Case Report

Two cases of dermatomyositis with anti-cN1A antibody positivity

Volume: 47 Number: 1 March 29, 2025
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Cumhuriyet Medical Journal
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Two cases of dermatomyositis with anti-cN1A antibody positivity

Abstract

Idiopathic inflammatory myopathies (IIMs) are a heterogeneous group of autoimmune-mediated disorders. One of the most important developments in recent years regarding IIMs is the clinical use of myositis-specific antibodies and myositis-associated antibodies. The identification of anti-cytosolic 5’-nucleotidase 1A (anti-cN1A), one of the myositis-associated antibodies, represents significant progress in understanding inclusion body myositis (IBM), with research focusing on its role in predicting survival, diagnostic potential, clinical phenotype, and histopathological correlations. With the increasing use of autoantibodies in recent years, it is essential to understand their specificity and sensitivity properties. We presented two cases of dermatomyositis with positive anti-cN1A antibodies, which are known to have high specificity in IBM. One of the cases is a male patient, and IBM was included in the differential diagnosis because of anti-cN1A antibody positivity and resistance to first-line immunosuppressive therapy. The other case is a female patient diagnosed with dermatomyositis twelve years ago, with a myositis antibodies panel performed during a disease flare revealing anti-cN1A antibody positivity.

Keywords

References

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Details

Primary Language

English

Subjects

Health Services and Systems (Other)

Journal Section

Case Report

Authors

Early Pub Date

March 29, 2025

Publication Date

March 29, 2025

Submission Date

October 26, 2024

Acceptance Date

March 8, 2025

Published in Issue

Year 2025 Volume: 47 Number: 1

DOI

https://doi.org/10.7197/cmj.1552096

IZ

https://izlik.org/JA62PZ72JD

Cite

RIS / Bibtex
AMA
1.Tay K, Toker Dinçer Z, Parlar K, Ünverengil G, Uğurlu S. Two cases of dermatomyositis with anti-cN1A antibody positivity. CMJ. 2025;47(1):55-58. doi:10.7197/cmj.1552096