Special types of breast cancer: Clinical, Histological Features and Survival Outcomes

Eda Erdiş; Mukaddes Yılmaz; Mahmut Uçar; Necla Demir; Celal Alandağ; Birsen Yücel

doi:10.7197/cmj.1568420

EN TR

Special types of breast cancer: Clinical, Histological Features and Survival Outcomes

Abstract

Purpose: In this study, we investigated the clinical characteristics and survival outcomes of patients diagnosed with special types of breast cancer who presented to our clinic. Material and Methods: The demographic, clinicopathological, and survival characteristics of all rare, histologically special subtype breast cancer patients who applied to Cumhuriyet University Oncology Center between 2010 and 2020 were retrospectively reviewed. Results: The records of 1198 patients with invasive breast cancer were examined, and 104 of them (8%) were identified as having other histological special subtypes. Of these, 19 (8%) had apocrine cancer, 19 (8%) had mucinous type, 17 (7%) had invasive cribriform, 15 (6%) had invasive papillary, 11 (4%) had metaplastic type, 9 (4%) had invasive micropapillary, 6 (2%) had neuroendocrine, 3 (1%) had tubular type, 3 (1%) had microinvasive type, and 2 (1%) had undifferentiated carcinoma. The majority of these patients, 102 (98%), were female, with a median age of 52 years (range 26-82). Of the women, 60 (59%) were postmenopausal, and 42 (41%) were premenopausal. The ECOG Performance Score (PS) was 0 in 79 (76%) patients, 1 in 17 (16%) patients, and 2 in 8 (8%) patients. Upon evaluation, 50 patients (48%) had comorbid conditions, and 26 patients (25%) had a family history of breast cancer. At diagnosis, 25 patients (24%) were stage I, 50 (48%) were stage II, 26 (25%) were stage III, and 3 (3%) were stage IV. Histopathologically, 75 patients (72%) were estrogen receptor (ER)-positive, 69 (66%) were progesterone receptor (PR)-positive, and 26 (25%) were HER2-positive. An intraductal component was detected in 54 (60%) patients, and multicentricity was observed in 15 (16%) patients. A modified radical mastectomy was performed on 56 (54%) patients, while breast-conserving surgery was performed on 45 (43%) patients. Adjuvant chemotherapy was administered to 76 (73%) patients, hormonal therapy to 73 (70%), and radiotherapy to 72 (68%). The median follow-up period was 54 months (range 1-201). During follow-up, metastasis was detected in 13 patients (13%), and recurrence was detected in 7 patients (7%). The 5-year and 10-year overall survival rates were 86% and 77%, respectively, while the 5-year and 10-year event-free survival rates were 79% and 70%, respectively. Conclusion: In our study, the majority of patients with special type breast carcinoma were non-metastatic, and histopathologically, they were hormone receptor-positive with low grade. There was no statistically significant difference in 5-year and 10-year overall survival or event-free survival among the special types.

Keywords

Özel Tip Meme Karsinomları: Klinik, Histolojik Özellikleri ve Sağkalım Sonuçları

Öz

Amaç: Bu çalışmada kliniğimize başvuran özel tip meme kanseri tanılı hastaların klinik özelliklerini ve sağkalım sonuçlarını araştırdık. Materyal-Metod: Cumhuriyet Üniversitesi Onkoloji Merkezi’ne 2010-2020 yılları arasında başvuran meme kanserli tüm nadir, histolojik olarak özel alt tip hastalarının demografik, klinikopatolojik ve sağkalım özellikleri retrospektif olarak incelenmiştir. Bulgular: Çalışmada 1198 invaziv meme kanserli hastaların dosyaları incelenmiş ve bunlardan 104’ünün (8%) diğer histolojik özel alt tipinde olduğu tespit edilmiştir. Apokrin kanser 19 (8%), musinöz tip 19 (8%), invaziv kribriform 17 (%7), invaziv papiller 15 (%6), metaplastik tip 11 (%4), invaziv mikropapiller 9 (%4), nöroendokrin 6 (%2), tubuler tip 3 (%1), mikroinvaziv 3 (%1), undifferansiye 2 (%1) hastada saptanmıştır. Bu hastaların büyük bir kısmı 102 (98%)’ si kadın olup median yaşı 52 (26-82) bulunmuştur. Kadınların 60 (%59)’u postmenopozal, 42 (41%)’isi de premenopozaldir. 79 (76%) hastanın ECOG Performans skoru (PS) 0, 17 (16%)’sinin ECOG PS 1, 8 (8%)’inin ECOG PS 2 olarak izlenmiştir. Hastalar sorgulandığında 50’sinde (48%) komorbid hastalıklar olduğu, 26’sinde (25%) ailede meme kanseri öyküsü olduğu görülmüştür. Tanıda 25 (24%) hastanın evre I, 50 (48%) hastanın evre II ve 26 (25%) hastanın evre III, 3 (%3) hastanın evre IV olduğu tespit edilmiştir. Histopatolojik değerlendirmelere göre hastaların 75’inde (72%) estrogen reseptörü (ER) pozitif, 69’ünde (66%) progesterone reseptörü (PR) pozitif, 26’sında (25%) HER2-pozitif olarak bulunmuştur. İntraduktal component 54 (60%) hastada tespit edilmiştir. Multisentrisite 15 (16%) hastada izlenmiştir. 56 (54%) hastaya modifiye radikal mastektomi, 45 (43%) hastaya meme koruyucu cerrahi uygulanmıştır. 76 (73%) hastaya adjuvant kemoterapi, 73 (70%) hastaya hormonterapi ve 72 (68%) hastaya radyoterapi verilmiştir. Medyan takip 54 (1-201) ay olup takipte 13 (13%) hastada metastaz, 7 (7%) hastada nüks tespit edilmiş. Hastaların 5 ve 10 yıllık overall survival sırasıyla 86% ve 77% olup, 5 ve 10 yıllık event-free survival sırasıyla %79 ve %70 olarak bulunmuştur. Sonuç: Çalışmamızda özel tip meme karsinomlu hastaların tamamına yakını nonmetastatik olup histopatolojik olarak hormon reseptörü pozitif ve düşük gradelidir. Özel tipler arasında, 5 ve 10 yıllık overall survival/ event-free survival istatistiki olarak anlamlı bulunmamıştır.

Anahtar Kelimeler

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Details

Primary Language

English

Subjects

Multimorbidity

Journal Section

Research Article

Authors

Eda Erdiş ^*
0000-0003-3003-8643
Türkiye

Mukaddes Yılmaz
0000-0002-7927-8480
Türkiye

Mahmut Uçar
0000-0002-3311-6152
Türkiye

Necla Demir
0000-0002-9722-3459
Türkiye

Celal Alandağ
0000-0002-2589-8174
Türkiye

Birsen Yücel
0000-0002-0083-6866
Türkiye

Publication Date

December 31, 2024

Submission Date

October 16, 2024

Acceptance Date

November 8, 2024

Published in Issue

Year 2024 Volume: 46 Number: 4

DOI

https://doi.org/10.7197/cmj.1568420

IZ

https://izlik.org/JA68MN29RL

Cite

RIS / Bibtex

AMA

1.Erdiş E, Yılmaz M, Uçar M, Demir N, Alandağ C, Yücel B. Special types of breast cancer: Clinical, Histological Features and Survival Outcomes. CMJ. 2024;46(4):247-252. doi:10.7197/cmj.1568420