Overutilization of proton pump inhibitors and H2 receptor antagonists in hospitalized medical patients

Nursel Çalık Başaran; Lale Özışık; Zhaleh Emaratpardaz; Mine Durusu Tanrıover; Serife Gül Öz

doi:10.7197/223.v39i29491.316370

EN TR

Overutilization of proton pump inhibitors and H2 receptor antagonists in hospitalized medical patients

Abstract

Objective: The aim of the study was to determine the frequency of the use of proton pump inhibitors (PPI) and histamine-2 receptor antagonists (H2RA), which are widely used drugs, in the medical wards.

Method: We retrospectively retrieved medical records of the patients who were hospitalized between January 1st and December 31th, 2010 in a tertiary care university hospital internal medicine wards and medical intensive care unit (MICU); one fourth of the cases who used a H2RA or a PPI drugs were randomly selected for the study.

Results: In 2010, half of 4730 patients who admitted to internal medicine wards was ordered a H2RA or a PPI. Of these, 556 patients (25.5%) were evaluated. Majority of the patient (76%) were on PPI. While 90.3% of the patients used a PPI in wards, 74.8% of the patients used a H2RA in the MICU (p<0.001). Sixty-one percent (58/95) of patients who were transferred from the MICU to wards were switched from a H2RA to a PPI without a specific reason. Before admission, 8% of patients was on PPI and 5% on H2RA but at discharge, utilization significantly increased, 79% for PPI and 21% for H2RA (p<0.001).

Conclusions: There is a high rate of acid suppressive therapy usage among hospitalized patients and similarly high rate of prescription at discharge. Further studies are required to evaluate the appropriateness of the utilization of these drugs.

Keywords

Proton pump inhibitor,histamine-2 receptor antagonist,gastrointestinal prophylaxis,internal medicine

Proton pompa inhibitörleri ve H2 reseptör antagonistlerinin iç hastalıkları servislerinde yatmakta olan hastalarda aşırı kullanımı

Öz

Amaç: Hastanede yatmakta olan hastalarda proton pompa inhibitörleri (PPİ) ve histamine-2 reseptör antagonistlerinin (H2RA) kullanılma sıklığı ve tercihine ilişkin veriler yoktur.

İç Hastalıkları servislerinde sık olarak kullanılan PPİ ve H2RA kullanım sıklıklarını belirlemektir.

Yöntem: Retrospektif olarak, 1 Ocak ve 31 Aralık 2010 tarihleri arasında bir üçüncü basamak üniversite hastanesinin İç Hastalıkları servislerinde ve yoğun bakım ünitelerinde (YBÜ) yatırılan hastaların tıbbi kayıtları incelendi; herhangi bir PPİ veya H2RA kullanımı olan olguların dörtte biri rastgele olacak şekilde seçildi.

Bulgular: 2010 yılında, İç Hastalıkları servislerinde yatırılan toplam 4730 hastanın yarısı bir H2RA veya PPİ kullanmıştı. Bunların içinden 556 (%25.5) olgu incelendi. Olguların büyük çoğunluğu (%76) PPİ kullanmaktaydı. Servislerde, PPİ olguların %90.3’ünde kullanılırken, YBÜ’de olguların %74.8’i H2RA kullanmaktaydı (p<0.001). YBÜ’den servislere transfer edilen olguların %61’inde (58/95), herhangi özel bir neden olmadan, H2RA kesilerek PPİ kullanımına geçildiği görüldü. Hastaneye yatmadan önce olguların %8’i PPİ ve %5’i bir H2RA kullanırken, taburculuk sırasında %79 PPİ ve %21 H2RA olacak şekilde kullanım anlamlı şekilde artmıştı (p<0.001).

Sonuç: Hastanede yatmakta olan hastalarda ve taburcu edilirken verilen reçetelerde yüksek oranda asit baskılayıcı tedavi kullanılmaktadır. Bu ilaçların akılcı şekilde kullanılma durumlarını değerlendirmek için ileri araştırmalara ihtiyaç vardır.

Anahtar Kelimeler

Proton pompa inhibitörü,histamine-2 reseptör antagonisti,gastrointestinal profilaksi,İç Hastalıkları,asit baskılayıcı tedavi

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Details

Primary Language

English

Subjects

Health Care Administration

Journal Section

Research Article

Authors

Nursel Çalık Başaran

Lale Özışık

Zhaleh Emaratpardaz

Mine Durusu Tanrıover

Serife Gül Öz

Publication Date

May 16, 2017

Submission Date

March 27, 2017

Acceptance Date

April 25, 2017

Published in Issue

Year 2017 Volume: 39 Number: 2

DOI

https://doi.org/10.7197/223.v39i29491.316370

IZ

https://izlik.org/JA53YG26PS

Cite

RIS / Bibtex

AMA

1.Çalık Başaran N, Özışık L, Emaratpardaz Z, Durusu Tanrıover M, Gül Öz S. Overutilization of proton pump inhibitors and H2 receptor antagonists in hospitalized medical patients. CMJ. 2017;39(2):487-493. doi:10.7197/223.v39i29491.316370

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