Epitel hücre anormalliği saptanan servikal smear olgularında sitolojik tanı dağılımı ve sito-histopatolojik korelasyon

Hatice Özer; Ersin Tuncer; Ayşe Çiftçi; Hande Keser; Handan Aker; Şahande Elagöz; Abdullah Boztosun

TR

Epitel hücre anormalliği saptanan servikal smear olgularında sitolojik tanı dağılımı ve sito-histopatolojik korelasyon

Öz

Özet

Amaç. Anabilim Dalı’mızda incelenen ve epitel hücre anormalliği saptanan servikovajinal smear sonuçlarının değerlendirilmesi ve histopatolojik incelemesi bulunan olgularda sito-histopatolojik korelasyonun araştırılması. Yöntem. Ocak 2008-Mayıs 2011 tarihleri arasında Cumhuriyet Üniversitesi Tıp Fakültesi Patoloji Anabilim Dalı’na gönderilen ve 2001 Bethesda sistemine göre tanı alan toplam 8102 servikal smear örneğine ait raporlar retrospektif olarak incelendi. Epitel hücre anormalliği tesbit edilen 97 olgu çalışmaya dahil edildi. Bunlardan histopatolojik incelemesi olan 25 olguda sito-histopatolojik korelasyon araştırıldı. Bulgular. Toplam 8102 servikal smear’in 97’sinde (%1.19) epitel hücre anormalliği saptandı. Epitel hücre anormalliği saptanan olguların 54’ü (%55.6) ASC-US, 14’ü (%14.4) ASC-H, 14’ü (%14.4) LSIL, 5’i (%5,2) HSIL, 5’i (%5,2) SCC, 3’ü (%3.1) AGC ve 2’si (%2.1) adenokarsinom, NOS olarak tanı almış idi. Bunlardan biyopsi tanısı olan 25 olgunun 10’unun (%40) nonneoplastik, 2’sinin CIN I (%8), 1’inin (%4) CIN II, 3’ünün (%12) CIN III ve 9’unun (%36) invaziv karsinom olarak rapor edildiği saptandı. Bu sonuçlara göre ASC-US, ASC-H, LSIL, HSIL, SCC, AGC ve adenokarsinomun pozitif öngörme değeri sırasıyla %0, %50, %100, %80, %100, %0 ve %100 olarak saptandı. Sonuç. Servikal smear’ de verilen karsinom, HSIL ve LSIL tanıları yüksek pozitif öngörme değerine sahip iken, serimizde bu değer ASC-US ve AGC tanıları için düşük bulunmuş, ancak bu gruplarda takipli olgu sayısının çok az olması nedeniyle bu sonuç güvenilir kabul edilmemiştir.

Anahtar sözcükler: Servikal smear, sito-histopatolojik korelasyon, epitel hücre anormalliği

Abstract

Aim. To evaluate the cervicovaginal smears with epithelial cell abnormality examined in our department and to investigate the cyto-histopathological correlation of these cases with their histopathological diagnoses. Method. The reports of cervical smears diagnosed according to 2001 Bethesda System in Cumhuriyet University, Faculty of Medicine, Pathology Department between January 2008 and May 2011 were reviewed retrospectively (n: 8102). Among them, cases with epithelial cell abnormality (n: 97) were included in the study. In 25 of these patients having also histopathological examinations, cyto-histopathological correlation was investigated. . Results. Epithelial cell abnormality was detected in 97 (1.19) out of 8102 cervical smears. In the cytopathological examination, 54 patients (55.6%) had ASC-US, 14 had (14.4%) ASC-H, 14 had (14.4%) LSIL, five had (5.2%) HSIL, five had (5.2%) squamous cell carcinoma (SCC), three had (3.1%) atypical glandular cells (AGC) and two had (2.1%) adenocarcinoma, NOS. Histopathological results of 25 patients revealed that 10 patients had (40%) nonneoplastic, two had CIN I (8%), one had (4%) CIN II, three had (12%) CIN III and nine had (36%) malignant lesion. The positive predictive values for the cases with diagnoses of ASC-US, ASC-H, LSIL, HSIL, SCC, AGC and adenocarcinoma were 0%, 50%, 100%, 80%, 100%, 0% ve 100%, respectively. Conclusion. Eventhough the positive predictive values in diagnosis of carcinoma, HSIL, and LSIL had been high, those values were found to be low in diagnosis of ASC-US and AGC in our series, but since the number of follow-up cases were very few in these groups this result was accepted as not reliable.

Keywords: Cervical smear, cyto-histopathological correlation, epithelial cell abnormality

Anahtar Kelimeler

Servikal smear, sito-histopatolojik korelasyon, epitel hücre anormalliği

References

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Details

Primary Language

Turkish

Subjects

-

Journal Section

-

Authors

Hatice Özer

Ersin Tuncer

Ayşe Çiftçi

Hande Keser

Handan Aker

Şahande Elagöz

Abdullah Boztosun

Publication Date

January 24, 2012

Submission Date

January 24, 2012

Acceptance Date

-

Published in Issue

Year 2012 Volume: 34 Number: 3

IZ

https://izlik.org/JA97CM66PH

Cite

RIS / Bibtex

AMA

1.Özer H, Tuncer E, Çiftçi A, et al. Epitel hücre anormalliği saptanan servikal smear olgularında sitolojik tanı dağılımı ve sito-histopatolojik korelasyon. CMJ. 2012;34(3):319-324. https://izlik.org/JA97CM66PH