Prevalence of Dyslipidemia at Onset and During Follow-Up in Pediatric Patients with Type 1 Diabetes Mellitus

Ayça Bilge Sönmez; Filiz Tütüncüler

doi:10.7197/cmj.1636303

TR EN

Tip 1 Diyabetes Mellitus Olan Pediatrik Hastalarda Tanı ve İzlemde Dislipidemi Prevalansı

Öz

Amaç: Bu çalışmada, tip 1 diabetes mellituslu (T1DM) pediatrik hastalarda tanı anı ile bir yıllık izlem sonundaki dislipidemi prevalansı değerlendirildi ve glisemik kontrolün lipid seviyeleri üzerindeki etkileri incelendi. Materyal ve yöntem: 10-18 yaş aralığındaki 56 (30 erkek, 26 kız) T1DM hastasının verileri retrospektif olarak analiz edildi. En az bir yıl boyunca her üç ayda bir görülen hastaların başlangıçtaki ve bir yıl sonraki lipid profilleri ve glisemik kontrol ile ilgili verileri değerlendirildi. Bulgular: Dislipidemi prevalansı başlangıçtaki %60.7 iken bir yıl sonra anlamlı bir azalma göstererek %26.8'e geriledi (p < 0.001). Takipte hemoglobin A1c (HbA1c), düşük yoğunluklu lipoprotein (LDL) ve trigliserid (TG) düzeyleri başlangıç değerlerine göre anlamlı azalma gösterdi (%7.95 ± 1.73'e karşı %13.45 ± 2.45, 84.07 ± 27.55 mg/dl'ye karşı 94.84 ± 27.87 mg/dl ve 78.75 ± 29.93 mg/dl'ye karşı 105.98 ± 58.95 mg/dl) (p < 0.001, p = 0.007, p = 0.001). Total kolesterol (TK) değerlerinde istatistiksel anlamlılık sınırında azalma görüldü (151.20 ± 25.55 mg/dl'ye karşı 159.79 ± 29.78 mg/dl, p = 0.05). Yüksek yoğunluklu lipoprotein (HDL) seviyeleri anlamlı artış gösterdi (55.60 ± 11.10 mg/dl'ye karşı 49.63 ± 13.46 mg/dl, p < 0.001). Kızların HDL seviyeleri erkeklerden daha yüksekti (60.08 ± 12.37 mg/dl'ye karşı 51.71 ± 8.24 mg/dl, p = 0.004). HbA1c seviyeleri TK, LDL ve TG seviyeleri ile pozitif korelasyon, HDL ile negatif korelasyon gösterdi. Sonuç: Bu çalışma, pediatrik T1DM hastaların bir yıllık izleminde dislipidemi prevalansındaki azalmanın, iyileşen glisemik kontrolle bağlantılı olduğunu vurgulamaktadır. Daha iyi lipid profilleri ve kardiyovasküler riskin azalması için etkili HbA1c yönetimi çok önemlidir.

Anahtar Kelimeler

Prevalence of Dyslipidemia at Onset and During Follow-Up in Pediatric Patients with Type 1 Diabetes Mellitus

Abstract

Objectives: This study assessed the prevalence of dyslipidemia in pediatric patients with type 1 diabetes mellitus (T1DM) at diagnosis and after one year, examining the effects of glycemic control on lipid levels. Material and methods: A retrospective analysis was conducted on 56 T1DM patients (30 males, 26 females) aged 10-18 years. These patients were monitored every three months for at least one year. Data on lipid profiles and glycemic control were collected at baseline and after one year. Results: Dyslipidemia prevalence significantly decreased from 60.7% at baseline to 26.8% after one year (p < 0.001). At follow-up, hemoglobin A1c (HbA1c), low-density lipoprotein (LDL), and triglyceride (TG) levels were significantly lower compared to baseline (7.95 ± 1.73% vs. 13.45 ± 2.45%, 84.07 ± 27.55 mg/dl vs. 94.84 ± 27.87 mg/dl, and 78.75 ± 29.93 mg/dl vs. 105.98 ± 58.95 mg/dl, respectively) (p < 0.001, p = 0.007, p = 0.001). Total cholesterol (TC) also decreased, though the difference was near significance (151.20 ± 25.55 mg/dl vs. 159.79 ± 29.78 mg/dl, p = 0.05). High-density lipoprotein (HDL) levels increased significantly (55.60 ± 11.10 mg/dl vs. 49.63 ± 13.46 mg/dl, p < 0.001). Females had higher HDL levels than males (60.08 ± 12.37 mg/dl vs. 51.71 ± 8.24 mg/dl, p = 0.004). HbA1c levels showed a positive correlation with TC, LDL, and TG, and a negative correlation with HDL. Conclusion: This study highlights a significant reduction in dyslipidemia in pediatric T1DM patients after one year, linked to improved glycemic control. Effective HbA1c management is crucial for better lipid profiles and reduced cardiovascular risk.

Keywords

References

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Details

Primary Language

English

Subjects

Health Services and Systems (Other)

Journal Section

Research Article

Authors

Ayça Bilge Sönmez ^*
0009-0006-0145-9042
Türkiye

Filiz Tütüncüler
0000-0003-3710-288X
Türkiye

Early Pub Date

March 29, 2025

Publication Date

March 29, 2025

Submission Date

February 11, 2025

Acceptance Date

March 13, 2025

Published in Issue

Year 2025 Volume: 47 Number: 1

DOI

https://doi.org/10.7197/cmj.1636303

IZ

https://izlik.org/JA46FZ85PE

Cite

RIS / Bibtex

AMA

1.Sönmez AB, Tütüncüler F. Prevalence of Dyslipidemia at Onset and During Follow-Up in Pediatric Patients with Type 1 Diabetes Mellitus. CMJ. 2025;47(1):26-31. doi:10.7197/cmj.1636303