The role of plasma exchange in hyperbilirubinemia from a different perspective
Abstract
Objective: In this retrospective study, we aimed to present our experience of managing hyperbilirubinemia.
Method: Twenty three patients with hyperbilirubinemia who received apharesis treatment between 2006 and 2017 at the apheresis unit of Cumhuriyet University School of Medicine were included in the study. Records of the patients were evaluated retrospectively and the following data were collected: patient’s age, sex, presenting symptoms, number of plasma exchange, adjuvant treatment modalities, use of replacement fluid, treatment outcomes, and plasma exchange complications.
Results: The median age of the patients was 57 years (range; 18-82). The median number of plasma exchange was 5,5 (range; 1-25). Fresh frozen plasma was the only replacement fluid used. There was significant statistical differences between pre- and post-plasma exchange bilirubine levels (p<0.05). Toxic hepatitis was the most common cause of hyperbilirubinemia in our patient population. In addition to plasma exchange, patients were treated with proper treatment of the underlying condition. We observed allergic reactions 2 (8.69%) patients and hypotension in 3 (13%) patients as complications
Conclusions: Plasma exchange is a safe method for the elimination of bilirubin. However, diminishing hyperbilirubinemia with plasma exchange together with the proper treatment of the underlying condition should be the primary goal in management.
Keywords
References
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Details
Primary Language
English
Subjects
Health Care Administration
Journal Section
Research Article
Authors
Hatice Terzi
*
Türkiye
Serdal Korkmaz
Türkiye
Mehmet Şencan
Türkiye
Özlem Yönem
Türkiye
Abdulkerim Yılmaz
Türkiye
Hilmi Ataseven
Türkiye
Publication Date
March 28, 2019
Submission Date
September 2, 2018
Acceptance Date
March 26, 2019
Published in Issue
Year 2019 Volume: 41 Number: 1