Preoperative and Early/Late Postoperative Evaluation of Endocrine Functions of Patients who Underwent Pituitary Surgery

Kübra Ağca; Fettah Acıbucu; Şekure Demet Küçük

EN TR

Preoperative and Early/Late Postoperative Evaluation of Endocrine Functions of Patients who Underwent Pituitary Surgery

Abstract

Introduction and Aim: Pituitary masses may lead to hormonal insufficiencies due to compression or postoperatively. We evaluated preoperative and early/late postoperative endocrine functions of the patients Material and Method: In our study, a total of 103 patients were included. Patients’ preoperative endocrine functions, as well as endocrine functions during early postoperative period (first 3 months), at the postoperative year 1 and at the final visit were recorded to be analyzed. Results: Of our patients, 52.4% were male and 47.6% female, with a mean age of 46.6±13.4 years. Patients were found to have a mean tumor diameter of 2.21±1.07 cm and a mean duration of follow-up of 2.6±1.5 years. Median number of pituitary insufficiency in our patients was 1 preoperatively, 3 within first 3 postoperative months, 2 at postoperative year 1, and 2 at the final visit. DI was found preoperatively in 6.8% preoperatively, at postoperative week 2 in 77.7%, at postoperative month 3 in 54.4%, and at the final visit in 54.4% patients. Hypothyroidism was observed preoperatively in 14.6% and at the 3rd month in 59.2%. Adrenal insufficiency developed preoperatively in 12.6%, and at the 3rd month in 56.3%. Hypogonadism, however, was observed preoperatively in 35.9% and at the 3rd month visit in 65%. Discussion: We observed that rates of particularly DI and adrenal insufficiency significantly increased at the postoperative month 3 compared with the preoperative period and tended to reduce at 12th month visits. Thusly, considering eventual recovery of hormonal deficiencies, postoperative monitoring of endocrine functions is crucial for treatment management.

Keywords

Hipofiz Ameliyatı Olan Hastaların Preoperatif ve Postoperatif Erken/Geç Dönemde Endokrin Fonksiyonlarının Değerlendirilmesi

Abstract

Giriş ve Amaç: Hipofiz kitlelerinde bası bulgularına bağlı veya cerrahi sonrası hormonal yetmezlikler gelişebilir. Post-op hipofizer yetmezlik gelişen hastalarda endokrin fonksiyonlar zamanla düzelebilir. Bu hastaların endokrin fonksiyonları açısından takibi; hastanın ömür boyu replasman tedavisi almaması açısından önemlidir. Çalışmamızda kliniğimizde takip olan hastaların preoperatif ve postoperatif erken/geç dönem endokrin fonksiyonlarını değerlendirdik ve endokrinolojik değerlendirmenin önemini vurgulamayı amaçladık. Materyal ve metod: Çalışmamıza hipofiz operasyonu geçirmiş olan ve kliniğimizde takipli 18 yaş ve üzeri 103 hasta dahil edildi. Hastaların preoperatif ve postoperatif erken dönem (ilk 3 ay), postoperatif 1. yıl ve hastanın son vizitindeki endokrin fonksiyonlar kaydedildi ve analizler gerçekleştirildi. Bulgular: Hastalarımızın 54 (%52,4)’ü erkek, 49 (%47,6)’u kadındı ve yaş ortalamaları 46,6±13,4 yıl olarak belirlendi. Çalışmaya dahil edilen hastalardan 85 (%82,5)’inin hipofiz adenomu tanısı aldığı tespit edildi. Hastaların ortalama tümör çapları 2,21±1,07 cm ve takip süreleri 2,6±1,5 yıl olduğu saptandı. Hastalarda hipofiz yetmezlik sayısı medyan değerleri preoperatif dönemde 1, postoperatif ilk 3 ayda 3, postoperatif 1. yılda 2, son vizitte ise 2 olarak tespit edildi. Preoperatif dönemde 7 hastada (%6.8) DI mevcutken, postoperatif 2. haftada 80 (%77,7), postoperatif 3. ayda 56 hastada (%54.4) DI mevcuttu. Hastaların son takiplerinde ise 33 hastada (%32) DI tespit edildi. Preoperatif hastaların %14,6’sında 3. ayda %59,2’sinde hipotiroidi mevcuttu. Adrenal yetmezlik, preoperatif dönemde %12,6 olarak görülürken 3. ayda %56,3 düzeylerinde tespit edildi. Hipogonadizm ise preoperatif dönemde %35,9 oranında görülürken 3. ay kontrollerinde %65 düzeylerindeydi. Fonksiyonel ve nonfonksiyel hipofiz adenomlarında cerrahi öncesi ve sonrasında gelişen hipofizer yetmezlik oranları karşılaştırıldığında aralarında anlamlılık bulunmadı.

Keywords

References

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Details

Primary Language

English

Subjects

Health Systems

Journal Section

Research Article

Authors

Kübra Ağca ^*
0009-0002-1826-0786
Türkiye

Fettah Acıbucu
0000-0002-2252-2112
Türkiye

Şekure Demet Küçük
0000-0003-3175-1256
Türkiye

Publication Date

June 21, 2025

Submission Date

January 3, 2025

Acceptance Date

May 20, 2025

Published in Issue

Year 2025 Volume: 47 Number: 2

IZ

https://izlik.org/JA58ZP37TX

Cite

RIS / Bibtex

APA

Ağca, K., Acıbucu, F., & Küçük, Ş. D. (2025). Preoperative and Early/Late Postoperative Evaluation of Endocrine Functions of Patients who Underwent Pituitary Surgery. Cumhuriyet Medical Journal, 47(2), 10-16. https://izlik.org/JA58ZP37TX

AMA

1.Ağca K, Acıbucu F, Küçük ŞD. Preoperative and Early/Late Postoperative Evaluation of Endocrine Functions of Patients who Underwent Pituitary Surgery. CMJ. 2025;47(2):10-16. https://izlik.org/JA58ZP37TX

Chicago

Ağca, Kübra, Fettah Acıbucu, and Şekure Demet Küçük. 2025. “Preoperative and Early Late Postoperative Evaluation of Endocrine Functions of Patients Who Underwent Pituitary Surgery”. Cumhuriyet Medical Journal 47 (2): 10-16. https://izlik.org/JA58ZP37TX.

EndNote

Ağca K, Acıbucu F, Küçük ŞD (June 1, 2025) Preoperative and Early/Late Postoperative Evaluation of Endocrine Functions of Patients who Underwent Pituitary Surgery. Cumhuriyet Medical Journal 47 2 10–16.

IEEE

[1]K. Ağca, F. Acıbucu, and Ş. D. Küçük, “Preoperative and Early/Late Postoperative Evaluation of Endocrine Functions of Patients who Underwent Pituitary Surgery”, CMJ, vol. 47, no. 2, pp. 10–16, June 2025, [Online]. Available: https://izlik.org/JA58ZP37TX

ISNAD

Ağca, Kübra - Acıbucu, Fettah - Küçük, Şekure Demet. “Preoperative and Early Late Postoperative Evaluation of Endocrine Functions of Patients Who Underwent Pituitary Surgery”. Cumhuriyet Medical Journal 47/2 (June 1, 2025): 10-16. https://izlik.org/JA58ZP37TX.

JAMA

1.Ağca K, Acıbucu F, Küçük ŞD. Preoperative and Early/Late Postoperative Evaluation of Endocrine Functions of Patients who Underwent Pituitary Surgery. CMJ. 2025;47:10–16.

MLA

Ağca, Kübra, et al. “Preoperative and Early Late Postoperative Evaluation of Endocrine Functions of Patients Who Underwent Pituitary Surgery”. Cumhuriyet Medical Journal, vol. 47, no. 2, June 2025, pp. 10-16, https://izlik.org/JA58ZP37TX.

Vancouver

1.Kübra Ağca, Fettah Acıbucu, Şekure Demet Küçük. Preoperative and Early/Late Postoperative Evaluation of Endocrine Functions of Patients who Underwent Pituitary Surgery. CMJ [Internet]. 2025 Jun. 1;47(2):10-6. Available from: https://izlik.org/JA58ZP37TX