Documentation of cervical cytological findings in Çankırı population
Abstract
Abstract
Aim. Cervical cancer is one of the most common female malignancy with high mortality rates in developing countries. Our purpose is to present cervical cytologic abnormalities and the detection rate of epithelial abnormalities by cervical cytology (CC). Method. A total of 8972 conventional pap smear tests collected between August 2010 and August 2012 from Çankırı State Hospital were retrospectively analyzed and results were based on the 2001 Bethesda system. Results. Total of 129 (1.4%) cases had epithelial abnormalities. The numbers and rates of epithelial abnormalities were as the followings: Atypical squamous cell of undetermined significance (ASCUS; n=75 [0.8%]); atypical squamous cell suspicious for high-grade squamous intraepithelial lesion (ASC-H; n=10 [0.11%]); atypical glandular cell of undetermined significance (AGUS; n=8 [0.08%]); low- grade squamous intraepithelial lesion (LSIL; n=22 [0.24%]); high-grade squamous intraepithelial lesion (HSIL; n=14 [0.15%]). Conclusion. The prevelence of cervical cytological abnormality in our study was 1.4% and the most of them were diagnosed as atypical squamous cell of undetermined significance (ASCUS). Our results partly correspond with the studies that were carried out on the large amounts of Turkish population.
Keywords: Cervical cancer, cytology, PAP smear
Özet
Amaç. Serviks kanseri gelişmekte olan ülkelerde kadınlarda yüksek mortalite oranına sahip en sık görülen malignitedir. Çalışmadaki amacımız Çankırı popülasyonunda servikal sitoloji materyallerinde epitelyal anormalliklerin saptanması ve dökümante edilmesidir. Yöntem. Çalışmada Çankırı Devlet Hastanesinde 2010-2012 ağustos tarihleri arasında toplanmış 8972 servikal pap smear retrospektif olarak 2001 Bethesda sistemi esas alınarak değerlendirilmiştir. Bulgular. Toplam 129 vakada (%1,4) epitelyal anormalite izlenmiş, bunların 75’inde (%0,8) önemi belirlenemeyen atipik skuamöz hücreler (ASCUS), 10’unda (%0,11) yüksek gradeli atipik intraepitelial lezyon şüpheli atipik skuamöz hücreler (ASC-H), 8’inde (%0,08) önemi belirlenemeyen atipik glandüler hücreler (AGUS), 22’sinde (%0,24) düşük dereceli skuamöz intraepitelyal lezyon (LSIL), 14’ünde (%0,15) yüksek dereceli skuamöz intraepitelyal lezyon (HSIL) saptanmıştır. Sonuç. Çalışmamızda servikal sitolojik anormalite prevalansı %1,4 olarak bulunmuş, bunlar arasında en yüksek oranı önemi belirlenemeyen atipik skuamoz hücrelerin (ASCUS) oluşturduğu saptanmıştır. Sonuçlar Türkiye genelinde daha geniş popülasyonda yapılan mevcut çalışmalarla kısmen örtüşmektedir.
Anahtar sözcükler: Servikal kanser, sitoloji, PAP smear
Keywords
References
- Pisani P, Parkin DM, Bray F, Ferlay J. Estimates of the worldwide mortality from 25 cancers in 1990. Int J Cancer 1999; 83: 18-29.
- Ferlay J, Bray F, Pisani P, Parkin DM. Cancer incidence, mortality and prevalence worldwide. Lyon, France: International agency for research on cancer (IARC); Cancer Base 2002.
- Yılmaz HH, Yazıhan N, Tunca D, Sevinç A, Olcayto EÖ, Ozgül N, Tuncer M. Cancer trends and Incidence and mortality patterns in Turkey. Jpn J Clin Oncol 2011; 41: 10-6.
- Karnon J, Peters J, Platt J, Chilcott J, McGoogan E, Brewer N. Liquid-based cytology in cervical screening: An updated rapid and systematic review and economic analysis. Health Technol Assess 2004; 8: iii, 1-78.
- Boyle P, Ferlay J. Cancer incidence and mortality in Europe, 2004. Ann Oncol 2005; 16: 481-8.
- Gustafsson L, Pontén J, Bergström R, Adami HO. International incidence rates of invasive cervical cancer before cytological screening. Int J Cancer 1997; 71: 159- 65.
- Dorn HF, Cutler SJ. Morbidity from cancer in the United States. Public health monograph, Washington, DC: US Department of Health, Education, and Welfare; 1959.
- Sadjadi A, Malekzadeh R, Derakhshan MH, Sepehr A, Nouraie M, Sotoudeh M, Yazdanbod A, Shokoohi B, Mashayekhi A, Arshi S, Majidpour A, Babaei M, Mosavi A, Mohagheghi MA, Alimohammadian M Cancer occurrence in Ardabil: results of a population-based cancer registry from Iran. Int J Cancer 2003; 107: 113-8.
Details
Primary Language
English
Subjects
-
Journal Section
-
Publication Date
August 23, 2012
Submission Date
August 23, 2012
Acceptance Date
-
Published in Issue
Year 2012 Volume: 34 Number: 4