The distribution of FV Leiden gene mutation in patients with obstructive sleep apnea

Taha T. Bekçi; Nadir Koçak; Filiz Özen; Turgut Teke

EN TR

The distribution of FV Leiden gene mutation in patients with obstructive sleep apnea

Abstract

Abstract

Aim. We aimed to investigate whether this polymorphism has any effects on the development of the differences in the progression of the OSAS patients. Methods. The patient group was selected from patients admitted to the our Sleep Laboratory. Total 122 subjects, 44 OSAS patients (only), 32 OSAS patients with cardio vascular diseases (CVD) and 46 controls, were enrolled in the study. The control group consisted of healthy volunteers who had no symptoms of OSAS and scored 0 on the Epworth sleepiness scale. In order to determine gene mutations, DNA isolation was performed from peripheral blood samples. Results. While mean weight and BMI were significantly different, no significant differences were found between patient and control groups in terms of FV Leiden allele distributions. Conclusion. FV Leiden mutation does not affect progression in patients with OSAS

Keywords: Obstructive sleep apnea, polymorphism, mutation

Özet

Amaç. Bu çalışmada OSAS hastalarının progresyonunda farklılıklar oluşmasında FV Leiden polimorfizminin herhangi bir etkisi olup olmadığını araştırmayı amaçladık. Yöntem. Hasta grubu uyku laboratuvarımıza başvuran hastalardan seçildi. Toplam 122 kişi ( 44 OSAS hastası (yalnızca), 32 kardiyovasküler hastalığı (KVH) olan OSAS hastası ve 46 kontrol grubu) çalışmamıza katıldı. Kontrol grubu OSAS semptomları bulunmayan, Epworth uykusuzluk skalası 0 olan sağlıklı gönülülerden oluşturuldu. Gen mutasyonlarını belirlemek için DNA izolasyonu periferik kandan yapıldı. Bulgular. BMI ve ağırlık ortalamaları önemli oranda farklıyken, FV Leiden allel dağılımları açısından hasta ve kontrol grupları arasında önemli bir farklılık bulunamadı. Sonuç. FV Leiden mutasyonu OSAS hastalarında progresyonu etkilememektedir

Anahtar sözcükler: Obstruktif uyku apnesi, polimorfizm, mutasyon

Keywords

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References

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Details

Primary Language

English

Subjects

-

Journal Section

-

Authors

Taha T. Bekçi

Nadir Koçak

Filiz Özen

Turgut Teke

Publication Date

March 11, 2010

Submission Date

December 9, 2009

Acceptance Date

-

Published in Issue

Year 2010 Volume: 32 Number: 1

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https://izlik.org/JA57MS23JS

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RIS / Bibtex

AMA

1.Bekçi TT, Koçak N, Özen F, Teke T. The distribution of FV Leiden gene mutation in patients with obstructive sleep apnea. CMJ. 2010;32(1):61-66. https://izlik.org/JA57MS23JS

The distribution of FV Leiden gene mutation in patients with obstructive sleep apnea

The distribution of FV Leiden gene mutation in patients with obstructive sleep apnea

Abstract

Keywords

Obstruktif uyku apneli hastalarda FV Leiden mutasyonun dağılımı

Öz

Anahtar Kelimeler

References

Details

Primary Language

Subjects

Journal Section

Authors

Publication Date

Submission Date

Acceptance Date

Published in Issue

IZ

Cite