The myocardial infarction in a young woman with heterozygous MTHRF and PAI-1 gene mutations
Abstract
Myocardial infarction in young patient accounts for 6% of all myocardial infarctions. Unlike older patients, the cause of the myocardial infarction in approximately 20% of young patients is not related to atherosclerosis. In this study, we report a case of myocardial infarction at a young woman who do not have classical risk factors for coronary artery disease, however, who was heterozygous for the methylene tetrahydrofolate reductase C677T/G gene mutation and plasminogen activator inhibitor- 1 4G/5G gene variant. Urgent coronary angiography revealed multi-vessel coronary disease, severe stenosis of the proximal left anterior descending artery, total occlusion of the first diagonal artery, and severe stenosis of the proximal circumflex artery. The lesions were thought to be not suitable for percutaneous revascularization and coronary by-pass surgery was performed. The postoperative course was uneventful and she was discharged on 8th day. In conclusion, coronary artery disease in young patient especially without classical risk factors, we suggest that prothrombotic factors should be evaluated.
Keywords
References
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Details
Primary Language
English
Subjects
Health Care Administration
Journal Section
Research Article
Publication Date
May 13, 2010
Submission Date
May 13, 2010
Acceptance Date
-
Published in Issue
Year 2010 Volume: 32 Number: 2