Leptomeningeal carcinomatosis in a younger patient with signet-ring cell carcinoma
Abstract
Abstract
Leptomeningeal metastasis (LMM) occurs in about 3-8% of patients with systemic cancer. It is very rare in patients with signet-ring cell carcinoma. But, the prognosis is also very poor. We report a case of a younger woman with signet-ring cell carcinoma of primary origin unknown who presented with meningeal carcinomatosis.
Keywords: Leptomeningeal metastasis; signet-ring cell carcinoma; prognosis.
Özet
Leptomenengeal metastazlar, sistemik kanserli hastaların yaklaşık %3-8’inde oluşur. Bu, signet-ring hücreli karsinomu olan hastalarda çok nadirdir. Ama, prognoz da çok kötüdür. Meningeal karsinomatozisi olan ve birincil orjini bilinmeyen signet-ring hücreli karsinomu olan genç bir bayan olguyu bildiriyoruz.
Anahtar sözcükler: Leptomeningeal karsinomatozis; taşlı yüzük hücreli karsinom; prognoz.Keywords
References
- Posner JB, Chernik NL. Intracranial metastases from systemic cancer. Adv Neurol 1978; 19: 579-92.
- De Angelis LM. Current diagnosis and treatment of leptomeningeal metastasis. J Neuro- Oncol 1998; 38: 245-52
- De Angelis LM, Boutros D. Leptomeningeal metastasis. Cancer Invest 2005; 23: 145-54.
- Wasserstrom WR, Glass JP, Posner JB. Diagnosis and treatment of leptomeningeal metastases from solid tumors: experience with 90 patients. Cancer 1982; 49: 759-72
- Grant R, Naylor B, Greenberg HS, Junck L. Clinical outcome in aggressively treated meningeal carcinomatosis. Arch Neurol 1994; 51: 457-61
- Grossman SA, Krabak MJ. Leptomeningeal carcinomatosis. Cancer Treat Rev 1999; 25: 103-19.
- Kim DY, Lee KW, Yun T, Park SR, Jung JY, Kim DW, Kim TY, Heo DS, Bang YJ, Kim NK. Comparison of intrathecal chemotherapy for leptomeningeal carcinomatosis of a solid tumor: methotrexate alone versus methotrexate in combination with cytosine arabinoside and hydrocortisone. Jpn J Clin Oncol 2003; 33: 608-12.
- Fuchizaki U, Ohta H, Kaneko S. Image of the month. Gastric signet-ring-cell carcinoma with leptomeningeal carcinomatosis. Gastroenterology 2005; 128: 1773.
Details
Primary Language
English
Subjects
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Journal Section
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Publication Date
September 27, 2011
Submission Date
October 28, 2010
Acceptance Date
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Published in Issue
Year 2011 Volume: 33 Number: 3