MDM2 SNP309 polymorphism in Turkish population

Ayca Taş; İsmail Sari; Tuğba Ağbektaş; Yavuz Siliğ

doi:10.7197/223.v39i32356.369012

EN TR

MDM2 SNP309 polymorphism in Turkish population

Abstract

Objective: Murine double minute 2 (MDM2) gene has a critical role on regulation of p53 tumor suppressor pathway. MDM2 is a major negative regulator of p53 function. MDM2 protein regulates p53 function through multiple independent pathways. The present study aims to determine the frequency of MDM2 gene SNP309 (rs2279744) polymorphism in the Turkish population.

Method: This study included a total of 301 healthy Turkish individuals (159 females (53.0%) and 141 males (47.0%) between 2014 and 2016. The frequency of T309G MDM2 rs2279744 polymorphism was identified using restriction fragment length polymorphism-polymerase chain reaction (RFLP-PCR) method.

Results: The mean age of the study population was 49,80±16,4 years (51,97±15,98 years in men and 47,58±16,82 years in women). Genotype frequencies for MDM2 rs2279744 polymorphism were found to be 17.9% TT, 55.2% TG, and 26.9% GG.

Conclusions: The present study provides information on the allele and genotype frequency distribution of MDM2 gene rs2279744 polymorphism in the Turkish population, which can be used as a reference parameter for the investigation of susceptibility to various disorders, particularly cancer.

Keywords

Murine double minute 2,MDM2,polymorphism,Turkish Population

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Details

Primary Language

English

Subjects

Health Care Administration

Journal Section

Research Article

Authors

Ayca Taş

İsmail Sari

Tuğba Ağbektaş

Yavuz Siliğ

Publication Date

December 18, 2017

Submission Date

September 24, 2017

Acceptance Date

December 4, 2017

Published in Issue

Year 2017 Volume: 39 Number: 4

DOI

https://doi.org/10.7197/223.v39i32356.369012

IZ

https://izlik.org/JA59GP37LW

Cite

RIS / Bibtex

APA

Taş, A., Sari, İ., Ağbektaş, T., & Siliğ, Y. (2017). MDM2 SNP309 polymorphism in Turkish population. Cumhuriyet Medical Journal, 39(4), 644-651. https://doi.org/10.7197/223.v39i32356.369012

AMA

1.Taş A, Sari İ, Ağbektaş T, Siliğ Y. MDM2 SNP309 polymorphism in Turkish population. CMJ. 2017;39(4):644-651. doi:10.7197/223.v39i32356.369012

Chicago

Taş, Ayca, İsmail Sari, Tuğba Ağbektaş, and Yavuz Siliğ. 2017. “MDM2 SNP309 Polymorphism in Turkish Population”. Cumhuriyet Medical Journal 39 (4): 644-51. https://doi.org/10.7197/223.v39i32356.369012.

EndNote

Taş A, Sari İ, Ağbektaş T, Siliğ Y (December 1, 2017) MDM2 SNP309 polymorphism in Turkish population. Cumhuriyet Medical Journal 39 4 644–651.

IEEE

[1]A. Taş, İ. Sari, T. Ağbektaş, and Y. Siliğ, “MDM2 SNP309 polymorphism in Turkish population”, CMJ, vol. 39, no. 4, pp. 644–651, Dec. 2017, doi: 10.7197/223.v39i32356.369012.

ISNAD

Taş, Ayca - Sari, İsmail - Ağbektaş, Tuğba - Siliğ, Yavuz. “MDM2 SNP309 Polymorphism in Turkish Population”. Cumhuriyet Medical Journal 39/4 (December 1, 2017): 644-651. https://doi.org/10.7197/223.v39i32356.369012.

JAMA

1.Taş A, Sari İ, Ağbektaş T, Siliğ Y. MDM2 SNP309 polymorphism in Turkish population. CMJ. 2017;39:644–651.

MLA

Taş, Ayca, et al. “MDM2 SNP309 Polymorphism in Turkish Population”. Cumhuriyet Medical Journal, vol. 39, no. 4, Dec. 2017, pp. 644-51, doi:10.7197/223.v39i32356.369012.

Vancouver

1.Ayca Taş, İsmail Sari, Tuğba Ağbektaş, Yavuz Siliğ. MDM2 SNP309 polymorphism in Turkish population. CMJ. 2017 Dec. 1;39(4):644-51. doi:10.7197/223.v39i32356.369012

MDM2 SNP309 polymorphism in Turkish population

Abstract

Keywords

Türk popülasyonunda MDM2 SNP309 polimorfizmi

Abstract

Keywords

References

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Subjects

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Authors

Publication Date

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Acceptance Date

Published in Issue

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