The Diagnostic Contribution of (18)F-FDG PET/CT Scan in Cancer of Unknown Primary

Serdar Savaş Gül

doi:10.7197/223.vi.412273

EN TR

The Diagnostic Contribution of (18)F-FDG PET/CT Scan in Cancer of Unknown Primary

Abstract

OBJECTIVE: The aim of the present study was to evaluate the clinically diagnostic contribution of ¹⁸F-fluorodeoxyglucose positron emission tomography combined with computed tomography(¹⁸F-FDG PET/CT) in patients with cancer of unknown primary (CUP).

METHODS: The retrospective investigation, cross-sectional analysis of 124 ¹⁸F-FDG PET/CT scans of patients with CUP between June 2014 and July 2015 was performed. The increased ¹⁸F-FDG uptake focus were assessed in correlation with histopathology. The diagnostic accuracy, sensitivity, specificity, positive predictive value and negative predictive values were assessed for ¹⁸F-FDG PET/CT.

RESULTS: The ¹⁸F-FDG PET/CT successfully detected primary tumor in 56 patients with high ¹⁸F-FDG uptake involvement (true positive, 45.2%). 58 patients whose final histopathology and clinically without evidence of a primary tumor (true negative, 46.8%). 8 patients whose final histopathologicallyand clinically without evidence of a primary tumor but high ¹⁸F-FDG uptake involvement (false positive, 6.4%). The ¹⁸F-FDG PET/CT scan results were negative for primary site localization in only 2 patients with no ¹⁸F-FDG uptake involvement (false negative, 1.6%). Generally, the diagnostic accuracy was found to be 91.9%, sensitivity 96.5%, specificity 87.8%, positive predictive value 87.5%, negative predictive value 96.6%, positive likelihood ratio 7.9% and negative likelihood ratio 0.04%.

CONCLUSION: It can be said that ¹⁸F-FDG PET/CT may be useful in the diagnosis of patients with CUP.

Keywords

cancer of unknown primary,(18)F-FDG,PET/CT,sensitivity,specificity

Primeri Bilinmeyen Kanserde F(18)-FDG PET/BT Tetkikinin Tanıya Katkısı

Öz

GİRİŞ: Bu çalışmanın amacı, primeri bilinmeyen kanser (PBK) hastalarında 18F-florodeoksiglukoz pozitron emisyon tomografisi/bilgisayarlı tomografinin (F18-FDG PET/BT) klinik olarak tanıya katkısını değerlendirmektir.

YÖNTEM: Retrospektif, kesitsel analiz çalışmasında Haziran 2014-Temmuz 2015 tarihleri arasında 124 PBK hastalarının F18-FDG PET/BT incelemesi yapıldı. Artmış 18F-FDG tutulum odağının histopatoloji ile korelasyonu değerlendirildi. F18-FDG PET/BT için tanısal doğruluk, duyarlılık, özgüllük, pozitif öngörü değeri ve negatif öngörü değerleri hesaplandı.

BULGULAR: F18-FDG PET/BT, yüksek F18-FDG tutulumu olan 56 hastada primer tümör odağını başarıyla saptadı (gerçek pozitif, % 45.2). 58 hastada histopatolojik ve klinik olarak primer tümör bulunamadı (gerçek negatif, % 46.8). 8 hastada yüksek F18-FDG uptake tutulumu olmasına karşın histopatolojik ve klinik olarak primer tümör kanıtı yoktu (yanlış pozitif, % 6.4). Sadece 2 hastada negatif F18-FDG PET/BT tarama sonuç bulunmasına karşın primer tümör histopatolojik olarak saptandı (yanlış negatif, % 1.6) primer yerleşim lokalizasyonu için negatif idi. Genel olarak tanısal doğruluk % 91.9, duyarlılık % 96.5, özgüllük % 87.8, pozitif öngörü değeri % 87.5, negatif öngörü değeri % 96.6, pozitif olabilirlik oranı % 7.9 ve negatif olabilirlik oranı % 0.04 olarak bulundu.

SONUÇ: PBK hastalarının tanısında F18-FDG PET/BT’nin yararlı olabileceği düşünülebilir.

Anahtar Kelimeler

primeri bilinmeyen kanser,F18-FDG PET/BT,duyarlılık,özgüllük

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Details

Primary Language

English

Subjects

Health Care Administration

Journal Section

Research Article

Authors

Serdar Savaş Gül ^*
0000-0003-4822-2588
Türkiye

Publication Date

September 30, 2018

Submission Date

April 3, 2018

Acceptance Date

July 31, 2018

Published in Issue

Year 2018 Volume: 40 Number: 3

DOI

https://doi.org/10.7197/223.vi.412273

IZ

https://izlik.org/JA24RB47MM

Cite

RIS / Bibtex

AMA

1.Gül SS. The Diagnostic Contribution of (18)F-FDG PET/CT Scan in Cancer of Unknown Primary. CMJ. 2018;40(3):238-245. doi:10.7197/223.vi.412273