Unveiling the Prognostic Potential of SLC2A Gene Family in Glioblastoma Multiforme Using Bioinformatics Approaches

Ayça Taş; Yavuz Siliğ

doi:10.7197/cmj.1601168

EN TR

Unveiling the Prognostic Potential of SLC2A Gene Family in Glioblastoma Multiforme Using Bioinformatics Approaches

Abstract

Objective: Glioblastomas (GBMs) are invasive and metastatic cancers with very low overall survival rates. Therefore, it is very important to propose a new biomarker for GBM diagnosis and prognosis. For this purpose, we aimed to investigate the prognostic potential of the SLC2A gene family, which has great importance in cancer, in GBM. Methods: Solute carrier 2A (SLC2A) gene family expression levels, methylation and overall survival rates were analyzed with TCGA, GEPIA and UALCAN databases. Mutations were evaluated with Kaplan-Meier Plot and UCSC Xena database. Protein-protein interactions were analyzed with String database. Results: No statistically significant mutation was detected in the SLC2A gene family. As a result of the analysis, high expression in SLC2A1 and SLC2A5 genes and decrease in SLC2A6 gene expression were found to be statistically significant. Hypermethylation was detected in the promoter regions of SLC2A1, SLC2A2, SLC2A3 and SLC2A5 genes, while hypomethylation was detected in SLC2A4 and SLC2A6 genes. The increase in SLC2A3 gene expression was associated with the overall survival rate of the patients. Conclusion: SLC2A1, SLC2A5 and SLC2A6 gene up-regulation may be a biomarker in the diagnosis of GBM, and SLC2A3 may be a marker in prognosis.

Keywords

References

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Details

Primary Language

English

Subjects

Medical Education

Journal Section

Research Article

Authors

Ayça Taş ^*
0000-0002-7132-1325
Türkiye

Yavuz Siliğ
0000-0002-0562-7457
Türkiye

Publication Date

December 31, 2024

Submission Date

December 13, 2024

Acceptance Date

December 23, 2024

Published in Issue

Year 1970 Volume: 46 Number: 4

DOI

https://doi.org/10.7197/cmj.1601168

IZ

https://izlik.org/JA44UY79YA

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RIS / Bibtex

AMA

1.Taş A, Siliğ Y. Unveiling the Prognostic Potential of SLC2A Gene Family in Glioblastoma Multiforme Using Bioinformatics Approaches. CMJ. 2024;46(4):259-269. doi:10.7197/cmj.1601168

Unveiling the Prognostic Potential of SLC2A Gene Family in Glioblastoma Multiforme Using Bioinformatics Approaches

Unveiling the Prognostic Potential of SLC2A Gene Family in Glioblastoma Multiforme Using Bioinformatics Approaches

Abstract

Keywords

Biyoinformatik Yaklaşımlar Kullanılarak Glioblastoma Multiform’ da SLC2A Gen Ailesinin Prognostik Potansiyelinin Ortaya Çıkarılması

Öz

Anahtar Kelimeler

References

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