Trombosit fonksiyon testlerini etkileyen faktörler
Abstract
Özet
Fizyolojik koşullarda sirkülasyondaki trombositlerin görevi bir damar hasarı oluştuğunda kan kaybını engellemektir. Subendotele trombosit-trombosit adezyonunu sağlayan ve hasara uğramış damar duvarında geçici olarak “trombosit tıkacı” oluşturan bu sistem ateroskleroz veya arterial tromboz gibi patolojik şartlarda ise lokal iskemiye veya aterosklerotik lezyona sebep olmaktadır. Klinik çalışmalarda temel alınan trombosit fonksiyon testleri trombositlerin agonistlere olan duyarlığı ve oluşan trombosit cevabındaki spesifiklik açısından öneme sahiptir. Bu çalışmada trombosit fonksiyon testlerini etkileyen parametreler, yapılmış çalışmalarla karşılaştırmalı olarak incelenmiştir.
Anahtar sözcükler: Trombosit, trombosit fonksiyonu, agonist
Abstract
Under physiological conditions the function of thrombocytes in circulation is to inhibit the blood loss upon endothelial damage. This system which establishes thrombocyte adhesion to sub-endothelium and forms temporary thrombocyte plug at the damaged endothelial wall causes ischemia or atherosclerotic lesions under pathological conditions such as atherosclerosis and arterial thrombosis. The thrombocyte function tests which are taken as basis for clinical studies, are important in determining the sensitivity of thrombocytes to agonists and specificity of thrombocyte answer. In this study, the parameters affecting thrombocyte function tests are examined comparatively with literature results.
Keywords: Thrombocyte, thrombocyte function, agonistKeywords
References
- Chan ER, Lavender H, Li G, Haviernik P, Bunting KD, Adams MD. An ENU- induced recessive mutation in Mpl leads to thrombocytopenia with overdominance. Exp Hematology 2009; 37: 276-84.
- Youssefian T, Drouin A, Massé JM, J Guichard J, Cramer EM. Host defense role of platelets: engulfment of HIV and Staphylococcus aureus occurs in a specific subcellular compartment and is enhanced by platelet activation. Blood 2002; 99: 4021-9.
- Battinelli E, Willoughby SR, Foxall T, Valeri CR, Loscalzo J. Induction of platelet formation from megakaryocytoid cells by nitric oxide. Proc Natl Acad Sci USA 2001; 98: 14458-63.
- Bendayan M, Rasio EA. Evidence of a tubular system for transendothelial transport in arterial capillaries of the rete mirabile. J Histochem Cytochem 1997; 45: 1365-78.
- Anitua E, Andia I, Ardanza B, Nurden P, Nurden AT. Autologous platelets as a source of proteins for healing and tissue regeneration. Thromb Haemost 2004; 91: 4-15.
- Mannaioni PF, Di Bello MG, Masini E. Platelets and inflammation: Role of platelet-derived growth factor, adhesion molecules and histamine. Inflamm Res 1997; 46: 4-18.
- Willoughby S, Holmes A, Loscalzo J. Platelets and cardiovascular disease. Eur J Cardiovasc Nurs 2002; 1: 273-88.
- Varga-Szabo D, Pleines I, Nieswandt B. Cell adhesion mechanisms in platelets. Arterioscler Thromb Vasc Biol 2008; 28: 403-12.
Details
Primary Language
English
Subjects
-
Journal Section
-
Publication Date
March 27, 2012
Submission Date
October 4, 2010
Acceptance Date
-
Published in Issue
Year 1970 Volume: 34 Number: 1