sigara içmeyenlerde ve daha önce SARS-CoV-2 ile enfekte olmamış kişilerde anlamlı olarak daha yüksektir.

Anahtar Kelimeler

Ethical Statement

The study protocol was approved by the Sivas Cumhuriyet University Clinical Research Ethics Committee (Date: 21.12.2020, Decision number: 12/03). Each stage of the research was performed per the ethical standards specified in the 1964 Declaration of Helsinki and its later amendments.

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Details

Primary Language

English

Subjects

Health Services and Systems (Other)

Journal Section

Research Article

Authors

Fatih Çubuk
0000-0002-8976-7691
Türkiye

Rukiye Aslan ^*
0000-0001-5843-626X
Türkiye

Mürşit Hasbek
0000-0002-5217-8607
Türkiye

Ayşe Hümeyra Taşkın Kafa
0000-0002-7282-4928
Türkiye

Publication Date

March 29, 2024

Submission Date

October 29, 2023

Acceptance Date

March 20, 2024

Published in Issue

Year 2024 Volume: 46 Number: 1

DOI

https://doi.org/10.7197/cmj.1382874

IZ

https://izlik.org/JA69HZ82RC

Cite

RIS / Bibtex

AMA

1.Çubuk F, Aslan R, Hasbek M, Taşkın Kafa AH. Evaluation of Antibody Response After COVID-19 Vaccination in Healthcare Workers: A Turkish Tertiary Hospital Experience. CMJ. 2024;46(1):23-28. doi:10.7197/cmj.1382874