Can lymphocyte to monocyte ratio be used as a predictor of atherosclerotic carotid plaques in elderly adults?

Asli Bolayir; Ertugrul Bolayir

doi:10.7197/223.v40i37154.406575

EN TR

Can lymphocyte to monocyte ratio be used as a predictor of atherosclerotic carotid plaques in elderly adults?

Abstract

Introduction: The lymphocyte/ monocyte ratio(LMR), a novel marker of inflammation, has been accepted as a predictor for atherosclerosis. However, the relationship between LMR and carotid atherosclerotic stenosis in older healthy adults remains undefined.

Aim: The aim of our study was to determine retrospectively the association of LMR with carotid stenosis, evaluated by carotid artery doppler ultrasonography.

Materials and Methods: Our study included 102 patients, aged ≥ 65 years,hospitalized in our clinic from January 2011 to December 2017.  Blood samples were taken from all of the patients to determine the levels of white blood cell subtypes. LMR was calculated as the ratio of lymphocyte count to monocyte count. Patients also underwent carotid artery doppler ultrasonography to define the presence of carotid stenosis.

Results:After dividing the patient group into two subgroups according to carotid stenosis, the patients with severe stenosis(carotid stenosis> 50% )(n=42) had lower lymphocyte count and LMR value but higher monocyte count. Then the patient group with carotid stenosis> 50% were divided into two subgroups again. While a statistically significant difference was found between the LMR values of these 3 groups, this difference was in favor of the first group(carotis stenosis ˂50%). The optimum cut-off LMR values was determined as 2.49 with a sensitivity of 72.6% and a specificity of 80.7%.

Conclusion: Lower levels of LMR can be used as a strong predictor of the presence of severe carotid stenosis in elderly adults.

Keywords

white blood cell subtypes,lymphocyte/ monocyte ratio,inflammation,atherosclerosis

Lenfosit/monosit oranı yaşlı erişkinlerde aterosklerotik karotis plaklarınının bir göstergesi olarak kullanılabilir mi?

Öz

Amaç: Bu çalışmadaki amacımız geriye dönük olarak LMO’nun karotis arter doppler ultrasonografi ile saptanmış karotis stenozu ile ilişkisini saptamaktır.

Yöntem: Çalışmamız 65 yaş ve üzerinde, Ocak 2011- Aralık 2017 tarihleri arasında kliniğimizde takip edilen 102 hastayı içermektedir. Tüm hastalardan beyaz küre alt tiplerinin ölçümü için kan örneği alındı. LMO değeri lenfosit sayısının monosit sayısına oranı olarak hesaplandı. Hastalara ayrıca karotis stenozunu saptamak için karotis arter doppler ultrasonografisi de uygulandı.

Bulgular: Hasta grubu karotis stenozu ciddiyetine göre iki alt gruba ayrıldıktan sonra, ciddi darlığı olan hastaların(karotis stenozu> %50)(n=42) daha düşük lenfosit sayısı ve LMO değerine ancak daha yüksek monosit sayısına sahip olduğu saptandı. Daha sonra karotis stenozu %50’nin üzerinde olan hastalar tekrar iki alt gruba ayrıldı. Her üç grup arasında LMO değeri açısından istatistiksel olarak anlamlı fark saptanırken; bu fark birinci grup lehineydi.(karotis stenozu ˂%50). LMO değeri için en iyi kesim noktası %72.6 duyarlılık ve %80.7 seçicilikle 2.49 olarak saptandı.

Sonuç: Düşük LMO seviyeleri yaşlı erişkinlerde ciddi karotis stenozunun varlığı için güçlü bir gösterge olarak kullanılabilir.

Anahtar Kelimeler

Beyaz küre alt tipleri,lenfosit/monosit oranı,inflamasyon,ateroskleroz,karotis arter stenozu;

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Details

Primary Language

English

Subjects

Health Care Administration

Journal Section

Research Article

Authors

Asli Bolayir ^*
Sivas Cumhuriyet University Neurology Department
0000-0001-6566-3751
Türkiye

Ertugrul Bolayir
Türkiye

Publication Date

June 5, 2018

Submission Date

March 15, 2018

Acceptance Date

May 15, 2018

Published in Issue

Year 2018 Volume: 40 Number: 2

DOI

https://doi.org/10.7197/223.v40i37154.406575

IZ

https://izlik.org/JA96TE87UZ

Cite

RIS / Bibtex

AMA

1.Bolayir A, Bolayir E. Can lymphocyte to monocyte ratio be used as a predictor of atherosclerotic carotid plaques in elderly adults? CMJ. 2018;40(2):120-127. doi:10.7197/223.v40i37154.406575

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