FOXP3 Promoter polymorphism (-3499 A/G) is not associated with osteoarthritis in a Turkish population

Nilgun Cekin; Ergun Pinarbasi; Gonca Donmez; Aslihan Esra Bildirici; Zekeriya Oztemur; Serdal Arslan; Okay Bulut

doi:10.7197/223.v39i32356.369052

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FOXP3 Promoter polymorphism (-3499 A/G) is not associated with osteoarthritis in a Turkish population

Abstract

Objective: In this study we aimed to find out whether FOXP3 promoter region -3499A/G polymorhism was associated with osteoarthiritis in a Turkish population.

Method: The study group consists of 50 patients in 3rd stage and 100 patients in 4th stage osteoarthiritis and control group consists of 150 healthy individuals. FOXP3 genotypes were examined by PCR-RFLP method.

Results: Our results show that there is no statisticially significant association between osteoarthiritis and FOXP3 -3499A/G polymorphism. The wild type AA genotype was 63%, polymorphic AG was 31% and GG was 6% in the control group, while they were 56%, 37% and 7% in the study group respectively.

Conclusions: Osteoarthiritis was seen higher in women than that of men in our study which is compatible with the results of previous results.

Keywords

FOXP3,Osteoarthritis,promoter,polymorphism

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Details

Primary Language

English

Subjects

Health Care Administration

Journal Section

Research Article

Authors

Nilgun Cekin

Ergun Pinarbasi

Gonca Donmez

Aslihan Esra Bildirici

Zekeriya Oztemur

Serdal Arslan

Okay Bulut

Publication Date

December 18, 2017

Submission Date

August 17, 2017

Acceptance Date

October 30, 2017

Published in Issue

Year 2017 Volume: 39 Number: 4

DOI

https://doi.org/10.7197/223.v39i32356.369052

IZ

https://izlik.org/JA37DP93SW

Cite

RIS / Bibtex

AMA

1.Cekin N, Pinarbasi E, Donmez G, et al. FOXP3 Promoter polymorphism (-3499 A/G) is not associated with osteoarthritis in a Turkish population. CMJ. 2017;39(4):659-664. doi:10.7197/223.v39i32356.369052

FOXP3 Promoter polymorphism (-3499 A/G) is not associated with osteoarthritis in a Turkish population

FOXP3 Promoter polymorphism (-3499 A/G) is not associated with osteoarthritis in a Turkish population

Abstract

Keywords

Türk popülasyonunda FOXP3 geni promotor polimorfizmi (A-3499G) osteoartit ile ilişkili değildir

Öz

Anahtar Kelimeler

References

Details

Primary Language

Subjects

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Authors

Publication Date

Submission Date

Acceptance Date

Published in Issue

DOI

IZ

Cite